Strain Name:

BXD99/RwwJ

Stock Number:

007142

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The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J (000664) females and DBA/2J (000671) males and were generated using a strategy of advanced intercrosses (AI). They may be used to study the genetics of behavioral phenotypes (including alcohol and drug addiction, stress, and locomotor activity) and complex or potentially complex physiologic phenotypes (including differences in organ weight and bone mineral density).

Description

Strain Information

Type Recombinant Inbred (RI);
Additional information on Recombinant Inbred Mice.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   14-NOV-08
Specieslaboratory mouse
RI progenitor C57BL/6J DBA/2J
GenerationF25+F13 (27-FEB-14)
Generation Definitions

Appearance
dilute brown
Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad

Description
The BXD recombinant inbred (RI) strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. The BXD set of RI strains also are used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in organ weight and bone mineral density.

The BXD#/Rww set was generated using a strategy of advanced intercrosses (AI). The AI technique produces recombinant RI strains which incorporate approximately twice as many recombinations as the standard RI strains. The addition of the AI BXD RI lines to the existing BXD set creates the largest of the mouse RI mapping panels. This set is useful in QTL mapping and analysis of gene function.

The strain distribution pattern (SDP) for the BXD RI strains is available through the Mouse Genome Informatics Contributed Data Sets and Gene Network. Additional tools and information are presented through the Mouse Phenome Database Specialized Strain Panel Query Form, and Gene Network .

Development
The BXD#/Rww advanced recombinant inbred (ARI) lines are derived from two independently derived advanced intercrosses between the C57BL/6J and DBA/2J progenitor strains generated at Princeton University and the University of Tennessee. Crosses at Princeton were initiated using B6D2F1/J mice crossed to generate B6D2F2 mice. These mice were randomly mated to generate a G3 population. Subsequent matings were chosen to minimize the number of common parents. AIL from the Tennessee crosses were initiated with reciprocal crosses of the parental strains. As a result, mice from the Tennessee set can have the Y chromosome and mitochondrial genome from either progenitor. Mice from the Princeton set have a Y chromosome from DBA/2J and the mitochondrial genome from C57BL/6J. All ARI lines were intercrossed for 9-14 generations before inbreeding. Like the Princeton crosses, the Tennessee crosses also sought to miminize common ancestors in each cross although fewer breeding cages per generation were used. As of early 2007, most lines were inbred for more than 20 generations.

The lines were donated to The Jackson Laboratory Repository in 2007 by Dr. Robert Williams.

Related Strains

BXD Strains
000036   BXD1/TyJ
007143   BXD100/RwwJ
007144   BXD101/RwwJ
007145   BXD102/RwwJ
000012   BXD11/TyJ
000045   BXD12/TyJ
000040   BXD13/TyJ
000329   BXD14/TyJ
000095   BXD15/TyJ
000013   BXD16/TyJ
000015   BXD18/TyJ
000010   BXD19/TyJ
000075   BXD2/TyJ
000330   BXD20/TyJ
000077   BXD21/TyJ
000043   BXD22/TyJ
005243   BXD24/TyJ
000031   BXD24/TyJ-Cep290rd16/J
000081   BXD25/TyJ
000041   BXD27/TyJ
000047   BXD28/TyJ
000029   BXD29-Tlr4lps-2J/J
010981   BXD29/Ty
000083   BXD31/TyJ
000078   BXD32/TyJ
003222   BXD33/TyJ
003223   BXD34/TyJ
003225   BXD36/TyJ
003227   BXD38/TyJ
003228   BXD39/TyJ
003229   BXD40/TyJ
003230   BXD42/TyJ
007093   BXD43/RwwJ
007094   BXD44/RwwJ
007096   BXD45/RwwJ
007097   BXD48/RwwJ
007139   BXD48a/RwwJ
007098   BXD49/RwwJ
000037   BXD5/TyJ
007099   BXD50/RwwJ
007100   BXD51/RwwJ
017749   BXD53/2RwwJ
007103   BXD55/RwwJ
007104   BXD56/RwwJ
000007   BXD6/TyJ
007105   BXD60/RwwJ
007106   BXD61/RwwJ
007107   BXD62/RwwJ
007108   BXD63/RwwJ
007109   BXD64/RwwJ
007109   BXD64/RwwJ
007110   BXD65/RwwJ
007140   BXD65a/RwwJ
009677   BXD65b/RwwJ
007111   BXD66/RwwJ
007112   BXD67/RwwJ
007113   BXD68/RwwJ
007114   BXD69/RwwJ
007115   BXD70/RwwJ
007116   BXD71/RwwJ
007117   BXD73/RwwJ
007124   BXD73a/RwwJ
007146   BXD73b/RwwJ
007118   BXD74/RwwJ
007119   BXD75/RwwJ
007121   BXD77/RwwJ
007123   BXD79/RwwJ
000084   BXD8/TyJ
007125   BXD81/RwwJ
007126   BXD83/RwwJ
007127   BXD84/RwwJ
007128   BXD85/RwwJ
007129   BXD86/RwwJ
007130   BXD87/RwwJ
017750   BXD88/2RwwJ
007132   BXD89/RwwJ
000105   BXD9/TyJ
007133   BXD90/RwwJ
017751   BXD91/2RwwJ
007138   BXD95/RwwJ
007141   BXD98/RwwJ
View BXD Strains     (81 strains)

Phenotype

Phenotype Information

View Phenotypic Data

Phenotypic Data
Mouse Phenome Database
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Research Tools
Genetics Research
      Gene Mapping
      Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis

Genes & Alleles

Gene & Allele Information provided by MGI

Currently there are no related genes or alleles for this strain.

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Peirce JL; Lu L; Gu J; Silver LM; Williams RW. 2004. A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet 5(1):7. [PubMed: 15117419]  [MGI Ref ID J:92427]

Additional References

Andreux PA; Williams EG; Koutnikova H; Houtkooper RH; Champy MF; Henry H; Schoonjans K; Williams RW; Auwerx J. 2012. Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits. Cell 150(6):1287-99. [PubMed: 22939713]  [MGI Ref ID J:187975]

DuBose CS; Chesler EJ; Goldowitz D; Hamre KM. 2013. Use of the expanded panel of BXD mice narrow QTL regions in ethanol-induced locomotor activation and motor incoordination. Alcohol Clin Exp Res 37(1):170-83. [PubMed: 23289978]  [MGI Ref ID J:204738]

Loos M; Staal J; Pattij T; Smit AB; Spijker S. 2012. Independent genetic loci for sensorimotor gating and attentional performance in BXD recombinant inbred strains. Genes Brain Behav 11(2):147-56. [PubMed: 22098762]  [MGI Ref ID J:198107]

Martin MV; Dong H; Vallera D; Lee D; Lu L; Williams RW; Rosen GD; Cheverud JM; Csernansky JG. 2006. Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of mice. Genes Brain Behav 5(8):614-23. [PubMed: 17081266]  [MGI Ref ID J:117408]

McLachlan SM; Lu L; Aliesky HA; Williams RW; Rapoport B. 2011. Distinct genetic signatures for variability in total and free serum thyroxine levels in four sets of recombinant inbred mice. Endocrinology 152(3):1172-9. [PubMed: 21209025]  [MGI Ref ID J:173883]

Swaminathan S; Lu H; Williams RW; Lu L; Jablonski MM. 2013. Genetic modulation of the iris transillumination defect: a systems genetics analysis using the expanded family of BXD glaucoma strains. Pigment Cell Melanoma Res 26(4):487-98. [PubMed: 23582180]  [MGI Ref ID J:204729]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           FGB27

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   14-NOV-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $125.00Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $162.50Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1500 unique mouse models across a vast array of research areas. Breeding colonies provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. If a Repository strain is not immediately available, then within 2 to 3 business days, you will receive an estimated availability timeframe for your inquiry or order along with various delivery options. Repository strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping. We will note and try to accommodate requests for specific ages of Repository strains but cannot guarantee provision of these strains at specific ages. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, please let us know.

General Supply Notes

  • This strain is included in the Special Mutant Stock Resource collection.

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