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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6.CBA-Tg(Camk2a-tTA)1Mmay/DboJ (Changed: 28-AUG-07 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered Mutant Mice. Mating System Noncarrier x Hemizygote (Female x Male) Species laboratory mouse Generation N9+N1 (20-DEC-07) Donating Investigator David Borchelt, McKnight Brain Inst, Univ of Florida Description
Transgenic mice expressing the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter are viable and fertile. When hemizygotes are mated to a second strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline (dox). These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease (when used in conjunction with Stock No. 005706, Stock No. 007049, Stock No. 007051, Stock No. 007052), Parkinson's disease, or other neurodegenerative diseases.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct was designed with 8.5 kb of the mouse CaMKIIalpha promoter placed upstream of the tetracycline-regulated transactivator (tTA or "Tet-Off") gene (flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end). Founder line B was established and maintained on a mixed B6;CBA genetic background upon its arrival at The Jackson Laboratory (as Stock No. 003010). These mice were obtained by Dr. David Borchelt (University of Florida) and then backcrossed to C57BL/6J inbred mice for at least 8 generations prior to sending back to The Jackson Laboratory (as Stock No. 007004).
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Camk2a-tTA)1Mmay allele
003010 B6;CBA-Tg(Camk2a-tTA)1Mmay/J View Strains carrying Tg(Camk2a-tTA)1Mmay (1 strain)
002362 B6.129P2-Camk2atm1Sva/J 007574 B6.Cg-Tg(Camk2a-Crebbp*)1364Tabe/J 005855 B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J 005359 B6.Cg-Tg(Camk2a-cre)T29-1Stl/J 004995 C3H-Tg(Camk2a-Creb1/ESR1)3Sva/J 006575 C57BL/6-Camk2atm1Vyb/J 006579 C57BL/6-Tg(Camk2a-Bdnf)A9Stl/J 005087 C57BL/6-Tg(Camk2a-IDE)1Selk/J 005086 C57BL/6-Tg(Camk2a-MME)3Selk/J
003767 B6.Cg-Tg(Eno2tTA)5021Nes/J 003763 B6.Cg-Tg(Eno2tTA)5030Nes/J 005964 B6.Cg-Tg(GFAP-tTA)110Pop/J 002618 B6.Cg-Tg(MMTVtTA)1Mam/J 006361 B6.Cg-Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/J 003563 B6.Cg-Tg(tTALap)5Bjd/J 002709 B6;C3-Tg(TettTALuc)1Dgs/J 008082 B6;SJL-Tg(Tagln-tTA)1Mrab Tg(tetO-Mcpt1)1Mrab/J 005625 FVB-Tg(Pcp2-tTA)3Horr/J 003170 FVB.Cg-Tg(Myh6-tTA)6Smbf/J 006209 FVB.Cg-Tg(Tal1-tTA)19Dgt/J 005942 FVB/N-Tg(Pf4-tTA/VP16)42Kra/J 004937 NOD.Cg-Tg(Ins2-tTA)1Doi/DoiJ 006999 STOCK Dbttm1Geh Tg(tTALap)5Bjd Tg(tetO-DBT)A1Geh/J 003272 STOCK Tg(tTALap)5Bjd/J 003271 STOCK Tg(tTAhCMV)3Bjd/J 003275 STOCK Tg(tetL)1Bjd/J 003274 STOCK Tg(tetNZL)2Bjd/J
Additional Web Information
Congenic Nomenclature
Tet Expression Systems
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Neurobiology Research
Alzheimer's Disease
Behavioral and Learning Defects
Parkinson's Disease
Tet Expression System (tTA/rtTA Expressing Strains)
Research Tools
Neurobiology Research (Tetop Tet System)
Tet Expression Systems (tTA/rtTA Expressing Strains)
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Camk2a-tTA)1Mmay | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Mark Mayford | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | CAMK-rTA; CaMKIIalpha-tTA; CamDAT; Tg(alphacre); Tg(CaMKIItTA)Mmay; Tgalpha-CaMkII-tTA; pCaMKII-tTA; | ||
| Mutation Made By | Mark Mayford, The Scripps Research Institute | ||
| Site of Expression | Expresses tTA in forebrain neurons. | ||
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli | ||
| The tetracycline-resistance gene (TetR), arose from chemically mutated Escherichia coli genome which was screened for tetracycline dependence (Gossen and Bujard, 1992). TetR was fused at the C-terminus with the viral co-activator, virion protein 16 of the herpes simplex virus (VP-16). The tetracycline-inhibitable transcription factor is a component of a bigenic system that allows doxycycline (a tetracycline analog) regulatable expression of genes that are under the direction of the tetracycline responsive promoter (TetOp)promoter. | |||
| Promoter | Camk2a, calcium/calmodulin-dependent protein kinase II alpha, mouse, laboratory | ||
| General Note |
This transgene is line B. Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression. | ||
| Molecular Note | The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. [MGI Ref ID J:37107] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(tTA), MCA, vers. 4
Tg(tTA), QPCR, vers. 3
Tg(tTA), STD PCR, vers. 2
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Mayford M; Bach ME; Huang YY; Wang L; Hawkins RD; Kandel ER. 1996. Control of memory formation through regulated expression of a CaMKII transgene. Science 274(5293):1678-83. [PubMed: 8939850] [MGI Ref ID J:37107]
Additional References
Tg(Camk2a-tTA)1Mmay relatedAleksic T; Baumann B; Wagner M; Adler G; Wirth T; Weber CK. 2007. Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut 56(2):227-36. [PubMed: 16870717] [MGI Ref ID J:130547]
Alvarez-Saavedra M; Saez MA; Kang D; Zoghbi HY; Young JI. 2007. Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis. Hum Mol Genet 16(19):2315-25. [PubMed: 17635839] [MGI Ref ID J:124365]
Barco A; Patterson S; Alarcon JM; Gromova P; Mata-Roig M; Morozov A; Kandel ER. 2005. Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture. Neuron 48(1):123-37. [PubMed: 16202713] [MGI Ref ID J:105355]
Bedford L; Hay D; Devoy A; Paine S; Powe DG; Seth R; Gray T; Topham I; Fone K; Rezvani N; Mee M; Soane T; Layfield R; Sheppard PW; Ebendal T; Usoskin D; Lowe J; Mayer RJ. 2008. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. J Neurosci 28(33):8189-98. [PubMed: 18701681] [MGI Ref ID J:138991]
Bejar R; Yasuda R; Krugers H; Hood K; Mayford M. 2002. Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory. J Neurosci 22(13):5719-26. [PubMed: 12097524] [MGI Ref ID J:112443]
Chandrasekaran K; Hazelton JL; Wang Y; Fiskum G; Kristian T. 2006. Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J Neurosci 26(51):13123-7. [PubMed: 17182763] [MGI Ref ID J:118452]
Chen AP; Ohno M; Giese KP; Kuhn R; Chen RL; Silva AJ. 2006. Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res 83(1):28-38. [PubMed: 16342120] [MGI Ref ID J:107042]
Chen L; Ding Y; Cagniard B; Van Laar AD; Mortimer A; Chi W; Hastings TG; Kang UJ; Zhuang X. 2008. Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. J Neurosci 28(2):425-33. [PubMed: 18184785] [MGI Ref ID J:131093]
Cheng HY; Dziema H; Papp J; Mathur DP; Koletar M; Ralph MR; Penninger JM; Obrietan K. 2006. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci 26(50):12984-95. [PubMed: 17167088] [MGI Ref ID J:116668]
Cruz JC; Tseng HC; Goldman JA; Shih H; Tsai LH. 2003. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40(3):471-83. [PubMed: 14642273] [MGI Ref ID J:104240]
Eckermann K; Mocanu MM; Khlistunova I; Biernat J; Nissen A; Hofmann A; Schonig K; Bujard H; Haemisch A; Mandelkow E; Zhou L; Rune G; Mandelkow EM. 2007. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem 282(43):31755-65. [PubMed: 17716969] [MGI Ref ID J:126788]
Engel T; Lucas JJ; Gomez-Ramos P; Moran MA; Avila J; Hernandez F. 2006. Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol Aging 27(9):1258-68. [PubMed: 16054268] [MGI Ref ID J:113439]
Fridmacher V; Kaltschmidt B; Goudeau B; Ndiaye D; Rossi FM; Pfeiffer J; Kaltschmidt C; Israel A; Memet S. 2003. Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection. J Neurosci 23(28):9403-8. [PubMed: 14561868] [MGI Ref ID J:86217]
Gomez-Sintes R; Hernandez F; Bortolozzi A; Artigas F; Avila J; Zaratin P; Gotteland JP; Lucas JJ. 2007. Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J 26(11):2743-54. [PubMed: 17510631] [MGI Ref ID J:122627]
Gross C; Zhuang X; Stark K; Ramboz S; Oosting R; Kirby L; Santarelli L; Beck S; Hen R. 2002. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416(6879):396-400. [PubMed: 11919622] [MGI Ref ID J:75722]
Hasan MT; Schonig K; Berger S; Graewe W; Bujard H. 2001. Long-term, noninvasive imaging of regulated gene expression in living mice. Genesis 29(3):116-22. [PubMed: 11252052] [MGI Ref ID J:127660]
Hidvegi T; Schmidt BZ; Hale P; Perlmutter DH. 2005. Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response. J Biol Chem 280(47):39002-15. [PubMed: 16183649] [MGI Ref ID J:104112]
Isiegas C; McDonough C; Huang T; Havekes R; Fabian S; Wu LJ; Xu H; Zhao MG; Kim JI; Lee YS; Lee HR; Ko HG; Lee N; Choi SL; Lee JS; Son H; Zhuo M; Kaang BK; Abel T. 2008. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci 28(24):6220-30. [PubMed: 18550764] [MGI Ref ID J:137375]
Jankowsky JL; Slunt HH; Gonzales V; Savonenko AV; Wen JC; Jenkins NA; Copeland NG; Younkin LH; Lester HA; Younkin SG; Borchelt DR. 2005. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med 2(12):e355. [PubMed: 16279840] [MGI Ref ID J:109829]
Jerecic J; Schulze CH; Jonas P; Sprengel R; Seeburg PH; Bischofberger J. 2001. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Brain Res Mol Brain Res 94(1-2):96-104. [PubMed: 11597769] [MGI Ref ID J:130561]
Kaltschmidt B; Ndiaye D; Korte M; Pothion S; Arbibe L; Prullage M; Pfeiffer J; Lindecke A; Staiger V; Israel A; Kaltschmidt C; Memet S. 2006. NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol Cell Biol 26(8):2936-46. [PubMed: 16581769] [MGI Ref ID J:107412]
Krestel HE; Mihaljevic AL; Hoffman DA; Schneider A. 2004. Neuronal co-expression of EGFP and beta-galactosidase in mice causes neuropathology and premature death. Neurobiol Dis 17(2):310-8. [PubMed: 15474368] [MGI Ref ID J:93090]
Krestel HE; Shimshek DR; Jensen V; Nevian T; Kim J; Geng Y; Bast T; Depaulis A; Schonig K; Schwenk F; Bujard H; Hvalby O; Sprengel R; Seeburg PH. 2004. A genetic switch for epilepsy in adult mice. J Neurosci 24(46):10568-78. [PubMed: 15548671] [MGI Ref ID J:96556]
Lindeberg J; Mattsson R; Ebendal T. 2002. Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene. J Neurosci Res 68(2):248-53. [PubMed: 11948670] [MGI Ref ID J:82535]
Lopez de Armentia M; Jancic D; Olivares R; Alarcon JM; Kandel ER; Barco A. 2007. cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons. J Neurosci 27(50):13909-18. [PubMed: 18077703] [MGI Ref ID J:130579]
Lucas JJ; Hernandez F; Gomez-Ramos P; Moran MA; Hen R; Avila J. 2001. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 20(1-2):27-39. [PubMed: 11226152] [MGI Ref ID J:67070]
Mack V; Burnashev N; Kaiser KM; Rozov A; Jensen V; Hvalby O; Seeburg PH; Sakmann B; Sprengel R. 2001. Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice. Science 292(5526):2501-4. [PubMed: 11431570] [MGI Ref ID J:76021]
Morozov A; Muzzio IA; Bourtchouladze R; Van-Strien N; Lapidus K; Yin D; Winder DG; Adams JP; Sweatt JD; Kandel ER. 2003. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Neuron 39(2):309-25. [PubMed: 12873387] [MGI Ref ID J:128795]
Muyllaert D; Terwel D; Kremer A; Sennvik K; Borghgraef P; Devijver H; Dewachter I; Van Leuven F. 2008. Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration. Am J Pathol 172(2):470-85. [PubMed: 18202185] [MGI Ref ID J:131373]
Nakagawa S; Kim JE; Lee R; Malberg JE; Chen J; Steffen C; Zhang YJ; Nestler EJ; Duman RS. 2002. Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci 22(9):3673-82. [PubMed: 11978843] [MGI Ref ID J:128620]
Nakashiba T; Young JZ; McHugh TJ; Buhl DL; Tonegawa S. 2008. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science 319(5867):1260-4. [PubMed: 18218862] [MGI Ref ID J:131852]
Nicholls RE; Alarcon JM; Malleret G; Carroll RC; Grody M; Vronskaya S; Kandel ER. 2008. Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility. Neuron 58(1):104-17. [PubMed: 18400167] [MGI Ref ID J:135145]
Nicholls RE; Zhang XL; Bailey CP; Conklin BR; Kandel ER; Stanton PK. 2006. mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses. Proc Natl Acad Sci U S A 103(16):6380-5. [PubMed: 16606834] [MGI Ref ID J:109030]
Niewoehner B; Single FN; Hvalby O; Jensen V; Borgloh SM; Seeburg PH; Rawlins JN; Sprengel R; Bannerman DM. 2007. Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur J Neurosci 25(3):837-46. [PubMed: 17313573] [MGI Ref ID J:119834]
Nuber S; Petrasch-Parwez E; Winner B; Winkler J; von Horsten S; Schmidt T; Boy J; Kuhn M; Nguyen HP; Teismann P; Schulz JB; Neumann M; Pichler BJ; Reischl G; Holzmann C; Schmitt I; Bornemann A; Kuhn W; Zimmermann F; Servadio A; Riess O. 2008. Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease. J Neurosci 28(10):2471-84. [PubMed: 18322092] [MGI Ref ID J:132774]
Ramsden M; Kotilinek L; Forster C; Paulson J; McGowan E; SantaCruz K; Guimaraes A; Yue M; Lewis J; Carlson G; Hutton M; Ashe KH. 2005. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci 25(46):10637-47. [PubMed: 16291936] [MGI Ref ID J:102973]
Sakai N; Tsubokawa H; Matsuzaki M; Kajimoto T; Takahashi E; Ren Y; Ohmori S; Shirai Y; Matsubayashi H; Chen J; Duman RS; Kasai H; Saito N. 2004. Propagation of gammaPKC translocation along the dendrites of Purkinje cell in gammaPKC-GFP transgenic mice. Genes Cells 9(10):945-57. [PubMed: 15461665] [MGI Ref ID J:133986]
Svenningsson P; Chergui K; Rachleff I; Flajolet M; Zhang X; Yacoubi ME; Vaugeois JM; Nomikos GG; Greengard P. 2006. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311(5757):77-80. [PubMed: 16400147] [MGI Ref ID J:104116]
Wang L; Xie C; Greggio E; Parisiadou L; Shim H; Sun L; Chandran J; Lin X; Lai C; Yang WJ; Moore DJ; Dawson TM; Dawson VL; Chiosis G; Cookson MR; Cai H. 2008. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci 28(13):3384-91. [PubMed: 18367605] [MGI Ref ID J:133490]
Ward NL; Putoczki T; Mearow K; Ivanco TL; Dumont DJ. 2005. Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes. J Comp Neurol 482(3):244-56. [PubMed: 15690488] [MGI Ref ID J:95553]
Wiltgen BJ; Law M; Ostlund S; Mayford M; Balleine BW. 2007. The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. Eur J Neurosci 25(8):2491-7. [PubMed: 17445244] [MGI Ref ID J:125036]
Yamasaki TR; Blurton-Jones M; Morrissette DA; Kitazawa M; Oddo S; LaFerla FM. 2007. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci 27(44):11925-33. [PubMed: 17978032] [MGI Ref ID J:127469]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, hemizygous mice can be bred together or to wildtype siblings or C57BL/6J inbred mice. Mating System Noncarrier x Hemizygote (Female x Male) Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $236.40 Female or Male Hemizygous for Tg(Camk2a-tTA)1Mmay *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $288.65 Hemizygous for Tg(Camk2a-tTA)1Mmay x Noncarrier $288.65 Noncarrier x Hemizygous for Tg(Camk2a-tTA)1Mmay
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $307.40 Female or Male Hemizygous for Tg(Camk2a-tTA)1Mmay *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $375.30 Hemizygous for Tg(Camk2a-tTA)1Mmay x Noncarrier $375.30 Noncarrier x Hemizygous for Tg(Camk2a-tTA)1Mmay
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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General Terms and Conditions
Use of the Tet-System may require a license, see Licenses for Strains Using TET-System Technology.
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
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