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Former Name	STOCK Tg(ACTB-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J    (Changed: 08-MAY-08 )
	STOCK Tg(ACTB-Bgeo,TEL/AML1,EGFP)A6Lbe/J    (Changed: 19-APR-07 )
Genes & Alleles	ACTB;   Bgeo;   GFP;   Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Transgenic Mating System Noncarrier x Hemizygote         (Female x Male) Species laboratory mouse Donating Investigator Corrinne Lobe,   Sunnybrook & Women's College HSC

Strain Description
Mice hemizygous for this Cre-conditional TEL-AML1 (or iZ/EG-TEL-AML1) transgene are viable and fertile. Homozygotes die in utero, presumably due to high lacZ expression. Prior to Cre-mediated excision of the "floxed" STOP sequence, high expression of lacZ is observed in cells and tissues. When bred to Cre recombinase transgenic mice, the STOP sequence (and beta-geo) is removed in the resulting offspring, allowing transcription/co-expression of both the human TEL-AML1 fusion protein and EGFP in all cre-expressing cells. TEL-AML1 transcripts are not observed in adult organ tissues prior to excision of the floxed sequences. Following Cre-mediated deletion of the STOP sequence (by B6.Cg-Tg(Tek-cre)12Flv/J, Stock No. 004128), Western blot analysis reveals that EGFP levels are well correlated with TEL-AML1 transcript levels. While global expression of TEL-AML1 leads to embryonic lethality (E7.5), hematopoietic and endothelial expression leads to malignancy in B- and T- lymphoid cells and secondary mutations that closely resemble human TEL-AML1 associated leukemia. These transgenic mice may be useful for global expression of lacZ or, when crossed to a cre-expressing strain, for studying hematopoietic development, cancer, and leukemia.

Strain Development
The iZ/EG-TEL-AML1 transgenic construct contains the CMV enhancer/chicken beta-actin promoter, a loxP-flanked STOP sequence (beta-geo reporter followed by SV40 polyadenylation signal), the human TEL-AML1 fusion protein sequence (coding for the translocation t(12;21)(p13;q22)), an internal ribosomal entry site, and an enhanced green fluorescent protein (EGFP) gene. This construct was electroporated into 129X1/SvJ x 129S1/Sv-derived R1 embryonic stem (ES) cells. ES cells with strong lacZ expression, single copy transgene integration, and efficient expression of EGFP following Cre-mediated excision of the STOP sequence were selected and aggregated with E2.5 8-cell CD1 mouse embryos. Following transfer into pseudo-pregnant females, chimeric males were mated to wildtype CD1 females to establish founder line A6. This strain was maintained by breeding hemizygous mice to CD1 or wildtype siblings for approximately six generations prior to arrival at The Jackson Laboratory. Upon arrival, these mice were bred at least one generation to C57BL/6J.

Gene & Allele Details

Allele Symbol		Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe
Allele Name		transgene insertion A6, Corinne G Lobe
Common Name(s)		Tg(ACTB-Bgeo,-TEL/AML1,-EGFP)A6Lbe; iZ/EG-TEL-AML1;
Mutation Made By		Corrinne Lobe,   Sunnybrook & Women's College HSC
Strain of Origin		(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
ES Cell Line Name		R1
ES Cell Line Strain		(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Expressed Gene		Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes , E. coli
Expressed Gene		GFP, Green Fluorescent Protein, jellyfish
		Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. The original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source.
Promoter		ACTB, actin, beta, chicken
Molecular Note		A transgenic construct was designed with the CMV enhancer/chicken beta-actin promoter, loxP-flanked STOP sequence (beta-geo reporter followed by SV40 polyadenylation signal), human TEL-AML1 fusion protein sequence (coding for the translocation t(12;21)(p13;q22)), internal ribosomal entry site, and an enhanced green fluorescent protein (EGFP) gene. Prior to Cre-mediated excision of the "floxed" STOP sequence, high expression of lacZ is observed in cells and tissues. When bred to Cre recombinase expressing mice, the STOP sequence (and beta-geo) is removed in the resulting offspring, allowing transcription/co-expression of both the human TEL-AML1 fusion protein and EGFP to proceed in the Cre recombinase expressing cells. [J:119130]

Control Information

	Control
	Noncarrier
Considerations for Choosing Controls
Control Pricing Information for JAX® GEMM® Strains

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony, hemizygotes are bred to wildtype siblings. Homozygous mice die in utero presumably due to high lacZ expression.
Diet Information	LabDiet® 5K52/5K67

Related Strains

Fluorescent Protein Strains

006053	129-Gt(ROSA)26Sortm1Luo/J
006067	129-Gt(ROSA)26Sortm2Luo/J
006041	129-Gt(ROSA)26Sortm3Luo/J
005483	129-Tg(CAG-EYFP)7AC5Nagy/J
003960	129S6-Tg(Prnp-GFP/cre)1Blw/J
006102	B10.Cg-H2k Tg(Il2/NFAT-luc)83Rinc/J
006100	B10.Cg-H2k Tg(NFkB/Fos-luc)26Rinc/J
005999	B6(SJL)-Tg(SBE/Tk-luc)7Twc/J
004218	B6.129(ICR)-Tg(CAG-ECFP)CK6Nagy/J
006071	B6.129-Gt(ROSA)26Sortm1Luo/J
006080	B6.129-Gt(ROSA)26Sortm2Luo/J
006075	B6.129-Gt(ROSA)26Sortm3Luo/J
006412	B6.129-Il12btm1Lky/J
005582	B6.129P-Cx3cr1tm1Litt/J
007572	B6.129P2(Cg)-Rorctm2Litt/J
005693	B6.129P2-Cxcr6tm1Litt/J
007669	B6.129S4-Pdgfratm11(EGFP)Sor/J
006852	B6.129S6-Per2tm1Jt/J
006148	B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J
003479	B6.C3-Tg(Fos-luc)1Rnd/J
006772	B6.Cg-Foxp3tm2Tch/J
005670	B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
005491	B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
005622	B6.Cg-Shhtm1(EGFP/cre)Cjt/J
007484	B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
006055	B6.Cg-Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
004178	B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J
006051	B6.Cg-Tg(CAG-DsRed*MST)1Nagy/J
005884	B6.Cg-Tg(CAG-mRFP1)1F1Hadj/J
006069	B6.Cg-Tg(HIST1H2BB/EGFP)1Pa/J
005029	B6.Cg-Tg(Hlxb9-GFP)1Tmj/J
006098	B6.Cg-Tg(Il2/NFAT-luc)83Rinc/J
006864	B6.Cg-Tg(Ins1-EGFP)1Hara/J
005244	B6.Cg-Tg(Krt1-15-EGFP)2Cot/J
007894	B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
006361	B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
004659	B6.Cg-Tg(TIE2GFP)287Sato/1J
006101	B6.Cg-Tg(TRE/Prl-luc)31FlvRinc/J
007901	B6.Cg-Tg(Thy1-Brainbow1.0)HLich/J
007911	B6.Cg-Tg(Thy1-Brainbow1.1)MLich/J
007921	B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
003710	B6.Cg-Tg(Thy1-CFP)23Jrs/J
007940	B6.Cg-Tg(Thy1-CFP/COX8A)C1Lich/J
007612	B6.Cg-Tg(Thy1-COP4/EYFP)18Gfng/J
007615	B6.Cg-Tg(Thy1-COP4/EYFP)9Gfng/J
005630	B6.Cg-Tg(Thy1-EYFP)15Jrs/J
003709	B6.Cg-Tg(Thy1-YFP)16Jrs/J
005627	B6.Cg-Tg(Thy1-YFP/Syp)10Jrs/J
003782	B6.Cg-Tg(Thy1-YFPH)2Jrs/J
007606	B6.Cg-Tg(Thy1-cre/ESR1,-EYFP)AGfng/J
007610	B6.Cg-Tg(Thy1-cre/ESR1,-EYFP)VGfng/J
006000	B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
004509	B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
006417	B6.FVB-Tg(Npy-hrGFP)1Lowl/J
005738	B6.FVB-Tg(tetO-EGFP,-Tgfbr2)8Mcle/J
004077	B6;129-Gt(ROSA)26Sortm2Sho/J
006676	B6;129P2-Olfr151tm26Mom/MomJ
006667	B6;129P2-Omptm3Mom/MomJ
004858	B6;129S1-Tshrtm1Rmar/J
007843	B6;129S4-Efnb2tm2Sor/J
008214	B6;129S4-Pou5f1tm2Jae/J
006614	B6;CB-Tg(Thy1-CFP/COX8A)C1Lich/J
006617	B6;CB-Tg(Thy1-CFP/COX8A)S2Lich/J
004966	B6;CBA-Tg(Acrv1-EGFP)2727Redd/J
004654	B6;CBA-Tg(Pou5f1-EGFP)2Mnn/J
007910	B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J
005621	B6;D2-Tg(S100B-EGFP)1Wjt/J
005620	B6;D2-Tg(S100B-EYFP)1Wjt/J
004690	B6;FVB-Tg(Pcp2-EGFP)2Yuza/J
006147	B6;FVB-Tg(Sfpi1,-EGFP)7Dgt/J
006043	B6;SJL-Tg(Oxt/EGFP)AI03Wsy/J
008004	B6;SJL-Tg(Thy1-ECFP/VAMP2)1Sud/J
007880	B6SJL-Tg(Thy1-Stx1a/EYFP)1Sud/J
007856	B6SJL-Tg(Thy1-Syt1/ECFP)1Sud/J
004190	C.129-Il4tm1Lky/J
005700	C.129P2-Cxcr6tm1Litt/J
006769	C.Cg-Foxp3tm2Tch/J
004512	C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
008242	C57BL/6-Gt(ROSA)26Sortm1(Ikbkb)Mass/J
006567	C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ
003291	C57BL/6-Tg(CAG-EGFP)1Osb/J
005070	C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J
004353	C57BL/6-Tg(UBC-GFP)30Scha/J
005706	C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
006618	C57BL/6-Tg(tetO-COX8A/EYFP)1Ksn/J
006362	C57BL/6J-Tg(CMV-Cox8a/EYFP)17J/J
003927	C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
007677	CB6-Tg(Gad1-EGFP)G42Zjh/J
007076	CByJ.B6-Tg(UBC-GFP)30Scha/J
003718	FVB-Tg(GadGFP)45704Swn/J
005515	FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
006421	FVB-Tg(Pomc1-hrGFP)1Lowl/J
005125	FVB.129S6(B6)-Gt(ROSA)26Sortm1(Luc)Kael/J
006206	FVB.129S6-Gt(ROSA)26Sortm1(HIF1A/luc)Kael/J
003516	FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
003257	FVB/N-Tg(GFAPGFP)14Mes/J
006698	NOD.Cg-Il4tm1Lky/JbsJ
008173	NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
005076	NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
005082	NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005328	NOD/ShiLt-Tg(Cd4-DsRed)4Lt/J
005334	NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
005282	NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
006331	STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005130	STOCK Gt(ROSA)26Sortm1(Smo/EYFP)Amc/J
005572	STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007576	STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
004808	STOCK Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
004779	STOCK Mapttm1(EGFP)Klt/J
006741	STOCK Olfr160tm1Mom Tg(Olfr151,taulacZ)BMom/MomJ
006678	STOCK Olfr160tm6Mom/MomJ
006669	STOCK Olfr17tm7Mom/MomJ
006570	STOCK Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj Tg(SMN2)89Ahmb/J
007879	STOCK Stx1atm2Sud/J
005438	STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
005441	STOCK Tg(CAG-DsRed*MST)1Nagy/J
003773	STOCK Tg(CAG-ECFP)CK6Nagy/J
003115	STOCK Tg(CAG-EGFP)B5Nagy/J
003116	STOCK Tg(CAG-EGFP)D4Nagy/J
005645	STOCK Tg(CAG-mRFP1)1F1Hadj/J
005105	STOCK Tg(Chx10-EGFP/cre-ALPP)2Clc/J
005854	STOCK Tg(Cp-EGFP)25Gaia/J
006334	STOCK Tg(Gad1-EGFP)94Agmo/J
006340	STOCK Tg(Gad1-EGFP)98Agmo/J
005418	STOCK Tg(HIST1H2BB/EGFP)1Pa/J
006866	STOCK Tg(Ins1-DsRed*T4)32Hara/J
006784	STOCK Tg(Ins1-ECFP)24Hara/J
003658	STOCK Tg(TIE2GFP)287Sato/J
006129	STOCK Tg(Zp3-EGFP)1Dean/J
003274	STOCK Tg(tetNZL)2Bjd/J
005104	STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699	STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J

View Fluorescent Protein Strains     (135 strains)

lacZ Expression Strains

002484	129-Alpltm1Sor/J
002292	129-Gt(ROSA)26Sor/J
006050	129-Sirt6tm1Fwa/J
003451	129-Smad3tm1Par/J
003310	129S-Gt(ROSA)26Sortm1Sor/J
003383	129S-Nogtm1Amc/J
004545	129S-Npytm1Rpa/J
005091	129S-Pnpla6tm1Blw/J
007199	129S-Sgpl1Gt(ROSA)78Sor/J
003082	129S1/SvImJ-Bcl2tm1Mpin/J
004478	B6.129-Foxd1tm1Lai/J
006939	B6.129-Fut1tm1Sdo/J
005768	B6.129-Htr5atm1Dgen/J
002938	B6.129-Kdrtm1Jrt/J
004158	B6.129-Maftm1Gsb/J
006497	B6.129-Skiltm2Spw/J
005772	B6.129P2-Acvrl1tm1Dgen/J
006431	B6.129P2-Adam21tm1Dgen/J
005770	B6.129P2-Adamts4tm1Dgen/J
005771	B6.129P2-Adamts5tm1Dgen/J
005773	B6.129P2-Adcy3tm1Dgen/J
005774	B6.129P2-Adcy7tm1Dgen/J
005775	B6.129P2-Adipor2tm1Dgen/J
005776	B6.129P2-Avpr1atm1Dgen/J
005777	B6.129P2-Axltm1Dgen/J
005783	B6.129P2-Cacna1ctm1Dgen/J
005780	B6.129P2-Cacna2d3tm1Dgen/J
005781	B6.129P2-Cacng3tm1Dgen/J
005782	B6.129P2-Cacng4tm1Dgen/J
005784	B6.129P2-Capn5tm1Dgen/J
005785	B6.129P2-Capn7tm1Dgen/J
005792	B6.129P2-Ccr1l1tm1Dgen/J
005793	B6.129P2-Ccr6tm1Dgen/J
005794	B6.129P2-Ccr7tm1Dgen/J
005779	B6.129P2-Celsr2tm1Dgen/J
005797	B6.129P2-Chrna2tm1Dgen/J
005787	B6.129P2-Ctsctm1Dgen/J
005796	B6.129P2-Cxcr3tm1Dgen/J
005798	B6.129P2-Drd5tm1Dgen/J
005800	B6.129P2-Efemp2tm1Dgen/J
005801	B6.129P2-Esrratm1Dgen/J
005802	B6.129P2-Faim2tm1Dgen/J
006262	B6.129P2-Fut2tm1Sdo/J
005803	B6.129P2-Fzd1tm1Dgen/J
005804	B6.129P2-Fzd8tm1Dgen/J
005811	B6.129P2-Gabra3tm1Dgen/J
005812	B6.129P2-Gabra4tm1Dgen/J
005810	B6.129P2-Gabrptm1Dgen/J
005809	B6.129P2-Galr1tm1Dgen/J
005816	B6.129P2-Glra3tm1Dgen/J
005805	B6.129P2-Gpr151tm1Dgen/J
005806	B6.129P2-Gpr37tm1Dgen/J
005807	B6.129P2-Gpr6tm1Dgen/J
005813	B6.129P2-Grik5tm1Dgen/J
005808	B6.129P2-Grk5tm1Dgen/J
005814	B6.129P2-Grm1tm1Dgen/J
005815	B6.129P2-Grm3tm1Dgen/J
005817	B6.129P2-Gsk3btm1Dgen/J
005818	B6.129P2-Hcrtr1tm1Dgen/J
005767	B6.129P2-Htr4tm1Dgen/J
005769	B6.129P2-Htr7tm1Dgen/J
005830	B6.129P2-Kcnq2tm1Dgen/J
005821	B6.129P2-Lats2tm1Dgen/J
005822	B6.129P2-Lmbr1tm1Dgen/J
005850	B6.129P2-Mapkapk2tm1Dgen/J
005824	B6.129P2-Mmp17tm1Dgen/J
005825	B6.129P2-Mtmr1tm1Dgen/J
005778	B6.129P2-Naip1tm1Dgen/J
005826	B6.129P2-Ntsr1tm1Dgen/J
005829	B6.129P2-Pkd2l2tm1Dgen/J
005828	B6.129P2-Ppardtm1Dgen/J
005831	B6.129P2-Ppm1ftm1Dgen/J
005827	B6.129P2-Ptch2tm1Dgen/J
005832	B6.129P2-Ptprotm1Dgen/J
005799	B6.129P2-S1pr4tm1Dgen/J
005837	B6.129P2-Scn11atm1Dgen/J
005836	B6.129P2-Scn9atm1Dgen/J
005834	B6.129P2-Sema5atm1Dgen/J
005835	B6.129P2-Sema6ctm1Dgen/J
006432	B6.129P2-Slc18a1tm1Dgen/J
005839	B6.129P2-Slc22a12tm1Dgen/J
005838	B6.129P2-Slc22a6tm1Dgen/J
005840	B6.129P2-Slc40a1tm1Dgen/J
005841	B6.129P2-Slc6a9tm1Dgen/J
005842	B6.129P2-Slc7a8tm1Dgen/J
005843	B6.129P2-Slc9a6tm1Dgen/J
005844	B6.129P2-Sstr1tm1Dgen/J
005847	B6.129P2-Tgfbr1tm1Dgen/J
005845	B6.129P2-Thbs4tm1Dgen/J
005790	B6.129P2-Tpp1tm1Dgen/J
005848	B6.129P2-Trpm5tm1Dgen/J
005791	B6.129P2-Xcr1tm1Dgen/J
003474	B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901	B6.129S4-Ppardtm2Rev/J
006142	B6.129S4-Ppargtm1Rev/J
003754	B6.129S4-Shroom3Gt(ROSA)53Sor/J
005119	B6.129S6-Npas2tm1Slm/J
002741	B6.129S7-Alpltm1Sor/J
005970	B6.129S7-Atoh1tm2Hzo/J
006039	B6.129S7-Efnb2tm1And/J
002192	B6.129S7-Gt(ROSA)26Sor/J
005981	B6.129S7-Rai1tm1Jrl/J
005039	B6.129X1-Adra1atm1Pcs/J
005085	B6.Cg-Cd44tm1Hbg/J
007745	B6.Cg-Mirn155tm1.1Rsky/J
005317	B6.Cg-Tg(BAT-lacZ)3Picc/J
006055	B6.Cg-Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
004178	B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J
006477	B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J
003139	B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229	B6.Cg-Tg(DRE-lacZ)2Gswz/J
002982	B6.Cg-Tg(xstpx-lacZ)32And/J
003504	B6;129-Gt(ROSA)26Sortm1Sho/J
005064	B6;129-Slc30a3tm1Rpa/J
005788	B6;129P2-Cd97tm1Dgen/J
005833	B6;129P2-Rgs4tm1Dgen/J
002073	B6;129S-Gt(ROSA)26Sor/J
006470	B6;129S-Hopxtm1Eno/J
004153	B6;129S-Mtap7Gt(ROSABetageo)1Sor/J
006958	B6;129S-Nkd1tm1Kwha/J
006960	B6;129S-Nkd2tm1Kwha/J
007204	B6;129S4-2610005L07RikGt(ROSA)73Sor/J
003309	B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365	B6;129S6-Srebf1tm1Mbr/J
002317	B6;129S7-Alpltm1Sor/J
003266	B6;129S7-Epas1tm1Rus/J
006044	B6;129S7-Ephb4tm1And/J
003471	B6;C3H-Tg(CNP-GEO)1Ldh/J
006465	B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680	B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671	B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672	B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673	B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141	B6;CBA-Tg(UAS-lacZ)65Rth/J
002369	B6;SJL-Tg(c177-lacZ)226Bri/J
002372	B6;SJL-Tg(c177-lacZ)227Bri/J
002621	B6;SJL-Tg(tetop-lacZ)2Mam/J
003299	B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865	B6CBA-Tg(Wnt1-lacZ)206Amc/J
002955	C.129S7-Gt(ROSA)26Sor/J
002754	C57BL/6-Tg(LacZpl)60Vij/J
002193	C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981	DBA/2-Tg(xstpx-lacZ)36And/J
004127	FVB-Tg(Nes-rtTA)306Rvs/J
007225	FVB.129(B6)-Usp18tm1Dzh/J
008203	FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
008209	FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
006214	FVB.Cg-Smn1tm1Msd/J
005024	FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
005026	FVB.Cg-Tg(SMN2)89Ahmb Tg(SMN1*A2G)2023Ahmb Smn1tm1Msd/J
005025	FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J
003140	FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856	FVB/N-Tg(TIE2-lacZ)182Sato/J
005941	FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315	FVB/N-Tg(tetORo1-lacZ)3Conk/J
003487	FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
005878	NOD.Cg-Cd44tm1Hbg/J
003899	STOCK Cd44tm1Hbg/J
006241	STOCK Hhiptm1Amc/J
006578	STOCK Myoz2tm1Eno/J
005707	STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
008212	STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
006882	STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438	STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006613	STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919	STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
004623	STOCK Tg(Fos-lacZ)34Efu/J
006674	STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
005493	STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395	STOCK Tg(Zfy1-lacZ)218Bri/J
003274	STOCK Tg(tetNZL)2Bjd/J
005728	STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J

View lacZ Expression Strains     (174 strains)

Strains carrying other alleles of ACTB

005483	129-Tg(CAG-EYFP)7AC5Nagy/J
004218	B6.129(ICR)-Tg(CAG-ECFP)CK6Nagy/J
004178	B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J
006051	B6.Cg-Tg(CAG-DsRed*MST)1Nagy/J
008111	B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
008112	B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
006477	B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J
005884	B6.Cg-Tg(CAG-mRFP1)1F1Hadj/J
006069	B6.Cg-Tg(HIST1H2BB/EGFP)1Pa/J
004682	B6.Cg-Tg(cre/Esr1)5Amc/J
002982	B6.Cg-Tg(xstpx-lacZ)32And/J
006465	B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006662	C57BL/6-Tg(ACTB-MAP2K1*K97M)1Stl/J
003291	C57BL/6-Tg(CAG-EGFP)1Osb/J
006481	C57BL/6J-Tg(ACTB-NOTCH1)1Shn/J
003516	FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
005082	NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
006882	STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006613	STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
005441	STOCK Tg(CAG-DsRed*MST)1Nagy/J
003773	STOCK Tg(CAG-ECFP)CK6Nagy/J
003115	STOCK Tg(CAG-EGFP)B5Nagy/J
003116	STOCK Tg(CAG-EGFP)D4Nagy/J
005645	STOCK Tg(CAG-mRFP1)1F1Hadj/J
005418	STOCK Tg(HIST1H2BB/EGFP)1Pa/J
004453	STOCK Tg(cre/Esr1)5Amc/J

View Strains carrying other alleles of ACTB     (28 strains)

Strains carrying other alleles of Bgeo

006055	B6.Cg-Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
004178	B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J
003504	B6;129-Gt(ROSA)26Sortm1Sho/J
004127	FVB-Tg(Nes-rtTA)306Rvs/J
006882	STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438	STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006613	STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919	STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J

View Strains carrying other alleles of Bgeo     (10 strains)

Strains carrying other alleles of GFP

006053	129-Gt(ROSA)26Sortm1Luo/J
006067	129-Gt(ROSA)26Sortm2Luo/J
006041	129-Gt(ROSA)26Sortm3Luo/J
003960	129S6-Tg(Prnp-GFP/cre)1Blw/J
006071	B6.129-Gt(ROSA)26Sortm1Luo/J
006080	B6.129-Gt(ROSA)26Sortm2Luo/J
006075	B6.129-Gt(ROSA)26Sortm3Luo/J
005582	B6.129P-Cx3cr1tm1Litt/J
005670	B6.Cg-Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
005622	B6.Cg-Shhtm1(EGFP/cre)Cjt/J
007484	B6.Cg-Tyrc-2J Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
004178	B6.Cg-Tg(CAG-Bgeo/GFP)21Lbe/J
008111	B6.Cg-Tg(CAG-Ub*G76V/GFP)1Dant/J
008112	B6.Cg-Tg(CAG-Ub*G76V/GFP)2Dant/J
006069	B6.Cg-Tg(HIST1H2BB/EGFP)1Pa/J
005029	B6.Cg-Tg(Hlxb9-GFP)1Tmj/J
006864	B6.Cg-Tg(Ins1-EGFP)1Hara/J
005244	B6.Cg-Tg(Krt1-15-EGFP)2Cot/J
007742	B6.Cg-Tg(Myh11-cre,-EGFP)2Mik/J
007902	B6.Cg-Tg(RP23-268L19-EGFP)2Mik/J
007894	B6.Cg-Tg(Rgs4-EGFP)4Lvt/J
006361	B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J
004659	B6.Cg-Tg(TIE2GFP)287Sato/1J
007921	B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J
006000	B6.FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
004509	B6.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
006417	B6.FVB-Tg(Npy-hrGFP)1Lowl/J
005738	B6.FVB-Tg(tetO-EGFP,-Tgfbr2)8Mcle/J
004077	B6;129-Gt(ROSA)26Sortm2Sho/J
006667	B6;129P2-Omptm3Mom/MomJ
004966	B6;CBA-Tg(Acrv1-EGFP)2727Redd/J
004654	B6;CBA-Tg(Pou5f1-EGFP)2Mnn/J
005621	B6;D2-Tg(S100B-EGFP)1Wjt/J
004690	B6;FVB-Tg(Pcp2-EGFP)2Yuza/J
006147	B6;FVB-Tg(Sfpi1,-EGFP)7Dgt/J
006043	B6;SJL-Tg(Oxt/EGFP)AI03Wsy/J
004512	C.FVB-Tg(Itgax-DTR/EGFP)57Lan/J
006567	C57BL/6-Tg(CAG-EGFP)131Osb/LeySopJ
003291	C57BL/6-Tg(CAG-EGFP)1Osb/J
005070	C57BL/6-Tg(Csf1r-EGFP-NGFR/FKBP1A/TNFRSF6)2Bck/J
007265	C57BL/6-Tg(Sry-EGFP)92Ei Chr YAKR/J/EiJ
007264	C57BL/6-Tg(Sry-EGFP)92Ei Tg(Sry)4Ei Chr YPOS/EiJ
004353	C57BL/6-Tg(UBC-GFP)30Scha/J
005706	C57BL/6-Tg(tetO-CDK5R1/GFP)337Lht/J
007567	C57BL/6J-Tg(Itgax-cre,-EGFP)4097Ach/J
003927	C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ
007677	CB6-Tg(Gad1-EGFP)G42Zjh/J
007076	CByJ.B6-Tg(UBC-GFP)30Scha/J
003718	FVB-Tg(GadGFP)45704Swn/J
005515	FVB-Tg(ITGAM-DTR/EGFP)34Lan/J
006421	FVB-Tg(Pomc1-hrGFP)1Lowl/J
003516	FVB.Cg-Tg(CAG-EGFP)B5Nagy/J
007483	FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
003257	FVB/N-Tg(GFAPGFP)14Mes/J
008173	NOD.Cg-Tg(Ins1-EGFP)1Hara/QtngJ
005076	NOD.Cg-Tg(tetO-EGFP/FADD)1Doi/DoiJ
005082	NOD/ShiLt-Tg(ACTB-Ica1/EGFP)18Mdos/MdosJ
005334	NOD/ShiLt-Tg(Cd4-EGFP)1Lt/J
005282	NOD/ShiLtJ-Tg(Ins1-EGFP/GH1)14Hara/HaraJ
006331	STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J
005572	STOCK Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/J
007576	STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
006741	STOCK Olfr160tm1Mom Tg(Olfr151,taulacZ)BMom/MomJ
006570	STOCK Smn1tm1Msd Tg(Hlxb9-GFP)1Tmj Tg(SMN2)89Ahmb/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
003115	STOCK Tg(CAG-EGFP)B5Nagy/J
003116	STOCK Tg(CAG-EGFP)D4Nagy/J
005105	STOCK Tg(Chx10-EGFP/cre-ALPP)2Clc/J
005854	STOCK Tg(Cp-EGFP)25Gaia/J
006334	STOCK Tg(Gad1-EGFP)94Agmo/J
006340	STOCK Tg(Gad1-EGFP)98Agmo/J
007896	STOCK Tg(Gt(ROSA)26Sor-EGFP)I1Able/J
005418	STOCK Tg(HIST1H2BB/EGFP)1Pa/J
003658	STOCK Tg(TIE2GFP)287Sato/J
006129	STOCK Tg(Zp3-EGFP)1Dean/J
005104	STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J
005699	STOCK Tg(tetO-Ipf1,EGFP)956.6Macd/J

View Strains carrying other alleles of GFP     (78 strains)

Additional Web Information

Cre-lox or FLP-FRT Systems
Fluorescent Proteins/lacZ Systems

Research Applications

This mouse can be used to support research in many areas including:

Cancer Research
Increased Tumor Incidence (Leukemia)

Developmental Biology Research
Embryonic Lethality (Homozygous)
Lymphoid Tissue Defects (hematopoietic defects)

Hematological Research
Hematopoietic Defects

Research Tools
Cancer Research (Leukemia)
Cre-lox-System (loxP-flanked Sequences)
Fluorescent Proteins
Genetics Research (Tissue/Cell Markers: Cre-lox system)
Hematological Research
lacZ Expression

Bgeo related

Research Tools
lacZ Expression

GFP related

Fluorescent Proteins

References

Additional References

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Price and Supply Information

Strain Name:	STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
Stock Number:	006876

 

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date: 25-FEB-08

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

View All Strains Under Development

Price(s) in US dollars ($)		Genotype(s) Provided
Individual Mouse Price	$236.40	Hemizygous for Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe
Pair	$286.40	Hemizygous for Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe x Noncarrier
Pair	$286.40	Noncarrier x Hemizygous for Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe

Supply Details

Standard Supply	Under Development for Distribution Colony
Supply Notes	Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-800-422-6423. Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions
Control Information	View Control Information in Strain Details. View Control Pricing Information for JAX® Strains.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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