Strain Name:

B6.129S6-Per2tm1Jt/J

Stock Number:

006852

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Availability:

Repository- Live

Use Restrictions Apply, see Terms of Use
These targeted reporter mutant mice express PER2::LUC bioluminescence similar to endogenous Per2 expression, and may be useful as a real-time reporter of circadian dynamics in different tissues.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Homozygote         (Female x Male)   12-FEB-08
Specieslaboratory mouse
GenerationN11+F14 (11-DEC-13)
Generation Definitions
 
Donating InvestigatorDr. Joseph S. Takahashi,   Univ Texas Southwestern Medical Ctr

Description
Mice homozygous for this "mPer2Luc" mutation are viable and fertile with no developmental or morphological differences compared to wildtype littermates. Expression of PERIOD2::LUCIFERASE (or mPER2::LUC) fusion protein during peak periods is similar to endogenous pPER2 patterns. Homozygous mice have normal entrainment and circadian behaviors. These mPer2Luc knock-in mice may be useful as a real-time reporter of circadian dynamics in different tissues.

Development
A targeting vector was designed to insert the firefly luciferase (luc) gene (followed by a loxP-flanked neomycin resistance gene) in-frame into exon 23 of the wild-type sequence. The construct was electroporated into 129S6/SvEvTac-derived W4 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts. Chimeric males were bred to C57BL/6J females. Heterozygotes were backcrossed to C57BL/6J inbred mice for 7-11 generations prior to arrival at The Jackson Laboratory.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

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007856   B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J
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012343   C57BL/6-Gt(ROSA)26Sortm7(Pik3ca*,EGFP)Rsky/J
012352   C57BL/6-Gt(ROSA)26Sortm8(Map2k1*,EGFP)Rsky/J
012361   C57BL/6-Gt(ROSA)26Sortm9(Rac1*,EGFP)Rsky/J
010724   C57BL/6-Trim21tm1Hm/J
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007898   CBy.Cg-Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
007075   CByJ.B6-Tg(CAG-EGFP)1Osb/J
007076   CByJ.B6-Tg(UBC-GFP)30Scha/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
003718   FVB-Tg(GadGFP)45704Swn/J
010947   FVB-Tg(Gstm5-EGFP)1Ilis/J
005515   FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
010588   FVB-Tg(Myh6/NFAT-luc)1Jmol/J
006421   FVB-Tg(Pomc1-hrGFP)1Lowl/J
005688   FVB-Tg(Rag2-EGFP)1Mnz/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
012429   FVB.Cg-Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/J
003516   FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
016573   FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd Tg(S100B-EGFP)1Wjt Tg(SMN2*delta7)4299Ahmb/J
007483   FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
008200   FVB/N-Tg(CAG-EGFP,-ALPP)2.6Ggc/J
009354   FVB/N-Tg(Dazl-EGFP)10Rarp/J
003257   FVB/N-Tg(GFAPGFP)14Mes/J
007800   FVB/N-Tg(Ins1-luc)VUPwrs/J
012370   FVB/NJ-Tg(Hspa1a-luc,-EGFP)2Chco/J
009618   NOD.129(B6)-Il12btm1Lky/JbsJ
013116   NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
013233   NOD.B6-Tg(Itgax-cre,-EGFP)4097Ach/J
006698   NOD.Cg-Il4tm1Lky/JbsJ
008173   NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
009422   NOD.Cg-Tg(Itgax-Venus)1Mnz/QtngJ
005076   NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008547   NOD.FVB-Tg(ITGAM-DTR/EGFP)34Lan/JdkJ
008549   NOD.FVB-Tg(Itgax-DTR/EGFP)57Lan/JdkJ
005082   NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005328   NOD/ShiLt-Tg(Cd4-DsRed)4Lt/J
005334   NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
008694   NOD/ShiLt-Tg(Foxp3-EGFP/cre)1cJbs/J
005282   NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
012881   STOCK Ascl1tm1Reed/J
008666   STOCK Fmn1tm1Made/J
013731   STOCK Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/J
006331   STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005130   STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
005572   STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
017922   STOCK Gt(ROSA)26Sortm10(ACTB-tdTomato)Luo/J
018903   STOCK Gt(ROSA)26Sortm2(EGFP/cre)Alj/J
007576   STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
024107   STOCK Gt(ROSA)26Sortm5(ACTB-tTA)Luo Igs7tm93.1(tetO-GCaMP6f)Hze/HzeJ
017912   STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*,-tdTomato)Luo/J
017921   STOCK Gt(ROSA)26Sortm7(ACTB-EGFP*)Luo/J
017909   STOCK Gt(ROSA)26Sortm8(ACTB-EGFP*,-tTA2)Luo/J
008876   STOCK Hprttm11(Ple176-EGFP/cre)Ems/Mmjax
009349   STOCK Hprttm31(Ple67-EGFP)Ems/Mmjax
009594   STOCK Hprttm32(Ple112-EGFP)Ems/Mmjax
022976   STOCK Igs2tm1(ACTB-EGFP,-tdTomato)Zng/J
022977   STOCK Igs2tm2(ACTB-tdTomato,-EGFP)Zng/J
013749   STOCK Iis2tm1(ACTB-EGFP,-tdTomato)Luo/J
013751   STOCK Iis2tm2(ACTB-tdTomato,-EGFP)Luo/J
017932   STOCK Iis3tm1.1(ACTB-EGFP*)Luo/J
017923   STOCK Iis3tm2.1(ACTB-EGFP*,-tdTomato)Luo/J
021458   STOCK Iis5tm1(ACTB-tdTomato,-EGFP)Luo/J
021457   STOCK Iis5tm2.1(ACTB-EGFP,-tdTomato)Luo/J
021461   STOCK Iis6tm1.1(ACTB-tdTomato,-EFGP)Luo/J
021460   STOCK Iis6tm2.1(ACTB-EFGP,-tdTomato)Luo/J
004808   STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779   STOCK Mapttm1(EGFP)Klt/J
005692   STOCK Nphs1tm1Rkl/J
006741   STOCK Olfr160tm1(Olfr151)Mom Tg(Olfr151,taulacZ)BMom/MomJ
006678   STOCK Olfr160tm6Mom/MomJ
006669   STOCK Olfr17tm7Mom/MomJ
009061   STOCK Osr1tm1(EGFP/cre/ERT2)Amc/J
007879   STOCK Stx1atm2Sud/J
014581   STOCK Trpm8tm1Apat/J
010911   STOCK Wt1tm1(EGFP/cre)Wtp/J
005438   STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850   STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876   STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
003920   STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
005441   STOCK Tg(CAG-DsRed*MST)1Nagy/J
003773   STOCK Tg(CAG-ECFP)CK6Nagy/J
003115   STOCK Tg(CAG-EGFP)B5Nagy/J
003116   STOCK Tg(CAG-EGFP)D4Nagy/J
011106   STOCK Tg(CAG-GFP*)1Hadj/J
013754   STOCK Tg(CAG-KikGR)75Hadj/J
025543   STOCK Tg(CAG-RFP*,-Dscam,-EGFP)1Pfu/J
011107   STOCK Tg(CAG-Venus)1Hadj/J
005645   STOCK Tg(CAG-mRFP1)1F1Hadj/J
005105   STOCK Tg(Chx10-EGFP/cre,-ALPP)2Clc/J
018322   STOCK Tg(Cp-EGFP)25Gaia/ReyaJ
008241   STOCK Tg(Cspg4-DsRed.T1)1Akik/J
006334   STOCK Tg(Gad1-EGFP)94Agmo/J
006340   STOCK Tg(Gad1-EGFP)98Agmo/J
007896   STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
016252   STOCK Tg(Hoxb7-Venus*)17Cos/J
006784   STOCK Tg(Ins1-Cerulean)24Hara/J
006866   STOCK Tg(Ins1-DsRed*T4)32Hara/J
016921   STOCK Tg(Myh2-DsRed2)1Jrs/J
012477   STOCK Tg(Myh6*/tetO-GCaMP2)1Mik/J
016922   STOCK Tg(Myh7-CFP)1Jrs/J
008579   STOCK Tg(PSCA-EGFP)1Witt/J
012452   STOCK Tg(Rr5-GFP/cre)1Sapc/J
006570   STOCK Tg(SMN2)89Ahmb Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj/J
009606   STOCK Tg(Six2-EGFP/cre)1Amc/J
003658   STOCK Tg(TIE2GFP)287Sato/J
013162   STOCK Tg(Thy1-Clomeleon)12Gjau/J
013163   STOCK Tg(Thy1-Clomeleon)13Gjau/J
007788   STOCK Tg(Thy1-EGFP)MJrs/J
012708   STOCK Tg(Thy1-cre/ERT2,-EYFP)HGfng/PyngJ
011108   STOCK Tg(Ttr-RFP)1Hadj/J
016981   STOCK Tg(Uchl1-HIST2H2BE/mCherry/EGFP*)FSout/J
006129   STOCK Tg(Zp3-EGFP)1Dean/J
003274   STOCK Tg(tetNZL)2Bjd/J
005104   STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699   STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J
017918   STOCK Tg(tetO-MAML1*/EGFP)2Akar/J
012345   STOCK Tg(tetO-tdTomato,-Syp/EGFP*)1.1Luo/J
View Fluorescent Protein Strains     (382 strains)

Strains carrying other alleles of Per2
010832   129S-Per2tm1Drw/J
016176   B6(Cg)-Tg(tetO-Per2)2Jt/J
010492   B6.129-Per2tm1Drw/J
003819   B6.Cg-Per2tm1Brd Tyrc-Brd/J
013082   B6.FVB-Tg(Per2-DsRed*T3)12Obr/Mmjax
View Strains carrying other alleles of Per2     (5 strains)

Strains carrying other alleles of luc
006102   B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100   B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
016187   B6.BTBR-Tg(Per1-luc,Per1)1Jt/J
003479   B6.C3-Tg(Fos-luc)1Rnd/J
006098   B6.Cg-Tg(Il2/NFAT-luc)83Rinc/J
006851   B6.Cg-Tg(Per1-luc)025Jt/J
016165   B6.Cg-Tg(Per1-luc)128Jt/J
016166   B6.Cg-Tg(Per1-luc)141Jt/J
005999   B6.Cg-Tg(SBE/TK-luc)7Twc/J
006101   B6.Cg-Tg(TRE/Prl-luc)31FlvRinc/J
025854   B6.FVB-Ptprca Tg(CAG-luc,-GFP)L2G85Chco Thy1a/J
011060   B6;129S4-Nanogtm1Jae/J
002709   B6;C3-Tg(TettTALuc)1Dgs/J
013781   B6;FVB-Tg(Myh6/NFAT-luc)1Jmol/J
010545   C.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
012943   C57BL/6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
010548   D1.FVB(Cg)-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
008450   FVB-Tg(CAG-luc,-GFP)L2G85Chco/J
009638   FVB-Tg(GFAP-luc,GAPDH-rluc)172.9Mes/J
010588   FVB-Tg(Myh6/NFAT-luc)1Jmol/J
018167   FVB-Tg(TERT-rluc)DJzhu/J
005125   FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
006206   FVB.129S6-Gt(ROSA)26Sortm2(HIF1A/luc)Kael/J
002060   FVB/N-Tg(HIV-luc)326Morr/J
007800   FVB/N-Tg(Ins1-luc)VUPwrs/J
012370   FVB/NJ-Tg(Hspa1a-luc,-EGFP)2Chco/J
013116   NOD.B6-Tg(Ins2-luc/EGFP/TK)300Kauf/J
010542   NOD.FVB-Tg(CAG-luc,-GFP)L2G85Chco/FathJ
017596   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#aAhmb/J
017597   STOCK Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb Tg(tetO-SMN2,-luc)#bAhmb/J
003275   STOCK Tg(tetL)1Bjd/J
003274   STOCK Tg(tetNZL)2Bjd/J
017599   STOCK Tg(tetO-SMN2,-luc)#aAhmb/J
017600   STOCK Tg(tetO-SMN2,-luc)#bAhmb/J
View Strains carrying other alleles of luc     (34 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Advanced Sleep Phase Syndrome, Familial, 1; FASPS1   (PER2)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Per2tm1Jt/Per2tm1Jt

        involves: 129S6/SvEvTac * C57BL/6J
  • normal phenotype
  • no abnormal phenotype detected
    • mice developed normally and showed no overt morphological abnormalities   (MGI Ref ID J:89256)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Circadian Rhythms

Research Tools
Fluorescent Proteins
Neurobiology Research

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Per2tm1Jt
Allele Name targeted mutation 1, Joseph S Takahashi
Allele Type Targeted (No functional change, Reporter)
Common Name(s) Per2Luc; mPER2::LUC; mPer2Luc; mPer2Luciferase;
Mutation Made ByDr. Joseph Takahashi,   Univ Texas Southwestern Medical Ctr
Strain of Origin129S6/SvEvTac
ES Cell Line NameW4
ES Cell Line Strain129S6/SvEvTac
Site of ExpressionCircadian patterns of Per2-Luc fusion protein expression is seen in the following peripheral tissues: SCN, cornea, liver, pituitary, kidney, RCA, lung and tail).
Expressed Gene luc, luciferase, firefly
Molecular Note A luciferase gene and floxed neo cassette were inserted between exon 23 and the 3' UTR. Mutant transcript was detected in Northern blot of mutant brains and the Per2-Luc fusion protein was detected in Western blots of mutant kidneys. [MGI Ref ID J:89256]
 
Gene Symbol and Name Per2, period circadian clock 2
Chromosome 1
Gene Common Name(s) FASPS; FASPS1; mKIAA0347; mPer2; rPER2;

Genotyping

Genotyping Information

Genotyping Protocols

Per2tm1Jt, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Yoo SH; Yamazaki S; Lowrey PL; Shimomura K; Ko CH; Buhr ED; Siepka SM; Hong HK; Oh WJ; Yoo OJ; Menaker M; Takahashi JS. 2004. PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A 101(15):5339-46. [PubMed: 14963227]  [MGI Ref ID J:89256]

Additional References

Per2tm1Jt related

Akashi M; Hayasaka N; Yamazaki S; Node K. 2008. Mitogen-activated protein kinase is a functional component of the autonomous circadian system in the suprachiasmatic nucleus. J Neurosci 28(18):4619-23. [PubMed: 18448638]  [MGI Ref ID J:134974]

An S; Harang R; Meeker K; Granados-Fuentes D; Tsai CA; Mazuski C; Kim J; Doyle FJ 3rd; Petzold LR; Herzog ED. 2013. A neuropeptide speeds circadian entrainment by reducing intercellular synchrony. Proc Natl Acad Sci U S A 110(46):E4355-61. [PubMed: 24167276]  [MGI Ref ID J:202892]

Anand SN; Maywood ES; Chesham JE; Joynson G; Banks GT; Hastings MH; Nolan PM. 2013. Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation. J Neurosci 33(17):7145-53. [PubMed: 23616524]  [MGI Ref ID J:196953]

Aton SJ; Huettner JE; Straume M; Herzog ED. 2006. GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons. Proc Natl Acad Sci U S A 103(50):19188-93. [PubMed: 17138670]  [MGI Ref ID J:118298]

Baeza-Raja B; Eckel-Mahan K; Zhang L; Vagena E; Tsigelny IF; Sassone-Corsi P; Ptacek LJ; Akassoglou K. 2013. p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci 33(25):10221-34. [PubMed: 23785138]  [MGI Ref ID J:199564]

Beaule C; Swanstrom A; Leone MJ; Herzog ED. 2009. Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. PLoS One 4(10):e7476. [PubMed: 19829696]  [MGI Ref ID J:154095]

Bedont JL; LeGates TA; Slat EA; Byerly MS; Wang H; Hu J; Rupp AC; Qian J; Wong GW; Herzog ED; Hattar S; Blackshaw S. 2014. Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell Rep 7(3):609-22. [PubMed: 24767996]  [MGI Ref ID J:211807]

Buhr ED; Van Gelder RN. 2014. Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin. Proc Natl Acad Sci U S A 111(23):8625-30. [PubMed: 24843129]  [MGI Ref ID J:211359]

Castanon-Cervantes O; Wu M; Ehlen JC; Paul K; Gamble KL; Johnson RL; Besing RC; Menaker M; Gewirtz AT; Davidson AJ. 2010. Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol 185(10):5796-805. [PubMed: 20944004]  [MGI Ref ID J:165628]

Chen R; Schirmer A; Lee Y; Lee H; Kumar V; Yoo SH; Takahashi JS; Lee C. 2009. Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell 36(3):417-30. [PubMed: 19917250]  [MGI Ref ID J:154857]

Cheng B; Anea CB; Yao L; Chen F; Patel V; Merloiu A; Pati P; Caldwell RW; Fulton DJ; Rudic RD. 2011. Tissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis. Proc Natl Acad Sci U S A 108(41):17147-52. [PubMed: 21969583]  [MGI Ref ID J:177448]

Cheng HY; Alvarez-Saavedra M; Dziema H; Choi YS; Li A; Obrietan K. 2009. Segregation of expression of mPeriod gene homologs in neurons and glia: possible divergent roles of mPeriod1 and mPeriod2 in the brain. Hum Mol Genet 18(16):3110-24. [PubMed: 19477955]  [MGI Ref ID J:150729]

Cho H; Zhao X; Hatori M; Yu RT; Barish GD; Lam MT; Chong LW; DiTacchio L; Atkins AR; Glass CK; Liddle C; Auwerx J; Downes M; Panda S; Evans RM. 2012. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485(7396):123-7. [PubMed: 22460952]  [MGI Ref ID J:183855]

Chu A; Zhu L; Blum ID; Mai O; Leliavski A; Fahrenkrug J; Oster H; Boehm U; Storch KF. 2013. Global but not gonadotrope-specific disruption of Bmal1 abolishes the luteinizing hormone surge without affecting ovulation. Endocrinology 154(8):2924-35. [PubMed: 23736292]  [MGI Ref ID J:201336]

Davidson AJ; Castanon-Cervantes O; Leise TL; Molyneux PC; Harrington ME. 2009. Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system. Eur J Neurosci 29(1):171-80. [PubMed: 19032592]  [MGI Ref ID J:145870]

DeBruyne JP; Weaver DR; Reppert SM. 2007. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat Neurosci 10(5):543-5. [PubMed: 17417633]  [MGI Ref ID J:121658]

DeBruyne JP; Weaver DR; Reppert SM. 2007. Peripheral circadian oscillators require CLOCK. Curr Biol 17(14):R538-9. [PubMed: 17637349]  [MGI Ref ID J:123965]

Dibner C; Sage D; Unser M; Bauer C; d'Eysmond T; Naef F; Schibler U. 2009. Circadian gene expression is resilient to large fluctuations in overall transcription rates. EMBO J 28(2):123-34. [PubMed: 19078963]  [MGI Ref ID J:144225]

Dolatshad H; Cary AJ; Davis FC. 2010. Differential expression of the circadian clock in maternal and embryonic tissues of mice. PLoS One 5(3):e9855. [PubMed: 20352049]  [MGI Ref ID J:158725]

Duhart JM; Leone MJ; Paladino N; Evans JA; Castanon-Cervantes O; Davidson AJ; Golombek DA. 2013. Suprachiasmatic astrocytes modulate the circadian clock in response to TNF-alpha. J Immunol 191(9):4656-64. [PubMed: 24062487]  [MGI Ref ID J:206251]

Eckle T; Hartmann K; Bonney S; Reithel S; Mittelbronn M; Walker LA; Lowes BD; Han J; Borchers CH; Buttrick PM; Kominsky DJ; Colgan SP; Eltzschig HK. 2012. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med 18(5):774-82. [PubMed: 22504483]  [MGI Ref ID J:183926]

Etchegaray JP; Machida KK; Noton E; Constance CM; Dallmann R; Di Napoli MN; DeBruyne JP; Lambert CM; Yu EA; Reppert SM; Weaver DR. 2009. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 29(14):3853-66. [PubMed: 19414593]  [MGI Ref ID J:150148]

Etchegaray JP; Yu EA; Indic P; Dallmann R; Weaver DR. 2010. Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 5(4):e10303. [PubMed: 20421981]  [MGI Ref ID J:160138]

Foley NC; Tong TY; Foley D; Lesauter J; Welsh DK; Silver R. 2011. Characterization of orderly spatiotemporal patterns of clock gene activation in mammalian suprachiasmatic nucleus. Eur J Neurosci 33(10):1851-65. [PubMed: 21488990]  [MGI Ref ID J:177307]

Godinho SI; Maywood ES; Shaw L; Tucci V; Barnard AR; Busino L; Pagano M; Kendall R; Quwailid MM; Romero MR; O'neill J; Chesham JE; Brooker D; Lalanne Z; Hastings MH; Nolan PM. 2007. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316(5826):897-900. [PubMed: 17463252]  [MGI Ref ID J:121578]

Guenthner CJ; Luitje ME; Pyle LA; Molyneux PC; Yu JK; Li AS; Leise TL; Harrington ME. 2014. Circadian rhythms of Per2::Luc in individual primary mouse hepatocytes and cultures. PLoS One 9(2):e87573. [PubMed: 24498336]  [MGI Ref ID J:212847]

Hirao A; Tahara Y; Kimura I; Shibata S. 2009. A balanced diet is necessary for proper entrainment signals of the mouse liver clock. PLoS One 4(9):e6909. [PubMed: 19738906]  [MGI Ref ID J:153628]

Hirota T; Lee JW; Lewis WG; Zhang EE; Breton G; Liu X; Garcia M; Peters EC; Etchegaray JP; Traver D; Schultz PG; Kay SA. 2010. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIalpha as a clock regulatory kinase. PLoS Biol 8(12):e1000559. [PubMed: 21179498]  [MGI Ref ID J:170592]

Hughes AT; Guilding C; Piggins HD. 2011. Neuropeptide Signaling Differentially Affects Phase Maintenance and Rhythm Generation in SCN and Extra-SCN Circadian Oscillators. PLoS One 6(4):e18926. [PubMed: 21559484]  [MGI Ref ID J:172445]

Inada Y; Uchida H; Umemura Y; Nakamura W; Sakai T; Koike N; Yagita K. 2014. Cell and tissue-autonomous development of the circadian clock in mouse embryos. FEBS Lett 588(3):459-65. [PubMed: 24374345]  [MGI Ref ID J:206370]

Jackson CR; Ruan GX; Aseem F; Abey J; Gamble K; Stanwood G; Palmiter RD; Iuvone PM; McMahon DG. 2012. Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision. J Neurosci 32(27):9359-9368. [PubMed: 22764243]  [MGI Ref ID J:185955]

Ko CH; Yamada YR; Welsh DK; Buhr ED; Liu AC; Zhang EE; Ralph MR; Kay SA; Forger DB; Takahashi JS. 2010. Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol 8(10):e1000513. [PubMed: 20967239]  [MGI Ref ID J:167074]

Kornmann B; Schaad O; Bujard H; Takahashi JS; Schibler U. 2007. System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol 5(2):e34. [PubMed: 17298173]  [MGI Ref ID J:141590]

Kuljis DA; Loh DH; Truong D; Vosko AM; Ong ML; McClusky R; Arnold AP; Colwell CS. 2013. Gonadal- and sex-chromosome-dependent sex differences in the circadian system. Endocrinology 154(4):1501-12. [PubMed: 23439698]  [MGI Ref ID J:197457]

Lee H; Chen R; Lee Y; Yoo S; Lee C. 2009. Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock. Proc Natl Acad Sci U S A 106(50):21359-64. [PubMed: 19948962]  [MGI Ref ID J:155524]

Marcheva B; Ramsey KM; Buhr ED; Kobayashi Y; Su H; Ko CH; Ivanova G; Omura C; Mo S; Vitaterna MH; Lopez JP; Philipson LH; Bradfield CA; Crosby SD; JeBailey L; Wang X; Takahashi JS; Bass J. 2010. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466(7306):627-31. [PubMed: 20562852]  [MGI Ref ID J:162641]

Maywood ES; Fraenkel E; McAllister CJ; Wood N; Reddy AB; Hastings MH; Morton AJ. 2010. Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding. J Neurosci 30(30):10199-204. [PubMed: 20668203]  [MGI Ref ID J:162853]

Miller JE; Granados-Fuentes D; Wang T; Marpegan L; Holy TE; Herzog ED. 2014. Vasoactive intestinal polypeptide mediates circadian rhythms in mammalian olfactory bulb and olfaction. J Neurosci 34(17):6040-6. [PubMed: 24760863]  [MGI Ref ID J:210611]

Mohawk JA; Baer ML; Menaker M. 2009. The methamphetamine-sensitive circadian oscillator does not employ canonical clock genes. Proc Natl Acad Sci U S A 106(9):3519-24. [PubMed: 19204282]  [MGI Ref ID J:146448]

Nakamura TJ; Sellix MT; Menaker M; Block GD. 2008. Estrogen directly modulates circadian rhythms of PER2 expression in the uterus. Am J Physiol Endocrinol Metab 295(5):E1025-31. [PubMed: 18728223]  [MGI Ref ID J:142256]

Nishide SY; Ono D; Yamada Y; Honma S; Honma K. 2012. De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide. Eur J Neurosci 35(2):291-9. [PubMed: 22236088]  [MGI Ref ID J:184332]

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Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as homozygotes.
Mating SystemHomozygote x Homozygote         (Female x Male)   12-FEB-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $199.90Female or MaleHomozygous for Per2tm1Jt  
Price per Pair (US dollars $)Pair Genotype
$399.80Homozygous for Per2tm1Jt x Homozygous for Per2tm1Jt  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $259.90Female or MaleHomozygous for Per2tm1Jt  
Price per Pair (US dollars $)Pair Genotype
$519.80Homozygous for Per2tm1Jt x Homozygous for Per2tm1Jt  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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