Strain Name: |
NOD/ShiLt-Tg(GFAP-Cd80)9Mdos/MdosJ |
|---|---|
Stock Number: |
006778 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Former Name |
NOD/ShiLt-Tg(Gfap-Cd80)9Mdos/MdosJ (Changed: 18-MAR-08
) |
| Strain Common Names | NOD.Gfap-B7-1; |
| Genes & Alleles | Cd80; GFAP; Tg(GFAP-CD80)9Mdos; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Coisogenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Stock Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Transgenic Species laboratory mouse Donating Investigator H. Dosch, University of Toronto H2 Haplotype g7 Appearance
albino, pink eyed
Related Genotype: A/A Tyrc/TyrcStrain Description
Gfap-Cd80 (GFAP-B7-1) transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. The donating investigator reports that transgenic mice are protected from diabetes development.Strain Development
This transgenic strain carries a T cell co-stimulatory molecule, Cd80 (B7-1), cDNA fused to the glial fibrillary acidic protein (Gfap) promoter. The transgenic construct was injected into NOD/ShiLt fertilized embryos, and progeny of founder 9 were mated to NOD/ShiLt. In 2006, the T1DR received hemizygous mice that were mated to NOD/ShiLtJ (Stock No. 001976) prior to sibling mating.
Gene & Allele Details
| Allele Symbol | Tg(GFAP-CD80)9Mdos | ||
|---|---|---|---|
| Allele Name | transgene insertion 9, H Michael Dosch | ||
| Common Name(s) | GFAP-B7-1Tg line 9; GFAP-B71; Tg(Gfap-CD80)9Mdos; | ||
| Strain of Origin | NOD/ShiLt | ||
| Expressed Gene | Cd80, CD80 antigen, mouse, laboratory | ||
| Promoter | GFAP, glial fibrillary acidic protein, human | ||
| Molecular Note | This transgene contains cDNA encoding CD80 under control of the glial fibrillary acidic protein promoter. [J:118933] | ||
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
Genotyping Protocols
Tg(GFAP-CD80)9Mdos
Related Strains
NOD Strains
001976 NOD/ShiLtJ View NOD Strains (1 strain)
004632 B6.Cg-Tg(GFAP-APOE*2)14Hol Apoetm1Unc/J 004633 B6.Cg-Tg(GFAP-APOE*3)37Hol Apoetm1Unc/J 004631 B6.Cg-Tg(GFAP-APOE*4)1Hol Apoetm1Unc/J 005964 B6.Cg-Tg(GFAP-tTA)110Pop/J 004600 FVB-Tg(GFAP-cre)25Mes/J 003257 FVB/N-Tg(GFAPGFP)14Mes/J 003528 STOCK Tg(GFAP-TVA)5Hev/J
Research Applications
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM)
Type 1 Diabetes (IDDM) Analysis Strains (NOD Transgenics)
Immunology and Inflammation Research
Autoimmunity (Type 1 Diabetes)
CD Antigens, Antigen Receptors, and Histocompatibility Markers
References
Additional ReferencesPrice and Supply Information
| Strain Name: | NOD/ShiLt-Tg(GFAP-Cd80)9Mdos/MdosJ |
| Stock Number: | 006778 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to the Supply Notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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