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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Peter Mombaerts, The Rockefeller University Description
The coding region of the olfactory receptor Olf151 was replaced by that of the mouse olfactory receptor Olfr16. Olfactory sensory neurons that express the mutated locus co-express taulacZ by virtue of IRES-mediated co-translation. These neurons can be revealed by histochemistry of beta-galactosidase enzymatic activity, or by immunofluorescence with anti-beta-galactosidase antibodies.Development
The Olfr151tm12(Olfr16)Mom mutation was generated in 129P2/OlaHsd derived E14 ES cells. To excise the loxP-flanked neomycin resistance sequence, the resulting mouse was bred with a mouse carrying an EIIa-cre transgene (Lakso et al. 1996, Proceedings of the National Academy of Sciences, v93 p5860), a transgene generated in FVB/N but having been backcrossed at least four generations to C57BL/6 before this cross and having unknown pedigree prior to that. The resulting mice, lacking the neomycin resistance cassette, were intercrossed and homozygotes were selected that were devoid of the EIIa-cre transgene.
Related Strains
Strains carrying other alleles of Olfr151
View Strains carrying other alleles of Olfr151 (29 strains)
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Olfr151tm12(Olfr16)Mom/Olfr151tm12(Olfr16)Mom
involves: 129P2/OlaHsd * C57BL/6
- nervous system phenotype
- *normal* nervous system phenotype (MGI Ref ID J:91160)
- glomeruli in the olfactory bulb converge normally
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Olfr151tm12(Olfr16)Mom | ||
|---|---|---|---|
| Allele Name | targeted mutation 12, Peter Mombaerts | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | MOR23-M71-IRES-taulacZ; MOR23-M71-LacZ; | ||
| Mutation Made By | Peter Mombaerts, The Rockefeller University | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Olfr151, olfactory receptor 151 | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | GA_x6K02T2PVTD-31408136-31407207; M71; MOR171-2; OR11-318; OST025; | ||
| Molecular Note | The coding region was replaced with Olfr16 followed by an IRES-taulacZ. Olfr16 was expressed and Xgal staining indicated lacZ expression. [MGI Ref ID J:91160] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Feinstein P; Bozza T; Rodriguez I; Vassalli A; Mombaerts P. 2004. Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor. Cell 117(6):833-46. [PubMed: 15186782] [MGI Ref ID J:91160]
Additional References
Olfr151tm12(Olfr16)Mom relatedZou DJ; Chesler AT; Le Pichon CE; Kuznetsov A; Pei X; Hwang EL; Firestein S. 2007. Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice. J Neurosci 27(25):6675-83. [PubMed: 17581954] [MGI Ref ID J:122798]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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Contact information
General inquiries
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