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Strain Name:

C57BL/6J-KitlSl-22J/J

Stock Number:

006839

Availability:

Repository- Live

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General Terms and Conditions

Genes & Alleles   Kitl;   KitlSl-22J;

Product Information

Strain Details

Type JAX® GEMM® Strain - Coisogenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Mutant Strain
Type JAX® GEMM® Strain - Spontaneous Mutation
Specieslaboratory mouse
GenerationF10 (06-DEC-07)

Strain Development
The KitlSl-22J mutation arose spontaneously at The Jackson Laboratory in 2004 on the C57BL/6J-Ins2Akita/J background. Although no allele test could be performed, mapping and phenotype support the idea that this is an allele of Kitl. This strain has been maintained by sibling breeding heterozygotes with wildtype and vice versa. In 2007 this strain reached generation +F9. Throughout this time, no indication of the Akita mutation has been seen.

Mammalian Phenotype Terms assigned by genotype

KitlSl-22J/Kitl+

        C57BL/6J-KitlSl-22J/J
  • pigmentation phenotype
  • abnormal retinal pigmentation (MGI Ref ID J:117733)
    • peripheral retina in the one animal assessed shows areas of pigment loss
  • abnormal skin pigmentation (MGI Ref ID J:117733)
    • lighter than normal ears, tail, and feet
  • belly spot (MGI Ref ID J:117733)
    • variable size
  • diluted coat color (MGI Ref ID J:117733)
  • skin/coat/nails phenotype
  • abnormal skin pigmentation (MGI Ref ID J:117733)
    • lighter than normal ears, tail, and feet
  • belly spot (MGI Ref ID J:117733)
    • variable size
  • diluted coat color (MGI Ref ID J:117733)
  • vision/eye phenotype
  • *normal* vision/eye phenotype (MGI Ref ID J:117733)
    • ERG test on one mutant was normal
    • abnormal retinal pigmentation (MGI Ref ID J:117733)
      • peripheral retina in the one animal assessed shows areas of pigment loss
  • hearing/vestibular/ear phenotype
  • *normal* hearing/vestibular/ear phenotype (MGI Ref ID J:117733)
    • ABR testing normal

Gene & Allele Details

Allele Symbol KitlSl-22J
Allele Name steel 22 Jackson
Gene Symbol and Name Kitl, kit ligand
Chromosome 10
Gene Common Name(s) Clo; Con; DKFZp686F2250; Gb; KL-1; Kl1; Kl2; MGF; Mgf; SCF; SF; SHEP7; SLF; Sl; Steel; Steel factor; cloud gray; contrasted; grizzle-belly; mast cell growth factor; steel; stem cell factor;

Control Information

  Control
   Wild-type from the colony
 
  Considerations for Choosing Controls

Related Strains

Strains carrying other alleles of Kitl
000090   129S1/Sv-Oca2+ Tyr+ KitlSl-J/J
002993   B6.Cg-KitlSl-18H/EiJ
000124   B6.Cg-KitlSl Krt71Ca/J
000160   B6.D2-KitlSl-d/J
000291   C3FeLe.Cg-a/a Hm KitlSl Krt71Ca-J/J
001380   C3Sn.Cg-KitlSl-con/J
003252   C57BL/6J-KitlSl-20J/J
000979   STOCK KitlSl-16J/J
000161   WB.D2-KitlSl-d/J
000693   WC/ReJ KitlSl/J
100401   WCB6F1/J KitlSl KitlSl-d
View Strains carrying other alleles of Kitl     (11 strains)

Animal Health Reports

Room Number           A1

References

Additional References

Price and Supply Information

Strain Name: C57BL/6J-KitlSl-22J/J
Stock Number: 006839

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Mouse Mutant Resource collection.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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