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Product Information

Strain Details

Type Recombinant Inbred (Ri) Additional information on Recombinant Inbred Mice. Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse RI progenitor C57BL/6J DBA/2J Generation F31 (24-JUN-08)

Appearance
dilute brown
Related Genotype: a/a Tyrp1^b/Tyrp1^b Myo5a^d/Myo5a^d

Strain Description
The BXD recombinant inbred (RI) strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.

The BXD#/Rww set was generated using a strategy of advanced intercrosses (AI). The AI technique produces recombinant RI strains which incorporate approximately twice as many recombinations as the standard RI strains. The addition of the AI BXD RI lines to the existing BXD set creates the largest of the mouse RI mapping panels. This set is useful in QTL mapping and analysis of gene function.

Strain Development
The BXD#/Rww advanced recombinant inbred (ARI) lines are derived from two independently derived advanced intercrosses between the C57BL/6J and DBA/2J progenitor strains generated at Princeton University and the University of Tennessee. Crosses at Princeton were intiated using B6D2F1/J mice crossed to generate B6D2F2 mice. These mice were randomly mated to generate a G3 population. Subsequent matings were chosen to minimize the number of common parents. AIL from the Tennessee crosses were initiated with reciprocal crosses of the parental strains. As a result, mice from the Tennessee set can have the Y chromosome and mitochondrial genome from either progenitor. Mice from the Princeton set have a Y chromosome from DBA/2J and the mitochondrial genome from C57BL/6J. All ARI lines were intercrossed for 9-14 generations before inbreeding. Like the Princeton crosses, the Tennessee crosses also sought to miminize common ancestors in each cross although fewer breeding cages per generation were used. As of early 2007, most lines were inbred for more than 20 generations. The lines were donated to The Jackson Laboratory Repository in 2007 by Dr. Robert Williams.

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

BXD Strains

000036	BXD1/TyJ
007143	BXD100/RwwJ
000012	BXD11/TyJ
000045	BXD12/TyJ
000040	BXD13/TyJ
000329	BXD14/TyJ
000095	BXD15/TyJ
000013	BXD16/TyJ
000015	BXD18/TyJ
000010	BXD19/TyJ
000075	BXD2/TyJ
000330	BXD20/TyJ
000077	BXD21/TyJ
000043	BXD22/TyJ
005243	BXD24a/TyJ
000031	BXD24b/TyJ
006255	BXD25/TyJRwwJ
000041	BXD27/TyJ
000047	BXD28/TyJ
000029	BXD29/TyJ
000083	BXD31/TyJ
000078	BXD32/TyJ
003222	BXD33/TyJ
003223	BXD34/TyJ
003225	BXD36/TyJ
003227	BXD38/TyJ
003228	BXD39/TyJ
003229	BXD40/TyJ
003230	BXD42/TyJ
007093	BXD43/RwwJ
007094	BXD44/RwwJ
007097	BXD48/RwwJ
000037	BXD5/TyJ
007099	BXD50/RwwJ
007103	BXD55/RwwJ
000007	BXD6/TyJ
007105	BXD60/RwwJ
007106	BXD61/RwwJ
007107	BXD62/RwwJ
007111	BXD66/RwwJ
007113	BXD68/RwwJ
007114	BXD69/RwwJ
007117	BXD73/RwwJ
007121	BXD77/RwwJ
000084	BXD8/TyJ
007124	BXD80/RwwJ
007129	BXD86/RwwJ
007130	BXD87/RwwJ
007132	BXD89/RwwJ
000105	BXD9/TyJ
007133	BXD90/RwwJ
007135	BXD92/RwwJ
007139	BXD96/RwwJ
007140	BXD97/RwwJ
007141	BXD98/RwwJ

View BXD Strains     (55 strains)

Research Applications

This mouse can be used to support research in many areas including:

Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)

References

Selected Reference(s)

Peirce JL; Lu L; Gu J; Silver LM; Williams RW. 2004. A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet 5(1):7. [PubMed: 15117419]  [MGI Ref ID J:92427]

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Price and Supply Information

Strain Name:	BXD70/RwwJ
Stock Number:	007115

 

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

View All Strains Under Development

Supply Details

Standard Supply	Under Development for Distribution Colony
Supply Notes	This strain is included in the Special Mutant Stock Resource collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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Ordering and Purchasing Information

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Contact Information
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Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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