| |||||||||||||||||||
- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Former Names B6.CBA-Tg(Camk2a-tTA)1Mmay/DboJ (Changed: 28-AUG-07 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 14-APR-08 Species laboratory mouse Generation N9+N1F9 (09-MAR-11)
Generation DefinitionsDonating Investigator David Borchelt, McKnight Brain Inst, Univ of Florida Description
Transgenic mice expressing the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain-specific calcium-calmodulin-dependent kinase II (Camk2a) promoter are viable and fertile. When hemizygotes are mated to a second strain carrying a gene of interest under the regulatory control of a tetracycline-responsive promoter element (TRE; tetO), expression of the target gene can be blocked by administration of the tetracycline analog, doxycycline (dox). These mice are a "Tet-Off" tool that allow the inducible expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease (when used in conjunction with Stock No. 005706, Stock No. 007049, Stock No. 007051, Stock No. 007052), Parkinson's disease (Stock No. 013583), or other neurodegenerative diseases.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A transgenic construct was designed with 8.5 kb of the mouse CaMKIIalpha promoter placed upstream of the tetracycline-regulated transactivator (tTA or "Tet-Off") gene (flanked by an artificial intron and splice sites at the 5' end and by a polyadenylation signal from SV40 at the 3' end). Founder line B was established and maintained on a mixed B6;CBA genetic background upon its arrival at The Jackson Laboratory (as Stock No. 003010). These mice were obtained by Dr. David Borchelt (University of Florida) and then backcrossed to C57BL/6J inbred mice for at least eight generations prior to sending back to The Jackson Laboratory (as Stock No. 007004). Upon arrival, transgenic mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Alzheimer's Disease Models
View Alzheimer's Disease Models (108 strains)
016198 129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ 003010 B6;CBA-Tg(Camk2a-tTA)1Mmay/J 015838 STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1*P242E*P249E)CPdav/J
016198 129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ 002362 B6.129P2-Camk2atm1Sva/J 007574 B6.Cg-Tg(Camk2a-Crebbp*)1364Tabe/J 005855 B6.Cg-Tg(Camk2a-Prkaca)426Tabe/J 005359 B6.Cg-Tg(Camk2a-cre)T29-1Stl/J 012362 B6;129S6-Tg(Camk2a-cre/ERT2)1Aibs/J 003010 B6;CBA-Tg(Camk2a-tTA)1Mmay/J 004995 C3H-Tg(Camk2a-Creb1/ESR1)3Sva/J 006575 C57BL/6-Camk2atm1Vyb/J 013760 C57BL/6-Tg(Camk2a-AIDPak)21Stl/J 006579 C57BL/6-Tg(Camk2a-Bdnf)A9Stl/J 005087 C57BL/6-Tg(Camk2a-IDE)1Selk/J 005086 C57BL/6-Tg(Camk2a-MME)3Selk/J 008833 C57BL/6-Tg(Camk2a-UBB)3413-1Fwvl/J 010712 C57BL/6-Tg(Camk2a-tTA)1Stl/J 008716 FVB/N-Tg(Myh6-AIP/PLN*)46Jded/J 015838 STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1*P242E*P249E)CPdav/J
016198 129S6.Cg-Tg(Camk2a-tTA)1Mmay/JlwsJ 003010 B6;CBA-Tg(Camk2a-tTA)1Mmay/J 015838 STOCK Tg(Camk2a-tTA)1Mmay Tg(tetO-ABL1*P242E*P249E)CPdav/J
Additional Web Information
Tet Expression Systems
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
Visit the Parkinson's Disease Resource site for helpful information on Parkinson's and research resources.
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
Neurobiology Research
Alzheimer's Disease
Behavioral and Learning Defects
Parkinson's Disease
Tet Expression System
tTA/rtTA Expressing Strains
Research Tools
Neurobiology Research
Tetop Tet System
Tet Expression Systems
tTA/rtTA Expressing Strains
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Camk2a-tTA)1Mmay | ||
|---|---|---|---|
| Allele Name | transgene insertion 1, Mark Mayford | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | CAMK-rTA; CaMKII-tTA; CaMKIIalpha-tTA; CamDAT; Tg(alphacre); Tg(CaMKIItTA)Mmay; Tgalpha-CaMkII-tTA; pCaMKII-tTA; | ||
| Mutation Made By | Mark Mayford, The Scripps Research Institute | ||
| Site of Expression | Expresses tTA in forebrain neurons. | ||
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli | ||
| The tetracycline-resistance gene (TetR), arose from chemically mutated Escherichia coli genome which was screened for tetracycline dependence (Gossen and Bujard, 1992). TetR was fused at the C-terminus with the viral co-activator, virion protein 16 of the herpes simplex virus (VP-16). The tetracycline-inhibitable transcription factor is a component of a bigenic system that allows doxycycline (a tetracycline analog) regulatable expression of genes that are under the direction of the tetracycline responsive promoter (TetOp)promoter. | |||
| Promoter | Camk2a, calcium/calmodulin-dependent protein kinase II alpha, mouse, laboratory | ||
| General Note |
This transgene is line B. Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression. | ||
| Molecular Note | The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. [MGI Ref ID J:37107] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Tg(tTA), Melt Curve Analysis
Tg(tTA), QPCR
Tg(tTA), Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Mayford M; Bach ME; Huang YY; Wang L; Hawkins RD; Kandel ER. 1996. Control of memory formation through regulated expression of a CaMKII transgene. Science 274(5293):1678-83. [PubMed: 8939850] [MGI Ref ID J:37107]
Additional References
Tg(Camk2a-tTA)1Mmay relatedAleksic T; Baumann B; Wagner M; Adler G; Wirth T; Weber CK. 2007. Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2. Gut 56(2):227-36. [PubMed: 16870717] [MGI Ref ID J:130547]
Alexander GM; Rogan SC; Abbas AI; Armbruster BN; Pei Y; Allen JA; Nonneman RJ; Hartmann J; Moy SS; Nicolelis MA; McNamara JO; Roth BL. 2009. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63(1):27-39. [PubMed: 19607790] [MGI Ref ID J:154952]
Alvarez-Saavedra M; Saez MA; Kang D; Zoghbi HY; Young JI. 2007. Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis. Hum Mol Genet 16(19):2315-25. [PubMed: 17635839] [MGI Ref ID J:124365]
Barco A; Patterson S; Alarcon JM; Gromova P; Mata-Roig M; Morozov A; Kandel ER. 2005. Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture. Neuron 48(1):123-37. [PubMed: 16202713] [MGI Ref ID J:105355]
Bedford L; Hay D; Devoy A; Paine S; Powe DG; Seth R; Gray T; Topham I; Fone K; Rezvani N; Mee M; Soane T; Layfield R; Sheppard PW; Ebendal T; Usoskin D; Lowe J; Mayer RJ. 2008. Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. J Neurosci 28(33):8189-98. [PubMed: 18701681] [MGI Ref ID J:138991]
Bejar R; Yasuda R; Krugers H; Hood K; Mayford M. 2002. Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory. J Neurosci 22(13):5719-26. [PubMed: 12097524] [MGI Ref ID J:112443]
Chandrasekaran K; Hazelton JL; Wang Y; Fiskum G; Kristian T. 2006. Neuron-specific conditional expression of a mitochondrially targeted fluorescent protein in mice. J Neurosci 26(51):13123-7. [PubMed: 17182763] [MGI Ref ID J:118452]
Chen AP; Ohno M; Giese KP; Kuhn R; Chen RL; Silva AJ. 2006. Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory. J Neurosci Res 83(1):28-38. [PubMed: 16342120] [MGI Ref ID J:107042]
Chen L; Ding Y; Cagniard B; Van Laar AD; Mortimer A; Chi W; Hastings TG; Kang UJ; Zhuang X. 2008. Unregulated cytosolic dopamine causes neurodegeneration associated with oxidative stress in mice. J Neurosci 28(2):425-33. [PubMed: 18184785] [MGI Ref ID J:131093]
Cheng HY; Dziema H; Papp J; Mathur DP; Koletar M; Ralph MR; Penninger JM; Obrietan K. 2006. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci 26(50):12984-95. [PubMed: 17167088] [MGI Ref ID J:116668]
Cheng N; Cai H; Belluscio L. 2011. In Vivo Olfactory Model of APP-Induced Neurodegeneration Reveals a Reversible Cell-Autonomous Function. J Neurosci 31(39):13699-704. [PubMed: 21957232] [MGI Ref ID J:176127]
Crook ZR; Housman D. 2011. Huntington's disease: can mice lead the way to treatment? Neuron 69(3):423-35. [PubMed: 21315254] [MGI Ref ID J:174750]
Cruz JC; Tseng HC; Goldman JA; Shih H; Tsai LH. 2003. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40(3):471-83. [PubMed: 14642273] [MGI Ref ID J:104240]
Diaz-Hernandez M; Diez-Zaera M; Sanchez-Nogueiro J; Gomez-Villafuertes R; Canals JM; Alberch J; Miras-Portugal MT; Lucas JJ. 2009. Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration. FASEB J 23(6):1893-906. [PubMed: 19171786] [MGI Ref ID J:150552]
Eckermann K; Mocanu MM; Khlistunova I; Biernat J; Nissen A; Hofmann A; Schonig K; Bujard H; Haemisch A; Mandelkow E; Zhou L; Rune G; Mandelkow EM. 2007. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem 282(43):31755-65. [PubMed: 17716969] [MGI Ref ID J:126788]
Engel T; Goni-Oliver P; Gomez-Ramos P; Moran MA; Lucas JJ; Avila J; Hernandez F. 2008. Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing frontotemporal dementia and parkinsonism linked to chromosome 17 tau and glycogen synthase kinase-3beta. Neuroscience 157(4):772-80. [PubMed: 18951953] [MGI Ref ID J:144874]
Engel T; Lucas JJ; Gomez-Ramos P; Moran MA; Avila J; Hernandez F. 2006. Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol Aging 27(9):1258-68. [PubMed: 16054268] [MGI Ref ID J:113439]
Favilla C; Abel T; Kelly MP. 2008. Chronic Galphas signaling in the striatum increases anxiety-related behaviors independent of developmental effects. J Neurosci 28(51):13952-6. [PubMed: 19091983] [MGI Ref ID J:143516]
Fridmacher V; Kaltschmidt B; Goudeau B; Ndiaye D; Rossi FM; Pfeiffer J; Kaltschmidt C; Israel A; Memet S. 2003. Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection. J Neurosci 23(28):9403-8. [PubMed: 14561868] [MGI Ref ID J:86217]
Fukui H; Moraes CT. 2009. Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons. Hum Mol Genet 18(6):1028-36. [PubMed: 19095717] [MGI Ref ID J:145737]
Giusti-Rodriguez P; Gao J; Graff J; Rei D; Soda T; Tsai LH. 2011. Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of beta-Secretase (BACE1). J Neurosci 31(44):15751-6. [PubMed: 22049418] [MGI Ref ID J:177847]
Gomez de Barreda E; Perez M; Gomez Ramos P; de Cristobal J; Martin-Maestro P; Moran A; Dawson HN; Vitek MP; Lucas JJ; Hernandez F; Avila J. 2010. Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis 37(3):622-9. [PubMed: 20004245] [MGI Ref ID J:158536]
Gomez-Sintes R; Hernandez F; Bortolozzi A; Artigas F; Avila J; Zaratin P; Gotteland JP; Lucas JJ. 2007. Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J 26(11):2743-54. [PubMed: 17510631] [MGI Ref ID J:122627]
Gross C; Zhuang X; Stark K; Ramboz S; Oosting R; Kirby L; Santarelli L; Beck S; Hen R. 2002. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416(6879):396-400. [PubMed: 11919622] [MGI Ref ID J:75722]
Hansen KF; Sakamoto K; Wayman GA; Impey S; Obrietan K. 2010. Transgenic miR132 alters neuronal spine density and impairs novel object recognition memory. PLoS One 5(11):e15497. [PubMed: 21124738] [MGI Ref ID J:167123]
Hasan MT; Schonig K; Berger S; Graewe W; Bujard H. 2001. Long-term, noninvasive imaging of regulated gene expression in living mice. Genesis 29(3):116-22. [PubMed: 11252052] [MGI Ref ID J:127660]
Hidvegi T; Schmidt BZ; Hale P; Perlmutter DH. 2005. Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response. J Biol Chem 280(47):39002-15. [PubMed: 16183649] [MGI Ref ID J:104112]
Igaz LM; Kwong LK; Lee EB; Chen-Plotkin A; Swanson E; Unger T; Malunda J; Xu Y; Winton MJ; Trojanowski JQ; Lee VM. 2011. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest 121(2):726-38. [PubMed: 21206091] [MGI Ref ID J:170756]
Isiegas C; McDonough C; Huang T; Havekes R; Fabian S; Wu LJ; Xu H; Zhao MG; Kim JI; Lee YS; Lee HR; Ko HG; Lee N; Choi SL; Lee JS; Son H; Zhuo M; Kaang BK; Abel T. 2008. A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci 28(24):6220-30. [PubMed: 18550764] [MGI Ref ID J:137375]
Jankowsky JL; Slunt HH; Gonzales V; Savonenko AV; Wen JC; Jenkins NA; Copeland NG; Younkin LH; Lester HA; Younkin SG; Borchelt DR. 2005. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med 2(12):e355. [PubMed: 16279840] [MGI Ref ID J:109829]
Jerecic J; Schulze CH; Jonas P; Sprengel R; Seeburg PH; Bischofberger J. 2001. Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression. Brain Res Mol Brain Res 94(1-2):96-104. [PubMed: 11597769] [MGI Ref ID J:130561]
Kaltschmidt B; Ndiaye D; Korte M; Pothion S; Arbibe L; Prullage M; Pfeiffer J; Lindecke A; Staiger V; Israel A; Kaltschmidt C; Memet S. 2006. NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol Cell Biol 26(8):2936-46. [PubMed: 16581769] [MGI Ref ID J:107412]
Karlen A; Karlsson TE; Mattsson A; Lundstromer K; Codeluppi S; Pham TM; Backman CM; Ogren SO; Aberg E; Hoffman AF; Sherling MA; Lupica CR; Hoffer BJ; Spenger C; Josephson A; Brene S; Olson L. 2009. Nogo receptor 1 regulates formation of lasting memories. Proc Natl Acad Sci U S A 106(48):20476-81. [PubMed: 19915139] [MGI Ref ID J:155587]
Kelly MP; Stein JM; Vecsey CG; Favilla C; Yang X; Bizily SF; Esposito MF; Wand G; Kanes SJ; Abel T. 2009. Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. Mol Psychiatry 14(4):398-415, 347. [PubMed: 19030002] [MGI Ref ID J:166114]
Kholodilov N; Kim SR; Yarygina O; Kareva T; Cho JW; Baohan A; Burke RE. 2011. Glial cell line-derived neurotrophic factor receptor-alpha1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. J Neurochem 116(4):486-98. [PubMed: 21133924] [MGI Ref ID J:170428]
Kolber BJ; Boyle MP; Wieczorek L; Kelley CL; Onwuzurike CC; Nettles SA; Vogt SK; Muglia LJ. 2010. Transient early-life forebrain corticotropin-releasing hormone elevation causes long-lasting anxiogenic and despair-like changes in mice. J Neurosci 30(7):2571-81. [PubMed: 20164342] [MGI Ref ID J:157835]
Kopeikina KJ; Carlson GA; Pitstick R; Ludvigson AE; Peters A; Luebke JI; Koffie RM; Frosch MP; Hyman BT; Spires-Jones TL. 2011. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol 179(4):2071-82. [PubMed: 21854751] [MGI Ref ID J:176290]
Krestel HE; Mihaljevic AL; Hoffman DA; Schneider A. 2004. Neuronal co-expression of EGFP and beta-galactosidase in mice causes neuropathology and premature death. Neurobiol Dis 17(2):310-8. [PubMed: 15474368] [MGI Ref ID J:93090]
Krestel HE; Shimshek DR; Jensen V; Nevian T; Kim J; Geng Y; Bast T; Depaulis A; Schonig K; Schwenk F; Bujard H; Hvalby O; Sprengel R; Seeburg PH. 2004. A genetic switch for epilepsy in adult mice. J Neurosci 24(46):10568-78. [PubMed: 15548671] [MGI Ref ID J:96556]
Larsen RS; Corlew RJ; Henson MA; Roberts AC; Mishina M; Watanabe M; Lipton SA; Nakanishi N; Perez-Otano I; Weinberg RJ; Philpot BD. 2011. NR3A-containing NMDARs promote neurotransmitter release and spike timing-dependent plasticity. Nat Neurosci 14(3):338-44. [PubMed: 21297630] [MGI Ref ID J:170349]
Le TT; McGovern VL; Alwine IE; Wang X; Massoni-Laporte A; Rich MM; Burghes AH. 2011. Temporal requirement for high SMN expression in SMA mice. Hum Mol Genet 20(18):3578-91. [PubMed: 21672919] [MGI Ref ID J:174960]
Lee AS; Duman RS; Pittenger C. 2008. A double dissociation revealing bidirectional competition between striatum and hippocampus during learning. Proc Natl Acad Sci U S A 105(44):17163-8. [PubMed: 18955704] [MGI Ref ID J:144070]
Lee B; Cao R; Choi YS; Cho HY; Rhee AD; Hah CK; Hoyt KR; Obrietan K. 2009. The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death. J Neurochem 108(5):1251-65. [PubMed: 19141071] [MGI Ref ID J:146168]
Lee HG; Casadesus G; Nunomura A; Zhu X; Castellani RJ; Richardson SL; Perry G; Felsher DW; Petersen RB; Smith MA. 2009. The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. Am J Pathol 174(3):891-7. [PubMed: 19164506] [MGI Ref ID J:146151]
Li YC; Kellendonk C; Simpson EH; Kandel ER; Gao WJ. 2011. D2 receptor overexpression in the striatum leads to a deficit in inhibitory transmission and dopamine sensitivity in mouse prefrontal cortex. Proc Natl Acad Sci U S A 108(29):12107-12. [PubMed: 21730148] [MGI Ref ID J:174363]
Licht T; Eavri R; Goshen I; Shlomai Y; Mizrahi A; Keshet E. 2010. VEGF is required for dendritogenesis of newly born olfactory bulb interneurons. Development 137(2):261-71. [PubMed: 20040492] [MGI Ref ID J:157255]
Lim Y; Kehm VM; Lee EB; Soper JH; Li C; Trojanowski JQ; Lee VM. 2011. {alpha}-Syn Suppression Reverses Synaptic and Memory Defects in a Mouse Model of Dementia with Lewy Bodies. J Neurosci 31(27):10076-87. [PubMed: 21734300] [MGI Ref ID J:174555]
Lim Y; Kehm VM; Li C; Trojanowski JQ; Lee VM. 2010. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exp Neurol 221(1):86-97. [PubMed: 19833127] [MGI Ref ID J:156801]
Lin X; Parisiadou L; Gu XL; Wang L; Shim H; Sun L; Xie C; Long CX; Yang WJ; Ding J; Chen ZZ; Gallant PE; Tao-Cheng JH; Rudow G; Troncoso JC; Liu Z; Li Z; Cai H. 2009. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron 64(6):807-27. [PubMed: 20064389] [MGI Ref ID J:156512]
Lindeberg J; Mattsson R; Ebendal T. 2002. Timing the doxycycline yields different patterns of genomic recombination in brain neurons with a new inducible Cre transgene. J Neurosci Res 68(2):248-53. [PubMed: 11948670] [MGI Ref ID J:82535]
Ljungberg MC; Ali YO; Zhu J; Wu CS; Oka K; Zhai RG; Lu HC. 2012. CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet 21(2):251-67. [PubMed: 22027994] [MGI Ref ID J:179018]
Lopez ME; Klein AD; Dimbil UJ; Scott MP. 2011. Anatomically defined neuron-based rescue of neurodegenerative niemann-pick type C disorder. J Neurosci 31(12):4367-78. [PubMed: 21430138] [MGI Ref ID J:170312]
Lopez de Armentia M; Jancic D; Olivares R; Alarcon JM; Kandel ER; Barco A. 2007. cAMP response element-binding protein-mediated gene expression increases the intrinsic excitability of CA1 pyramidal neurons. J Neurosci 27(50):13909-18. [PubMed: 18077703] [MGI Ref ID J:130579]
Lucas JJ; Hernandez F; Gomez-Ramos P; Moran MA; Hen R; Avila J. 2001. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 20(1-2):27-39. [PubMed: 11226152] [MGI Ref ID J:67070]
Mack V; Burnashev N; Kaiser KM; Rozov A; Jensen V; Hvalby O; Seeburg PH; Sakmann B; Sprengel R. 2001. Conditional restoration of hippocampal synaptic potentiation in Glur-A-deficient mice. Science 292(5526):2501-4. [PubMed: 11431570] [MGI Ref ID J:76021]
Marxreiter F; Nuber S; Kandasamy M; Klucken J; Aigner R; Burgmayer R; Couillard-Despres S; Riess O; Winkler J; Winner B. 2009. Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein. Eur J Neurosci 29(5):879-90. [PubMed: 19291219] [MGI Ref ID J:147049]
McKinney BC; Schneider JS; Schafer GL; Lowing JL; Mohan S; Zhao MX; Heng MY; Albin RL; Seasholtz AF; Akil H; Murphy GG. 2008. Decreased locomotor activity in mice expressing tTA under control of the CaMKII alpha promoter. Genes Brain Behav 7(2):203-13. [PubMed: 17640289] [MGI Ref ID J:145601]
Morozov A; Muzzio IA; Bourtchouladze R; Van-Strien N; Lapidus K; Yin D; Winder DG; Adams JP; Sweatt JD; Kandel ER. 2003. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory. Neuron 39(2):309-25. [PubMed: 12873387] [MGI Ref ID J:128795]
Muyllaert D; Terwel D; Kremer A; Sennvik K; Borghgraef P; Devijver H; Dewachter I; Van Leuven F. 2008. Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration. Am J Pathol 172(2):470-85. [PubMed: 18202185] [MGI Ref ID J:131373]
Nakagawa S; Kim JE; Lee R; Malberg JE; Chen J; Steffen C; Zhang YJ; Nestler EJ; Duman RS. 2002. Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci 22(9):3673-82. [PubMed: 11978843] [MGI Ref ID J:128620]
Nakashiba T; Young JZ; McHugh TJ; Buhl DL; Tonegawa S. 2008. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science 319(5867):1260-4. [PubMed: 18218862] [MGI Ref ID J:131852]
Nicholls RE; Alarcon JM; Malleret G; Carroll RC; Grody M; Vronskaya S; Kandel ER. 2008. Transgenic mice lacking NMDAR-dependent LTD exhibit deficits in behavioral flexibility. Neuron 58(1):104-17. [PubMed: 18400167] [MGI Ref ID J:135145]
Nicholls RE; Zhang XL; Bailey CP; Conklin BR; Kandel ER; Stanton PK. 2006. mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses. Proc Natl Acad Sci U S A 103(16):6380-5. [PubMed: 16606834] [MGI Ref ID J:109030]
Nie T; McDonough CB; Huang T; Nguyen PV; Abel T. 2007. Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory. J Neurosci 27(38):10278-88. [PubMed: 17881534] [MGI Ref ID J:145104]
Niewoehner B; Single FN; Hvalby O; Jensen V; Borgloh SM; Seeburg PH; Rawlins JN; Sprengel R; Bannerman DM. 2007. Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur J Neurosci 25(3):837-46. [PubMed: 17313573] [MGI Ref ID J:119834]
Nuber S; Petrasch-Parwez E; Winner B; Winkler J; von Horsten S; Schmidt T; Boy J; Kuhn M; Nguyen HP; Teismann P; Schulz JB; Neumann M; Pichler BJ; Reischl G; Holzmann C; Schmitt I; Bornemann A; Kuhn W; Zimmermann F; Servadio A; Riess O. 2008. Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease. J Neurosci 28(10):2471-84. [PubMed: 18322092] [MGI Ref ID J:132774]
Palais G; Nguyen Dinh Cat A; Friedman H; Panek-Huet N; Millet A; Tronche F; Gellen B; Mercadier JJ; Peterson A; Jaisser F. 2009. Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genomics 37(2):140-6. [PubMed: 19141541] [MGI Ref ID J:157969]
Parisiadou L; Xie C; Cho HJ; Lin X; Gu XL; Long CX; Lobbestael E; Baekelandt V; Taymans JM; Sun L; Cai H. 2009. Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. J Neurosci 29(44):13971-80. [PubMed: 19890007] [MGI Ref ID J:154755]
Pickrell AM; Fukui H; Wang X; Pinto M; Moraes CT. 2011. The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions. J Neurosci 31(27):9895-904. [PubMed: 21734281] [MGI Ref ID J:174561]
Pletnikov MV; Ayhan Y; Nikolskaia O; Xu Y; Ovanesov MV; Huang H; Mori S; Moran TH; Ross CA. 2008. Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. Mol Psychiatry 13(2):173-86, 115. [PubMed: 17848917] [MGI Ref ID J:146881]
Pujadas L; Gruart A; Bosch C; Delgado L; Teixeira CM; Rossi D; de Lecea L; Martinez A; Delgado-Garcia JM; Soriano E. 2010. Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation. J Neurosci 30(13):4636-49. [PubMed: 20357114] [MGI Ref ID J:159385]
Ramsden M; Kotilinek L; Forster C; Paulson J; McGowan E; SantaCruz K; Guimaraes A; Yue M; Lewis J; Carlson G; Hutton M; Ashe KH. 2005. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). J Neurosci 25(46):10637-47. [PubMed: 16291936] [MGI Ref ID J:102973]
Robbins EM; Krupp AJ; Perez de Arce K; Ghosh AK; Fogel AI; Boucard A; Sudhof TC; Stein V; Biederer T. 2010. SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron 68(5):894-906. [PubMed: 21145003] [MGI Ref ID J:167742]
Roberts AC; Diez-Garcia J; Rodriguiz RM; Lopez IP; Lujan R; Martinez-Turrillas R; Pico E; Henson MA; Bernardo DR; Jarrett TM; Clendeninn DJ; Lopez-Mascaraque L; Feng G; Lo DC; Wesseling JF; Wetsel WC; Philpot BD; Perez-Otano I. 2009. Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron 63(3):342-56. [PubMed: 19679074] [MGI Ref ID J:154942]
Rocher AB; Crimins JL; Amatrudo JM; Kinson MS; Todd-Brown MA; Lewis J; Luebke JI. 2010. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs. Exp Neurol 223(2):385-93. [PubMed: 19665462] [MGI Ref ID J:162373]
Sakai N; Tsubokawa H; Matsuzaki M; Kajimoto T; Takahashi E; Ren Y; Ohmori S; Shirai Y; Matsubayashi H; Chen J; Duman RS; Kasai H; Saito N. 2004. Propagation of gammaPKC translocation along the dendrites of Purkinje cell in gammaPKC-GFP transgenic mice. Genes Cells 9(10):945-57. [PubMed: 15461665] [MGI Ref ID J:133986]
Samuels BA; Hsueh YP; Shu T; Liang H; Tseng HC; Hong CJ; Su SC; Volker J; Neve RL; Yue DT; Tsai LH. 2007. Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56(5):823-37. [PubMed: 18054859] [MGI Ref ID J:169741]
Sano Y; Ornthanalai VG; Yamada K; Homma C; Suzuki H; Suzuki T; Murphy NP; Itohara S. 2009. X11-like protein deficiency is associated with impaired conflict resolution in mice. J Neurosci 29(18):5884-96. [PubMed: 19420255] [MGI Ref ID J:148481]
Santacruz K; Lewis J; Spires T; Paulson J; Kotilinek L; Ingelsson M; Guimaraes A; DeTure M; Ramsden M; McGowan E; Forster C; Yue M; Orne J; Janus C; Mariash A; Kuskowski M; Hyman B; Hutton M; Ashe KH. 2005. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309(5733):476-81. [PubMed: 16020737] [MGI Ref ID J:99626]
Schonig K; Schwenk F; Rajewsky K; Bujard H. 2002. Stringent doxycycline dependent control of CRE recombinase in vivo. Nucleic Acids Res 30(23):e134. [PubMed: 12466566] [MGI Ref ID J:81196]
Sorolla MA; Rodriguez-Colman MJ; Tamarit J; Tamarit J; Ortega Z; Lucas JJ; Ferrer I; Rosa J; Cabiscol E. 2010. Protein oxidation in Huntington disease affects energy production and vitamin B6 metabolism. Free Radic Biol Med 49(4):612-21. [PubMed: 20639122] [MGI Ref ID J:162547]
Suh J; Rivest AJ; Nakashiba T; Tominaga T; Tonegawa S. 2011. Entorhinal Cortex Layer III Input to the Hippocampus Is Crucial for Temporal Association Memory. Science :. [PubMed: 22052975] [MGI Ref ID J:178297]
Sundaram JR; Chan ES; Poore CP; Pareek TK; Cheong WF; Shui G; Tang N; Low CM; Wenk MR; Kesavapany S. 2012. Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration. J Neurosci 32(3):1020-34. [PubMed: 22262900] [MGI Ref ID J:179887]
Svenningsson P; Chergui K; Rachleff I; Flajolet M; Zhang X; Yacoubi ME; Vaugeois JM; Nomikos GG; Greengard P. 2006. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311(5757):77-80. [PubMed: 16400147] [MGI Ref ID J:104116]
Sydow A; Van der Jeugd A; Zheng F; Ahmed T; Balschun D; Petrova O; Drexler D; Zhou L; Rune G; Mandelkow E; D'Hooge R; Alzheimer C; Mandelkow EM. 2011. Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic tau mutant. J Neurosci 31(7):2511-25. [PubMed: 21325519] [MGI Ref ID J:169532]
Wang L; Xie C; Greggio E; Parisiadou L; Shim H; Sun L; Chandran J; Lin X; Lai C; Yang WJ; Moore DJ; Dawson TM; Dawson VL; Chiosis G; Cookson MR; Cai H. 2008. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci 28(13):3384-91. [PubMed: 18367605] [MGI Ref ID J:133490]
Ward NL; Putoczki T; Mearow K; Ivanco TL; Dumont DJ. 2005. Vascular-specific growth factor angiopoietin 1 is involved in the organization of neuronal processes. J Comp Neurol 482(3):244-56. [PubMed: 15690488] [MGI Ref ID J:95553]
Weible AP; Schwarcz L; Wickersham IR; Deblander L; Wu H; Callaway EM; Seung HS; Kentros CG. 2010. Transgenic targeting of recombinant rabies virus reveals monosynaptic connectivity of specific neurons. J Neurosci 30(49):16509-13. [PubMed: 21147990] [MGI Ref ID J:166740]
Wieczorek L; Maas JW Jr; Muglia LM; Vogt SK; Muglia LJ. 2010. Temporal and regional regulation of gene expression by calcium-stimulated adenylyl cyclase activity during fear memory. PLoS One 5(10):e13385. [PubMed: 20976279] [MGI Ref ID J:166523]
Wiltgen BJ; Law M; Ostlund S; Mayford M; Balleine BW. 2007. The influence of Pavlovian cues on instrumental performance is mediated by CaMKII activity in the striatum. Eur J Neurosci 25(8):2491-7. [PubMed: 17445244] [MGI Ref ID J:125036]
Wortge S; Eshkind L; Cabezas-Wallscheid N; Lakaye B; Kim J; Heck R; Abassi Y; Diken M; Sprengel R; Bockamp E. 2010. Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression. BMC Dev Biol 10:95. [PubMed: 20815887] [MGI Ref ID J:165820]
Wu D; Qiu Y; Gao X; Yuan XB; Zhai Q. 2011. Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function. PLoS One 6(6):e21759. [PubMed: 21738790] [MGI Ref ID J:174424]
Yamamoto A; Lucas JJ; Hen R. 2000. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease [see comments] Cell 101(1):57-66. [PubMed: 10778856] [MGI Ref ID J:61490]
Yamasaki TR; Blurton-Jones M; Morrissette DA; Kitazawa M; Oddo S; LaFerla FM. 2007. Neural stem cells improve memory in an inducible mouse model of neuronal loss. J Neurosci 27(44):11925-33. [PubMed: 17978032] [MGI Ref ID J:127469]
Yasuda M; Johnson-Venkatesh EM; Zhang H; Parent JM; Sutton MA; Umemori H. 2011. Multiple forms of activity-dependent competition refine hippocampal circuits in vivo. Neuron 70(6):1128-42. [PubMed: 21689599] [MGI Ref ID J:175245]
Yasuda M; Mayford MR. 2006. CaMKII activation in the entorhinal cortex disrupts previously encoded spatial memory. Neuron 50(2):309-18. [PubMed: 16630840] [MGI Ref ID J:108340]
Yue M; Hanna A; Wilson J; Roder H; Janus C. 2011. Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy. Neurobiol Aging 32(4):590-603. [PubMed: 19427061] [MGI Ref ID J:173738]
Zeng H; Horie K; Madisen L; Pavlova MN; Gragerova G; Rohde AD; Schimpf BA; Liang Y; Ojala E; Kramer F; Roth P; Slobodskaya O; Dolka I; Southon EA; Tessarollo L; Bornfeldt KE; Gragerov A; Pavlakis GN; Gaitanaris GA. 2008. An inducible and reversible mouse genetic rescue system. PLoS Genet 4(5):e1000069. [PubMed: 18464897] [MGI Ref ID J:136987]
Zhou M; Rebholz H; Brocia C; Warner-Schmidt JL; Fienberg AA; Nairn AC; Greengard P; Flajolet M. 2010. Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD. Proc Natl Acad Sci U S A 107(9):4401-6. [PubMed: 20145109] [MGI Ref ID J:158611]
de Calignon A; Fox LM; Pitstick R; Carlson GA; Bacskai BJ; Spires-Jones TL; Hyman BT. 2010. Caspase activation precedes and leads to tangles. Nature 464(7292):1201-4. [PubMed: 20357768] [MGI Ref ID J:159296]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, hemizygous mice can be bred together, to wildtype (noncarrier) mice from the colony, or to C57BL/6J inbred mice (Stock No. 000664). Mating System Noncarrier x Hemizygote (Female x Male) 14-APR-08 Diet Information LabDiet® 5K52/5K67
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
 |
Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $261.00 Female or Male Hemizygous for Tg(Camk2a-tTA)1Mmay
Pairs /Price (US dollars $) Pair Genotype $321.00 Hemizygous for Tg(Camk2a-tTA)1Mmay x Noncarrier $321.00 Noncarrier x Hemizygous for Tg(Camk2a-tTA)1Mmay Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
|
Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $339.30 Female or Male Hemizygous for Tg(Camk2a-tTA)1Mmay
Pairs /Price (US dollars $) Pair Genotype $417.30 Hemizygous for Tg(Camk2a-tTA)1Mmay x Noncarrier $417.30 Noncarrier x Hemizygous for Tg(Camk2a-tTA)1Mmay Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Induced Mutant Resource Colony collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Use of the Tet-System may require a license, see Licenses for Strains Using TET-System Technology.
Contact information
General inquiriesContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.