Strain Name: |
C57BL/6-Tg(Thy1-APPSwDutIowa)BWevn/J |
|---|---|
Stock Number: |
007027 |
Availability: |
Under Development |
Burgess BL; McIsaac SA; Naus KE; Chan JY; Tansley GH; Yang J; Miao F; Ross CJ; van Eck M; Hayden MR; van Nostrand W; St George-Hyslop P; Westaway D; Wellington CL. 2006. Elevated plasma triglyceride levels precede amyloid deposition in Alzheimer's disease mouse models with abundant A beta in plasma. Neurobiol Dis 24(1):114-27. [PubMed: 16899370] [MGI Ref ID J:113199]
Carrasco J; Adlard P; Cotman C; Quintana A; Penkowa M; Xu F; Van Nostrand WE; Hidalgo J. 2006. Metallothionein-I and -III expression in animal models of Alzheimer disease. Neuroscience 143(4):911-22. [PubMed: 17027170] [MGI Ref ID J:117948]
Chow N; Bell RD; Deane R; Streb JW; Chen J; Brooks A; Van Nostrand W; Miano JM; Zlokovic BV. 2007. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A 104(3):823-8. [PubMed: 17215356] [MGI Ref ID J:119251]
Davis J; Xu F; Miao J; Previti ML; Romanov G; Ziegler K; Van Nostrand WE. 2006. Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double Ass in human AssPP transgenic mice. Neurobiol Aging 27(7):946-54. [PubMed: 16105708] [MGI Ref ID J:108851]
Fan R; Defilippis K; Van Nostrand WE. 2007. Induction of complement proteins in a mouse model of cerebral microvascular Abeta deposition. J Neuroinflammation 4(1):22. [PubMed: 17877807] [MGI Ref ID J:124911]
Hirsch-Reinshagen V; Maia LF; Burgess BL; Blain JF; Naus KE; McIsaac SA; Parkinson PF; Chan JY; Tansley GH; Hayden MR; Poirier J; Van Nostrand W; Wellington CL. 2005. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J Biol Chem 280(52):43243-56. [PubMed: 16207707] [MGI Ref ID J:105900]
Hutchinson D; Ho V; Dodd M; Dawson HN; Zumwalt AC; Schmitt D; Colton CA. 2007. Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. Neuroscience 148(4):825-32. [PubMed: 17764851] [MGI Ref ID J:128390]
Miao J; Vitek MP; Xu F; Previti ML; Davis J; Van Nostrand WE. 2005. Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. J Neurosci 25(27):6271-7. [PubMed: 16000616] [MGI Ref ID J:99430]
Miao J; Xu F; Davis J; Otte-Holler I; Verbeek MM; Van Nostrand WE. 2005. Cerebral Microvascular Amyloid {beta} Protein Deposition Induces Vascular Degeneration and Neuroinflammation in Transgenic Mice Expressing Human Vasculotropic Mutant Amyloid {beta} Precursor Protein. Am J Pathol 167(2):505-15. [PubMed: 16049335] [MGI Ref ID J:99946]
Van Vickle GD; Esh CL; Daugs ID; Kokjohn TA; Kalback WM; Patton RL; Luehrs DC; Walker DG; Lue LF; Beach TG; Davis J; Van Nostrand WE; Castano EM; Roher AE. 2008. Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy. Am J Pathol 173(2):483-93. [PubMed: 18599612] [MGI Ref ID J:137886]
Wilcock DM; Lewis MR; Van Nostrand WE; Davis J; Previti ML; Gharkholonarehe N; Vitek MP; Colton CA. 2008. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 28(7):1537-45. [PubMed: 18272675] [MGI Ref ID J:132221]
Xu F; Grande AM; Robinson JK; Previti ML; Vasek M; Davis J; Van Nostrand WE. 2007. Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice. Neuroscience 146(1):98-107. [PubMed: 17331655] [MGI Ref ID J:122063]
Xu F; Vitek MP; Colton CA; Previti ML; Gharkholonarehe N; Davis J; Van Nostrand WE. 2008. Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. J Neurosci 28(20):5312-20. [PubMed: 18480287] [MGI Ref ID J:136318]