Strain Name:

C.Cg-Foxp3tm2Tch/J

Stock Number:

006769

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Availability:

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Common Names: C.Cg-Foxp3tm2(EGFP)Tch/J;    
TThese "Foxp3EGFP" mice co-express EGFP and the regulatory T cell-specific transcription factor Foxp3 under the control of the endogenous promoter. These mutant mice may be useful in immunological studies, including studies of regulatory T cell proliferation, localization, and antigen independence during the primary immune response.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Hemizygote         (Female x Male)   04-FEB-08
Specieslaboratory mouse
GenerationN8+N2 (09-JUL-13)
Generation Definitions
 
Donating Investigator Talal Chatila,   Boston Children's Hospital

Description
Homozygous mice are viable and fertile with normal T and B cell development. These "Foxp3EGFP" mice co-express EGFP and the regulatory T cell-specific transcription factor Foxp3 under the control of the endogenous promoter. EGFP expression accurately identifies the Foxp3+ T cell population (more than 97% of Foxp3+ T cells were EGFP+), and Foxp3 mRNA expression strictly segregates with EGFP+ T cells. Due to X-inactivation in females, the number of EGFP+ CD4+ T cells found in the peripheral blood of heterozygous females was approximately half that of hemizygous males. CD4+ EGFP+ cells also exhibit normal regulatory T cell suppression of effector cell proliferation (following stimulation with anti-CD3 and anti-CD28 monoclonal antibodies). Some EGFP expression is noted in a small population of CD8+ thymocytes. These mutant mice may be useful in immunological studies, including studies of regulatory T cell proliferation, localization, and antigen independence during the primary immune response.

This allele is also on a C57BL/6 genetic background (see Stock No. 006772).

Development
A targeting vector was designed to place an IRES-EGFP-SV40 polyA sequence immediately downstream of the endogenous Foxp3 translational stop codon but upstream of the endogenous polyA signal. The construct also introduced a loxP-flanked PGKneo cassette into intron 9. This vector was electroporated into 129X1Sv/J-derived SCC10 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts and chimeric males were mated with BALB/c females. The PGKneo cassette was removed by mating founder males with Cre-deleter female mice on a BALB/c congenic background. The resulting mice (now harboring this Foxp3EGFP allele) were then backcrossed for 8 generations to BALB/cAnNTac inbred mice prior to arrival at The Jackson Laboratory. During the importation process, this strain may have been bred with BALB/cJ inbred mice (Stock No. 000651) for at least one generation.

Control Information

  Control
   Wild-type from the colony
   000651 BALB/cJ
 
  Considerations for Choosing Controls

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009593   C57BL/6J-Tg(Pomc-EGFP)1Low/J
003927   C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
008234   CB6-Tg(CAG-EGFP/CETN2)3-4Jgg/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
007075   CByJ.B6-Tg(CAG-EGFP)1Osb/J
007076   CByJ.B6-Tg(UBC-GFP)30Scha/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
003718   FVB-Tg(GadGFP)45704Swn/J
010947   FVB-Tg(Gstm5-EGFP)1Ilis/J
005515   FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
010588   FVB-Tg(Myh6/NFAT-luc)1Jmol/J
006421   FVB-Tg(Pomc1-hrGFP)1Lowl/J
005688   FVB-Tg(Rag2-EGFP)1Mnz/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
003516   FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008200   FVB/N-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
009354   FVB/N-Tg(Dazl-EGFP)10Rarp/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
007800   FVB/N-Tg(Ins1-luc)VUPwrs/J
012370   FVB/NJ-Tg(Hspa1a-luc,-EGFP)2Chco/J
009618   NOD.129(B6)-Il12btm1Lky/JbsJ
013116   NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
008173   NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
009422   NOD.Cg-Tg(Itgax-Venus)1Mnz/QtngJ
005076   NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008547   NOD.FVB-Tg(ITGAM-DTR/EGFP)34Lan/JdkJ
008549   NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
005082   NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005328   NOD/ShiLt-Tg(Cd4-DsRed)4Lt/J
005334   NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
005282   NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
012881   STOCK Ascl1tm1Reed/J
008666   STOCK Fmn1tm1Made/J
013731   STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
017922   STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
024107   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ
017912   STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
017921   STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
017909   STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
009349   STOCK Hprttm31(Ple67-EGFP)Ems/Mmjax
009594   STOCK Hprttm32(Ple112-EGFP)Ems/Mmjax
022976   STOCK Igs2tm1(ACTB-EGFP,-tdTomato)Zng/J
022977   STOCK Igs2tm2(ACTB-tdTomato,-EGFP)Zng/J
013749   STOCK Iis2tm1(ACTB-EGFP,-tdTomato)Luo/J
013751   STOCK Iis2tm2(ACTB-tdTomato,-EGFP)Luo/J
017932   STOCK Iis3tm1.1(ACTB-EGFP*)Luo/J
017923   STOCK Iis3tm2.1(ACTB-EGFP*,-tdTomato)Luo/J
021458   STOCK Iis5tm1(ACTB-tdTomato,-EGFP)Luo/J
021457   STOCK Iis5tm2.1(ACTB-EGFP,-tdTomato)Luo/J
021461   STOCK Iis6tm1.1(ACTB-tdTomato,-EFGP)Luo/J
021460   STOCK Iis6tm2.1(ACTB-EFGP,-tdTomato)Luo/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
005692   STOCK Nphs1tm1Rkl/J
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006678   STOCK Olfr160tm6Mom/MomJ
006669   STOCK Olfr17tm7Mom/MomJ
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
007879   STOCK Stx1atm2Sud/J
014581   STOCK Trpm8tm1Apat/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
005441   STOCK Tg(CAG-DsRed*MST)1Nagy/J
003773   STOCK Tg(CAG-ECFP)CK6Nagy/J
003115   STOCK Tg(CAG-EGFP)B5Nagy/J
003116   STOCK Tg(CAG-EGFP)D4Nagy/J
011106   STOCK Tg(CAG-GFP*)1Hadj/J
013754   STOCK Tg(CAG-KikGR)75Hadj/J
011107   STOCK Tg(CAG-Venus)1Hadj/J
005645   STOCK Tg(CAG-mRFP1)1F1Hadj/J
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
018322   STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
008241   STOCK Tg(Cspg4-DsRed.T1)1Akik/J
006334   STOCK Tg(Gad1-EGFP)94Agmo/J
006340   STOCK Tg(Gad1-EGFP)98Agmo/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
016252   STOCK Tg(Hoxb7-Venus*)17Cos/J
006784   STOCK Tg(Ins1-Cerulean)24Hara/J
006866   STOCK Tg(Ins1-DsRed*T4)32Hara/J
016921   STOCK Tg(Myh2-DsRed2)1Jrs/J
012477   STOCK Tg(Myh6*/tetO-GCaMP2)1Mik/J
016922   STOCK Tg(Myh7-CFP)1Jrs/J
008579   STOCK Tg(PSCA-EGFP)1Witt/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
003658   STOCK Tg(TIE2GFP)287Sato/J
013162   STOCK Tg(Thy1-Clomeleon)12Gjau/J
013163   STOCK Tg(Thy1-Clomeleon)13Gjau/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
011108   STOCK Tg(Ttr-RFP)1Hadj/J
016981   STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J
006129   STOCK Tg(Zp3-EGFP)1Dean/J
003274   STOCK Tg(tetNZL)2Bjd/J
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
017918   STOCK Tg(tetO-MAML1*/EGFP)2Akar/J
012345   STOCK Tg(tetO-tdTomato,-Syp/EGFP*)1.1Luo/J
View Fluorescent Protein Strains     (377 strains)

Strains carrying   Foxp3tm2Tch allele
006772   B6.Cg-Foxp3tm2Tch/J
025097   NOD.129X1(Cg)-Foxp3tm2Tch/DvsJ
View Strains carrying   Foxp3tm2Tch     (2 strains)

View Strains carrying other alleles of Foxp3     (15 strains)

Strains carrying other alleles of GFP
006053   129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
006067   129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006041   129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
016925   129;B6-Grin3b/Tmem259tm1Zhang Tg(Prnp-C19ORF6,-GFP)6Zhang/J
016251   129S.Cg-Tg(Hoxb7-EGFP)33Cos/J
003960   129S6-Tg(Prnp-GFP/cre)1Blw/J
017458   B6(C)-Tg(UAS-EGFP,-SOD1*G37R)135Gsn/J
017460   B6(C)-Tg(UAS-EGFP,-SOD1*G37R)677Gsn/J
008242   B6(Cg)-Gt(ROSA)26Sortm4(Ikbkb)Rsky/J
021011   B6(D2)-Tg(CAG-Brainbow1.0)2Eggn/J
021012   B6(D2)-Tg(CAG-Brainbow1.0)3Eggn/J
021469   B6(D2)-Tg(CAG-GFP,-Uprt)985Cdoe/J
016958   B6.129(Cg)-Foxp3tm3(DTR/GFP)Ayr/J
007676   B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
004178   B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
018979   B6.129(Cg)-Tg(CAG-EGFP)D4Nagy/KnwJ
010635   B6.129(FVB)-Alcamtm1Jawe/J
006071   B6.129-Gt(ROSA)26Sortm1(CAG-EGFP)Luo/J
008606   B6.129-Gt(ROSA)26Sortm1Joe/J
006080   B6.129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J
006075   B6.129-Gt(ROSA)26Sortm3(CAG-EGFP/Dsred2)Luo/J
011036   B6.129-Hoxa11tm1Dmwe/J
008451   B6.129P(Cg)-Ptprca Cx3cr1tm1Litt/LittJ
005582   B6.129P-Cx3cr1tm1Litt/J
008710   B6.129P2(129S4)-Hprttm10(Ple162-EGFP/cre)Ems/Mmjax
008877   B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems/Mmjax
009114   B6.129P2(129S4)-Hprttm14(Ple103-EGFP/cre)Ems/Mmjax
008709   B6.129P2(129S4)-Hprttm9(Ple178-EGFP/cre)Ems/Mmjax
009113   B6.129P2(Cg)-Hprttm13(Ple54-EGFP)Ems/Mmjax
009115   B6.129P2(Cg)-Hprttm15(Ple111-EGFP)Ems/Mmjax
009118   B6.129P2(Cg)-Hprttm18(Ple90-EGFP)Ems/Mmjax
009353   B6.129P2(Cg)-Hprttm20(Ple53-EGFP)Ems/Mmjax
009596   B6.129P2(Cg)-Hprttm33(Ple183-EGFP)Ems/Mmjax
010770   B6.129P2(Cg)-Hprttm34(Ple186-EGFP)Ems/Mmjax
008706   B6.129P2(Cg)-Hprttm4(Ple88-EGFP)Ems/Mmjax
010789   B6.129P2(Cg)-Hprttm54(Ple233-EGFP)Ems/Mmjax
008707   B6.129P2(Cg)-Hprttm7(Ple185-EGFP)Ems/Mmjax
008708   B6.129P2(Cg)-Hprttm8(Ple151-EGFP)Ems/Mmjax
007766   B6.129P2(Cg)-Olfr160tm6Mom/MomJ
007572   B6.129P2(Cg)-Rorctm2Litt/J
005693   B6.129P2-Cxcr6tm1Litt/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
021794   B6.129S1(Cg)-Ascl3tm1.1(EGFP/cre)Ovi/J
009380   B6.129S1-Irf4tm1Rdf/J
021930   B6.129S1-Tg(CAG-EGFP)S1C2Tpo/KnwPeaJ
022510   B6.129S4-Gpr88tm1.1(cre/GFP)Rpa/J
007669   B6.129S4-Pdgfratm11(EGFP)Sor/J
013061   B6.129S6-Ccr6tm1(EGFP)Irw/J
008379   B6.129S6-Il10tm1Flv/J
012644   B6.129S7-Pcdhgtm2Xzw/J
008466   B6.129X1(Cg)-Shhtm6Amc/J
009081   B6.129X1-Id1tm1Xhsu/J
005670   B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007906   B6.Cg-Gt(ROSA)26Sortm6(CAG-ZsGreen1)Hze/J
005491   B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
022486   B6.Cg-Ptprca Tg(UBC-PA-GFP)1Mnz/J
013115   B6.Cg-Rag1tm1Mom Tg(UBC-GFP)30Scha/J
005622   B6.Cg-Shhtm1(EGFP/cre)Cjt/J
007484   B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008705   B6.Cg-Tg(CAG-DsRed,-EGFP)5Gae/J
007575   B6.Cg-Tg(CAG-Ngb,-EGFP)1Dgrn/J
008111   B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
008112   B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
022148   B6.Cg-Tg(CSNK1D*,-EGFP)827Yfu/J
022149   B6.Cg-Tg(CSNK1D,-EGFP)432Yfu/J
023404   B6.Cg-Tg(CSNK1D,-EGFP)433Yfu/J
022787   B6.Cg-Tg(Chst4-EGFP)23Nrud/J
013134   B6.Cg-Tg(Col1a1*2.3-GFP)1Rowe/J
017466   B6.Cg-Tg(Col1a1*3.6-Topaz)2Rowe/J
018306   B6.Cg-Tg(Fos-tTA,Fos-EGFP*)1Mmay/J
014135   B6.Cg-Tg(Fos/EGFP)1-3Brth/J
007673   B6.Cg-Tg(Gad1-EGFP)3Gfng/J
010835   B6.Cg-Tg(Gfap-EGFP)3739Sart/J
007897   B6.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
006069   B6.Cg-Tg(HIST1H2BB/EGFP)1Pa/J
005029   B6.Cg-Tg(Hlxb9-GFP)1Tmj/J
024808   B6.Cg-Tg(Inpp5d-EGFP)DLrr/CprJ
006864   B6.Cg-Tg(Ins1-EGFP)1Hara/J
005244   B6.Cg-Tg(Krt1-15-EGFP)2Cot/J
012643   B6.Cg-Tg(Ly6a-EGFP)G5Dzk/J
008323   B6.Cg-Tg(Mc4r-MAPT/Sapphire)21Rck/J
007742   B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
008321   B6.Cg-Tg(Npy-MAPT/Sapphire)1Rck/J
021232   B6.Cg-Tg(Nrl-EGFP)1Asw/J
008324   B6.Cg-Tg(Pmch-MAPT/CFP)1Rck/J
008322   B6.Cg-Tg(Pomc-MAPT/Topaz)1Rck/J
007902   B6.Cg-Tg(RP23-268L19-EGFP)2Mik/J
022086   B6.Cg-Tg(RP24-131B16/EGFP)13Ghan/J
019494   B6.Cg-Tg(RP24-131B16/EGFP)37Ghan/J
007894   B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
021614   B6.Cg-Tg(S100A8-cre,-EGFP)1Ilw/J
012893   B6.Cg-Tg(S100a4-EGFP)M1Egn/YunkJ
006361   B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
016998   B6.Cg-Tg(TetO-Axin1,EGFP)TA6Cos/J
007921   B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
007919   B6.Cg-Tg(Thy1-EGFP)OJrs/GfngJ
021069   B6.Cg-Tg(Thy1-PA-GFP)5Rmpl/J
021070   B6.Cg-Tg(Thy1-PA-GFP)6Rmpl/J
015805   B6.Cg-Tg(UBC-GFP,-TVA)1Clc/J
015806   B6.Cg-Tg(UBC-GFP,-TVA)2Clc/J
015807   B6.Cg-Tg(UBC-GFP,-TVA)3Clc/J
024688   B6.FVB(129S)-Tg(Pax6-GFP/cre)1Rilm/J
008226   B6.FVB-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
018056   B6.FVB-Tg(CAG-boNT/B,-EGFP)U75-56Fwp/J
018055   B6.FVB-Tg(H2-K-S100a9,GFP)1Gabr/J
006000   B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
004509   B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
006417   B6.FVB-Tg(Npy-hrGFP)1Lowl/J
024033   B6.FVB-Tg(Shank3-EGFP)1Hzo/J
005738   B6.FVB-Tg(tetO-EGFP,-Tgfbr2)8Mcle/J
008126   B6.NOD-Tg(Cd4-EGFP)1Lt/J
023161   B6129S-Tg(Foxp3-EGFP/cre)1aJbs/J
008516   B6;129-Gt(ROSA)26Sortm1Joe/J
004077   B6;129-Gt(ROSA)26Sortm2Sho/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
008678   B6;129-Ubbtm1Rrk/J
010988   B6;129P-Cyp11a1tm1(GFP/cre)Pzg/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
008769   B6;129P2-Gpr15tm1.1Litt/J
012601   B6;129P2-Lyve1tm1.1(EGFP/cre)Cys/J
021162   B6;129P2-Mapttm2Arbr/J
006717   B6;129P2-Olfr124tm1Mom/MomJ
006665   B6;129P2-Olfr151tm13(rI7)Mom/MomJ
006666   B6;129P2-Olfr151tm24(Olfr2)Mom/MomJ
006676   B6;129P2-Olfr151tm26Mom/MomJ
006734   B6;129P2-Olfr151tm35(Adrb2)Mom/MomJ
006714   B6;129P2-Olfr160tm11(Olfr545)Mom/MomJ
006649   B6;129P2-Olfr17tm5(Olfr6)Mom/MomJ
006712   B6;129P2-Olfr545tm1Mom/MomJ
006715   B6;129P2-Olfr545tm3(Olfr160)Mom/MomJ
004946   B6;129P2-Omptm2(spH)Mom/J
006667   B6;129P2-Omptm3Mom/MomJ
006728   B6;129P2-Vmn2r26tm2Mom/MomJ
012735   B6;129S-Gt(ROSA)26Sortm35.1(CAG-aop3/GFP)Hze/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017592   B6;129S-Sox2tm2Hoch/J
004858   B6;129S1-Tshrtm1Rmar/J
007843   B6;129S4-Efnb2tm2Sor/J
012463   B6;129S4-Foxd1tm1(GFP/cre)Amc/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
016836   B6;129S4-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm7(tetO-HIST1H2BJ/GFP)Jae/J
008214   B6;129S4-Pou5f1tm2Jae/J
008078   B6;129S4-Tcf3tm5Zhu/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
012436   B6;129S7-Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/Mmjax
008605   B6;C3-Tg(CAG-DsRed,-EGFP)5Gae/J
008080   B6;C3-Tg(CAG-SAC/EGFP)35Rang/J
010827   B6;C3-Tg(FOXJ1-EGFP)85Leo/J
010930   B6;CB-Tg(Pbsn-Hpn,-GFP)DVv/J
010704   B6;CBA-Tg(ATP6V1B1-EGFP)1Rnel/Mmjax
004966   B6;CBA-Tg(Acrv1-EGFP)2727Redd/J
021588   B6;CBA-Tg(Gast-EGFP)1Tcw/J
007986   B6;CBA-Tg(H*/Olfr16-GFP)11Mom/MomJ
007987   B6;CBA-Tg(H*/Olfr16-GFP)25Mom/MomJ
007979   B6;CBA-Tg(H/Olfr16-GFP)3Mom/MomJ
007980   B6;CBA-Tg(H/Olfr16-GFP)4Mom/MomJ
007981   B6;CBA-Tg(H/Olfr16-GFP)6Mom/MomJ
007984   B6;CBA-Tg(H/Olfr16-taumCherry,-tauGFP)11Mom/MomJ
007985   B6;CBA-Tg(H/Olfr16-taumCherry,-tauGFP)13Mom/MomJ
007982   B6;CBA-Tg(H/Olfr16-taumRFP,-tauGFP)8Mom/MomJ
007983   B6;CBA-Tg(H/Olfr16-taumRFP,-tauGFP)9Mom/MomJ
007978   B6;CBA-Tg(Hf/Olfr16-GFP)47Mom/MomJ
007977   B6;CBA-Tg(Hf/Olfr16-GFP)7Mom/MomJ
004654   B6;CBA-Tg(Pou5f1-EGFP)2Mnn/J
011070   B6;CBA-Tg(Thy1-EGFP)SJrs/NdivJ
014651   B6;CBA-Tg(Thy1-spH)21Vnmu/J
015814   B6;CBA-Tg(Thy1-spH)64Vnmu/FrkJ
017494   B6;D-Tg(Tshz3-GFP/cre)43Amc/J
025122   B6;D2-Tg(RP24-330G11-EGFP)1Mik/J
005621   B6;D2-Tg(S100B-EGFP)1Wjt/J
008344   B6;DBA-Tg(Fos-tTA,Fos-EGFP*)1Mmay Tg(tetO-lacZ,tTA*)1Mmay/J
014160   B6;DBA-Tg(S100b-EGFP/cre/ERT2)22Amc/J
014159   B6;DBA-Tg(Tmem100-EGFP/cre/ERT2)30Amc/J
015855   B6;DBA-Tg(Upk3a-GFP/cre/ERT2)26Amc/J
009159   B6;FVB-Tg(Cnp-EGFP/Rpl10a)JD368Htz/J
021187   B6;FVB-Tg(Pbsn-rtTA*M2)42Xy/J
004690   B6;FVB-Tg(Pcp2-EGFP)2Yuza/J
006147   B6;FVB-Tg(Sfpi1,-EGFP)7Dgt/J
019381   B6;FVB-Tg(Zfp423-EGFP)7Brsp/J
021022   B6;SJL-Tg(AMELX-EGFP/RHOA*T19N)13Gibs/Mmjax
006043   B6;SJL-Tg(Oxt/EGFP)AI03Wsy/J
021078   B6N.129S1-Mrgprb4tm4.1(flpo)And/J
019013   B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
018974   B6N.B6-Tg(Nr4a1-EGFP/cre)820Khog/J
018549   B6N.Cg-Tg(Csf1r-EGFP)1Hume/J
020650   B6N.Cg-Tg(Trpm8-EGFP)1Dmck/J
018913   B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J
007732   B6SJL-Tg(Dazl-hrGFP)4Gar/J
004190   C.129-Il4tm1Lky/J
005700   C.129P2-Cxcr6tm1Litt/J
011010   C.B6-Tg(Foxp3-DTR/EGFP)23.2Spar/Mmjax
010545   C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
004512   C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
008591   C57BL/6-Ackr3tm1Litt/J
023520   C57BL/6-Bcrtm1(BCR/ABL)Tsr/J
012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
010724   C57BL/6-Trim21tm1Hm/J
017469   C57BL/6-Tg(BGLAP-Topaz)1Rowe/J
006567   C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ
003291   C57BL/6-Tg(CAG-EGFP)1Osb/J
005070   C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J
017467   C57BL/6-Tg(Dmp1-Topaz)1Ikal/J
011003   C57BL/6-Tg(Foxp3-DTR/EGFP)23.2Spar/Mmjax
023800   C57BL/6-Tg(Foxp3-GFP)90Pkraj/J
012943   C57BL/6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
016617   C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J
012890   C57BL/6-Tg(Scgb1a1-Il17f,GFP)1Cdon/J
007265   C57BL/6-Tg(Sry-EGFP)92Ei Chr YAKR/J/EiJ
007264   C57BL/6-Tg(Sry-EGFP)92Ei Tg(Sry)4Ei Chr YPOS/EiJ
004353   C57BL/6-Tg(UBC-GFP)30Scha/J
022476   C57BL/6-Tg(Uchl1-EGFP)G1Phoz/J
005706   C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
007567   C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
018895   C57BL/6J-Tg(Krt6,-cre,-Cerulean)1Grsr/Grsr
018896   C57BL/6J-Tg(Krt6,-cre,-Cerulean)2Grsr/Grsr
018898   C57BL/6J-Tg(Krt6,-cre,-Cerulean)4Grsr/Grsr
018899   C57BL/6J-Tg(Krt6,-cre,-Cerulean)5Grsr/Grsr
009593   C57BL/6J-Tg(Pomc-EGFP)1Low/J
003927   C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
019363   C57BL/6J-Tg(Trp63,-cre,-Cerulean)10Grsr/Grsr
018792   C57BL/6J-Tg(Trp63,-cre,-Cerulean)4Grsr/GrsrJ
018151   C57BL/6N-Krt17tm1(cre,Cerulean)Murr/GrsrJ
024753   C57BL/6N-Tg(Ddx25*-EGFP)1Mld/J
024752   C57BL/6N-Tg(Ddx25-EGFP)1Mld/J
008234   CB6-Tg(CAG-EGFP/CETN2)3-4Jgg/J
007677   CB6-Tg(Gad1-EGFP)G42Zjh/J
007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
007075   CByJ.B6-Tg(CAG-EGFP)1Osb/J
007076   CByJ.B6-Tg(UBC-GFP)30Scha/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
003718   FVB-Tg(GadGFP)45704Swn/J
010947   FVB-Tg(Gstm5-EGFP)1Ilis/J
005515   FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
017484   FVB-Tg(JPH3-GFP,-JPH3*)GXwy/J
006421   FVB-Tg(Pomc1-hrGFP)1Lowl/J
005688   FVB-Tg(Rag2-EGFP)1Mnz/J
024636   FVB.B6-Tg(CAG-cat,-EGFP)1Rbns/KrnzJ
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
003516   FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
022735   FVB.Cg-Tg(Cspg4-EGFP*)HDbe/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008200   FVB/N-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
018393   FVB/N-Tg(CAG-EGFP,TGFB1*)C8Kul/J
009354   FVB/N-Tg(Dazl-EGFP)10Rarp/J
018548   FVB/N-Tg(GFAP-Cadm1/EGFP)42Oje/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
013116   NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
021937   NOD.Cg-Prkdcscid Il2rgtm1Wjl Tg(CAG-EGFP)1Osb/SzJ
017619   NOD.Cg-Prkdcscid Tg(CAG-EGFP)1Osb/KupwJ
008173   NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
005076   NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008547   NOD.FVB-Tg(ITGAM-DTR/EGFP)34Lan/JdkJ
008549   NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
005082   NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005334   NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
005282   NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
012881   STOCK Ascl1tm1Reed/J
008666   STOCK Fmn1tm1Made/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
009349   STOCK Hprttm31(Ple67-EGFP)Ems/Mmjax
009594   STOCK Hprttm32(Ple112-EGFP)Ems/Mmjax
017530   STOCK Igs2tm2(ACTB-tdTomato,-EGFP)Luo Trp53tm1Tyj Nf1tm1Par/J
013749   STOCK Iis2tm1(ACTB-EGFP,-tdTomato)Luo/J
013751   STOCK Iis2tm2(ACTB-tdTomato,-EGFP)Luo/J
017932   STOCK Iis3tm1.1(ACTB-EGFP*)Luo/J
017923   STOCK Iis3tm2.1(ACTB-EGFP*,-tdTomato)Luo/J
017701   STOCK Kiss1tm1.1(cre/EGFP)Stei/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
005692   STOCK Nphs1tm1Rkl/J
006702   STOCK Ntstm1Mom/MomJ
006622   STOCK Olfr151tm10Mom/MomJ
006646   STOCK Olfr151tm11(Olfr160)Mom/MomJ
006692   STOCK Olfr151tm16(Olfr160/Olfr161)Mom/MomJ
006627   STOCK Olfr151tm4Mom/MomJ
006626   STOCK Olfr151tm6Mom/MomJ
006625   STOCK Olfr151tm7Mom/MomJ
006624   STOCK Olfr151tm8Mom/MomJ
006623   STOCK Olfr151tm9Mom/MomJ
006740   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)AMom/MomJ
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006647   STOCK Olfr160tm1(Olfr151)Mom/MomJ
006636   STOCK Olfr160tm5(Cnga2)Mom/MomJ
006678   STOCK Olfr160tm6Mom/MomJ
006650   STOCK Olfr17tm6(Olfr713)Mom/MomJ
006669   STOCK Olfr17tm7Mom/MomJ
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
006770   STOCK Rag1tm1Mom Tg(TIE2GFP)287Sato/J
006633   STOCK Vmn1r49tm3Mom/MomJ
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
017472   STOCK Tg(Acp5-CFP,Ibsp-YFP,Dmp1-RFP)1Pmay/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
003115   STOCK Tg(CAG-EGFP)B5Nagy/J
003116   STOCK Tg(CAG-EGFP)D4Nagy/J
017919   STOCK Tg(CAG-EGFP,-dsRed2/RNAi:Tardbp)6Zxu/J
011106   STOCK Tg(CAG-GFP*)1Hadj/J
013753   STOCK Tg(CAG-KikGR)33Hadj/J
013754   STOCK Tg(CAG-KikGR)75Hadj/J
019082   STOCK Tg(CMV-GFP,-BBS4)4T25Vcs/J
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
017468   STOCK Tg(Col1a1*3.6-Cyan)2Rowe/J
018322   STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
006334   STOCK Tg(Gad1-EGFP)94Agmo/J
006340   STOCK Tg(Gad1-EGFP)98Agmo/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
017952   STOCK Tg(Isl1-EGFP*)1Slp/J
012477   STOCK Tg(Myh6*/tetO-GCaMP2)1Mik/J
008579   STOCK Tg(PSCA-EGFP)1Witt/J
024578   STOCK Tg(Pax6-GFP/cre)1Rilm/J
023345   STOCK Tg(Pgk1-Ccnb1/EGFP)1Aklo/J
012276   STOCK Tg(Piwil2/EGFP)1Ghan/J
012277   STOCK Tg(Piwil4/EGFP)1Ghan/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
018148   STOCK Tg(Slc17a8-EGFP)1Edw/SealJ
013752   STOCK Tg(TCF/Lef1-HIST1H2BB/EGFP)61Hadj/J
003658   STOCK Tg(TIE2GFP)287Sato/J
021226   STOCK Tg(Thy1-Brainbow3.1)18Jrs/J
021225   STOCK Tg(Thy1-Brainbow3.1)3Jrs/J
021227   STOCK Tg(Thy1-Brainbow3.2)7Jrs/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
016981   STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J
025193   STOCK Tg(Vmn1r232-Mapt/EGFP)1Dlc/J
018281   STOCK Tg(Wnt7a-EGFP/cre)#Bhr/Mmjax
006129   STOCK Tg(Zp3-EGFP)1Dean/J
023724   STOCK Tg(mI56i-cre,EGFP)1Kc/J
017755   STOCK Tg(tetO-GCAMP2)12iRyu/J
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
017918   STOCK Tg(tetO-MAML1*/EGFP)2Akar/J
017906   STOCK Tg(tetO-hop/EGFP,-COP4/mCherry)6Kftnk/J
012345   STOCK Tg(tetO-tdTomato,-Syp/EGFP*)1.1Luo/J
View Strains carrying other alleles of GFP     (352 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Diabetes Mellitus, Insulin-Dependent; IDDM   (FOXP3)
Immunodysregulation, Polyendocrinopathy, and Enteropathy, X-Linked;   (FOXP3)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Foxp3tm2Tch/Foxp3+

        C.129X1-Foxp3tm2Tch
  • immune system phenotype
  • *normal* immune system phenotype
    • females are phenotypically normal and indistinguishable from wild-type littermates   (MGI Ref ID J:120713)
    • EGFP expression in cells concordant with Foxp3 expression allows the kinetics of regulatory T cell proliferation and localization during a primary immune response   (MGI Ref ID J:120713)

Foxp3tm2Tch/Y

        C.129X1-Foxp3tm2Tch
  • immune system phenotype
  • *normal* immune system phenotype
    • males are phenotypically normal and indistinguishable from wild-type littermates   (MGI Ref ID J:120713)
    • EGFP expression in cells concordant with Foxp3 expression allows the kinetics of regulatory T cell proliferation and localization during a primary immune response   (MGI Ref ID J:120713)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency
      T cell deficiency

Research Tools
Fluorescent Proteins
Genetics Research
      Tissue/Cell Markers
      Tissue/Cell Markers: T cell specific surface marker
Immunology, Inflammation and Autoimmunity Research
      T cell specific surface marker

GFP related

Research Tools
Fluorescent Proteins

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Foxp3tm2Tch
Allele Name targeted mutation 2, Talal A Chatila
Allele Type Targeted (Reporter)
Common Name(s) FoxP3.GFP; Foxp3-GFP KI; Foxp3EGFP; Foxp3IRES-GFP; Foxp3tm2(EGFP)Tch;
Mutation Made By Talal Chatila,   Boston Children's Hospital
Strain of Origin129X1/SvJ
ES Cell Line NameSCC10
ES Cell Line Strain129X1/SvJ
Site of ExpressionEGFP is expressed in the Foxp3+ T cell population. Some EGFP expression is noted in a small population of CD8+ thymocytes.
Expressed Gene GFP, Green Fluorescent Protein, jellyfish
Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source.
Molecular Note An IRES-EGFP-SV40 poly A sequence was inserted immediately downstream of the endogenous Foxp3 translational stop codon, but upstream of the endogenous polyA signal, generating a bicistronic locus encoding both Foxp3 and EGFP. Expression of EGFP is restricted to the T cell lineage, primarily to the CD4+ T cell population. [MGI Ref ID J:120713]
 
Gene Symbol and Name Foxp3, forkhead box P3
Chromosome X
Gene Common Name(s) AIID; DIETER; IPEX; JM2; PIDX; RGD1562112; XPID; scurfin; scurfy; sf;

Genotyping

Genotyping Information

Genotyping Protocols

Foxp3tm2Tchalternate1, High Resolution Melting
Foxp3tm2Tch, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Haribhai D; Lin W; Relland LM; Truong N; Williams CB; Chatila TA. 2007. Regulatory T cells dynamically control the primary immune response to foreign antigen. J Immunol 178(5):2961-72. [PubMed: 17312141]  [MGI Ref ID J:120713]

Lin W; Haribhai D; Relland LM; Truong N; Carlson MR; Williams CB; Chatila TA. 2007. Regulatory T cell development in the absence of functional Foxp3. Nat Immunol 8(4):359-68. [PubMed: 17273171]  [MGI Ref ID J:120636]

Additional References

Foxp3tm2Tch related

Abel S; Luckheide N; Westendorf AM; Geffers R; Roers A; Muller W; Sparwasser T; Matuschewski K; Buer J; Hansen W. 2012. Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection. J Immunol 188(11):5467-77. [PubMed: 22544931]  [MGI Ref ID J:188734]

Atarashi K; Tanoue T; Shima T; Imaoka A; Kuwahara T; Momose Y; Cheng G; Yamasaki S; Saito T; Ohba Y; Taniguchi T; Takeda K; Hori S; Ivanov II; Umesaki Y; Itoh K; Honda K. 2011. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331(6015):337-41. [PubMed: 21205640]  [MGI Ref ID J:172265]

Benson A; Murray S; Divakar P; Burnaevskiy N; Pifer R; Forman J; Yarovinsky F. 2012. Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism. J Immunol 188(2):800-10. [PubMed: 22147768]  [MGI Ref ID J:180888]

Betts RJ; Prabhu N; Ho AW; Lew FC; Hutchinson PE; Rotzschke O; Macary PA; Kemeny DM. 2012. Influenza a virus infection results in a robust, antigen-responsive, and widely disseminated foxp3+ regulatory T cell response. J Virol 86(5):2817-25. [PubMed: 22205730]  [MGI Ref ID J:181233]

Cai SF; Cao X; Hassan A; Fehniger TA; Ley TJ. 2010. Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease. Blood 115(9):1669-77. [PubMed: 19965675]  [MGI Ref ID J:157876]

Cavassani KA; Carson WF 4th; Moreira AP; Wen H; Schaller MA; Ishii M; Lindell DM; Dou Y; Lukacs NW; Keshamouni VG; Hogaboam CM; Kunkel SL. 2010. The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth. Blood 115(22):4403-11. [PubMed: 20130237]  [MGI Ref ID J:161572]

Centuori SM; Trad M; LaCasse CJ; Alizadeh D; Larmonier CB; Hanke NT; Kartchner J; Janikashvili N; Bonnotte B; Larmonier N; Katsanis E. 2012. Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-beta-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells. J Leukoc Biol 92(5):987-97. [PubMed: 22891289]  [MGI Ref ID J:189810]

Chen C; Liu Y; Liu Y; Zheng P. 2010. Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice. J Clin Invest 120(11):4091-101. [PubMed: 20972332]  [MGI Ref ID J:167563]

Chen X; Das R; Komorowski R; Beres A; Hessner MJ; Mihara M; Drobyski WR. 2009. Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease. Blood 114(4):891-900. [PubMed: 19491393]  [MGI Ref ID J:150726]

Chen X; Dodge J; Komorowski R; Drobyski WR. 2013. A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease. Blood 121(19):3970-80. [PubMed: 23529927]  [MGI Ref ID J:198223]

Cho WY; Choi HM; Lee SY; Kim MG; Kim HK; Jo SK. 2010. The role of Tregs and CD11c(+) macrophages/dendritic cells in ischemic preconditioning of the kidney. Kidney Int 78(10):981-92. [PubMed: 20686446]  [MGI Ref ID J:184252]

Choi J; Ritchey J; Prior JL; Holt M; Shannon WD; Deych E; Piwnica-Worms DR; DiPersio JF. 2010. In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia. Blood 116(1):129-39. [PubMed: 20424188]  [MGI Ref ID J:162801]

Chougnet CA; Tripathi P; Lages CS; Raynor J; Sholl A; Fink P; Plas DR; Hildeman DA. 2011. A major role for Bim in regulatory T cell homeostasis. J Immunol 186(1):156-63. [PubMed: 21098226]  [MGI Ref ID J:168007]

Chung HS; Lee JH; Kim H; Lee HJ; Kim SH; Kwon HK; Im SH; Bae H. 2010. Foxp3 is a novel repressor of microglia activation. Glia 58(10):1247-56. [PubMed: 20544860]  [MGI Ref ID J:168043]

Clambey ET; McNamee EN; Westrich JA; Glover LE; Campbell EL; Jedlicka P; de Zoeten EF; Cambier JC; Stenmark KR; Colgan SP; Eltzschig HK. 2012. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A 109(41):E2784-93. [PubMed: 22988108]  [MGI Ref ID J:190110]

Cong Y; Feng T; Fujihashi K; Schoeb TR; Elson CO. 2009. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc Natl Acad Sci U S A 106(46):19256-61. [PubMed: 19889972]  [MGI Ref ID J:154759]

Deiuliis JA; Kampfrath T; Zhong J; Oghumu S; Maiseyeu A; Chen LC; Sun Q; Satoskar AR; Rajagopalan S. 2012. Pulmonary T cell activation in response to chronic particulate air pollution. Am J Physiol Lung Cell Mol Physiol 302(4):L399-409. [PubMed: 22160305]  [MGI Ref ID J:183449]

Deppong CM; Bricker TL; Rannals BD; Van Rooijen N; Hsieh CS; Green JM. 2013. CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-beta. J Immunol 191(6):3082-9. [PubMed: 23956428]  [MGI Ref ID J:205876]

Ehrentraut H; Westrich JA; Eltzschig HK; Clambey ET. 2012. Adora2b adenosine receptor engagement enhances regulatory T cell abundance during endotoxin-induced pulmonary inflammation. PLoS One 7(2):e32416. [PubMed: 22389701]  [MGI Ref ID J:185292]

Feng T; Cong Y; Qin H; Benveniste EN; Elson CO. 2010. Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic Acid. J Immunol 185(10):5915-25. [PubMed: 20944006]  [MGI Ref ID J:165627]

Fyhrquist N; Lehtimaki S; Lahl K; Savinko T; Lappetelainen AM; Sparwasser T; Wolff H; Lauerma A; Alenius H. 2012. Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis. J Invest Dermatol 132(6):1672-80. [PubMed: 22402436]  [MGI Ref ID J:188756]

Guo Z; Khattar M; Schroder PM; Miyahara Y; Wang G; He X; Chen W; Stepkowski SM. 2013. A Dynamic Dual Role of IL-2 Signaling in the Two-Step Differentiation Process of Adaptive Regulatory T Cells. J Immunol 190(7):3153-62. [PubMed: 23427250]  [MGI Ref ID J:194525]

Guo Z; Wen Z; Qin A; Zhou Y; Liao Z; Liu Z; Liang Y; Ren T; Xu L. 2013. Antisense Oligonucleotide Treatment Enhances the Recovery of Acute Lung Injury through IL-10-Secreting M2-like Macrophage-Induced Expansion of CD4+ Regulatory T Cells. J Immunol 190(8):4337-48. [PubMed: 23514739]  [MGI Ref ID J:195286]

Hams E; McCarron MJ; Amu S; Yagita H; Azuma M; Chen L; Fallon PG. 2011. Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J Immunol 186(10):5648-55. [PubMed: 21490158]  [MGI Ref ID J:173223]

Haribhai D; Williams JB; Jia S; Nickerson D; Schmitt EG; Edwards B; Ziegelbauer J; Yassai M; Li SH; Relland LM; Wise PM; Chen A; Zheng YQ; Simpson PM; Gorski J; Salzman NH; Hessner MJ; Chatila TA; Williams CB. 2011. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 35(1):109-22. [PubMed: 21723159]  [MGI Ref ID J:174377]

Idoyaga J; Fiorese C; Zbytnuik L; Lubkin A; Miller J; Malissen B; Mucida D; Merad M; Steinman RM. 2013. Specialized role of migratory dendritic cells in peripheral tolerance induction. J Clin Invest :. [PubMed: 23298832]  [MGI Ref ID J:194499]

Jeon SG; Kayama H; Ueda Y; Takahashi T; Asahara T; Tsuji H; Tsuji NM; Kiyono H; Ma JS; Kusu T; Okumura R; Hara H; Yoshida H; Yamamoto M; Nomoto K; Takeda K. 2012. Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon. PLoS Pathog 8(5):e1002714. [PubMed: 22693446]  [MGI Ref ID J:195381]

Kaminitz A; Yolcu ES; Askenasy EM; Stein J; Yaniv I; Shirwan H; Askenasy N. 2011. Effector and Naturally Occurring Regulatory T Cells Display No Abnormalities in Activation Induced Cell Death in NOD Mice. PLoS One 6(6):e21630. [PubMed: 21738739]  [MGI Ref ID J:174547]

Kong KF; Fu G; Zhang Y; Yokosuka T; Casas J; Canonigo-Balancio AJ; Becart S; Kim G; Yates JR 3rd; Kronenberg M; Saito T; Gascoigne NR; Altman A. 2014. Protein kinase C-eta controls CTLA-4-mediated regulatory T cell function. Nat Immunol 15(5):465-72. [PubMed: 24705298]  [MGI Ref ID J:209959]

Lathrop SK; Bloom SM; Rao SM; Nutsch K; Lio CW; Santacruz N; Peterson DA; Stappenbeck TS; Hsieh CS. 2011. Peripheral education of the immune system by colonic commensal microbiota. Nature 478(7368):250-4. [PubMed: 21937990]  [MGI Ref ID J:177128]

Lee H; Nho D; Chung HS; Lee H; Shin MK; Kim SH; Bae H. 2010. CD4+CD25+ regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice. Kidney Int 78(11):1100-9. [PubMed: 20463654]  [MGI Ref ID J:184263]

Liu Z; Falo LD Jr; You Z. 2011. Knockdown of HMGB1 in tumor cells attenuates their ability to induce regulatory T cells and uncovers naturally acquired CD8 T cell-dependent antitumor immunity. J Immunol 187(1):118-25. [PubMed: 21642542]  [MGI Ref ID J:176186]

Lobo PI; Bajwa A; Schlegel KH; Vengal J; Lee SJ; Huang L; Ye H; Deshmukh U; Wang T; Pei H; Okusa MD. 2012. Natural IgM anti-leukocyte autoantibodies attenuate excess inflammation mediated by innate and adaptive immune mechanisms involving Th-17. J Immunol 188(4):1675-85. [PubMed: 22262657]  [MGI Ref ID J:181303]

Mahmud SA; Manlove LS; Schmitz HM; Xing Y; Wang Y; Owen DL; Schenkel JM; Boomer JS; Green JM; Yagita H; Chi H; Hogquist KA; Farrar MA. 2014. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol 15(5):473-81. [PubMed: 24633226]  [MGI Ref ID J:210316]

Mashayekhi M; Sandau MM; Dunay IR; Frickel EM; Khan A; Goldszmid RS; Sher A; Ploegh HL; Murphy TL; Sibley LD; Murphy KM. 2011. CD8alpha(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity 35(2):249-59. [PubMed: 21867928]  [MGI Ref ID J:176232]

Mayne CG; Spanier JA; Relland LM; Williams CB; Hayes CE. 2011. 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. Eur J Immunol 41(3):822-32. [PubMed: 21287548]  [MGI Ref ID J:175424]

Morlacchi S; Soldani C; Viola A; Sarukhan A. 2011. Self-antigen presentation by mouse B cells results in regulatory T-cell induction rather than anergy or clonal deletion. Blood 118(4):984-91. [PubMed: 21652680]  [MGI Ref ID J:174859]

Niess JH; Adler G. 2010. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J Immunol 184(4):2026-37. [PubMed: 20089703]  [MGI Ref ID J:159471]

Oh J; Wu N; Baravalle G; Cohn B; Ma J; Lo B; Mellman I; Ishido S; Anderson M; Shin JS. 2013. MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med 210(6):1069-77. [PubMed: 23712430]  [MGI Ref ID J:201198]

Oh S; Aitken M; Simons DM; Basehoar A; Garcia V; Kropf E; Caton AJ. 2012. Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis. J Immunol 188(9):4171-80. [PubMed: 22450809]  [MGI Ref ID J:188463]

Pallotta MT; Orabona C; Volpi C; Vacca C; Belladonna ML; Bianchi R; Servillo G; Brunacci C; Calvitti M; Bicciato S; Mazza EM; Boon L; Grassi F; Fioretti MC; Fallarino F; Puccetti P; Grohmann U. 2011. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol 12(9):870-8. [PubMed: 21804557]  [MGI Ref ID J:176469]

Patterson SJ; Han JM; Garcia R; Assi K; Gao T; O'Neill A; Newton AC; Levings MK. 2011. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol 186(10):5533-7. [PubMed: 21498666]  [MGI Ref ID J:173220]

Procaccini C; De Rosa V; Galgani M; Abanni L; Cali G; Porcellini A; Carbone F; Fontana S; Horvath TL; La Cava A; Matarese G. 2010. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 33(6):929-41. [PubMed: 21145759]  [MGI Ref ID J:167293]

Procaccini C; De Rosa V; Galgani M; Carbone F; Cassano S; Greco D; Qian K; Auvinen P; Cali G; Stallone G; Formisano L; La Cava A; Matarese G. 2012. Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses. J Immunol 189(6):2941-53. [PubMed: 22904304]  [MGI Ref ID J:189915]

Ramakrishna C; Newo AN; Shen YW; Cantin E. 2011. Passively administered pooled human immunoglobulins exert IL-10 dependent anti-inflammatory effects that protect against fatal HSV encephalitis. PLoS Pathog 7(6):e1002071. [PubMed: 21655109]  [MGI Ref ID J:182197]

Ray A; Basu S; Williams CB; Salzman NH; Dittel BN. 2012. A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. J Immunol 188(7):3188-98. [PubMed: 22368274]  [MGI Ref ID J:183107]

Relland LM; Williams JB; Relland GN; Haribhai D; Ziegelbauer J; Yassai M; Gorski J; Williams CB. 2012. The TCR repertoires of regulatory and conventional T cells specific for the same foreign antigen are distinct. J Immunol 189(7):3566-74. [PubMed: 22933635]  [MGI Ref ID J:190344]

Rivas EI; Driver JP; Garabatos N; Presa M; Mora C; Rodriguez F; Serreze DV; Stratmann T. 2011. Targeting of a T cell agonist Peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse. J Immunol 186(7):4078-87. [PubMed: 21346228]  [MGI Ref ID J:170837]

Roychoudhuri R; Hirahara K; Mousavi K; Clever D; Klebanoff CA; Bonelli M; Sciume G; Zare H; Vahedi G; Dema B; Yu Z; Liu H; Takahashi H; Rao M; Muranski P; Crompton JG; Punkosdy G; Bedognetti D; Wang E; Hoffmann V; Rivera J; Marincola FM; Nakamura A; Sartorelli V; Kanno Y; Gattinoni L; Muto A; Igarashi K; O'Shea JJ; Restifo NP. 2013. BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature 498(7455):506-10. [PubMed: 23728300]  [MGI Ref ID J:204571]

Sahu RP; Petrache I; Van Demark MJ; Rashid BM; Ocana JA; Tang Y; Yi Q; Turner MJ; Konger RL; Travers JB. 2013. Cigarette Smoke Exposure Inhibits Contact Hypersensitivity via the Generation of Platelet-Activating Factor Agonists. J Immunol 190(5):2447-54. [PubMed: 23355733]  [MGI Ref ID J:193474]

Salti SM; Hammelev EM; Grewal JL; Reddy ST; Zemple SJ; Grossman WJ; Grayson MH; Verbsky JW. 2011. Granzyme B regulates antiviral CD8+ T cell responses. J Immunol 187(12):6301-9. [PubMed: 22084442]  [MGI Ref ID J:180386]

Sawant DV; Sehra S; Nguyen ET; Jadhav R; Englert K; Shinnakasu R; Hangoc G; Broxmeyer HE; Nakayama T; Perumal NB; Kaplan MH; Dent AL. 2012. Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J Immunol 189(10):4759-69. [PubMed: 23053511]  [MGI Ref ID J:190587]

Schallenberg S; Petzold C; Tsai PY; Sparwasser T; Kretschmer K. 2012. Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells. PLoS One 7(8):e41971. [PubMed: 22879902]  [MGI Ref ID J:189833]

Schallenberg S; Tsai PY; Riewaldt J; Kretschmer K. 2010. Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice. J Exp Med 207(7):1393-407. [PubMed: 20584884]  [MGI Ref ID J:163388]

Schmidt-Christensen A; Hansen L; Ilegems E; Fransen-Pettersson N; Dahl U; Gupta S; Larefalk A; Hannibal TD; Schulz A; Berggren PO; Holmberg D. 2013. Imaging dynamics of CD11c(+) cells and Foxp3(+) cells in progressive autoimmune insulitis in the NOD mouse model of type 1 diabetes. Diabetologia 56(12):2669-78. [PubMed: 23963325]  [MGI Ref ID J:203961]

Schmitt EG; Haribhai D; Jeschke JC; Co DO; Ziegelbauer J; Yan K; Iwakura Y; Mishra MK; Simpson P; Salzman NH; Williams CB. 2013. Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol 191(11):5460-76. [PubMed: 24163409]  [MGI Ref ID J:207015]

Schmitt EG; Haribhai D; Williams JB; Aggarwal P; Jia S; Charbonnier LM; Yan K; Lorier R; Turner A; Ziegelbauer J; Georgiev P; Simpson P; Salzman NH; Hessner MJ; Broeckel U; Chatila TA; Williams CB. 2012. IL-10 Produced by Induced Regulatory T Cells (iTregs) Controls Colitis and Pathogenic Ex-iTregs during Immunotherapy. J Immunol 189(12):5638-48. [PubMed: 23125413]  [MGI Ref ID J:190976]

Surls J; Nazarov-Stoica C; Kehl M; Olsen C; Casares S; Brumeanu TD. 2012. Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response. PLoS One 7(6):e38733. [PubMed: 22723880]  [MGI Ref ID J:187823]

Tessmer MS; Reilly EC; Brossay L. 2011. Salivary gland NK cells are phenotypically and functionally unique. PLoS Pathog 7(1):e1001254. [PubMed: 21249177]  [MGI Ref ID J:172475]

Tischner D; Wiegers GJ; Fiegl H; Drach M; Villunger A. 2012. Mutual antagonism of TGF-beta and Interleukin-2 in cell survival and lineage commitment of induced regulatory T cells. Cell Death Differ 19(8):1277-87. [PubMed: 22322859]  [MGI Ref ID J:204633]

Venet F; Chung CS; Huang X; Lomas-Neira J; Chen Y; Ayala A. 2009. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J Immunol 183(5):3472-80. [PubMed: 19641139]  [MGI Ref ID J:151875]

Xiong Y; Khanna S; Grzenda AL; Sarmento OF; Svingen PA; Lomberk GA; Urrutia RA; Faubion WA Jr. 2012. Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. J Biol Chem 287(41):34372-85. [PubMed: 22896699]  [MGI Ref ID J:191582]

Yokosuka T; Kobayashi W; Takamatsu M; Sakata-Sogawa K; Zeng H; Hashimoto-Tane A; Yagita H; Tokunaga M; Saito T. 2010. Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation. Immunity 33(3):326-39. [PubMed: 20870175]  [MGI Ref ID J:164647]

Zaiss DM; van Loosdregt J; Gorlani A; Bekker CP; Grone A; Sibilia M; van Bergen En Henegouwen PM; Roovers RC; Coffer PJ; Sijts AJ. 2013. Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor. Immunity 38(2):275-84. [PubMed: 23333074]  [MGI Ref ID J:193394]

Zhang W; Zhang D; Shen M; Liu Y; Tian Y; Thomson AW; Lee WP; Zheng XX. 2010. Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance. J Immunol 185(8):4750-9. [PubMed: 20844194]  [MGI Ref ID J:164884]

Zhang Y; Liu C; Wei B; Pei G. 2013. Loss of beta-arrestin 2 exacerbates experimental autoimmune encephalomyelitis with reduced number of Foxp3+ CD4+ regulatory T cells. Immunology 140(4):430-40. [PubMed: 23859136]  [MGI Ref ID J:209555]

Zou Q; Wu B; Xue J; Fan X; Feng C; Geng S; Wang M; Wang B. 2014. CD8+ Treg cells suppress CD8+ T cell-responses by IL-10-dependent mechanism during H5N1 influenza virus infection. Eur J Immunol 44(1):103-14. [PubMed: 24114149]  [MGI Ref ID J:208656]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryThis mutant allele is located on the X chromosome. When maintaining a live colony, homozygous females are bred with hemizygous males.
Mating SystemHomozygote x Hemizygote         (Female x Male)   04-FEB-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90MaleHemizygous for Foxp3tm2Tch  
$199.90FemaleHomozygous for Foxp3tm2Tch  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Foxp3tm2Tch x Hemizygous for Foxp3tm2Tch  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90MaleHemizygous for Foxp3tm2Tch  
$259.90FemaleHomozygous for Foxp3tm2Tch  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Foxp3tm2Tch x Hemizygous for Foxp3tm2Tch  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   Wild-type from the colony
   000651 BALB/cJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Terms of Use


General Terms and Conditions


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phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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