Strain Name:

FVB-Tg(Col2a1-cre/ERT)KA3Smac/J

Stock Number:

006774

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
Common Names: Col2CreERT;    
When these Col2CreERT mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in cartilage cells (both during embryogenesis and postnatally), as well as in other cell types that normally express the endogenous Type II collagen gene.

Description

Strain Information

Former Names FVB-Tg(Col2a1-cre/ESR1)KA3Smac/J    (Changed: 01-APR-10 )
Type Coisogenic; Transgenic;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Mating SystemHomozygote x Homozygote         (Female x Male)   18-APR-08
Specieslaboratory mouse
GenerationF14+F13 (05-MAY-15)
Generation Definitions
 
Donating Investigator Susan Mackem,   National Cancer Institute

Description
Mice hemizygous or homozygous for the Col2CreERT transgene are viable and fertile. Mice from this founder line (line K from founder mouse A3) have strong tamoxifen-inducible cre expression directed to cells of the chondrogenic lineage (cartilage), with minimal (<0.1%) cre activity in the absence of tamoxifen. The CreERT protein consists of Cre recombinase fused to a mutant form of the human estrogen receptor; which does not bind its natural ligand (17β-estradiol) at physiological concentrations but will bind the synthetic estrogen receptor ligand 4-hydroxytamoxifen. Restricted to the cytoplasm, CreERT can only gain access to the nuclear compartment after exposure to tamoxifen. To counteract the mixed estrogen agonist effects of tamoxifen injections, which can result in late fetal abortions in pregnant mice, progesterone may be coadministered. When these Col2CreERT mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in cartilage cells (both during embryogenesis and postnatally), as well as in other cell types that normally express the endogenous Type II collagen gene.

Development
The Col2CreERT transgene was designed with the mouse Col2a-1 (procollagen type II, alpha 1) promoter sequence, beta-globin intron, Cre-ERT fusion gene (Cre recombinase fused to a mutated ligand-binding domain of the human estrogen receptor (ER)), SV40 pA signal, and Col2a-1 intron 1 enhancer. This transgene was injected into FVB/N zygotes. Founder mice determined to have the strongest tamoxifen-inducible Cre recombinase activity with minimal activity in the absence of tamoxifen (founder line K from founder mouse A3) were subsequently bred to FVB/N to generate hemizygotes. Mice were then interbred for more than 10 generations prior to arrival at The Jackson Laboratory.

Control Information

  Control
   001800 FVB/NJ
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying other alleles of Col2a1     (7 strains)

Strains carrying other alleles of cre/ERT2
017611   129-Mcm2tm1(cre/ERT2)Scpr/J
009575   B6(129S4)-Et(cre/ERT2)119Rdav/J
009580   B6(129S4)-Et(cre/ERT2)1382Rdav/J
012688   B6(129S4)-Et(cre/ERT2)13866Rdav/J
009581   B6(129S4)-Et(cre/ERT2)1642Rdav/J
009582   B6(129S4)-Et(cre/ERT2)1645Rdav/J
009583   B6(129S4)-Et(cre/ERT2)1957Rdav/J
009584   B6(129S4)-Et(cre/ERT2)2007Rdav/J
009585   B6(129S4)-Et(cre/ERT2)2047Rdav/J
009574   B6(129S4)-Et(cre/ERT2)21Rdav/J
009577   B6(129S4)-Et(cre/ERT2)296Rdav/J
009578   B6(129S4)-Et(cre/ERT2)398Rdav/J
009573   B6(129S4)-Et(cre/ERT2)4Rdav/J
010688   B6(129S4)-Et(cre/ERT2)6691Rdav/J
010689   B6(129S4)-Et(cre/ERT2)6959Rdav/J
010690   B6(129S4)-Et(cre/ERT2)7089Rdav/J
010691   B6(129S4)-Et(cre/ERT2)7149Rdav/J
010692   B6(129S4)-Et(cre/ERT2)7381Rdav/J
010693   B6(129S4)-Et(cre/ERT2)8120Rdav/J
010694   B6(129S4)-Et(cre/ERT2)8131Rdav/J
009579   B6(129S4)-Et(cre/ERT2)837Rdav/J
010695   B6(129S4)-Et(cre/ERT2)9699Rdav/J
010696   B6(129S4)-Et(icre/ERT2)10596Rdav/J
010697   B6(129S4)-Et(icre/ERT2)10727Rdav/J
012689   B6(129S4)-Et(icre/ERT2)14163Rdav/J
012690   B6(129S4)-Et(icre/ERT2)14208Rdav/J
012694   B6(129S4)-Et(icre/ERT2)14915Rdav/J
022356   B6(129X1)-Tg(Cd4-cre/ERT2)11Gnri/J
013730   B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J
010705   B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J
013048   B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J
010776   B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J
010777   B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J
010708   B6(Cg)-Ssttm1(cre/ERT2)Zjh/J
026512   B6(Cg)-Tg(TPO-cre/ERT2)1139Tyj/J
021881   B6.129(Cg)-Arctm1.1(cre/ERT2)Luo/J
018867   B6.129(Cg)-Axin2tm1(cre/ERT2)Rnu/J
021882   B6.129(Cg)-Fostm1.1(cre/ERT2)Luo/J
008463   B6.129-Gt(ROSA)26Sortm1(cre/ERT2)Tyj/J
020940   B6.129P2(C)-Cx3cr1tm2.1(cre/ERT2)Jung/J
021160   B6.129P2(Cg)-Cx3cr1tm2.1(cre/ERT)Litt/WganJ
027116   B6.129P2-Cd19tm1(cre/ERT2)Rsky/J
008875   B6.129P2-Lgr5tm1(cre/ERT2)Cle/J
016934   B6.129P2-Lgr6tm2.1(cre/ERT2)Cle/J
016222   B6.129S(Cg)-Id2tm1.1(cre/ERT2)Blh/ZhuJ
005623   B6.129S6-Shhtm2(cre/ERT2)Cjt/J
019148   B6.Cg-Acantm1(cre/ERT2)Crm/J
012360   B6.Cg-Erbb4tm1.1(cre/ERT2)Aibs/J
023676   B6.Cg-Hprttm331(Ple275-icre/ERT2)Ems/Mmjax
023677   B6.Cg-Hprttm332(Ple272-icre/ERT2)Ems/Mmjax
023678   B6.Cg-Hprttm333(Ple281-icre/ERT2)Ems/Mmjax
023679   B6.Cg-Hprttm334(Ple279-icre/ERT2)Ems/Mmjax
023680   B6.Cg-Hprttm335(Ple277-icre/ERT2)Ems/Mmjax
023681   B6.Cg-Hprttm336(Ple134-icre/ERT2)Ems/Mmjax
023682   B6.Cg-Hprttm337(Ple285-icre/ERT2)Ems/Mmjax
023683   B6.Cg-Hprttm338(Ple284-icre/ERT2)Ems/Mmjax
023684   B6.Cg-Hprttm339(Ple280-icre/ERT2)Ems/Mmjax
023685   B6.Cg-Hprttm340(Ple252-icre/ERT2)Ems/Mmjax
023686   B6.Cg-Hprttm341(Ple273-icre/ERT2)Ems/Mmjax
023687   B6.Cg-Hprttm342(Ple282-icre/ERT2)Ems/Mmjax
023688   B6.Cg-Hprttm343(Ple270-icre/ERT2)Ems/Mmjax
023689   B6.Cg-Hprttm344(Ple5-icre/ERT2)Ems/Mmjax
023690   B6.Cg-Hprttm345(icre/ERT2)Ems/Mmjax
023691   B6.Cg-Hprttm346(Ple264-icre/ERT2)Ems/Mmjax
023692   B6.Cg-Hprttm347(Ple155-icre/ERT2)Ems/Mmjax
023693   B6.Cg-Hprttm348(Ple265-icre/ERT2)Ems/Mmjax
023694   B6.Cg-Hprttm349(Ple293-icre/ERT2)Ems/Mmjax
023695   B6.Cg-Hprttm350(Ple232-icre/ERT2)Ems/Mmjax
023696   B6.Cg-Hprttm351(Ple198-icre/ERT2)Ems/Mmjax
023697   B6.Cg-Hprttm352(Ple291-icre/ERT2)Ems/Mmjax
022861   B6.Cg-Nxph4tm1.1(cre/ERT2)Hze/J
017763   B6.Cg-Pax7tm1(cre/ERT2)Gaka/J
022862   B6.Cg-Penktm1.1(cre/ERT2)Hze/J
021189   B6.Cg-Pvalbtm1.1(cre/ERT2)Hze/J
022865   B6.Cg-Trib2tm1.1(cre/ERT2)Hze/J
022357   B6.Cg-Tg(Arc-cre/ERT2)MRhn/CdnyJ
026516   B6.Cg-Tg(Avil-cre/ERT2)AJwo/J
022390   B6.Cg-Tg(CDX2-Cre/ERT2)752Erf/J
016241   B6.Cg-Tg(Col1a1-cre/ERT2)1Crm/J
016237   B6.Cg-Tg(Col1a2-cre/ERT)7Cpd/J
024709   B6.Cg-Tg(Ins1-cre/ERT)1Lphi/J
007606   B6.Cg-Tg(Thy1-cre/ERT2,-EYFP)AGfng/J
021961   B6;129-Abcg2tm3.1(cre/ERT2)Bsor/J
010531   B6;129-Bmi1tm1(cre/ERT)Mrc/J
004847   B6;129-Gt(ROSA)26Sortm1(cre/ERT)Nat/J
010557   B6;129-Gt(ROSA)26Sortm3(rtTA,tetO-cre/ERT)Nat/J
024475   B6;129-Myod1tm1.1(cre/ERT,TVA)Gcg/J
008363   B6;129-Nefltm1(cre/ERT)Nat/J
012476   B6;129-Pax7tm2.1(cre/ERT2)Fan/J
009600   B6;129-Six2tm3(EGFP/cre/ERT2)Amc/J
008532   B6;129-Thtm1(cre/Esr1)Nat/J
008531   B6;129-Vamp2tm1(cre/ERT)Nat/J
010985   B6;129P-Klf3tm1(cre/ERT2)Pzg/J
015854   B6;129P2-Foxl2tm1(GFP/cre/ERT2)Pzg/J
014541   B6;129S-Nos1tm1.1(cre/ERT2)Zjh/J
010987   B6;129S-Sox18tm1(GFP/cre/ERT2)Pzg/J
017593   B6;129S-Sox2tm1(cre/ERT2)Hoch/J
014551   B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J
012464   B6;129S4-Foxd1tm2(GFP/cre/ERT2)Amc/J
009576   B6;129S4-Et(cre/ERT2)278Rdav/J
024948   B6;129S6-Gdnftm1(cre/ERT2)Cos/J
012362   B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J
017495   B6;129S7-Crim1tm1(GFP/cre/ERT2)Pzg/J
014638   B6;129X1-Cldn6tm1(cre/ERT2)Dam/J
025809   B6;CBA-Tg(Fgfr3-icre/ERT2)4-2Wdr/J
025808   B6;CBA-Tg(Nkx2-1-cre/ERT2)1Kess/J
024768   B6;CBA-Tg(Upk2-icre/ERT2)1Ccc/J
007610   B6;SJL-Tg(Thy1-cre/ERT2,-EYFP)VGfng/J
016225   B6N.129S6(Cg)-Scgb1a1tm1(cre/ERT)Blh/J
010550   B6N.FVB-Tg(Penk-glc-2-cre/ERT2)2And/J
017743   B6N;129S-Prom1tm1(cre/ERT2)Gilb/J
025124   C57BL/6-Tg(Adipoq-cre/ERT2)1Soff/J
025867   C57BL/6J-Tg(Neurod1-cre/ERT2)M1Fcal/J
024760   FVB/N-Tg(Ddx4-cre/ERT2)1Dcas/J
012882   STOCK Ascl1tm1.1(Cre/ERT2)Jejo/J
012710   STOCK Ccktm2.1(cre/ERT2)Zjh/J
007924   STOCK En2tm4(cre/ERT2)Alj/J
016961   STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J
010702   STOCK Gad2tm1(cre/ERT2)Zjh/J
022135   STOCK Gbx2tm1.1(cre/ERT2)Jyhl/J
007913   STOCK Gli1tm3(cre/ERT2)Alj/J
024283   STOCK Hcn4tm2.1(cre/ERT2)Sev/J
017606   STOCK Hopxtm2.1(cre/ERT2)Joe/J
018418   STOCK Lrig1tm1.1(cre/ERT2)Rjc/J
014552   STOCK Nkx2-1tm1.1(cre/ERT2)Zjh/J
017536   STOCK Nkx6-2tm1(cre/ERT2)Fsh/J
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
017569   STOCK Polr2atm1(cre/ERT2)Bbd E4f1tm1.1Llca/J
017585   STOCK Polr2atm1(cre/ERT2)Bbd/J
022757   STOCK Prg4tm1(GFP/cre/ERT2)Abl/J
010912   STOCK Wt1tm2(cre/ERT2)Wtp/J
012691   STOCK Et(icre/ERT2)14374Rdav/J
012692   STOCK Et(icre/ERT2)14602Rdav/J
012693   STOCK Et(icre/ERT2)14624Rdav/J
007684   STOCK Tg(Atoh1-cre/Esr1*)14Fsh/J
025736   STOCK Tg(Cela1-cre/ERT)1Lgdn/J
027681   STOCK Tg(Hnf1b-cre/ERT2)1Jfer/J
025520   STOCK Tg(T-cre/ERT2)1Lwd/J
View Strains carrying other alleles of cre/ERT2     (138 strains)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Tg(Col2a1-cre/ERT)KA3Smac/0

        involves: FVB/N
  • normal phenotype
  • no abnormal phenotype detected
    • mice are viable and fertile   (MGI Ref ID J:111627)

Tg(Col2a1-cre/ERT)KA3Smac/Tg(Col2a1-cre/ERT)KA3Smac

        involves: FVB/N
  • normal phenotype
  • no abnormal phenotype detected
    • mice are viable and fertile   (MGI Ref ID J:111627)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Craniofacial and Palate Defects
      Orofacial clefting-specific cre expression

Research Tools
Cre-lox System
      Cre Recombinase Expression
      Cre Recombinase Expression: Germline/Embryonic Expression
      Cre Recombinase Expression: Inducible
Developmental Biology Research
      Cre-lox System
Genetics Research
      Mutagenesis and Transgenesis
      Mutagenesis and Transgenesis: Cre-lox System
      Tissue/Cell Markers
      Tissue/Cell Markers: Cre-lox System
      Tissue/Cell Markers: chondrocytes

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tg(Col2a1-cre/ERT)KA3Smac
Allele Name transgene insertion KA3, Susan Mackem
Allele Type Transgenic (Inducible, cre- or Flp-expressing)
Common Name(s) Col2CreERT; Tg(Col2a1-cre/ESR1)1Smac; Tg(Col2a1-cre/ESR1)KA3Smac;
Mutation Made By Susan Mackem,   National Cancer Institute
Strain of OriginFVB/N
Site of Expressiontamoxifen-inducible cre expression is directed to cells of the chondrogenic lineage (cartilage) during embryogenesis and postnatally
Expressed Gene cre/ERT2, Cre recombinase and estrogen receptor 1 (human) fusion gene,
Promoter Col2a1, collagen, type II, alpha 1, mouse, laboratory
Driver Note Col2a1
Inducible Note induced by tamoxifen
Molecular Note This transgene expresses a tamoxifen inducible form of cre recombinase driven by the Col2a1 promoter in cartilage. The cre recombinase coding region is joined to sequence encoding the ligand binding domain of the human estrogen receptor with a glycine toarginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability. [MGI Ref ID J:111627] [MGI Ref ID J:35420]
 
 

Genotyping

Genotyping Information

Genotyping Protocols

Generic Cre Quantitative PCR, QPCR
Generic Cre, Standard PCR
Tg(Col2a1-cre/ESR1)KA3Smac, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Nakamura E; Nguyen MT; Mackem S. 2006. Kinetics of tamoxifen-regulated Cre activity in mice using a cartilage-specific CreER(T) to assay temporal activity windows along the proximodistal limb skeleton. Dev Dyn 235(9):2603-2612. [PubMed: 16894608]  [MGI Ref ID J:111627]

Additional References

Tg(Col2a1-cre/ERT)KA3Smac related

Ahrens MJ; Romereim S; Dudley AT. 2011. A re-evaluation of two key reagents for in vivo studies of Wnt signaling. Dev Dyn :. [PubMed: 21793100]  [MGI Ref ID J:174609]

Blitz E; Sharir A; Akiyama H; Zelzer E. 2013. Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors. Development 140(13):2680-90. [PubMed: 23720048]  [MGI Ref ID J:198653]

Chang W; Tu C; Chen TH; Bikle D; Shoback D. 2008. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal 1(35):ra1. [PubMed: 18765830]  [MGI Ref ID J:180651]

Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 Direct Data Submission from Genetic Resource Science :.  [MGI Ref ID J:184578]

Hirai T; Chagin AS; Kobayashi T; Mackem S; Kronenberg HM. 2011. Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life. Proc Natl Acad Sci U S A 108(1):191-6. [PubMed: 21173257]  [MGI Ref ID J:169005]

Hou B; Kolpakova-Hart E; Fukai N; Wu K; Olsen BR. 2009. The polycystic kidney disease 1 (Pkd1) gene is required for the responses of osteochondroprogenitor cells to midpalatal suture expansion in mice. Bone 44(6):1121-33. [PubMed: 19264154]  [MGI Ref ID J:150386]

Koyama E; Young B; Nagayama M; Shibukawa Y; Enomoto-Iwamoto M; Iwamoto M; Maeda Y; Lanske B; Song B; Serra R; Pacifici M. 2007. Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis. Development 134(11):2159-69. [PubMed: 17507416]  [MGI Ref ID J:122610]

Lehoczky JA; Robert B; Tabin CJ. 2011. Mouse digit tip regeneration is mediated by fate-restricted progenitor cells. Proc Natl Acad Sci U S A 108(51):20609-14. [PubMed: 22143790]  [MGI Ref ID J:180520]

Maeda Y; Nakamura E; Nguyen MT; Suva LJ; Swain FL; Razzaque MS; Mackem S; Lanske B. 2007. Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc Natl Acad Sci U S A 104(15):6382-7. [PubMed: 17409191]  [MGI Ref ID J:120822]

Maeda Y; Schipani E; Densmore MJ; Lanske B. 2010. Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor. Bone 46(2):472-8. [PubMed: 19761883]  [MGI Ref ID J:157202]

Maes C; Kobayashi T; Selig MK; Torrekens S; Roth SI; Mackem S; Carmeliet G; Kronenberg HM. 2010. Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell 19(2):329-44. [PubMed: 20708594]  [MGI Ref ID J:163667]

Mak KK; Kronenberg HM; Chuang PT; Mackem S; Yang Y. 2008. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development 135(11):1947-56. [PubMed: 18434416]  [MGI Ref ID J:134987]

Matsumoto K; Irie F; Mackem S; Yamaguchi Y. 2010. A mouse model of chondrocyte-specific somatic mutation reveals a role for Ext1 loss of heterozygosity in multiple hereditary exostoses. Proc Natl Acad Sci U S A 107(24):10932-7. [PubMed: 20534475]  [MGI Ref ID J:161395]

Patra D; DeLassus E; Hayashi S; Sandell LJ. 2011. Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice. J Biol Chem 286(33):29227-40. [PubMed: 21652717]  [MGI Ref ID J:175925]

Romereim SM; Conoan NH; Chen B; Dudley AT. 2014. A dynamic cell adhesion surface regulates tissue architecture in growth plate cartilage. Development 141(10):2085-95. [PubMed: 24764078]  [MGI Ref ID J:220911]

Sgariglia F; Candela ME; Huegel J; Jacenko O; Koyama E; Yamaguchi Y; Pacifici M; Enomoto-Iwamoto M. 2013. Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice. Bone 57(1):220-31. [PubMed: 23958822]  [MGI Ref ID J:203836]

Tsumaki N; Kimura T; Matsui Y; Nakata K; Ochi T. 1996. Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage. J Cell Biol 134(6):1573-82. [PubMed: 8830784]  [MGI Ref ID J:35420]

Yasuhara R; Ohta Y; Yuasa T; Kondo N; Hoang T; Addya S; Fortina P; Pacifici M; Iwamoto M; Enomoto-Iwamoto M. 2011. Roles of beta-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest 91(12):1739-52. [PubMed: 21968810]  [MGI Ref ID J:180101]

Yuasa T; Kondo N; Yasuhara R; Shimono K; Mackem S; Pacifici M; Iwamoto M; Enomoto-Iwamoto M. 2009. Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. Am J Pathol 175(5):1993-2003. [PubMed: 19815716]  [MGI Ref ID J:154696]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, hemizygous or homozygous mice may be bred.
Mating SystemHomozygote x Homozygote         (Female x Male)   18-APR-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $246.90Female or MaleHomozygous for Tg(Col2a1-cre/ESR1)KA3Smac  
Price per Pair (US dollars $)Pair Genotype
$493.80Homozygous for Tg(Col2a1-cre/ESR1)KA3Smac x Homozygous for Tg(Col2a1-cre/ESR1)KA3Smac  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $321.00Female or MaleHomozygous for Tg(Col2a1-cre/ESR1)KA3Smac  
Price per Pair (US dollars $)Pair Genotype
$642.00Homozygous for Tg(Col2a1-cre/ESR1)KA3Smac x Homozygous for Tg(Col2a1-cre/ESR1)KA3Smac  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   001800 FVB/NJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Mice are subject to US Patent 6040430.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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