Strain Name:

B6;129P2-Olfr151tm29Mom/MomJ

Stock Number:

006681

Availability:

Repository-Cryopreserved

Use Restrictions Apply, see Terms of Use
Common Names: M71 prom Home+O/E-IRES-taulacZ;    

Description

Strain Information

Type Mutant Stock; Targeted Mutation;
Additional information on Genetically Engineered Mutant Mice.
Specieslaboratory mouse
 
Donating Investigator Peter Mombaerts,   Max Planck Institute of Biophysics

Development
The Olfr151tm29Mom mutation was generated in 129P2/OlaHsd derived E14 ES cells and resulting mice were bred to C57BL/6J before being intercrossed to homozygosity. This mutation was generated using the ACN neo cassette, which self-excises during transmission in the male chimera. In 2007 sperm was cryopreserved from homozygous males on this mixed B6;129P2 background.

Related Strains

View Strains carrying other alleles of Olfr151     (28 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms
      assigned by genotype

Olfr151tm29Mom/Olfr151tm29Mom

        involves: 129P2/OlaHsd * C57BL/6J
  • nervous system phenotype
  • abnormal olfactory neuron morphology (MGI Ref ID J:115911)
    • fewer cells expressing the mutant allele are present compared to control mice expressing Olfr151 promotor driven LacZ transgene
  • abnormal sensory neuron projections (MGI Ref ID J:115911)
    • olfactory sensory neuron axons form ectopic, ventral glomeruli in the olfactory bulb in addition to glomeruli in the expected position
    • two pairs of glomeruli are present in 44% of bulbs
    • presence of extra glomeruli correlates to presence of 12-fold fewer cells in dorsal regions and 4- to 10-fold more cells in theventral region of the epithelium of endoturbinates II and III

Genes & Alleles

Gene & Allele Information

Allele Symbol Olfr151tm29Mom
Allele Name targeted mutation 29, Peter Mombaerts
Allele Type Targeted (Reporter)
Common Name(s) M71 prom Home+O/E-IRES-taulacZ; M71(Hom+O/E)-lacZ;
Mutation Made By Peter Mombaerts,   Max Planck Institute of Biophysics
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Olfr151, olfactory receptor 151
Chromosome 9
Gene Common Name(s) GA_x6K02T2PVTD-31408136-31407207; M71; MOR171-2; OR11-318; OST025;
Molecular Note Five nucleotide substitutions were made in the promoter, altering both the homeodomain and the O/E-like binding site, and an IRES-taulacZ-ACNf cassette was inserted immediately following the endogenous stop codon. The ACNf cassette self-excised in the male germline leaving no neo sequence. [MGI Ref ID J:115911]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Rothman A; Feinstein P; Hirota J; Mombaerts P. 2005. The promoter of the mouse odorant receptor gene M71. Mol Cell Neurosci 28(3):535-46. [PubMed: 15737743]  [MGI Ref ID J:115911]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

  • This strain is included in the Induced Mutant Resource Colony collection.

General Terms and Conditions


See Terms of Use


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Terms of Use

Terms of Use


General Terms and Conditions


Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries

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phone:207-288-6470
fax:207-288-6655

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“Each recipient institution, including its employees and other researchers under its control (RECIPIENT), of mice or services using mice from The Jackson Laboratory (TJL) agrees that such mice, descendants of those mice derived by inbreeding or crossbreeding, including unmodified derivatives of those mice or their descendants (“MICE”) shall not be: (i) used for any purpose other than the internal research of the RECIPIENT, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services with respect to MICE. Acceptance of MICE from TJL shall be deemed agreement by RECIPIENT to these conditions, and departure from these conditions requires The Jackson Laboratory’s prior written authorization.”

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