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| Thin hair homozygotes have a sparse coat discernible by two weeks of age. By three weeks of age the pelt has fewer zigzag hairs than normal and by four weeks of age skin follicles are somewhat dilated with degeneration of the deepest portions of the anagen hair follicles. Hair fragments from degenerating follicles are found in the connective tissue and granulomatous inflammation develops. | |||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Major Histocompatibility Congenic; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Backcross-Intercross (Female x Male) 07-JAN-09 Species laboratory mouse Generation N5F1 (05-NOV-09) Appearance
albino with thin hair growth
Associated genotype: Tyrc/Tyrc thnh/thnh
albino, unaffected
Associated genotypes: Tyrc/Tyrc thnh/+ or Tyrc/Tyrc thnh/?Description
Thin hair homozygotes have a sparse coat discernible by two weeks of age. By three weeks of age the pelt has fewer zigzag hairs than normal and by four weeks of age skin follicles are somewhat dilated with degeneration of the deepest portions of the anagen hair follicles. Hair fragments from degenerating follicles are found in the connective tissue and granulomatous inflammation develops.Development
The thin hair mutation arose spontaneously on the NOD/ShiLtJ inbred background at The Jackson Laboratory in 2006. This mutation was backcrossed onto the NOD.B10Sn-H2b/J (Stock No. 002591) background via repeated backcross-intercross breeding in order to remove the diabetic phenotype, which complicated strain maintenance. In 2008 this strain reached generation N4F1.
Control Information
| Control | ||
|---|---|---|
| +/? from the colony | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying H2b allele
002089 AK.B6-H2b Fv1b/J 002090 AK.B6-H2b/J 001094 AK.L-H2b/1CyTyJ 002995 B6 x C.B10-H2b/LiMcdJ-Fbn2fp-2J/J 000944 B6.SJL-H2b C3c/2CyJ 001041 BKS.B6-H2b/J 001892 BRVR.B10-H2b/J 002845 C.B-H2b Tg(H2-Dd)D8Gja/LilJ 001952 C.B10-H2b/LilMcdJ 000438 C3.SW-H2b/SnJ 000435 D1.LP-H2b H2-T18b?/SnJ 002591 NOD.B10Sn-H2b/J View Strains carrying H2b (12 strains)
Phenotype
Phenotype Information
assigned by genotype
thnh/thnh
NOD.Cg-H2b thnh/J
- skin/coat/nails phenotype
- abnormal hair follicle morphology (MGI Ref ID J:142872)
- the follicles are somewhat dilated with the deepest portions of anagen hair follicles in the subcutaneous adipose layer degenerating
- folliculitis (MGI Ref ID J:142872)
- at 3 weeks of age crowded follicles and skin inflammation are found
- at 4 weeks of age pieces of hair from broken down follicles are found free in the connective tissue and seem to cause severe foreign body granulomatous inflammation within giant cells
- decreased zigzag hair amount (MGI Ref ID J:142872)
- all four hair types are present, but there are fewer zigzags than normal
- sparse hair (MGI Ref ID J:142872)
- evident by 2 weeks of age
- immune system phenotype
- folliculitis (MGI Ref ID J:142872)
- at 3 weeks of age crowded follicles and skin inflammation are found
- at 4 weeks of age pieces of hair from broken down follicles are found free in the connective tissue and seem to cause severe foreign body granulomatous inflammation within giant cells
This mouse can be used to support research in many areas including:H2b related
thnh relatedImmunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Dermatology Research
Skin and Hair Texture Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | H2b | ||
|---|---|---|---|
| Allele Name | b variant | ||
| Allele Type | Not Applicable | ||
| Allele Symbol | thnh | ||
| Allele Name | thin hair | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | NOD/ShiLtJ | ||
| Gene Symbol and Name | thnh, thin hair | ||
| Chromosome | UN | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Dionne L; Samples R; Johnson KR. 2009. A new recessive hair mutation on Chromosome 9 MGI Direct Data Submission :. [MGI Ref ID J:142872]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A1
Colony Maintenance
Mating System Backcross-Intercross (Female x Male) 07-JAN-09
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $169.60 Female or Male Heterozygous for H2b, Homozygous for thnh $257.80 Female or Male Homozygous for H2b, Homozygous for thnh
Pairs /Price (US dollars $) Pair Genotype $339.20 Heterozygous for H2b thnh x Heterozygous for H2b thnh
Additional Supply Details
| Pricing for International shipping destinations |
|
Weeks of Age Price (US dollars $) Gender Genotypes Provided Individual Mouse $220.50 Female or Male Heterozygous for H2b, Homozygous for thnh $335.20 Female or Male Homozygous for H2b, Homozygous for thnh
Pairs /Price (US dollars $) Pair Genotype $441.00 Heterozygous for H2b thnh x Heterozygous for H2b thnh
Additional Supply Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of approximately nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within two business days following order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| +/? from the colony | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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