Strain Name: |
STOCK Leprdb-9J/Jgn |
|---|---|
Stock Number: |
006846 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | Lepr; Leprdb-9J; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Spontaneous Mutation Species laboratory mouse Strain Description
Mice homozygous for this mutation exhibit moderate obesity and extreme diabetes. The primary investigator reports blood glucose levels reaching 600-850 mg/ml and low plasma insulin levels (1-4 ng/ml). Pancreatic beta cells are small, degranulated and atrophic. The liver is steatotic and strongly PAS-positive for glycogen. Adrenal glands are large with a hyperplastic zona reticularis and appear to be missing the medulla.
Homozygous females have fewer primary oocytes and follicles, as well as a decreased amount of developing and ovulated follices. Fecundity is decreased resulting in smaller litter sizes and fewer litters.Strain Development
This spontaneous mutation arose at The Jackson Laboratory on a mixed C57BL/6J, SWR/J and CBA background. The mutation was mapped to Chromosome 4 and complementation testing in the laboratory of Dr. Jurgen Naggert demonstrated that it was a remutation at Leprdb. The strain was cryopreserved in 2007.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Leprdb-9J | ||
|---|---|---|---|
| Allele Name | diabetes 9 Jackson | ||
| Common Name(s) | fuldib; | ||
| Gene Symbol and Name | Lepr, leptin receptor | ||
| Chromosome | 4 | ||
| Gene Common Name(s) | CD295; Fa; LEPROT; Leprb; Modb1; OB-RGRP; OBR; db; diabetes; leptin receptor gene-related protein; obese-like; obl; | ||
| General Note | This mutation arose spontaneously in mice of a mixed genetic background (~46% C57BL/6, ~50% SWR, and ~3% CBA estimated from the breeding records). | ||
| Molecular Note | This mutation was shown to be an allele of the leptin receptor gene by its failure to complement the original diabetes mutation, Leprdb. | ||
Related Strains
Strains carrying other alleles of Lepr
000709 129P3/J-Leprdb-3J/J 002048 B6 x C57BLKS-m Leprdb Myo15sh2-J/J 000697 B6.Cg-m +/+ Leprdb/J 000699 B6.Cg-m Leprdb/+ +/J 000642 BKS.Cg-m +/+ Leprdb/J 000700 BKS.Cg-m Leprdb/+ +/J 001192 BKS.Cg-meaJ Leprdb +/+ + m/J 000707 CBA.Cg-m Leprdb/+ +/J 006654 FVB.BKS(D)-Leprdb/ChuaJ 004939 NOD/ShiLtJ-Leprdb-5J/LtJ View Strains carrying other alleles of Lepr (10 strains)
Research Applications
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Hyperglycemia
Hypoinsulinemia
Obesity With Diabetes
Type 2 Diabetes (NIDDM)
Reproductive Biology Research
Fertility Defects
References
Selected Reference(s)
Naggert JK; Young J. 2008. A new spontaneous obesity mutation, fuldib/diabetes 9 Jackson, is a allele of the leptin receptor gene MGI Direct Data Submission :. [MGI Ref ID J:129982]
Price and Supply Information
| Strain Name: | STOCK Leprdb-9J/Jgn |
| Stock Number: | 006846 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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