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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 27-NOV-07 Species laboratory mouse Generation ?+F4 (08-JAN-09) Donating Investigator Peter Mombaerts, Max Planck Institute of Biophysics Description
Olfactory sensory neurons that express the olfactory receptor Olfr151 also co-express the taulacZ fusion protein by virtue of IRES-mediated co-translation. These neurons can be revealed by histochemistry of beta-galactosidase enzymatic activity, or by immunofluorescence with anti-beta-galactosidase antibodies.Development
Homologous recombination to generate this allele was done in 129P2/OlaHsd derived E14 ES cells. The loxP-flanked neo cassette was then removed by transient transfection of cre recombinase prior to injection of these ES cells into blastocysts. The resulting mice were bred to C57BL/6 and intercrossed.
Control Information
| Control | ||
|---|---|---|
| 100903 B6129PF2/J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Olfr151
View Strains carrying other alleles of Olfr151 (29 strains)
Phenotype
Phenotype Information
assigned by genotype
Olfr151tm25Mom/Olfr151tm25Mom
involves: 129 * C57BL/6
- no phenotypic analysis
- *normal* no phenotypic analysis (MGI Ref ID J:91160)
- used for expression analysis only
This mouse can be used to support research in many areas including:Olfr151tm25Mom related
Research Tools
Sensorineural Research
Sensorineural Research
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Olfr151tm25Mom | ||
|---|---|---|---|
| Allele Name | targeted mutation 25, Peter Mombaerts | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | M71-IRES-taulacZ; M71-lacZ; Olfr7tm1Mom; | ||
| Gene Symbol and Name | Olfr151, olfactory receptor 151 | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | GA_x6K02T2PVTD-31408136-31407207; M71; MOR171-2; | ||
| Molecular Note | An IRES-taulacZ gene was inserted 3 nucleotides downstream of the endogenous stop codon. Crossing with EIIa-Cre mice excised a floxed neo at the 3' end of the inserted cassette. [MGI Ref ID J:78878] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Olfr151tm25Mom, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Feinstein P; Mombaerts P. 2004. A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell 117(6):817-31. [PubMed: 15186781] [MGI Ref ID J:90716]
Additional References
Olfr151tm25Mom relatedFeinstein P; Bozza T; Rodriguez I; Vassalli A; Mombaerts P. 2004. Axon guidance of mouse olfactory sensory neurons by odorant receptors and the beta2 adrenergic receptor. Cell 117(6):833-46. [PubMed: 15186782] [MGI Ref ID J:91160]
Hasegawa S; Hamada S; Kumode Y; Esumi S; Katori S; Fukuda E; Uchiyama Y; Hirabayashi T; Mombaerts P; Yagi T. 2008. The protocadherin-alpha family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse. Mol Cell Neurosci 38(1):66-79. [PubMed: 18353676] [MGI Ref ID J:136920]
Vassalli A; Rothman A; Feinstein P; Zapotocky M; Mombaerts P. 2002. Minigenes impart odorant receptor-specific axon guidance in the olfactory bulb. Neuron 35(4):681-96. [PubMed: 12194868] [MGI Ref ID J:78878]
Zou DJ; Chesler AT; Le Pichon CE; Kuznetsov A; Pei X; Hwang EL; Firestein S. 2007. Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice. J Neurosci 27(25):6675-83. [PubMed: 17581954] [MGI Ref ID J:122798]
Zou DJ; Feinstein P; Rivers AL; Mathews GA; Kim A; Greer CA; Mombaerts P; Firestein S. 2004. Postnatal refinement of peripheral olfactory projections. Science 304(5679):1976-9. [PubMed: 15178749] [MGI Ref ID J:91565]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number FGB29
Colony Maintenance
Mating System Homozygote x Homozygote (Female x Male) 27-NOV-07 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $160.40 Female or Male Homozygous for Olfr151tm25Mom
Pairs /Price (US dollars $) Pair Genotype $320.80 Homozygous for Olfr151tm25Mom x Homozygous for Olfr151tm25Mom
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $208.60 Female or Male Homozygous for Olfr151tm25Mom
Pairs /Price (US dollars $) Pair Genotype $417.10 Homozygous for Olfr151tm25Mom x Homozygous for Olfr151tm25Mom
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 100903 B6129PF2/J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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