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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Background Strain NOD/ShiLtJ Donor Strain C57BL/6J H2 Haplotype g7 Generation N3+N2F5p
Generation DefinitionsDonating Investigator T1DR Colony, The Jackson Laboratory Appearance
albino, pink-eyed
Related Genotype: A/? Tyrc/TyrcDescription
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described on a NOD/ShiLt genetic background. We will modify the strain description if necessary as published results become available.
Chromosome 11 congenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. The reported conclusion of diabetes resistance in this Chr 11 congenic has been re-evaluated now that the B6 contaminating genome on Chr 1 has been eliminated. Diabetes incidence studies preformed at The Jackson Laboratory show an accelerated onset and incidence of diabetes in females when compared with NOD/ShiLtJ controls and the original stock 005311, while the diabetes onset and incidence in males is accelerated compared to the original Stock 005311 and is slightly reduced compared to NOD/ShiLtJ controls. 006809 incidence study and fine mapping data.This strain may be useful for identifying genes involved with diabetes located within the Idd4 region of Chr 11.
Development
Idd4 subloci map to Chr 11. Due to a genetic contamination identified in the Idd5 region of Chr 1, Stock No. 005311 was further backcrossed to Stock No. 001976 - NOD/ShiLtJ for 2 generations. Genetic Quality Control indicates all previously C57BL/6 identified Chr 1 markers and all other known Idd's are of NOD origin; while Chr 11 markers D11Nds1 (43.8 cM) through D11Mit41 (49 cM) are of C57BL/6 origin. This Idd4 congenic strain containing a 5.2cM region located between D11Nds1 and D11Mit41 of Chr 11 is known to contain Nos2 (45.6cM) Mpmv4 (48cM), Xmv42 (53cM), Mpo, (49cM) and the beta-chemokine gene family, including, Ccl1 (Tcr3, 47cM), Ccl2(Mcp1, 46.5cM), Ccl3 (Mip1a, 47.59cM), Ccl4 (Mip1b, 47.6cM) (Gill et al, 1995 and Grattan et al, 2002). In 2008 this congenic strain is at generation N3+N2F2.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of D11Mit41
005311 NOD.B6-(D1Mit18-D1Mit445)(D11Nds1-D11Mit41)/DelJ 005313 NOD.B6-(D1Mit180-D1Mit143)(D11Mit38-D11Mit41)/DelJ 005312 NOD.B6-(D1Mit18-D1Jmp12)(D11Mit325-D11Mit41)/DelJ View Strains carrying other alleles of D11Mit41 (3 strains)
005311 NOD.B6-(D1Mit18-D1Mit445)(D11Nds1-D11Mit41)/DelJ
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains
NOD/ShiLtJ Non-MHC Congenics
Immunology and Inflammation Research
Autoimmunity
Type 1 Diabetes
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Inflammation
Genes & Alleles
Gene & Allele Information provided by MGI
| Gene Symbol and Name | D11Nds1, DNA segment, Chr 11, Nuffield Department of Surgery 1 | ||
|---|---|---|---|
| Chromosome | 11 | ||
| Gene Symbol and Name | D11Mit41, DNA segment, Chr 11, Massachusetts Institute of Technology 41 | ||
| Chromosome | 11 | ||
| Gene Symbol and Name | Idd4, insulin dependent diabetes susceptibility 4 | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | Idd-4; | ||
References
References provided by MGI
Selected Reference(s)
Gill BM; Jaramillo A; Ma L; Laupland KB; Delovitch TL. 1995. Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. A possible role for chemokine genes. Diabetes 44(6):614-9. [PubMed: 7789623] [MGI Ref ID J:25969]
Grattan M; Mi QS; Meagher C; Delovitch TL. 2002. Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci. Diabetes 51(1):215-23. [PubMed: 11756344] [MGI Ref ID J:73763]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, RG10/RG30.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $1980.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2574.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
Supply Notes
- Cryorecovery - Standard.
We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. The total number of animals provided, their gender and genotype will vary. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 13 and 16 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information.
General Supply Notes
- This strain is included in the Type 1 Diabetes Repository collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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| fax: | 207-288-6655 |
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