JAX Mice Database - 007048 DBA/2J-Gpnmb<+>/SjJ

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Strain Name:	DBA/2J-Gpnmb⁺/SjJ
Stock Number:	007048
Availability:	Under Development for Distribution Colony
	To register your interest in this strain go to the Strain Interest Form.

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General Terms and Conditions

Genes & Alleles

Cdh23; Cdh23^ahl; Gpnmb; Gpnmb⁺; Hc; Hc⁰;

Product Information

Strain Details

Type JAX^® GEMM^® Strain - Coisogenic

Additional information on JAX^® GEMM^® Strains.

Type Inbred Strain

Additional information on Inbred Strains.

Species laboratory mouse

H2 Haplotype d

Appearance
dilute brown
Related Genotype: a/a Tyrp1^b/Tyrp1^b Myo5a^d/Myo5a^d
Important Note
This strain is homozygous for Cdh23^ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss that is already severe by 3 months of age.
Strain Description
This coisogenic strain has a functional allele of Gpnmb. Homozygous mice do not develop elevated intraocular pressure or glaucoma, although they exhibit a mild iris stromal atrophy (ISA). This strain provides a genetically matched control for DBA/2J (Stock No. 000671). The inbred strain DBA/2J is homozygous for the glaucoma-related Gpnmb^R150X and Tyrp1^isa mutations.
Strain Development
The wildtype allele of Gpnmb is present in the mutant strain DBA/2J-Dtnbp1^sdy/J. The sandy mutation occurred in 1983 prior to the appearance of the Gpnmb^R150X mutation in the The Jackson Laboratory DBA/2J production colony. To generate this strain, mice from DBA/2J-Dtnbp1^sdy/J were crossed to "modern" DBA/2J mice, and progeny were selected for the Gpnmb wildtype allele. The wildtype allele was backcrossed to DBA/2J for a minimum of six generations. Dr. Simon John of The Jackson Laboratory provided the colony to the Repository in 2007.

Gene & Allele Details

Allele Symbol		Gpnmb⁺
Allele Name		wild type
Gene Symbol and Name		Gpnmb, glycoprotein (transmembrane) nmb
Chromosome		6
Gene Common Name(s)		Dchil; HGFIN; NMB; Osteoactivin; dendritic cell associated heparan sulfate proteoglycans dependent integrin ligand; ipd; iris pigment dispersion;

Allele Symbol		Cdh23^ahl
Allele Name		age related hearing loss 1
Common Name(s)		Cdh23^753A; mdfw;
Strain of Origin		C57BL/6J
Gene Symbol and Name		Cdh23, cadherin 23 (otocadherin)
Chromosome		10
Gene Common Name(s)		4930542A03Rik; DFNB12; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; RIKEN cDNA 4930542A03 gene; USH1D; W; age related hearing loss 1; ahl; bob; bobby; bus; bustling; mdfw; modifier of deaf waddler; neuroscience mutagenesis facility, 112; neuroscience mutagenesis facility, 181; neuroscience mutagenesis facility, 252; nmf112; nmf181; nmf252; v; waltzer;
Molecular Note		Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. Further analysis has identified an association between ahl and a G to A transition at nucleotide position 753 of Cdh23. This hypomorphic allele causes in frame skipping of exon 7 and reduced message stability. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129/ScJ, NOR/LtJ, A/J, C57BL/6, NOD/LyJ, DBA/2J, ALR/LtJ, C57L/J. Strains classified with ahl that DO NOT carry this mutation include: C3H/HeSnJ, I/LnJ,YBR/Ei, MRL/MpJ. [J:86905]

Allele Symbol		Hc⁰
Allele Name		deficient
Common Name(s)		C5-; C5-d; C5-def; C5-deficient; hc^o;
Gene Symbol and Name		Hc, hemolytic complement
Chromosome		2
Gene Common Name(s)		C5; C5a; CPAMD4; FLJ17816; FLJ17822; He; MGC142298; RGD1561905;
General Note		This is an allele characteristic of various inbred mouse strains including the following: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ Hc was identified as a candidate gene for Abhr2 in a microarray analysis of lung mRNA from A/J, C3H/HeJ, and (A/J x C3H/HeJ)F1 x A/J backcross animals. Hc genotype shows statistically significant correlation to allergen-induced bronchial hyperresponsive phenotype. The A/J allele contains a 2 bp deletion resulting in deficient Hc mRNA and protein production and is associated with susceptibility to allergen-induced bronchial hyperresponsiveness. (J:108211)
Molecular Note		A 2 base "TA" deletion at positions 62 and 63 of an 83 base pair exon near the 5' end of the gene is found in the following mouse strains: A/HeJ, AKR/J, DBA/2J, NZB/B1NJ, SWR/J, B10.D2/oSnJ. The consequence of this deletion is the creation of a stop codon starting four bases after the deletion. A truncated product of 216 amino acids is predicted as a result although contradictory reports exist that a larger pro-C5 protein may be synthesized. Nevertheless, macrophages from mouse strains carrying this allele do not secrete complement 5. [J:23983]

Control Information

	Control
	000671 DBA/2J

Considerations for Choosing Controls

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony these mice can be bred as homozygotes.
Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying Cdh23^ahl allele

001137 129P1/ReJ

000690 129P3/J

002065 129T2/SvEmsJ

000691 129X1/SvJ

000646 A/J

000647 A/WySnJ

003070 ALR/LtJ

003072 ALS/LtJ

004502 B6;AKR-Lxl2/J

001026 BALB/cByJ

000653 BUB/BnJ

005494 C3.129S1(B6)-Grm1^rcw/J

000664 C57BL/6J

004764 C57BL/6J-Cdh23^v-8J/J

003129 C57BL/6J-Epha4^rb-2J/J

004820 C57BL/6J-Kcne1^2J/J

004703 C57BL/6J-Nmf134/J

004811 C57BL/6J-nmf110/J

004812 C57BL/6J-nmf111/J

004747 C57BL/6J-nmf118/J

004656 C57BL/6J-nmf88/J

004391 C57BL/6J-Chr 13^A/J/NaJ

004385 C57BL/6J-Chr 7^A/J/NaJ

000662 C57BLKS/J

000667 C57BR/cdJ

000668 C57L/J

000669 C58/J

000657 CE/J

000670 DBA/1J

001140 DBA/1LacJ

000671 DBA/2J

002106 KK/HlJ

000675 LG/J

000676 LP/J

000677 MA/MyJ

001976 NOD/ShiLtJ

002050 NOR/LtJ

000679 P/J

002747 SENCARB/PtJ

002335 SKH2/J

003392 STOCK Crb1^rd8/J

View Strains carrying Cdh23^ahl (41 strains)

Strains carrying Hc⁰ allele

000645 A/HeJ

000646 A/J

000647 A/WySnJ

000648 AKR/J

000460 B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ

000461 B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ

000657 CE/J

000671 DBA/2J

001800 FVB/NJ

001491 FVB/NMob

001303 NOD.CB17-Prkdc^scid/J

001976 NOD/ShiLtJ

000684 NZB/BlNJ

000682 RF/J

000688 ST/bJ

000689 SWR/J

View Strains carrying Hc⁰ (16 strains)

Strains carrying other alleles of Cdh23

002756 B6.CAST-Cdh23^Ahl+/Kjn

002432 B6J x B6.C-H2^bm1/ByJ-Cdh23^v-J/J

002552 C57BL/6J-Cdh23^v-2J/J

004764 C57BL/6J-Cdh23^v-8J/J

004819 C57BL/6J-Cdh23^v-9J/J

005016 CByJ;B6-Cdh23^v-10J/J

000275 V/LeJ

View Strains carrying other alleles of Cdh23 (7 strains)

Strains carrying other alleles of Gpnmb

000671 DBA/2J

View Strains carrying other alleles of Gpnmb (1 strain)

Strains carrying other alleles of Hc

000470 AK.M-H2^m H2-T18^a/nSnJ

005308 B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ

000463 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ

003147 B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J

004306 NOD.CBALs-Hc¹/LtJ

View Strains carrying other alleles of Hc (5 strains)

Research Applications

This mouse can be used to support research in many areas including:

Sensorineural Research
Eye Defects (control)

Cdh23^ahl related

Neurobiology Research
Vestibular and Hearing Defects (Age related hearing loss)

Sensorineural Research
Vestibular and Hearing Defects (Age related hearing loss)

Hc⁰ related

Immunology and Inflammation Research
Immunodeficiency (specific complement deficiency)

Research Tools
Immunology and Inflammation Research (specific complement deficiency) (C5 complement)

References

Selected Reference(s)

Howell GR; Libby RT; Marchant JK; Wilson LA; Cosma IM; Smith RS; Anderson MG; John SW. 2007. Absence of glaucoma in DBA/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1. BMC Genet 8(1):45. [PubMed: 17608931] [J:123136]

Additional References

Price and Supply Information

Strain Name:	*DBA/2J-Gpnmb⁺/SjJ*
Stock Number:	007048

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

View All Strains Under Development

Supply Details

Standard Supply	Under Development for Distribution Colony
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Ordering and Purchasing Information

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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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Go to JAX^® Mice Query Form

001137	129P1/ReJ
000690	129P3/J
002065	129T2/SvEmsJ
000691	129X1/SvJ
000646	A/J
000647	A/WySnJ
003070	ALR/LtJ
003072	ALS/LtJ
004502	B6;AKR-Lxl2/J
001026	BALB/cByJ
000653	BUB/BnJ
005494	C3.129S1(B6)-Grm1^rcw/J
000664	C57BL/6J
004764	C57BL/6J-Cdh23^v-8J/J
003129	C57BL/6J-Epha4^rb-2J/J
004820	C57BL/6J-Kcne1^2J/J
004703	C57BL/6J-Nmf134/J
004811	C57BL/6J-nmf110/J
004812	C57BL/6J-nmf111/J
004747	C57BL/6J-nmf118/J
004656	C57BL/6J-nmf88/J
004391	C57BL/6J-Chr 13^A/J/NaJ
004385	C57BL/6J-Chr 7^A/J/NaJ
000662	C57BLKS/J
000667	C57BR/cdJ
000668	C57L/J
000669	C58/J
000657	CE/J
000670	DBA/1J
001140	DBA/1LacJ
000671	DBA/2J
002106	KK/HlJ
000675	LG/J
000676	LP/J
000677	MA/MyJ
001976	NOD/ShiLtJ
002050	NOR/LtJ
000679	P/J
002747	SENCARB/PtJ
002335	SKH2/J
003392	STOCK Crb1^rd8/J

000645	A/HeJ
000646	A/J
000647	A/WySnJ
000648	AKR/J
000460	B10.D2-Hc⁰ H2^d H2-T18^c/o2SnJ
000461	B10.D2-Hc⁰ H2^d H2-T18^c/oSnJ
000657	CE/J
000671	DBA/2J
001800	FVB/NJ
001491	FVB/NMob
001303	NOD.CB17-Prkdc^scid/J
001976	NOD/ShiLtJ
000684	NZB/BlNJ
000682	RF/J
000688	ST/bJ
000689	SWR/J

002756	B6.CAST-Cdh23^Ahl+/Kjn
002432	B6J x B6.C-H2^bm1/ByJ-Cdh23^v-J/J
002552	C57BL/6J-Cdh23^v-2J/J
004764	C57BL/6J-Cdh23^v-8J/J
004819	C57BL/6J-Cdh23^v-9J/J
005016	CByJ;B6-Cdh23^v-10J/J
000275	V/LeJ

000470	AK.M-H2^m H2-T18^a/nSnJ
005308	B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
000463	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ
003147	B10.D2-Hc¹ H2^d H2-T18^c/nSnJ-Tg(DO11.10)10Dlo/J
004306	NOD.CBALs-Hc¹/LtJ

Strain Name:

DBA/2J-Gpnmb+/SjJ

Stock Number:

007048

Availability:

Under Development for Distribution Colony

General Terms and Conditions

Product Information

Strain Details

Gene & Allele Details

Control Information

Colony Maintenance

Related Strains

Research Applications

References

Price and Supply Information

Supply Details

General Terms and Conditions

The Jackson Laboratory's Genotype Promise

DBA/2J-Gpnmb⁺/SjJ