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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6;129P2-Olfr151tm24(mOlfr2)Mom/MomJ (Changed: 08-FEB-07 ) Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Peter Mombaerts, The Rockefeller University Description
The coding region of the Olfr151 olfactory receptor was replaced by that of the mouse Olfr2 olfactory receptor. Olfactory sensory neurons that express the mutated locus co-express both GFP and taulacZ by virtue of IRES-mediated co-translation. These neurons can be revealed by the intrinsic fluorescence of GFP, by immunofluorescence with anti-GFP antibodies, by histochemistry of beta-galactosidase enzymatic activity, or by immunofluorescence with anti-beta-galactosidase antibodies. Although endogenous Olfr2 is normally expressed in the most ventral zone of the olfactory epithelium, this mutation redirects neurons to the most dorsal zone. These neurons respond to octanal.Development
The Olfr151tm24(mOlfr2)Mom mutation was generated in 129P2/OlaHsd derived E14 ES cells and the ACNf neomycin resistance cassette was self-excised by cre-recombination in the germline of male chimeras. This line was subsequently bred to C57BL/6J, bred to homozygosity and maintained on a segregating background.
Related Strains
Strains carrying other alleles of Olfr151
View Strains carrying other alleles of Olfr151 (29 strains)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Olfr151tm24(Olfr2)Mom | ||
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| Allele Name | targeted mutation 24, Peter Mombaerts | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | mI7-M71-IRES-tauGFP; | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Gene Symbol and Name | Olfr151, olfactory receptor 151 | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | GA_x6K02T2PVTD-31408136-31407207; M71; MOR171-2; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Olfr151tm24(Olfr2)Mom, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Additional References
Olfr151tm24(Olfr2)Mom relatedBozza T; Feinstein P; Zheng C; Mombaerts P. 2002. Odorant receptor expression defines functional units in the mouse olfactory system. J Neurosci 22(8):3033-43. [PubMed: 11943806] [MGI Ref ID J:76148]
Yan Z; Tan J; Qin C; Lu Y; Ding C; Luo M. 2008. Precise circuitry links bilaterally symmetric olfactory maps. Neuron 58(4):613-24. [PubMed: 18498741] [MGI Ref ID J:145291]
Health & husbandry
Health & Colony Maintenance Information
Currently there no information available for this strain. This may be due to the supply level of this strain.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
| Pricing for International shipping destinations |
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Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Additional Supply Details
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Supply Details
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
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| Supply Notes |
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Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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