Strain Name:

B6.Cg-Lepob Ldlrtm1Her/J

Stock Number:

006906

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Availability:

Cryopreserved - Ready for recovery

The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Spontaneous Mutation; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationF?+N1F3pN1
Generation Definitions
 
Donating InvestigatorDr. Jan L. Breslow,   Rockefeller University

Description
Independently, the C57BL/6-Lepob homozygotes (Stock No. 000632) model the increasingly prevalent metabolic disorder seen in humans (hyperglycemia, hyperinsulinemia, and hyperlipidemia), while LDLR-deficient mice (Stock No. 002207) are predisposed to atherosclerosis. When mutant mice are homozygous for both mutant alleles, they exhibit exacerbated hyperlipidemia and extensive atherosclerotic lesions in the aorta. The mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, and hypercholesterolemia.

Development
The Ldlrtm1Her mutation was made by Dr. Robert Hammer and Joachim Herz (HHMI, University of Texas Southwestern Medical Center). Briefly, a targeting vector was used to insert a neo cassette into exon 4. The vector was electroporated into 129S7/SvEvBrd-derived AB1 embryonic stem (ES) cells. Chimeric mice were bred to C57BL/6J, and the strain was made congenic on a C57BL/6J genetic background at The Jackson Laboratory (Stock No. 002207). The ob spontaneous mutation in the leptin gene is maintained on a congenic C57BL/6J genetic background at The Jackson Laboratory (Stock No. 000632). To generate the double mutant strain, Stock No. 002207 mice were bred with Stock No. 000632 mice in the laboratory of Dr. Jan Breslow at The Rockefeller University. Double mutant mice were bred as heterozygous for the ob mutation and homozygous for the LDLR mutation for many generations prior to arrival at The Jackson Laboratory.

Control Information

  Control
   Wild-type for Lepob, Homozygous for Ldlrtm1Her
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

View Strains carrying   Ldlrtm1Her     (15 strains)

Strains carrying   Lepob allele
000632   B6.Cg-Lepob/J
000696   BKS.Cg-Lepob/J
004824   BTBR.Cg-Lepob/WiscJ
View Strains carrying   Lepob     (3 strains)

View Strains carrying other alleles of Ldlr     (4 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Hypercholesterolemia, Familial
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Leptin Deficiency; LEPD   (LEP)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Ldlrtm1Her/Ldlr+ Lepob/Lepob

        B6.Cg-Lepob Ldlrtm1Her
  • homeostasis/metabolism phenotype
  • increased circulating cholesterol level
    • age dependent increase in cholesterol levels between 1 and 4 months of age, with maximal values at 3-4 months of age (282 mg/dl vs 81 md/dl in wild-type) that are maintained thereafter   (MGI Ref ID J:72027)
    • increased circulating HDL cholesterol level
      • slightly elevated at 3 and 8 months of age   (MGI Ref ID J:72027)
  • increased liver cholesterol level
    • livers exhibit slightly, but significantly, higher levels of cholesterol   (MGI Ref ID J:72027)
  • increased liver triglyceride level
    • livers exhibit about 10x higher levels of triglyceride, however no increase in plasma triglyceride levels   (MGI Ref ID J:72027)
  • liver/biliary system phenotype
  • increased liver cholesterol level
    • livers exhibit slightly, but significantly, higher levels of cholesterol   (MGI Ref ID J:72027)
  • increased liver triglyceride level
    • livers exhibit about 10x higher levels of triglyceride, however no increase in plasma triglyceride levels   (MGI Ref ID J:72027)

Ldlrtm1Her/Ldlrtm1Her Lepob/Lepob

        B6.Cg-Lepob Ldlrtm1Her
  • cardiovascular system phenotype
  • atherosclerotic lesions
    • extensive atherosclerotic lesions throughout the aorta by 6 months of age   (MGI Ref ID J:72027)
  • homeostasis/metabolism phenotype
  • abnormal circulating cholesterol level
    • plasma contains severely elevated and broadened lipoprotein peak, ranging from VLDL/LDL-sized particles to LDL-sized particles   (MGI Ref ID J:72027)
    • increased circulating cholesterol level
      • age dependent increase in cholesterol levels between 1 and 4 months of age, with maximal values at 3-4 months of age (1715 mg/dl vs. 81 mg/dl in wild-type), followed by a gradual decrease by 8 months   (MGI Ref ID J:72027)
      • fasting, diet restriction, and low-level leptin treatment only slightly lowers plasma cholesterol levels   (MGI Ref ID J:72027)
      • increased circulating HDL cholesterol level
        • elevated at 3 and 8 months of age   (MGI Ref ID J:72027)
  • hyperlipidemia   (MGI Ref ID J:72027)
  • increased circulating triglyceride level
    • age dependent increase in triglyceride levels between 1 and 4 months of age, with maximal values at 3-4 months of age, followed by a gradual decrease by 8 months   (MGI Ref ID J:72027)
    • fasting, diet restriction, and low-level leptin treatment significantly lowers plasma triglyceride levels   (MGI Ref ID J:72027)
  • increased liver cholesterol level
    • livers exhibit slightly, but significantly, higher levels of cholesterol   (MGI Ref ID J:72027)
  • increased liver triglyceride level
    • livers exhibit about 10x higher levels of triglyceride   (MGI Ref ID J:72027)
  • liver/biliary system phenotype
  • increased liver cholesterol level
    • livers exhibit slightly, but significantly, higher levels of cholesterol   (MGI Ref ID J:72027)
  • increased liver triglyceride level
    • livers exhibit about 10x higher levels of triglyceride   (MGI Ref ID J:72027)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cardiovascular Research
Atherosclerosis
Hypercholesterolemia
Other
      altered fat metabolism

Diabetes and Obesity Research
Hyperglycemia
Hyperinsulinemia

Metabolism Research
Lipid Metabolism

Research Tools
Cardiovascular Research
Diabetes and Obesity Research
Metabolism Research

Ldlrtm1Her related

Cardiovascular Research
Atherosclerosis
Hypercholesterolemia

Metabolism Research
Lipid Metabolism

Lepob related

Diabetes and Obesity Research
Hyperinsulinemia
Impaired Wound Healing
Insulin Resistance
Obesity With Diabetes

Endocrine Deficiency Research
Adipose Defects
Hypothalamus/Pituitary Defects
Pancreas Defects

Immunology, Inflammation and Autoimmunity Research
Immunodeficiency Associated with Other Defects

Internal/Organ Research
Adipose Defects

Metabolism Research

Reproductive Biology Research
Fertility Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ldlrtm1Her
Allele Name targeted mutation 1, Joachim Herz
Allele Type Targeted (Null/Knockout)
Common Name(s) LDLR KO; LDLR-; LDLr-KO; LDLr0; LDLrKO; Ldlrtm1Her;
Mutation Made ByDr. Joachim Herz,   Univ of Texas Southwest Med Ctr Dallas
Strain of Origin129S7/SvEvBrd-Hprt<+>
ES Cell Line NameAB1
ES Cell Line Strain129S7/SvEvBrd-Hprt<+>
Site of ExpressionImmunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals.
Gene Symbol and Name Ldlr, low density lipoprotein receptor
Chromosome 9
Gene Common Name(s) FH; FHC; LDLCQ2; LDLRA;
General Note When used in bone marrow transplant into Ldlrtm1Her homozygous mice, Abca1tm1Jdm Abcg1tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777)
Phenotypic Similarity to Human Syndrome: Type 1 Diabetic Macrovascular Disease (J:174983)
Molecular Note Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals. [MGI Ref ID J:37394]
 
Allele Symbol Lepob
Allele Name obese
Allele Type Spontaneous (Null/Knockout)
Common Name(s) ob; ob/ob;
Strain of OriginSTOCK Mlph a Tgfa Cdh23 Ednrb
Gene Symbol and Name Lep, leptin
Chromosome 6
Gene Common Name(s) LEPD; OB; OBS; ob; obese;
Molecular Note Sequencing of RT-PCR products revealed a nonsense mutation in codon 105 resulting from a C to T point mutation. The 16 kDa leptin protein, expressed predominantly in adipose tissue of normal mice, is missing from homozygous mutant mice (J:29081). [MGI Ref ID J:20512] [MGI Ref ID J:29081] [MGI Ref ID J:45748]

Genotyping

Genotyping Information

Genotyping Protocols

Ldlrtm1Her-alternate 1, High Resolution Melting
Lep ob, End Point Analysis
Lepob, Pyrosequencing
Lepob, Restriction Enzyme Digest


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Ishibashi S; Brown MS; Goldstein JL; Gerard RD; Hammer RE; Herz J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments] J Clin Invest 92(2):883-93. [PubMed: 8349823]  [MGI Ref ID J:37394]

Zhang Y; Proenca R; Maffei M; Barone M; Leopold L; Friedman JM. 1994. Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 1995 Mar 30;374(6521):479] [see comments] Nature 372(6505):425-32. [PubMed: 7984236]  [MGI Ref ID J:20512]

Ldlrtm1Her related

Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. [PubMed: 10727439]  [MGI Ref ID J:61147]

Adachi H; Kondo T; Koh GY; Nagy A; Oike Y; Araki E. 2011. Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice. Biochem Biophys Res Commun 409(2):177-80. [PubMed: 21549101]  [MGI Ref ID J:172599]

Afek A; Keren G; Harats D; George J. 2001. Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice. Exp Mol Pathol 71(1):63-72. [PubMed: 11502098]  [MGI Ref ID J:106255]

Ahmad PJ; Trcka D; Xue S; Franco C; Speer MY; Giachelli CM; Bendeck MP. 2009. Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization. Am J Pathol 175(6):2686-96. [PubMed: 19893047]  [MGI Ref ID J:155320]

Ait-Oufella H; Kinugawa K; Zoll J; Simon T; Boddaert J; Heeneman S; Blanc-Brude O; Barateau V; Potteaux S; Merval R; Esposito B; Teissier E; Daemen MJ; Leseche G; Boulanger C; Tedgui A; Mallat Z. 2007. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 115(16):2168-77. [PubMed: 17420351]  [MGI Ref ID J:135906]

Ait-Oufella H; Pouresmail V; Simon T; Blanc-Brude O; Kinugawa K; Merval R; Offenstadt G; Leseche G; Cohen PL; Tedgui A; Mallat Z. 2008. Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol 28(8):1429-31. [PubMed: 18467644]  [MGI Ref ID J:159811]

Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178-80. [PubMed: 16462800]  [MGI Ref ID J:105800]

Albrecht C; Preusch MR; Hofmann G; Morris-Rosenfeld S; Blessing E; Rosenfeld ME; Katus HA; Bea F. 2010. Egr-1 deficiency in bone marrow-derived cells reduces atherosclerotic lesion formation in a hyperlipidaemic mouse model. Cardiovasc Res 86(2):321-9. [PubMed: 20110335]  [MGI Ref ID J:175882]

Alger HM; Brown JM; Sawyer JK; Kelley KL; Shah R; Wilson MD; Willingham MC; Rudel LL. 2010. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. J Biol Chem 285(19):14267-74. [PubMed: 20231283]  [MGI Ref ID J:162960]

Allred KF; Smart EJ; Wilson ME. 2006. Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors. J Biol Chem 281(3):1419-25. [PubMed: 16299001]  [MGI Ref ID J:107322]

Altenburg M; Arbones-Mainar J; Johnson L; Wilder J; Maeda N. 2008. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol 28(6):1104-10. [PubMed: 18369154]  [MGI Ref ID J:149026]

Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. [PubMed: 15485633]  [MGI Ref ID J:93917]

Anggraeni VY; Emoto N; Yagi K; Mayasari DS; Nakayama K; Izumikawa T; Kitagawa H; Hirata K. 2011. Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis. Biochem Biophys Res Commun 406(1):36-41. [PubMed: 21284936]  [MGI Ref ID J:170936]

Arai S; Shelton JM; Chen M; Bradley MN; Castrillo A; Bookout AL; Mak PA; Edwards PA; Mangelsdorf DJ; Tontonoz P; Miyazaki T. 2005. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metab 1(3):201-13. [PubMed: 16054063]  [MGI Ref ID J:129845]

Aslanian AM; Chapman HA; Charo IF. 2005. Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions. Arterioscler Thromb Vasc Biol 25(3):628-32. [PubMed: 15591216]  [MGI Ref ID J:110061]

Aslanian AM; Charo IF. 2006. Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosis. Circulation 114(6):583-90. [PubMed: 16880330]  [MGI Ref ID J:123851]

Asterholm IW; Rutkowski JM; Fujikawa T; Cho YR; Fukuda M; Tao C; Wang ZV; Gupta RK; Elmquist JK; Scherer PE. 2014. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia 57(6):1209-18. [PubMed: 24623101]  [MGI Ref ID J:210884]

Avraham-Davidi I; Ely Y; Pham VN; Castranova D; Grunspan M; Malkinson G; Gibbs-Bar L; Mayseless O; Allmog G; Lo B; Warren CM; Chen TT; Ungos J; Kidd K; Shaw K; Rogachev I; Wan W; Murphy PM; Farber SA; Carmel L; Shelness GS; Iruela-Arispe ML; Weinstein BM; Yaniv K. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med 18(6):967-73. [PubMed: 22581286]  [MGI Ref ID J:187459]

Azhar S; Luo Y; Medicherla S; Reaven E. 1999. Upregulation of selective cholesteryl ester uptake pathway in mice with deletion of low-density lipoprotein receptor function. J Cell Physiol 180(2):190-202. [PubMed: 10395289]  [MGI Ref ID J:56099]

Babaev VR; Chew JD; Ding L; Davis S; Breyer MD; Breyer RM; Oates JA; Fazio S; Linton MF. 2008. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab 8(6):492-501. [PubMed: 19041765]  [MGI Ref ID J:144376]

Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. [PubMed: 16380543]  [MGI Ref ID J:121507]

Babaev VR; Ishiguro H; Ding L; Yancey PG; Dove DE; Kovacs WJ; Semenkovich CF; Fazio S; Linton MF. 2007. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 116(12):1404-12. [PubMed: 17724261]  [MGI Ref ID J:139843]

Babaev VR; Yancey PG; Ryzhov SV; Kon V; Breyer MD; Magnuson MA; Fazio S; Linton MF. 2005. Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1647-53. [PubMed: 15947238]  [MGI Ref ID J:114332]

Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. [PubMed: 16888235]  [MGI Ref ID J:128048]

Barish GD; Yu RT; Karunasiri MS; Becerra D; Kim J; Tseng TW; Tai LJ; Leblanc M; Diehl C; Cerchietti L; Miller YI; Witztum JL; Melnick AM; Dent AL; Tangirala RK; Evans RM. 2012. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab 15(4):554-62. [PubMed: 22465074]  [MGI Ref ID J:184208]

Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis. J Leukoc Biol 82(2):226-36. [PubMed: 17329566]  [MGI Ref ID J:123530]

Bartelt A; Bruns OT; Reimer R; Hohenberg H; Ittrich H; Peldschus K; Kaul MG; Tromsdorf UI; Weller H; Waurisch C; Eychmuller A; Gordts PL; Rinninger F; Bruegelmann K; Freund B; Nielsen P; Merkel M; Heeren J. 2011. Brown adipose tissue activity controls triglyceride clearance. Nat Med 17(2):200-5. [PubMed: 21258337]  [MGI Ref ID J:168555]

Barthwal MK; Anzinger JJ; Xu Q; Bohnacker T; Wymann MP; Kruth HS. 2013. Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation. PLoS One 8(3):e58054. [PubMed: 23536783]  [MGI Ref ID J:199527]

Bassett CM; Edel AL; Patenaude AF; McCullough RS; Blackwood DP; Chouinard PY; Paquin P; Lamarche B; Pierce GN. 2010. Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice. J Nutr 140(1):18-24. [PubMed: 19923390]  [MGI Ref ID J:155556]

Basso F; Amar MJ; Wagner EM; Vaisman B; Paigen B; Santamarina-Fojo S; Remaley AT. 2006. Enhanced ABCG1 expression increases atherosclerosis in LDLr-KO mice on a western diet. Biochem Biophys Res Commun 351(2):398-404. [PubMed: 17070501]  [MGI Ref ID J:116554]

Basso F; Freeman LA; Ko C; Joyce C; Amar MJ; Shamburek RD; Tansey T; Thomas F; Wu J; Paigen B; Remaley AT; Santamarina-Fojo S; Brewer HB Jr. 2007. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited. J Lipid Res 48(1):114-26. [PubMed: 17060690]  [MGI Ref ID J:117682]

Bavendiek U; Zirlik A; LaClair S; MacFarlane L; Libby P; Schonbeck U. 2005. Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells. Arterioscler Thromb Vasc Biol 25(6):1244-9. [PubMed: 15746436]  [MGI Ref ID J:114293]

Becker L; Liu NC; Averill MM; Yuan W; Pamir N; Peng Y; Irwin AD; Fu X; Bornfeldt KE; Heinecke JW. 2012. Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS One 7(3):e33297. [PubMed: 22428014]  [MGI Ref ID J:186914]

Becker M; Rabe K; Lebherz C; Zugwurst J; Goke B; Parhofer KG; Lehrke M; Broedl UC. 2010. Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet. Diabetes 59(11):2898-903. [PubMed: 20724582]  [MGI Ref ID J:169337]

Bell TA 3rd; Kelley K; Wilson MD; Sawyer JK; Rudel LL. 2007. Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice. Arterioscler Thromb Vasc Biol 27(6):1396-402. [PubMed: 17431188]  [MGI Ref ID J:134910]

Bernal-Mizrachi C; Weng S; Feng C; Finck BN; Knutsen RH; Leone TC; Coleman T; Mecham RP; Kelly DP; Semenkovich CF. 2003. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med 9(8):1069-75. [PubMed: 12847522]  [MGI Ref ID J:84844]

Bernhagen J; Krohn R; Lue H; Gregory JL; Zernecke A; Koenen RR; Dewor M; Georgiev I; Schober A; Leng L; Kooistra T; Fingerle-Rowson G; Ghezzi P; Kleemann R; McColl SR; Bucala R; Hickey MJ; Weber C. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587-596. [PubMed: 17435771]  [MGI Ref ID J:121807]

Bhasin KK; van Nas A; Martin LJ; Davis RC; Devaskar SU; Lusis AJ. 2009. Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. Diabetes 58(3):559-66. [PubMed: 19073773]  [MGI Ref ID J:146932]

Bhatia VK; Yun S; Leung V; Grimsditch DC; Benson GM; Botto MB; Boyle JJ; Haskard DO. 2007. Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice. Am J Pathol 170(1):416-26. [PubMed: 17200212]  [MGI Ref ID J:117210]

Bie J; Wang J; Yuan Q; Kakiyama G; Ghosh SS; Ghosh S. 2014. Liver-specific transgenic expression of cholesteryl ester hydrolase reduces atherosclerosis in Ldlr-/- mice. J Lipid Res 55(4):729-38. [PubMed: 24563511]  [MGI Ref ID J:208896]

Bie J; Zhao B; Ghosh S. 2011. Atherosclerotic lesion progression is attenuated by reconstitution with bone marrow from macrophage-specific cholesteryl ester hydrolase transgenic mice. Am J Physiol Regul Integr Comp Physiol 301(4):R967-74. [PubMed: 21795638]  [MGI Ref ID J:178811]

Bie J; Zhao B; Song J; Ghosh S. 2010. Improved insulin sensitivity in high fat- and high cholesterol-fed Ldlr-/- mice with macrophage-specific transgenic expression of cholesteryl ester hydrolase: role of macrophage inflammation and infiltration into adipose tissue. J Biol Chem 285(18):13630-7. [PubMed: 20189995]  [MGI Ref ID J:163056]

Bieghs V; Van Gorp PJ; Wouters K; Hendrikx T; Gijbels MJ; van Bilsen M; Bakker J; Binder CJ; Lutjohann D; Staels B; Hofker MH; Shiri-Sverdlov R. 2012. LDL receptor knock-out mice are a physiological model particularly vulnerable to study the onset of inflammation in non-alcoholic fatty liver disease. PLoS One 7(1):e30668. [PubMed: 22295101]  [MGI Ref ID J:184219]

Bietrix F; Lombardo E; van Roomen CP; Ottenhoff R; Vos M; Rensen PC; Verhoeven AJ; Aerts JM; Groen AK. 2010. Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 30(5):931-7. [PubMed: 20167657]  [MGI Ref ID J:175820]

Billon-Gales A; Fontaine C; Douin-Echinard V; Delpy L; Berges H; Calippe B; Lenfant F; Laurell H; Guery JC; Gourdy P; Arnal JF. 2009. Endothelial estrogen receptor-alpha plays a crucial role in the atheroprotective action of 17beta-estradiol in low-density lipoprotein receptor-deficient mice. Circulation 120(25):2567-76. [PubMed: 19996016]  [MGI Ref ID J:168125]

Billon-Gales A; Fontaine C; Filipe C; Douin-Echinard V; Fouque MJ; Flouriot G; Gourdy P; Lenfant F; Laurell H; Krust A; Chambon P; Arnal JF. 2009. The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol. Proc Natl Acad Sci U S A 106(6):2053-8. [PubMed: 19188600]  [MGI Ref ID J:144952]

Billon-Gales A; Krust A; Fontaine C; Abot A; Flouriot G; Toutain C; Berges H; Gadeau AP; Lenfant F; Gourdy P; Chambon P; Arnal JF. 2011. Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing. Proc Natl Acad Sci U S A 108(32):13311-6. [PubMed: 21788522]  [MGI Ref ID J:175619]

Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. [PubMed: 15286809]  [MGI Ref ID J:118092]

Binder CJ; Horkko S; Dewan A; Chang MK; Kieu EP; Goodyear CS; Shaw PX; Palinski W; Witztum JL; Silverman GJ. 2003. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med 9(6):736-43. [PubMed: 12740573]  [MGI Ref ID J:83726]

Bischoff ED; Daige CL; Petrowski M; Dedman H; Pattison J; Juliano J; Li AC; Schulman IG. 2010. Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice. J Lipid Res 51(5):900-6. [PubMed: 20388921]  [MGI Ref ID J:160160]

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Xue P; Hou Y; Chen Y; Yang B; Fu J; Zheng H; Yarborough K; Woods CG; Liu D; Yamamoto M; Zhang Q; Andersen ME; Pi J. 2013. Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes 62(3):845-54. [PubMed: 23238296]  [MGI Ref ID J:208590]

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Yahagi N; Shimano H; Matsuzaka T; Najima Y; Sekiya M; Nakagawa Y; Ide T; Tomita S; Okazaki H; Tamura Y; Iizuka Y; Ohashi K; Gotoda T; Nagai R; Kimura S; Ishibashi S; Osuga J; Yamada N. 2003. p53 Activation in adipocytes of obese mice. J Biol Chem 278(28):25395-400. [PubMed: 12734185]  [MGI Ref ID J:120652]

Yahagi N; Shimano H; Matsuzaka T; Sekiya M; Najima Y; Okazaki S; Okazaki H; Tamura Y; Iizuka Y; Inoue N; Nakagawa Y; Takeuchi Y; Ohashi K; Harada K; Gotoda T; Nagai R; Kadowaki T; Ishibashi S; Osuga J; Yamada N. 2004. p53 involvement in the pathogenesis of fatty liver disease. J Biol Chem 279(20):20571-5. [PubMed: 14985341]  [MGI Ref ID J:124263]

Yamada N; Katsuura G; Ochi Y; Ebihara K; Kusakabe T; Hosoda K; Nakao K. 2011. Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology 152(7):2634-43. [PubMed: 21521746]  [MGI Ref ID J:174906]

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Yang G; Badeanlou L; Bielawski J; Roberts AJ; Hannun YA; Samad F. 2009. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab 297(1):E211-24. [PubMed: 19435851]  [MGI Ref ID J:151166]

Yang M; Sun J; Zhang T; Liu J; Zhang J; Shi MA; Darakhshan F; Guerre-Millo M; Clement K; Gelb BD; Dolgnov G; Shi GP. 2008. Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arterioscler Thromb Vasc Biol 28(12):2202-8. [PubMed: 18818416]  [MGI Ref ID J:159791]

Yang M; Zhang Y; Pan J; Sun J; Liu J; Libby P; Sukhova GK; Doria A; Katunuma N; Peroni OD; Guerre-Millo M; Kahn BB; Clement K; Shi GP. 2007. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol 9(8):970-7. [PubMed: 17643114]  [MGI Ref ID J:129484]

Yang R; Sikka G; Larson J; Watts VL; Niu X; Ellis C; Miller K; Camara A; Reinke C; Savransky V; Polotsky VY; O'Donnell CP; Berkowitz DE; Barouch LA. 2011. Restoring Leptin Signaling Reduces Hyperlipidemia and Improves Vascular Stiffness Induced by Chronic Intermittent Hypoxia. Am J Physiol Heart Circ Physiol :. [PubMed: 21278136]  [MGI Ref ID J:168540]

Yang RY; Yu L; Graham JL; Hsu DK; Lloyd KC; Havel PJ; Liu FT. 2011. Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci U S A 108(46):18696-701. [PubMed: 21969596]  [MGI Ref ID J:180097]

Yang S; Lin HZ; Hwang J; Chacko VP; Diehl AM. 2001. Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? Cancer Res 61(13):5016-23. [PubMed: 11431335]  [MGI Ref ID J:70169]

Yang SQ; Lin HZ; Mandal AK; Huang J; Diehl AM. 2001. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. Hepatology 34(4 Pt 1):694-706. [PubMed: 11584365]  [MGI Ref ID J:106504]

Yang X; Wang X; Liu D; Yu L; Xue B; Shi H. 2014. Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b. Mol Endocrinol 28(4):565-74. [PubMed: 24597547]  [MGI Ref ID J:213063]

Ye H; Charpin-El Hamri G; Zwicky K; Christen M; Folcher M; Fussenegger M. 2013. Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome. Proc Natl Acad Sci U S A 110(1):141-6. [PubMed: 23248313]  [MGI Ref ID J:192622]

Ye J; Gao Z; Yin J; He Q. 2007. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293(4):E1118-28. [PubMed: 17666485]  [MGI Ref ID J:125547]

Yeh JK; Evans JF; Niu QT; Aloia JF. 2006. A possible role for melanocortin peptides in longitudinal growth. J Endocrinol 191(3):677-86. [PubMed: 17170224]  [MGI Ref ID J:116680]

Yekollu SK; Thomas R; O'Sullivan B. 2011. Targeting curcusomes to inflammatory dendritic cells inhibits NF-kappaB and improves insulin resistance in obese mice. Diabetes 60(11):2928-38. [PubMed: 21885868]  [MGI Ref ID J:189374]

Yi CX; Tschop MH; Woods SC; Hofmann SM. 2012. High-fat-diet exposure induces IgG accumulation in hypothalamic microglia. Dis Model Mech 5(5):686-90. [PubMed: 22381575]  [MGI Ref ID J:187483]

Yi P; Park JS; Melton DA. 2013. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 153(4):747-58. [PubMed: 23623304]  [MGI Ref ID J:197679]

Yin J; Gao Z; He Q; Zhou D; Guo Z; Ye J. 2009. Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab 296(2):E333-42. [PubMed: 19066318]  [MGI Ref ID J:146063]

Yin J; Lee JH; Zhang J; Gao Z; Polotsky VY; Ye J. 2014. Regulation of hepatocyte growth factor expression by NF-kappaB and PPARgamma in adipose tissue. Am J Physiol Endocrinol Metab 306(8):E929-36. [PubMed: 24569592]  [MGI Ref ID J:212286]

Yoon JC; Puigserver P; Chen G; Donovan J; Wu Z; Rhee J; Adelmant G; Stafford J; Kahn CR; Granner DK; Newgard CB; Spiegelman BM. 2001. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413(6852):131-8. [PubMed: 11557972]  [MGI Ref ID J:120036]

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Yu Y; Liu Y; Shi FD; Zou H; Matarese G; La Cava A. 2013. Cutting Edge: Leptin-Induced RORgammat Expression in CD4+ T Cells Promotes Th17 Responses in Systemic Lupus Erythematosus. J Immunol 190(7):3054-8. [PubMed: 23447682]  [MGI Ref ID J:194839]

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Zhang F; Dey D; Branstrom R; Forsberg L; Lu M; Zhang Q; Sjoholm A. 2009. BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity, raises cytosolic Ca2+, and enhances glucose-stimulated insulin secretion in a PI3K-dependent manner. Am J Physiol Cell Physiol 296(2):C346-54. [PubMed: 19052259]  [MGI Ref ID J:146323]

Zhang H; Shen WJ; Cortez Y; Kraemer FB; Azhar S. 2013. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARalpha-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol 304(1):G72-86. [PubMed: 23104557]  [MGI Ref ID J:194703]

Zhang J; Nakatsu Y; Shinjo T; Guo Y; Sakoda H; Yamamotoya T; Otani Y; Okubo H; Kushiyama A; Fujishiro M; Fukushima T; Tsuchiya Y; Kamata H; Iwashita M; Nishimura F; Katagiri H; Takahashi S; Kurihara H; Uchida T; Asano T. 2013. Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions. J Biol Chem 288(28):20692-701. [PubMed: 23720771]  [MGI Ref ID J:201792]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, these mice are bred as heterozygous for the ob mutation and homozygous for the LDLR mutation.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2140.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2782.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.

    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 10 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   Wild-type for Lepob, Homozygous for Ldlrtm1Her
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice
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Terms of Use

Terms of Use


General Terms and Conditions


Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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