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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
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Description
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Homozygote x Homozygote (Female x Male) 17-APR-08 Species laboratory mouse Generation N11+F5 (02-FEB-09) Donating Investigator Klaus Rajewsky, Immune Disease Institute (formerly CBRI) Description
Homozygous mutant mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Homozygotes have a deficiency in the B-1 subset of B-lymphocytes along with a concomitant reduction in serum IgM. Their ability to respond to T-cell-dependent antigens is severely impaired, and they fail to form splenic germinal centers.In addition to disrupting the targeted gene, the targeting construct also introduced a cre cassette into exon 2 of the targeted gene, effectively placing cre expression under the control of the endogenous promoter. The Cd19 promoter specifically directs cre expression at the earliest stages and throughout B-lymphocyte development and differentiation. Although homozygous mutant mice are Cd19-deficient, heterozygous mice are phenotypically normal, and can be used for specific deletion of loxP-flanked (floxed) targets in B-lymphocytes.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A targeting vector containing Cre recombinase, the rabbit beta-globin intron /poly A signal sequence, and an FRT-flanked neomycin resistance gene, was used to disrupt exon 2 of the Cd19 gene and to express cre under the regulation of the endogenous promoter. Herpes simplex virus thymidine kinase gene was placed 3' of the Cd19 sequence to allow for the selection against random integration. The construct was transfected into 129P2/OlaHsd-derived E14-1 embryonic stem cells. Correctly targeted ES cells were injected into 129/Sv blastocysts. The resulting chimeric animals were backcrossed to BALB/c IgHb congenics for a number of generations and then backcrossed to C57BL/6 for 10 generations.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Cd19tm1(cre)Cgn allele
004126 C.Cg-Cd19tm1(cre)Cgn Ighb/J View Strains carrying Cd19tm1(cre)Cgn (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
involves: 129P2/OlaHsd
- hematopoietic system phenotype
- abnormal B cell differentiation (MGI Ref ID J:27463)
- absent spleen germinal center (MGI Ref ID J:27463)
- failure of germinal center formation
- decreased B-1 B cell number (MGI Ref ID J:27463)
- reduced numbers of B1 cells (cd23-, IgM hi, IgD lo)
- immune system phenotype
- abnormal B cell differentiation (MGI Ref ID J:27463)
- abnormal B cell physiology (MGI Ref ID J:27463)
- impaired Cd19-/- B cell response to T cell dependent antigens
- abnormal immunoglobulin level (MGI Ref ID J:27463)
- failure of affinity maturation of serum antibodies
- decreased IgM level (MGI Ref ID J:27463)
- reduction in serum IgM
- absent spleen germinal center (MGI Ref ID J:27463)
- failure of germinal center formation
- decreased B-1 B cell number (MGI Ref ID J:27463)
- reduced numbers of B1 cells (cd23-, IgM hi, IgD lo)
This mouse can be used to support research in many areas including:
cre relatedHematological Research
Hematopoietic Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
B cell defects
Research Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Cd19tm1(cre)Cgn relatedResearch Tools
Cre-lox System
Hematological Research
Hematopoietic Defects
Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
B cell defects
Research Tools
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Cd19tm1(cre)Cgn | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, University of Cologne | ||
| Allele Type | Targeted (knock-in) | ||
| Common Name(s) | CD19-; CD19-Cre; CD19-KO; Cd19Cre; Cd19cre; | ||
| Mutation Made By | Robert Rickert, The Burnham Institute | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Name | E14.1 | ||
| ES Cell Line Strain | 129P2/OlaHsd | ||
| Site of Expression | B cells | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Gene Symbol and Name | Cd19, CD19 antigen | ||
| Chromosome | 7 | ||
| Gene Common Name(s) | AW495831; B4; MGC109570; MGC12802; expressed sequence AW495831; | ||
| Driver Note | Cd19 | ||
| Molecular Note | In frame insertion of a cre recombinase gene into the first coding exon followed by an frt-flanked neomycin cassette. A frameshift mutation was also introduced into exon 5. This allele expresses cre recombinase specifically in B lineage cells throughout development. [MGI Ref ID J:27463] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Cd19tm1(cre)Cgn, Melt Curve Analysis
Cd19tm1(cre)Cgn, Separated PCR
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Rickert RC; Roes J; Rajewsky K. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res 25(6):1317-8. [PubMed: 9092650] [MGI Ref ID J:67676]
Additional References
Cd19tm1(cre)Cgn relatedAltuwaijri S; Chuang KH; Lai KP; Lai JJ; Lin HY; Young FM; Bottaro A; Tsai MY; Zeng WP; Chang HC; Yeh S; Chang C. 2009. Susceptibility to autoimmunity and B cell resistance to apoptosis in mice lacking androgen receptor in B cells. Mol Endocrinol 23(4):444-53. [PubMed: 19164450] [MGI Ref ID J:146896]
Anderson LJ; Longnecker R. 2009. Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo. Blood 113(1):108-16. [PubMed: 18815281] [MGI Ref ID J:144258]
Anz D; Thaler R; Stephan N; Waibler Z; Trauscheid MJ; Scholz C; Kalinke U; Barchet W; Endres S; Bourquin C. 2009. Activation of melanoma differentiation-associated gene 5 causes rapid involution of the thymus. J Immunol 182(10):6044-50. [PubMed: 19414755] [MGI Ref ID J:148244]
Anzelon AN; Wu H; Rickert RC. 2003. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol 4(3):287-94. [PubMed: 12563260] [MGI Ref ID J:83213]
Arana E; Vehlow A; Harwood NE; Vigorito E; Henderson R; Turner M; Tybulewicz VL; Batista FD. 2008. Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. Immunity 28(1):88-99. [PubMed: 18191593] [MGI Ref ID J:131150]
Beisner DR; Ch'en IL; Kolla RV; Hoffmann A; Hedrick SM. 2005. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J Immunol 175(6):3469-73. [PubMed: 16148088] [MGI Ref ID J:116713]
Bessa J; Jegerlehner A; Hinton HJ; Pumpens P; Saudan P; Schneider P; Bachmann MF. 2009. Alveolar macrophages and lung dendritic cells sense RNA and drive mucosal IgA responses. J Immunol 183(6):3788-99. [PubMed: 19710454] [MGI Ref ID J:152307]
Brockschnieder D; Lappe-Siefke C; Goebbels S; Boesl MR; Nave KA; Riethmacher D. 2004. Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination. Mol Cell Biol 24(17):7636-42. [PubMed: 15314171] [MGI Ref ID J:92789]
Buch T; Heppner FL; Tertilt C; Heinen TJ; Kremer M; Wunderlich FT; Jung S; Waisman A. 2005. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2(6):419-26. [PubMed: 15908920] [MGI Ref ID J:131076]
Cantor J; Browne CD; Ruppert R; Feral CC; Fassler R; Rickert RC; Ginsberg MH. 2009. CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol 10(4):412-9. [PubMed: 19270713] [MGI Ref ID J:148000]
Cazac BB; Roes J. 2000. TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13(4):443-51. [PubMed: 11070163] [MGI Ref ID J:90558]
Cervantes-Barragan L; Kalinke U; Zust R; Konig M; Reizis B; Lopez-Macias C; Thiel V; Ludewig B. 2009. Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection. J Immunol 182(2):1099-106. [PubMed: 19124753] [MGI Ref ID J:143484]
Chiarle R; Simmons WJ; Cai H; Dhall G; Zamo A; Raz R; Karras JG; Levy DE; Inghirami G. 2005. Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target. Nat Med 11(6):623-9. [PubMed: 15895073] [MGI Ref ID J:101120]
Cinamon G; Zachariah MA; Lam OM; Foss FW Jr; Cyster JG. 2008. Follicular shuttling of marginal zone B cells facilitates antigen transport. Nat Immunol 9(1):54-62. [PubMed: 18037889] [MGI Ref ID J:130200]
Cobaleda C; Jochum W; Busslinger M. 2007. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449(7161):473-7. [PubMed: 17851532] [MGI Ref ID J:126362]
Coles MC; Veiga-Fernandes H; Foster KE; Norton T; Pagakis SN; Seddon B; Kioussis D. 2006. Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proc Natl Acad Sci U S A 103(36):13457-62. [PubMed: 16938836] [MGI Ref ID J:112903]
Cucak H; Yrlid U; Reizis B; Kalinke U; Johansson-Lindbom B. 2009. Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31(3):491-501. [PubMed: 19733096] [MGI Ref ID J:152690]
Dai X; Chen Y; Di L; Podd A; Li G; Bunting KD; Hennighausen L; Wen R; Wang D. 2007. Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol 179(2):1068-79. [PubMed: 17617599] [MGI Ref ID J:143004]
Del Nagro CJ; Kolla RV; Rickert RC. 2005. A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis. J Immunol 175(8):5379-89. [PubMed: 16210644] [MGI Ref ID J:119107]
Delogu A; Schebesta A; Sun Q; Aschenbrenner K; Perlot T; Busslinger M. 2006. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity 24(3):269-81. [PubMed: 16546096] [MGI Ref ID J:113322]
Dengler HS; Baracho GV; Omori SA; Bruckner S; Arden KC; Castrillon DH; DePinho RA; Rickert RC. 2008. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol 9(12):1388-98. [PubMed: 18978794] [MGI Ref ID J:143228]
Depoil D; Fleire S; Treanor BL; Weber M; Harwood NE; Marchbank KL; Tybulewicz VL; Batista FD. 2008. CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nat Immunol 9(1):63-72. [PubMed: 18059271] [MGI Ref ID J:130478]
Diamant E; Keren Z; Melamed D. 2005. CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. Blood 105(8):3247-54. [PubMed: 15644414] [MGI Ref ID J:98448]
Donahue AC; Hess KL; Ng KL; Fruman DA. 2004. Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85{alpha} Int Immunol 16(12):1789-1798. [PubMed: 15520044] [MGI Ref ID J:94022]
Ellinghaus U; Rupec RA; Pabst O; Ignatius R; Forster R; Dorken B; Jundt F. 2008. IkappaBalpha is required for marginal zone B cell lineage development. Eur J Immunol 38(8):2096-105. [PubMed: 18604869] [MGI Ref ID J:138198]
Fagone P; Gunter C; Sage CR; Gunn KE; Brewer JW; Jackowski S. 2009. CTP:phosphocholine cytidylyltransferase alpha is required for B-cell proliferation and class switch recombination. J Biol Chem 284(11):6847-54. [PubMed: 19139091] [MGI Ref ID J:148370]
Fehr T; Rickert RC; Odermatt B; Roes J; Rajewsky K; Hengartner H; Zinkernagel RM. 1998. Antiviral protection and germinal center formation, but impaired B cell memory in the absence of CD19. J Exp Med 188(1):145-55. [PubMed: 9653091] [MGI Ref ID J:110754]
Fleige A; Alberti S; Grobe L; Frischmann U; Geffers R; Muller W; Nordheim A; Schippers A. 2007. Serum response factor contributes selectively to lymphocyte development. J Biol Chem 282(33):24320-8. [PubMed: 17591768] [MGI Ref ID J:124767]
Fornek JL; Tygrett LT; Waldschmidt TJ; Poli V; Rickert RC; Kansas GS. 2006. Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood 107(3):1085-91. [PubMed: 16223771] [MGI Ref ID J:127212]
Forster N; Gallinat S; Jablonska J; Weiss S; Elsasser HP; Lutz W. 2007. p300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice. J Immunol 178(11):6941-8. [PubMed: 17513743] [MGI Ref ID J:147840]
Frommer F; Heinen TJ; Wunderlich FT; Yogev N; Buch T; Roers A; Bettelli E; Muller W; Anderton SM; Waisman A. 2008. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol 181(8):5748-59. [PubMed: 18832734] [MGI Ref ID J:140751]
Garbi N; Tanaka S; Momburg F; Hammerling GJ. 2006. Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57. Nat Immunol 7(1):93-102. [PubMed: 16311600] [MGI Ref ID J:112606]
Gardam S; Sierro F; Basten A; Mackay F; Brink R. 2008. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 28(3):391-401. [PubMed: 18313334] [MGI Ref ID J:132877]
Gardby E; Chen XJ; Lycke NY. 2001. Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching. Scand J Immunol 53(1):13-23. [PubMed: 11169202] [MGI Ref ID J:103806]
Gardby E; Lycke NY. 2000. CD19-deficient mice exhibit poor responsiveness to oral immunization despite evidence of unaltered total IgA levels, germinal centers and IgA-isotype switching in Peyer's patches Eur J Immunol 30(7):1861-71. [PubMed: 10940875] [MGI Ref ID J:63502]
Geisberger R; Kiermayer C; Homig C; Conrad M; Schmidt J; Zimber-Strobl U; Brielmeier M. 2007. B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance. Biol Chem 388(10):1083-90. [PubMed: 17937622] [MGI Ref ID J:147683]
Grivennikov SI; Tumanov AV; Liepinsh DJ; Kruglov AA; Marakusha BI; Shakhov AN; Murakami T; Drutskaya LN; Forster I; Clausen BE; Tessarollo L; Ryffel B; Kuprash DV; Nedospasov SA. 2005. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity 22(1):93-104. [PubMed: 15664162] [MGI Ref ID J:95684]
Guo F; Velu CS; Grimes HL; Zheng Y. 2009. Rho GTPase Cdc42 is essential for B-lymphocyte development and activation. Blood 114(14):2909-16. [PubMed: 19671922] [MGI Ref ID J:153368]
Habib T; Park H; Tsang M; de Alboran IM; Nicks A; Wilson L; Knoepfler PS; Andrews S; Rawlings DJ; Eisenman RN; Iritani BM. 2007. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol 179(4):717-31. [PubMed: 17998397] [MGI Ref ID J:135554]
Han JH; Akira S; Calame K; Beutler B; Selsing E; Imanishi-Kari T. 2007. Class switch recombination and somatic hypermutation in early mouse B Cells are mediated by B Cell and toll-like receptors. Immunity 27(1):64-75. [PubMed: 17658280] [MGI Ref ID J:123630]
Hao Z; Duncan GS; Seagal J; Su YW; Hong C; Haight J; Chen NJ; Elia A; Wakeham A; Li WY; Liepa J; Wood GA; Casola S; Rajewsky K; Mak TW. 2008. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity 29(4):615-27. [PubMed: 18835195] [MGI Ref ID J:141441]
Hao Z; Hampel B; Yagita H; Rajewsky K. 2004. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med 199(10):1355-65. [PubMed: 15148335] [MGI Ref ID J:114948]
Hayashi K; Yamamoto M; Nojima T; Goitsuka R; Kitamura D. 2003. Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity 18(6):825-36. [PubMed: 12818163] [MGI Ref ID J:84040]
Haynes NM; Allen CD; Lesley R; Ansel KM; Killeen N; Cyster JG. 2007. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol 179(8):5099-108. [PubMed: 17911595] [MGI Ref ID J:153037]
Henley T; Kovesdi D; Turner M. 2008. B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta. Eur J Immunol 38(12):3543-3548. [PubMed: 19016531] [MGI Ref ID J:141373]
Hobeika E; Thiemann S; Storch B; Jumaa H; Nielsen PJ; Pelanda R; Reth M. 2006. Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A 103(37):13789-94. [PubMed: 16940357] [MGI Ref ID J:113645]
Horcher M; Souabni A; Busslinger M. 2001. Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity 14(6):779-90. [PubMed: 11420047] [MGI Ref ID J:75504]
Igarashi H; Kuwahara K; Yoshida M; Xing Y; Maeda K; Nakajima K; Sakaguchi N. 2009. GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells. Mol Immunol 46(6):1031-41. [PubMed: 19181385] [MGI Ref ID J:146863]
Inui S; Maeda K; Hua DR; Yamashita T; Yamamoto H; Miyamoto E; Aizawa S; Sakaguchi N. 2002. BCR signal through alpha 4 is involved in S6 kinase activation and required for B cell maturation including isotype switching and V region somatic hypermutation. Int Immunol 14(2):177-87. [PubMed: 11809737] [MGI Ref ID J:74619]
Iwasaki H; Somoza C; Shigematsu H; Duprez EA; Iwasaki-Arai J; Mizuno S; Arinobu Y; Geary K; Zhang P; Dayaram T; Fenyus ML; Elf S; Chan S; Kastner P; Huettner CS; Murray R; Tenen DG; Akashi K. 2005. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood 106(5):1590-600. [PubMed: 15914556] [MGI Ref ID J:114150]
Janas ML; Hodson D; Stamataki Z; Hill S; Welch K; Gambardella L; Trotman LC; Pandolfi PP; Vigorito E; Turner M. 2008. The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells. J Immunol 180(2):739-46. [PubMed: 18178811] [MGI Ref ID J:130950]
Jude CD; Climer L; Xu D; Artinger E; Fisher JK; Ernst P. 2007. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 1(3):324-37. [PubMed: 18371366] [MGI Ref ID J:147265]
Jungbeck M; Stopfer P; Bataille F; Nedospasov SA; Mannel DN; Hehlgans T. 2008. Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation-Opposite functions for surface lymphotoxin expressed by T and B lymphocytes. Mol Immunol 45(1):34-41. [PubMed: 17590442] [MGI Ref ID J:124292]
Junt T; Tumanov AV; Harris N; Heikenwalder M; Zeller N; Kuprash DV; Aguzzi A; Ludewig B; Nedospasov SA; Zinkernagel RM. 2006. Expression of lymphotoxin beta governs immunity at two distinct levels. Eur J Immunol 36(8):2061-75. [PubMed: 16841297] [MGI Ref ID J:116025]
Kamphuis E; Junt T; Waibler Z; Forster R; Kalinke U. 2006. Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood 108(10):3253-61. [PubMed: 16868248] [MGI Ref ID J:140450]
Kang TB; Oh GS; Scandella E; Bolinger B; Ludewig B; Kovalenko A; Wallach D. 2008. Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J Immunol 181(4):2522-32. [PubMed: 18684943] [MGI Ref ID J:140185]
Keren Z; Diamant E; Ostrovsky O; Bengal E; Melamed D. 2004. Modification of ligand-independent B cell receptor tonic signals activates receptor editing in immature B lymphocytes. J Biol Chem 279(14):13418-24. [PubMed: 14668327] [MGI Ref ID J:89118]
Kharas MG; Janes MR; Scarfone VM; Lilly MB; Knight ZA; Shokat KM; Fruman DA. 2008. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest 118(9):3038-50. [PubMed: 18704194] [MGI Ref ID J:140852]
Khiem D; Cyster JG; Schwarz JJ; Black BL. 2008. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A 105(44):17067-72. [PubMed: 18955699] [MGI Ref ID J:144071]
Kirstetter P; Anderson K; Porse BT; Jacobsen SE; Nerlov C. 2006. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol 7(10):1048-56. [PubMed: 16951689] [MGI Ref ID J:112660]
Kitaura Y; Jang IK; Wang Y; Han YC; Inazu T; Cadera EJ; Schlissel M; Hardy RR; Gu H. 2007. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 26(5):567-78. [PubMed: 17493844] [MGI Ref ID J:123596]
Klaewsongkram J; Yang Y; Golech S; Katz J; Kaestner KH; Weng NP. 2007. Kruppel-like factor 4 regulates B cell number and activation-induced B cell proliferation. J Immunol 179(7):4679-84. [PubMed: 17878366] [MGI Ref ID J:152342]
Klein J; Ju W; Heyer J; Wittek B; Haneke T; Knaus P; Kucherlapati R; Bottinger EP; Nitschke L; Kneitz B. 2006. B cell-specific deficiency for Smad2 in vivo leads to defects in TGF-beta-directed IgA switching and changes in B cell fate. J Immunol 176(4):2389-96. [PubMed: 16455997] [MGI Ref ID J:108099]
Knoetig SM; Torrey TA; Naghashfar Z; McCarty T; Morse HC rd. 2002. CD19 signaling pathways play a major role for murine AIDS induction and progression. J Immunol 169(10):5607-14. [PubMed: 12421939] [MGI Ref ID J:80060]
Kobayashi T; Kim TS; Jacob A; Walsh MC; Kadono Y; Fuentes-Panana E; Yoshioka T; Yoshimura A; Yamamoto M; Kaisho T; Akira S; Monroe JG; Choi Y. 2009. TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses. PLoS ONE 4(3):e4736. [PubMed: 19270748] [MGI Ref ID J:147371]
Kontoyiannis D; Boulougouris G; Manoloukos M; Armaka M; Apostolaki M; Pizarro T; Kotlyarov A; Forster I; Flavell R; Gaestel M; Tsichlis P; Cominelli F; Kollias G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196(12):1563-74. [PubMed: 12486099] [MGI Ref ID J:108572]
Kracker S; Bergmann Y; Demuth I; Frappart PO; Hildebrand G; Christine R; Wang ZQ; Sperling K; Digweed M; Radbruch A. 2005. Nibrin functions in Ig class-switch recombination. Proc Natl Acad Sci U S A 102(5):1584-9. [PubMed: 15668383] [MGI Ref ID J:96104]
Kroll J; Shi X; Caprioli A; Liu HH; Waskow C; Lin KM; Miyazaki T; Rodewald HR; Sato TN. 2005. The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol Cell Biol 25(19):8531-40. [PubMed: 16166635] [MGI Ref ID J:101363]
Kuwahara K; Fujimura S; Takahashi Y; Nakagata N; Takemori T; Aizawa S; Sakaguchi N. 2004. Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses. Proc Natl Acad Sci U S A 101(4):1010-5. [PubMed: 14715907] [MGI Ref ID J:88276]
Kwon K; Hutter C; Sun Q; Bilic I; Cobaleda C; Malin S; Busslinger M. 2008. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity 28(6):751-62. [PubMed: 18538592] [MGI Ref ID J:137719]
Lacy-Hulbert A; Smith AM; Tissire H; Barry M; Crowley D; Bronson RT; Roes JT; Savill JS; Hynes RO. 2007. Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proc Natl Acad Sci U S A 104(40):15823-8. [PubMed: 17895374] [MGI Ref ID J:125508]
Le Bon A; Thompson C; Kamphuis E; Durand V; Rossmann C; Kalinke U; Tough DF. 2006. Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN. J Immunol 176(4):2074-8. [PubMed: 16455962] [MGI Ref ID J:129128]
Lemmers B; Salmena L; Bidere N; Su H; Matysiak-Zablocki E; Murakami K; Ohashi PS; Jurisicova A; Lenardo M; Hakem R; Hakem A. 2007. Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling. J Biol Chem 282(10):7416-23. [PubMed: 17213198] [MGI Ref ID J:120896]
Li ZW; Omori SA; Labuda T; Karin M; Rickert RC. 2003. IKK beta is required for peripheral B cell survival and proliferation. J Immunol 170(9):4630-7. [PubMed: 12707341] [MGI Ref ID J:82995]
Liu B; Li Z. 2008. Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin. Blood 112(4):1223-30. [PubMed: 18509083] [MGI Ref ID J:138420]
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Sasaki Y; Calado DP; Derudder E; Zhang B; Shimizu Y; Mackay F; Nishikawa S; Rajewsky K; Schmidt-Supprian M. 2008. NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. Proc Natl Acad Sci U S A 105(31):10883-8. [PubMed: 18663224] [MGI Ref ID J:139293]
Sasaki Y; Derudder E; Hobeika E; Pelanda R; Reth M; Rajewsky K; Schmidt-Supprian M. 2006. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity 24(6):729-39. [PubMed: 16782029] [MGI Ref ID J:113365]
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Schmidt-Supprian M; Wunderlich FT; Rajewsky K. 2007. Excision of the Frt-flanked neo ( R ) cassette from the CD19cre knock-in transgene reduces Cre-mediated recombination. Transgenic Res 16(5):657-60. [PubMed: 17541717] [MGI Ref ID J:125035]
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Shapiro-Shelef M; Lin KI; McHeyzer-Williams LJ; Liao J; McHeyzer-Williams MG; Calame K. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19(4):607-20. [PubMed: 14563324] [MGI Ref ID J:101890]
Shih TA; Roederer M; Nussenzweig MC. 2002. Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat Immunol 3(4):399-406. [PubMed: 11896394] [MGI Ref ID J:75653]
Shimoda M; Li T; Pihkala JP; Koni PA. 2006. Role of MHC class II on memory B cells in post-germinal center B cell homeostasis and memory response. J Immunol 176(4):2122-33. [PubMed: 16455968] [MGI Ref ID J:129125]
Siggins SL; Nguyen NY; McCormack MP; Vasudevan S; Villani R; Jane SM; Wainwright BJ; Curtis DJ. 2009. The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. Blood 114(5):995-1004. [PubMed: 19483124] [MGI Ref ID J:151338]
Stranges PB; Watson J; Cooper CJ; Choisy-Rossi CM; Stonebraker AC; Beighton RA; Hartig H; Sundberg JP; Servick S; Kaufmann G; Fink PJ; Chervonsky AV. 2007. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 26(5):629-41. [PubMed: 17509906] [MGI Ref ID J:123556]
Suzuki A; Kaisho T; Ohishi M; Tsukio-Yamaguchi M; Tsubata T; Koni PA; Sasaki T; Mak TW; Nakano T. 2003. Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med 197(5):657-67. [PubMed: 12615906] [MGI Ref ID J:91501]
Takeuchi O; Fisher J; Suh H; Harada H; Malynn BA; Korsmeyer SJ. 2005. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102(32):11272-7. [PubMed: 16055554] [MGI Ref ID J:100463]
Tanigaki K; Han H; Yamamoto N; Tashiro K; Ikegawa M; Kuroda K; Suzuki A; Nakano T; Honjo T. 2002. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol 3(5):443-50. [PubMed: 11967543] [MGI Ref ID J:76240]
Thomas MD; Kremer CS; Ravichandran KS; Rajewsky K; Bender TP. 2005. c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity 23(3):275-86. [PubMed: 16169500] [MGI Ref ID J:113271]
Todd DJ; McHeyzer-Williams LJ; Kowal C; Lee AH; Volpe BT; Diamond B; McHeyzer-Williams MG; Glimcher LH. 2009. XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J Exp Med 206(10):2151-9. [PubMed: 19752183] [MGI Ref ID J:153424]
Tokoyoda K; Egawa T; Sugiyama T; Choi BI; Nagasawa T. 2004. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20(6):707-18. [PubMed: 15189736] [MGI Ref ID J:109147]
Tsai CM; Chiu YK; Hsu TL; Lin IY; Hsieh SL; Lin KI. 2008. Galectin-1 promotes immunoglobulin production during plasma cell differentiation. J Immunol 181(7):4570-9. [PubMed: 18802059] [MGI Ref ID J:141296]
Tumanov A; Kuprash D; Lagarkova M; Grivennikov S; Abe K; Shakhov A; Drutskaya L; Stewart C; Chervonsky A; Nedospasov S. 2002. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity 17(3):239-50. [PubMed: 12354378] [MGI Ref ID J:79129]
Tumanov AV; Grivennikov SI; Shakhov AN; Rybtsov SA; Koroleva EP; Takeda J; Nedospasov SA; Kuprash DV. 2003. Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol Rev 195:106-16. [PubMed: 12969314] [MGI Ref ID J:85493]
Twohig J; Kulik L; Haluszczak C; Reuter J; Rossbach A; Bull M; Holers VM; Marchbank KJ. 2007. Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21) transgenic mice is partially recovered in the absence of C3. Mol Immunol 44(13):3434-44. [PubMed: 17379312] [MGI Ref ID J:123562]
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Walmsley MJ; Ooi SK; Reynolds LF; Smith SH; Ruf S; Mathiot A; Vanes L; Williams DA; Cancro MP; Tybulewicz VL. 2003. Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302(5644):459-62. [PubMed: 14564011] [MGI Ref ID J:86765]
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Health & husbandry
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Breeding & Husbandry When maintaining a live colony, these mice may be bred as heterozygotes or homozygotes. The donating investigator reports that homozygotes older than 3 months of age do not breed well. Homozygous breeding pairs maintained at The Jackson Laboratory have shown no such problems. Mating System Homozygote x Homozygote (Female x Male) 17-APR-08 Diet Information LabDiet® 5K52/5K67
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $160.40 Female or Male Homozygous for Cd19tm1(cre)Cgn
Pairs /Price (US dollars $) Pair Genotype $320.80 Homozygous for Cd19tm1(cre)Cgn x Homozygous for Cd19tm1(cre)Cgn
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Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $208.60 Female or Male Homozygous for Cd19tm1(cre)Cgn
Pairs /Price (US dollars $) Pair Genotype $417.10 Homozygous for Cd19tm1(cre)Cgn x Homozygous for Cd19tm1(cre)Cgn
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
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In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.