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Genes & Alleles

Fut1;   Fut1tm1Sdo;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Mating System Heterozygote x Heterozygote         (Female x Male) Species laboratory mouse Donating Investigator Steven Domino,   University of Michigan Generation N13+ (18-JUL-08)

Strain Description
Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Alpha(1,2)fucosylated glycans are not detected in the epididymis of homozygotes. Fucosylated glycolipids (fucosyl GA1) are not detected in the pancreatic acinar glands of homozygotes. Homozygotes exhibit delayed maturation of nerve fibers in the glomerular layer of the olfactory bulb due to absence of cell surface carbohydrate, blood group H carbohydrate, expression in primary sensory neurons. The Donating Investigator reports that the beta-galatosidase is expressed. This mutant mouse strain may be useful in studies of glycosidic molecular interactions and function, and olfactory nerve pathway development.

This strain was transferred from the collection of the Consortium for Functional Glycomics.

Strain Development
A targeting vector containing neomycin resistance and beta-galactosidase genes was used to disrupt the one coding exon. The construct was electroporated into 129X1/SvJ derived Pat5 OR (129X1/SvJ x 129S1/Sv)F1-Kitl⁺ derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient C57BL/6J blastocysts. The resulting male chimeric animals were crossed to C57BL/6J female mice. Heterozygotes were crossed to obtain homozygotes. The mice were then backcrossed to C57BL/6 for 12 generations before arriving at The Jackson Laboratory. The mice were crossed once to C57BL/6J upon arrival at The Jackson Laboratory.

Mammalian Phenotype Terms assigned by genotype The following phenotype information may relate to a genetic background differing from this JAX® Mice strain. Fut1tm1Sdo/Fut1tm1Sdo         involves: 129X1/SvJ * C57BL/6J reproductive system phenotype abnormal male reproductive system physiology (MGI Ref ID J:72946) absence of fucosylated glycans in the epididymal epithelium but normal male fertility digestive/alimentary phenotype abnormal pancreas physiology (MGI Ref ID J:89929) absence of fucosylated glycolipids endocrine/exocrine gland phenotype abnormal pancreas physiology (MGI Ref ID J:89929) absence of fucosylated glycolipids

Gene & Allele Details

Allele Symbol		Fut1tm1Sdo
Allele Name		targeted mutation 1, Steven E Domino
Common Name(s)		FUT1-;
Mutation Made By		Peter Sobieszczuk,   Consortium for Functional Glycomics,TSRI
Strain of Origin		129
ES Cell Line Name		Other (see notes)
ES Cell Line Strain		129
Site of Expression		lacZ expression patterns have not been characterized.
Gene Symbol and Name		Fut1, fucosyltransferase 1
Chromosome		7
Gene Common Name(s)		Futa; H; H transferase; HH; HSC;
General Note		ES cell line = Pat5 (129X1/SvJ) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+).
Molecular Note		Most of the single coding exon of the gene was replaced with a lacZ-PGK-neo cassette via homologous recombination resulting in deletion of the catalytic domain. Homozygous mutant animals were identified by Southern blot and PCR genotype analysis. [MGI Ref ID J:72946]

Genotyping Protocols

Fut1^tm1Sdo

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony, these mice can be bred as homozygotes.
Diet Information	LabDiet® 5K52/5K67

Related Strains

lacZ Expression Strains

002484	129-Alpltm1Sor/J
002292	129-Gt(ROSA)26Sor/J
006050	129-Sirt6tm1Fwa/J
003451	129-Smad3tm1Par/J
003310	129S-Gt(ROSA)26Sortm1Sor/J
003383	129S-Nogtm1Amc/J
004545	129S-Npytm1Rpa/J
005091	129S-Pnpla6tm1Blw/J
007199	129S-Sgpl1Gt(ROSA)78Sor/J
003082	129S1/SvImJ-Bcl2tm1Mpin/J
004178	B6.129(Cg)-Tg(CAG-Bgeo/GFP)21Lbe/J
004478	B6.129-Foxd1tm1Lai/J
005768	B6.129-Htr5atm1Dgen/J
002938	B6.129-Kdrtm1Jrt/J
004158	B6.129-Maftm1Gsb/J
006497	B6.129-Skiltm2Spw/J
005772	B6.129P2-Acvrl1tm1Dgen/J
006431	B6.129P2-Adam21tm1Dgen/J
005770	B6.129P2-Adamts4tm1Dgen/J
005771	B6.129P2-Adamts5tm1Dgen/J
005773	B6.129P2-Adcy3tm1Dgen/J
005774	B6.129P2-Adcy7tm1Dgen/J
005775	B6.129P2-Adipor2tm1Dgen/J
005776	B6.129P2-Avpr1atm1Dgen/J
005777	B6.129P2-Axltm1Dgen/J
005783	B6.129P2-Cacna1ctm1Dgen/J
005780	B6.129P2-Cacna2d3tm1Dgen/J
005781	B6.129P2-Cacng3tm1Dgen/J
005782	B6.129P2-Cacng4tm1Dgen/J
005784	B6.129P2-Capn5tm1Dgen/J
005785	B6.129P2-Capn7tm1Dgen/J
005792	B6.129P2-Ccr1l1tm1Dgen/J
005793	B6.129P2-Ccr6tm1Dgen/J
005794	B6.129P2-Ccr7tm1Dgen/J
005779	B6.129P2-Celsr2tm1Dgen/J
005797	B6.129P2-Chrna2tm1Dgen/J
005787	B6.129P2-Ctsctm1Dgen/J
005796	B6.129P2-Cxcr3tm1Dgen/J
005798	B6.129P2-Drd5tm1Dgen/J
005800	B6.129P2-Efemp2tm1Dgen/J
005801	B6.129P2-Esrratm1Dgen/J
005802	B6.129P2-Faim2tm1Dgen/J
005803	B6.129P2-Fzd1tm1Dgen/J
005804	B6.129P2-Fzd8tm1Dgen/J
005811	B6.129P2-Gabra3tm1Dgen/J
005812	B6.129P2-Gabra4tm1Dgen/J
005810	B6.129P2-Gabrptm1Dgen/J
005809	B6.129P2-Galr1tm1Dgen/J
005816	B6.129P2-Glra3tm1Dgen/J
005805	B6.129P2-Gpr151tm1Dgen/J
005806	B6.129P2-Gpr37tm1Dgen/J
005807	B6.129P2-Gpr6tm1Dgen/J
005813	B6.129P2-Grik5tm1Dgen/J
005808	B6.129P2-Grk5tm1Dgen/J
005814	B6.129P2-Grm1tm1Dgen/J
005815	B6.129P2-Grm3tm1Dgen/J
005817	B6.129P2-Gsk3btm1Dgen/J
005818	B6.129P2-Hcrtr1tm1Dgen/J
005767	B6.129P2-Htr4tm1Dgen/J
005769	B6.129P2-Htr7tm1Dgen/J
005830	B6.129P2-Kcnq2tm1Dgen/J
005821	B6.129P2-Lats2tm1Dgen/J
005822	B6.129P2-Lmbr1tm1Dgen/J
005850	B6.129P2-Mapkapk2tm1Dgen/J
005824	B6.129P2-Mmp17tm1Dgen/J
005825	B6.129P2-Mtmr1tm1Dgen/J
005778	B6.129P2-Naip1tm1Dgen/J
005826	B6.129P2-Ntsr1tm1Dgen/J
005829	B6.129P2-Pkd2l2tm1Dgen/J
005828	B6.129P2-Ppardtm1Dgen/J
005831	B6.129P2-Ppm1ftm1Dgen/J
005827	B6.129P2-Ptch2tm1Dgen/J
005832	B6.129P2-Ptprotm1Dgen/J
005799	B6.129P2-S1pr4tm1Dgen/J
005837	B6.129P2-Scn11atm1Dgen/J
005836	B6.129P2-Scn9atm1Dgen/J
005834	B6.129P2-Sema5atm1Dgen/J
005835	B6.129P2-Sema6ctm1Dgen/J
006432	B6.129P2-Slc18a1tm1Dgen/J
005839	B6.129P2-Slc22a12tm1Dgen/J
005838	B6.129P2-Slc22a6tm1Dgen/J
005840	B6.129P2-Slc40a1tm1Dgen/J
005841	B6.129P2-Slc6a9tm1Dgen/J
005842	B6.129P2-Slc7a8tm1Dgen/J
005843	B6.129P2-Slc9a6tm1Dgen/J
005844	B6.129P2-Sstr1tm1Dgen/J
005847	B6.129P2-Tgfbr1tm1Dgen/J
005845	B6.129P2-Thbs4tm1Dgen/J
005790	B6.129P2-Tpp1tm1Dgen/J
005848	B6.129P2-Trpm5tm1Dgen/J
005791	B6.129P2-Xcr1tm1Dgen/J
003474	B6.129S4-Gt(ROSA)26Sortm1Sor/J
005901	B6.129S4-Ppardtm2Rev/J
006142	B6.129S4-Ppargtm1Rev/J
003754	B6.129S4-Shroom3Gt(ROSA)53Sor/J
005119	B6.129S6-Npas2tm1Slm/J
002741	B6.129S7-Alpltm1Sor/J
005970	B6.129S7-Atoh1tm2Hzo/J
006039	B6.129S7-Efnb2tm1And/J
002192	B6.129S7-Gt(ROSA)26Sor/J
005981	B6.129S7-Rai1tm1Jrl/J
005039	B6.129X1-Adra1atm1Pcs/J
006262	B6.129X1-Fut2tm1Sdo/J
005085	B6.Cg-Cd44tm1Hbg/J
007745	B6.Cg-Mirn155tm1.1Rsky/J
005317	B6.Cg-Tg(BAT-lacZ)3Picc/J
006055	B6.Cg-Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006477	B6.Cg-Tg(CAG-lacZ-WGA)330Bbm/J
003139	B6.Cg-Tg(DBHn-lacZ)8Rpk/J
006229	B6.Cg-Tg(DRE-lacZ)2Gswz/J
002982	B6.Cg-Tg(xstpx-lacZ)32And/J
003504	B6;129-Gt(ROSA)26Sortm1Sho/J
005064	B6;129-Slc30a3tm1Rpa/J
005788	B6;129P2-Cd97tm1Dgen/J
005833	B6;129P2-Rgs4tm1Dgen/J
002073	B6;129S-Gt(ROSA)26Sor/J
006470	B6;129S-Hopxtm1Eno/J
004153	B6;129S-Mtap7Gt(ROSABetageo)1Sor/J
006958	B6;129S-Nkd1tm1Kwha/J
006960	B6;129S-Nkd2tm1Kwha/J
007204	B6;129S4-2610005L07RikGt(ROSA)73Sor/J
003309	B6;129S4-Gt(ROSA)26Sortm1Sor/J
004365	B6;129S6-Srebf1tm1Mbr/J
002317	B6;129S7-Alpltm1Sor/J
003266	B6;129S7-Epas1tm1Rus/J
006044	B6;129S7-Ephb4tm1And/J
003471	B6;C3H-Tg(CNP-GEO)1Ldh/J
006465	B6;CBA-Tg(CAG-lacZ-WGA)330Bbm/J
006680	B6;CBA-Tg(Olfr16*,taulacZ)19Mom/MomJ
006671	B6;CBA-Tg(Olfr16*,taulacZ)5Mom/MomJ
006672	B6;CBA-Tg(Olfr16*,taulacZ)7Mom/MomJ
006673	B6;CBA-Tg(Olfr16,taulacZ)sn2Mom/MomJ
004141	B6;CBA-Tg(UAS-lacZ)65Rth/J
002369	B6;SJL-Tg(c177-lacZ)226Bri/J
002372	B6;SJL-Tg(c177-lacZ)227Bri/J
002621	B6;SJL-Tg(tetop-lacZ)2Mam/J
003299	B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J
002865	B6CBA-Tg(Wnt1-lacZ)206Amc/J
002955	C.129S7-Gt(ROSA)26Sor/J
002754	C57BL/6-Tg(LacZpl)60Vij/J
002193	C57BL/6J-Tg(MTn-lacZ)204Bri/J
002981	DBA/2-Tg(xstpx-lacZ)36And/J
004127	FVB-Tg(Nes-rtTA)306Rvs/J
007225	FVB.129(B6)-Usp18tm1Dzh/J
008203	FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)63Ahmb Tg(SMN2)89Ahmb/J
008209	FVB.Cg-Smn1tm1Msd Tg(ACTA1-SMN)69Ahmb Tg(SMN2)89Ahmb/J
006214	FVB.Cg-Smn1tm1Msd/J
005024	FVB.Cg-Tg(SMN2)89Ahmb Smn1tm1Msd/J
005026	FVB.Cg-Tg(SMN2)89Ahmb Tg(SMN1*A2G)2023Ahmb Smn1tm1Msd/J
005025	FVB.Cg-Tg(SMN2*delta7)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J
003140	FVB/N-Tg(PAI1-lacZ)1Jjb/J
002856	FVB/N-Tg(TIE2-lacZ)182Sato/J
005941	FVB/N-Tg(tetO-Aurkb,lacZ)41Kra/J
003315	FVB/N-Tg(tetORo1-lacZ)3Conk/J
003487	FVB/NJ-Tg(XGFAP-lacZ)3Mes/J
005878	NOD.Cg-Cd44tm1Hbg/J
003899	STOCK Cd44tm1Hbg/J
006241	STOCK Hhiptm1Amc/J
006578	STOCK Myoz2tm1Eno/J
005707	STOCK Rag1tm1Mom Tg(TIE2-lacZ)182Sato/J
008212	STOCK Smn1tm1Msd Tg(Prnp-SMN)92Ahmb Tg(SMN2)89Ahmb/J
006882	STOCK Tg(CAG-Bgeo,-AML1/ETO,-ALPP)1Lbe/J
005438	STOCK Tg(CAG-Bgeo,-DsRed*MST)1Nagy/J
006850	STOCK Tg(CAG-Bgeo,-NOTCH1,-EGFP)1Lbe/J
006876	STOCK Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe/J
006613	STOCK Tg(CAG-Bgeo,-Tle1,-ALPP)1Lbe/J
003919	STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
003920	STOCK Tg(CAG-Bgeo/GFP)21Lbe/J
004623	STOCK Tg(Fos-lacZ)34Efu/J
006674	STOCK Tg(Olfr16,taulacZ)2030Mom/MomJ
005493	STOCK Tg(Tek-rtTA,TRE-lacZ)1425Tpr/J
002395	STOCK Tg(Zfy1-lacZ)218Bri/J
003274	STOCK Tg(tetNZL)2Bjd/J
005728	STOCK Tg(tetO-Ipf1,lacZ)958.1Macd/J

View lacZ Expression Strains     (174 strains)

Additional Web Information

Fluorescent Proteins/lacZ Systems

Research Applications

This mouse can be used to support research in many areas including:

Cell Biology Research
Protein Processing

Developmental Biology Research
Neurodevelopmental Defects

Neurobiology Research
Neurodevelopmental Defects

Research Tools
lacZ Expression
Cell Biology Research

References

Selected Reference(s)

Domino SE; Zhang L; Gillespie PJ; Saunders TL; Lowe JB. 2001. Deficiency of Reproductive Tract alpha(1,2)Fucosylated Glycans and Normal Fertility in Mice with Targeted Deletions of the FUT1 or FUT2 alpha(1,2)Fucosyltransferase Locus. Mol Cell Biol 21(24):8336-45. [PubMed: 11713270]  [MGI Ref ID J:72946]

Additional References

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Price and Supply Information

Strain Name:	B6.129-Fut1tm1Sdo/J
Stock Number:	006939

 

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date: 22-SEP-08

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

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Supply Details

Standard Supply	Under Development for Distribution Colony
Supply Notes	This strain is included in the Induced Mutant Resource Colony collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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