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- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Donating Investigator Peter Mombaerts, Max Planck Institute of Biophysics Description
Olfactory sensory neurons with the Olfr124 locus actively transcribed can be identified as expressing red fluorescent protein, even though no OLFR124 protein is expressed. The density of these cells in the septal organ is 14 times lower than OLFR124 expressing cells in mice with an intact Olfr124 locus tagged with an IRES-tauGFP. Of the OLFR124 deficient neurons, only 18% in the septal organ and only 14% in the main olfactory epithelium responded to all 5 odorants that stimulate 100% of OLFR124 expressing olfactory sensory neurons. This indicates that OLFR124 is responsible for the unusually broad response profile of the olfactory sensory neurons that express it.Development
This null allele was generated by replacing the endogenous coding sequence with sequence encoding monomeric red fluorescent protein 1, along with an ACNF cassette which self-excised during male germline transmission. Homologous recombination was done in 129P2-derived E14 ES cells, the chimeric founder was bred with C57BL/6J and this strain was maintained on a B6;129P2 segregating background until sperm were cryopreserved in 2007.
Related Strains
Strains carrying other alleles of Olfr124
006717 B6;129P2-Olfr124tm1Mom/MomJ View Strains carrying other alleles of Olfr124 (1 strain)
Phenotype
Phenotype Information
assigned by genotype
Olfr124tm4Mom/Olfr124tm4Mom
B6;129P2-Olfr124tm4Mom/MomJ
- nervous system phenotype
- abnormal olfactory neuron morphology
- the density of olfactory sensory neurons with the Olfr124 locus actively transcribed is 14 times lower than normal in the septal organ (MGI Ref ID J:154360)
- lacking the endogenous OLFR124 protein, olfactory sensory neurons actively transcribing this locus have significantly reduced response to odorants that stimulate olfactory sensory neurons expressing normal OLFR124 (MGI Ref ID J:154360)
- abnormal olfactory receptor morphology (MGI Ref ID J:154360)
- taste/olfaction phenotype
- abnormal olfactory receptor morphology (MGI Ref ID J:154360)
This mouse can be used to support research in many areas including:Olfr124tm4Mom related
Research Tools
Fluorescent Proteins
Neurobiology Research
cell marker
Sensorineural Research
Sensorineural Research
Olfactory Defects
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Olfr124tm4Mom | ||
|---|---|---|---|
| Allele Name | targeted mutation 4, Peter Mombearts | ||
| Allele Type | Targeted (knock-out) | ||
| Common Name(s) | deltaSR1-RFP; mRFP1->SR1; | ||
| Strain of Origin | 129P2/OlaHsd | ||
| Site of Expression | RFP is expressed in olfactory sensory neurons. | ||
| Expressed Gene | RFP, Red Fluorescent Protein, coral | ||
| Red Fluorescent Protein (RFP), derived from marine invertebrate organisms such as the soft coral Discosoma spp and reef coral, Heteractis crispa, is a versatile reporter molecule which has found use in many biological applications. The wild type protein, which is an obligate tetramer, is not well tolerated in mammalian systems. The original molecule has been modified in order to optimize expression to mammalian physiology (examples include monomeric RFP, mRFP1, DsRed, etc). | |||
| Molecular Note | This null allele was generated by replacing the endogenous coding sequence with sequence encoding monomeric red fluorescent protein 1, along with an ACNF cassette which self-excised during male germline transmission. [MGI Ref ID J:154360] | ||
| Gene Symbol and Name | Olfr124, olfactory receptor 124 | ||
| Chromosome | 17 | ||
| Gene Common Name(s) | A3; GA_x6K02T2PSCP-2264806-2265753; MOR256-3; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Olfr124tm4Mom, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Grosmaitre X; Fuss SH; Lee AC; Adipietro KA; Matsunami H; Mombaerts P; Ma M. 2009. SR1, a Mouse Odorant Receptor with an Unusually Broad Response Profile. J Neurosci 29(46):14545-14552. [PubMed: 19923288] [MGI Ref ID J:154360]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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JAX® Mice, Products & Services Conditions of Use
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