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General Terms and Conditions	Additional Licensing and Use Restrictions

Strain Common Names	OMP-GFP;
Genes & Alleles	GFP;   Omp;   Omptm3Mom;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Targeted Mutation Mating System Heterozygote x Heterozygote         (Female x Male) Species laboratory mouse Donating Investigator Peter Mombaerts,   The Rockefeller University Generation N?+F1 (19-DEC-07)

Strain Description
The coding region and part of the 3' non-translated region of the Omp gene was replaced by GFP. The targeted mutation results in a knockout. Mature olfactory sensory neurons express GFP at high levels. These neurons can be revealed by the intrinsic fluorescence of GFP, or by immunofluorescence with anti-GFP antibodies. Homozygous mice are subfertile.

Strain Development
This mutation was generated in 129P2/OlaHsd derived E14 ES cells, the loxP flanked tk-neo cassette was excised by transient transfection of a plasmid expressing Cre recombinase, and the resulting mice were bred to C57BL/6 before intercrossing to homozygosity.

Mammalian Phenotype Terms assigned by genotype Omptm3Mom/?         involves: 129P2/OlaHsd * C57BL/6 no phenotypic analysis *normal* no phenotypic analysis (J:115857) mice were used to trace olfactory sensory neurons

Gene & Allele Details

Allele Symbol		Omptm3Mom
Allele Name		targeted mutation 3, Peter Mombaerts
Common Name(s)		OMP-GFP;
Mutation Made By		Peter Mombaerts,   The Rockefeller University
Strain of Origin		129P2/OlaHsd
ES Cell Line Name		E14
ES Cell Line Strain		129P2/OlaHsd
Expressed Gene		GFP, Green Fluorescent Protein, jellyfish
		Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. The original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source.
Gene Symbol and Name		Omp, olfactory marker protein
Chromosome		7
Molecular Note		The coding sequence was replaced with a GFP-LTNL sequence and the LTNL cassette was recombined out through the transfection of the targeted ES cells with cre recombinase. [J:73384]

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

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006041	129-Gt(ROSA)26Sortm3Luo/J
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006080	B6.129-Gt(ROSA)26Sortm2Luo/J
006075	B6.129-Gt(ROSA)26Sortm3Luo/J
006412	B6.129-Il12btm1Lky/J
005582	B6.129P-Cx3cr1tm1Litt/J
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006864	B6.Cg-Tg(Ins1-EGFP)1Hara/J
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006361	B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
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007901	B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J
007911	B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J
007921	B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
003710	B6.Cg-Tg(Thy1-CFP)23Jrs/J
007940	B6.Cg-Tg(Thy1-CFP/COX8A)C1Lich/J
007612	B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J
007615	B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J
005630	B6.Cg-Tg(Thy1-EYFP)15Jrs/J
003709	B6.Cg-Tg(Thy1-YFP)16Jrs/J
005627	B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J
003782	B6.Cg-Tg(Thy1-YFPH)2Jrs/J
007606	B6.Cg-Tg(Thy1-cre/ESR1,-EYFP)AGfng/J
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006000	B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
004509	B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
006417	B6.FVB-Tg(Npy-hrGFP)1Lowl/J
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004858	B6;129S1-Tshrtm1Rmar/J
007843	B6;129S4-Efnb2tm2Sor/J
008214	B6;129S4-Pou5f1tm2Jae/J
006614	B6;CB-Tg(Thy1-CFP/COX8A)C1Lich/J
006617	B6;CB-Tg(Thy1-CFP/COX8A)S2Lich/J
004966	B6;CBA-Tg(Acrv1-EGFP)2727Redd/J
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005620	B6;D2-Tg(S100B-EYFP)1Wjt/J
004690	B6;FVB-Tg(Pcp2-EGFP)2Yuza/J
006147	B6;FVB-Tg(Sfpi1,-EGFP)7Dgt/J
006043	B6;SJL-Tg(Oxt/EGFP)AI03Wsy/J
008004	B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J
007880	B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
007856	B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J
004190	C.129-Il4tm1Lky/J
005700	C.129P2-Cxcr6tm1Litt/J
006769	C.Cg-Foxp3tm2Tch/J
004512	C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
008242	C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Mass/J
006567	C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ
003291	C57BL/6-Tg(CAG-EGFP)1Osb/J
005070	C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J
004353	C57BL/6-Tg(UBC-GFP)30Scha/J
005706	C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618	C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
006362	C57BL/6J-Tg(CMV-Cox8a/EYFP)17J/J
003927	C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
007677	CB6-Tg(Gad1-EGFP)G42Zjh/J
007076	CByJ.B6-Tg(UBC-GFP)30Scha/J
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006421	FVB-Tg(Pomc1-hrGFP)1Lowl/J
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006206	FVB.129S6-Gt(ROSA)26Sortm1(HIF1A/luc)Kael/J
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003257	FVB/N-Tg(GFAPGFP)14Mes/J
006698	NOD.Cg-Il4tm1Lky/JbsJ
008173	NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
005076	NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
005082	NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005328	NOD/ShiLt-Tg(Cd4-DsRed)4Lt/J
005334	NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
005282	NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
006331	STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005130	STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
005572	STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
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004779	STOCK Mapttm1(EGFP)Klt/J
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006678	STOCK Olfr160tm6Mom/MomJ
006669	STOCK Olfr17tm7Mom/MomJ
006570	STOCK Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj Tg(SMN2)89Ahmb/J
007879	STOCK Stx1atm2Sud/J
005438	STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876	STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
005441	STOCK Tg(CAG-DsRed*MST)1Nagy/J
003773	STOCK Tg(CAG-ECFP)CK6Nagy/J
003115	STOCK Tg(CAG-EGFP)B5Nagy/J
003116	STOCK Tg(CAG-EGFP)D4Nagy/J
005645	STOCK Tg(CAG-mRFP1)1F1Hadj/J
005105	STOCK Tg(Chx10-EGFP/cre-ALPP)2Clc/J
005854	STOCK Tg(Cp-EGFP)25Gaia/J
006334	STOCK Tg(Gad1-EGFP)94Agmo/J
006340	STOCK Tg(Gad1-EGFP)98Agmo/J
005418	STOCK Tg(HIST1H2BB/EGFP)1Pa/J
006866	STOCK Tg(Ins1-DsRed*T4)32Hara/J
006784	STOCK Tg(Ins1-ECFP)24Hara/J
003658	STOCK Tg(TIE2GFP)287Sato/J
006129	STOCK Tg(Zp3-EGFP)1Dean/J
003274	STOCK Tg(tetNZL)2Bjd/J
005104	STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699	STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J

View Fluorescent Protein Strains     (135 strains)

Strains carrying other alleles of GFP

006053	129-Gt(ROSA)26Sortm1Luo/J
006067	129-Gt(ROSA)26Sortm2Luo/J
006041	129-Gt(ROSA)26Sortm3Luo/J
003960	129S6-Tg(Prnp-GFP/cre)1Blw/J
006071	B6.129-Gt(ROSA)26Sortm1Luo/J
006080	B6.129-Gt(ROSA)26Sortm2Luo/J
006075	B6.129-Gt(ROSA)26Sortm3Luo/J
005582	B6.129P-Cx3cr1tm1Litt/J
005670	B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
005622	B6.Cg-Shhtm1(EGFP/cre)Cjt/J
007484	B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
004178	B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J
008111	B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
008112	B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
006069	B6.Cg-Tg(HIST1H2BB/EGFP)1Pa/J
005029	B6.Cg-Tg(Hlxb9-GFP)1Tmj/J
006864	B6.Cg-Tg(Ins1-EGFP)1Hara/J
005244	B6.Cg-Tg(Krt1-15-EGFP)2Cot/J
007742	B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
007902	B6.Cg-Tg(RP23-268L19-EGFP)2Mik/J
007894	B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
006361	B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
004659	B6.Cg-Tg(TIE2GFP)287Sato/1J
007921	B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
006000	B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
004509	B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
006417	B6.FVB-Tg(Npy-hrGFP)1Lowl/J
005738	B6.FVB-Tg(tetO-EGFP,-Tgfbr2)8Mcle/J
004077	B6;129-Gt(ROSA)26Sortm2Sho/J
004966	B6;CBA-Tg(Acrv1-EGFP)2727Redd/J
004654	B6;CBA-Tg(Pou5f1-EGFP)2Mnn/J
005621	B6;D2-Tg(S100B-EGFP)1Wjt/J
004690	B6;FVB-Tg(Pcp2-EGFP)2Yuza/J
006147	B6;FVB-Tg(Sfpi1,-EGFP)7Dgt/J
006043	B6;SJL-Tg(Oxt/EGFP)AI03Wsy/J
004512	C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
006567	C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ
003291	C57BL/6-Tg(CAG-EGFP)1Osb/J
005070	C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J
007265	C57BL/6-Tg(Sry-EGFP)92Ei Chr YAKR/J/EiJ
007264	C57BL/6-Tg(Sry-EGFP)92Ei Tg(Sry)4Ei Chr YPOS/EiJ
004353	C57BL/6-Tg(UBC-GFP)30Scha/J
005706	C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
007567	C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
003927	C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
007677	CB6-Tg(Gad1-EGFP)G42Zjh/J
007076	CByJ.B6-Tg(UBC-GFP)30Scha/J
003718	FVB-Tg(GadGFP)45704Swn/J
005515	FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
006421	FVB-Tg(Pomc1-hrGFP)1Lowl/J
003516	FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
003257	FVB/N-Tg(GFAPGFP)14Mes/J
008173	NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
005076	NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
005082	NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005334	NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
005282	NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
006331	STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005572	STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007576	STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
006741	STOCK Olfr160tm1Mom Tg(Olfr151,taulacZ)BMom/MomJ
006570	STOCK Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj Tg(SMN2)89Ahmb/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876	STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
003115	STOCK Tg(CAG-EGFP)B5Nagy/J
003116	STOCK Tg(CAG-EGFP)D4Nagy/J
005105	STOCK Tg(Chx10-EGFP/cre-ALPP)2Clc/J
005854	STOCK Tg(Cp-EGFP)25Gaia/J
006334	STOCK Tg(Gad1-EGFP)94Agmo/J
006340	STOCK Tg(Gad1-EGFP)98Agmo/J
007896	STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
005418	STOCK Tg(HIST1H2BB/EGFP)1Pa/J
003658	STOCK Tg(TIE2GFP)287Sato/J
006129	STOCK Tg(Zp3-EGFP)1Dean/J
005104	STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699	STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J

View Strains carrying other alleles of GFP     (78 strains)

Strains carrying other alleles of Omp

007768	B6.129S2-Omptm1Mom/MomJ
004946	B6;129P2-Omptm2(spH)Mom/J
006668	B6;129P2-Omptm4(cre)Mom/MomJ
006594	B6;129S2-Omptm1Mom/MomJ

View Strains carrying other alleles of Omp     (4 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Fluorescent Proteins

GFP related

Research Tools
Fluorescent Proteins

Omp^tm3Mom related

Research Tools
Sensorineural Research

Sensorineural Research

References

Selected Reference(s)

Potter SM; Zheng C; Koos DS; Feinstein P; Fraser SE; Mombaerts P. 2001. Structure and emergence of specific olfactory glomeruli in the mouse. J Neurosci 21(24):9713-23. [PubMed: 11739580]  [J:73384]

Additional References

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Price and Supply Information

Strain Name:	B6;129P2-Omptm3Mom/MomJ
Stock Number:	006667

 

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date: 25-FEB-08

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

View All Strains Under Development

Supply Details

Standard Supply	Under Development for Distribution Colony
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license from The Rockefeller University (“INSTITUTION”) prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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