Strain Name:

C.129X1(B6)-Ptprctm1Weis/J

Stock Number:

007173

Order this mouse

Availability:

Cryopreserved - Ready for recovery

Use Restrictions Apply, see Terms of Use
Common Names: C45 E613R/BALB/c.F10;    

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
GenerationN10pN1
Generation Definitions
 
Donating InvestigatorDr. Arthur Weiss,   University of California, San Francisco

Description
Mice homozygous for this targeted point mutation are viable and fertile. The phenotype of this mutation, which inactivates the inhibitory wedge of the protein, is dependent upon the genetic background. On the BALB/c background, B, T, and myeloid cells are hyperresponsive to stimulation at a biochemical and cellular level. B cell development is skewed to the B1 cell lineage. A mild lymphoproliferative disorder is developed. Mice develop anti-DS antibodies with 100% penetrance between 1.5 and 3 months of age, but no glomerulonephritis. Cell surface expression of the protein is indistinguishable from wildtype as determined by flow cytometry of hematpoietic lineages in bone marrow, lymph node, spleen, thymus, peritoneal lavage, and peripheral blood.

Development
A targeting vector carrying the glutamate 613 (E613R) mutation in exon 18 and a loxP-flanked neomycin resistance cassette in the downstream intron was transfected into 129X1/SvJ-derived JM-1 embryonic stem (ES) cells. Targeted clones were microinjected into C57BL/6 blastocysts and mice derived from the resultant lines were bred to a C57BL/6 background Actb-Cre transgenic mouse to eliminate the neomycin resistance cassette. This line was crossed to C57BL/6, and later backcrossed to BALB/c for ten generations by the donating laboratory.

Related Strains

Strains carrying   Ptprctm1Weis allele
007172   129S6.129X1(B6)-Ptprctm1Weis/J
007171   B6.129X1-Ptprctm1Weis/J
View Strains carrying   Ptprctm1Weis     (2 strains)

View Strains carrying other alleles of Ptprc     (15 strains)

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies are distinct. Human genes are associated with this disease. Orthologs of these genes do not appear in the mouse genotype(s).
Systemic Lupus Erythematosus; SLE
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Hepatitis C Virus, Susceptibility to   (PTPRC)
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive   (PTPRC)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Ptprctm1Weis/Ptprc+

        involves: 129X1/SvJ * C57BL/6
  • mortality/aging
  • premature death
    • mice die prematurely from multiple pathologies starting as early as 15 weeks of age   (MGI Ref ID J:66501)
    • 25% of mutant mice have died by 50 weeks of age compared to none in the wild-type control group   (MGI Ref ID J:66501)
  • immune system phenotype
  • increased IgG2a level
    • there is a 12-fold increase in IgG2a levels over controls in 16 week old mice   (MGI Ref ID J:66501)
  • increased anti-double stranded DNA antibody level
    • 25% of heterozygous mice express auto-antibodies as early as 18 weeks of age   (MGI Ref ID J:66501)
  • increased susceptibility to autoimmune disorder
    • autoimmune lupus nephritis with autoantibody production leading to renal failure   (MGI Ref ID J:66501)
  • renal/urinary system phenotype
  • increased urine protein level
    • proteinura greater than 30 mg/dl is observed at 6 weeks of age   (MGI Ref ID J:66501)
    • 33% of mice exhibit abnormal proteinura by 26 weeks of age   (MGI Ref ID J:66501)
  • homeostasis/metabolism phenotype
  • increased urine protein level
    • proteinura greater than 30 mg/dl is observed at 6 weeks of age   (MGI Ref ID J:66501)
    • 33% of mice exhibit abnormal proteinura by 26 weeks of age   (MGI Ref ID J:66501)
  • hematopoietic system phenotype
  • increased IgG2a level
    • there is a 12-fold increase in IgG2a levels over controls in 16 week old mice   (MGI Ref ID J:66501)

Ptprctm1Weis/Ptprctm1Weis

        involves: 129X1/SvJ * C57BL/6
  • mortality/aging
  • premature death
    • mice die prematurely from multiple pathologies starting as early as 15 weeks of age   (MGI Ref ID J:66501)
    • 43% of mutant mice have died by 50 weeks of age compared to none in the wild-type control group   (MGI Ref ID J:66501)
  • immune system phenotype
  • abnormal B cell activation
    • B cells expressing activation markers are increased 26% in wild-type to 62% and 70%, in mild and severe lymphadenopathy, respectively   (MGI Ref ID J:66501)
  • abnormal T cell activation
    • T cells expressing activation markers are increased from 21% in wild-type to 34% in mice with mild lymphadenopathy, and 57% in mice with severe lymphadenopathy   (MGI Ref ID J:66501)
  • abnormal granulocyte differentiation
    • granulopoiesis is increased in the bone marrow   (MGI Ref ID J:66501)
  • abnormal immune system organ morphology   (MGI Ref ID J:66501)
    • enlarged lymph nodes
      • 70% of mice over 15 weeks of age develop lymphadenopathy with about half the cases being severe   (MGI Ref ID J:66501)
      • generalized lymphadenopathy is observed in severe cases while lymphadenopathy is often confined to the cervical and submandibular lymph nodes in mild cases   (MGI Ref ID J:66501)
      • lymph node hyperplasia
        • lymph node cell numbers are 2- to 8- fold greater than controls in older mice with swollen lymph nodes   (MGI Ref ID J:66501)
    • enlarged spleen
      • spleens of mice over 15 weeks of age weigh 3-10 times as much as controls   (MGI Ref ID J:66501)
    • increased spleen red pulp amount
      • expansion of the red pulp is noted in mice over 15 weeks of age   (MGI Ref ID J:66501)
    • increased spleen white pulp amount
      • expansion of the white pulp is noted in mice over 15 weeks of age   (MGI Ref ID J:66501)
  • abnormal leukocyte cell number   (MGI Ref ID J:66501)
    • increased B cell number
      • B cell numbers are increased in older mice 2- to 8- fold   (MGI Ref ID J:66501)
    • increased T cell number
      • T cell numbers are increased in older mice 2- to 8- fold   (MGI Ref ID J:66501)
    • increased plasmacytoid dendritic cell number
      • increased plasmacytoid cells are found in the lymph nodes   (MGI Ref ID J:66501)
  • glomerulonephritis
    • kidneys have interstitial nephritis characterized by the presence of numerous mononuclear cells, tubular epithelial cell injury, interstitial fibrosis, and edema   (MGI Ref ID J:66501)
    • the glomeruli exhibited increase cellularity, thickened capillary loops, and an increase in mesangial matrix   (MGI Ref ID J:66501)
    • karyorrhexis was noted in a segmental pattern   (MGI Ref ID J:66501)
    • numerous subendothelial and mesangial deposits of immunoglobulin proteins are visible, along with widespread epithelial cell foot process effacement   (MGI Ref ID J:66501)
  • increased IgA level
    • mean IgA levels are 35-fold higher than controls by 14 weeks of age   (MGI Ref ID J:66501)
  • increased IgG2a level
    • there is a 12-fold increase in IgG2a levels over controls in 14 week old mice   (MGI Ref ID J:66501)
  • increased anti-double stranded DNA antibody level
    • 63% of homozygous mice have anti-dsDNA antibodies   (MGI Ref ID J:66501)
    • auto-antibodies are detected as earlier as 9 weeks of age   (MGI Ref ID J:66501)
  • increased susceptibility to autoimmune disorder
    • autoimmune lupus nephritis with autoantibody production leading to renal failure   (MGI Ref ID J:66501)
  • renal/urinary system phenotype
  • glomerulonephritis
    • kidneys have interstitial nephritis characterized by the presence of numerous mononuclear cells, tubular epithelial cell injury, interstitial fibrosis, and edema   (MGI Ref ID J:66501)
    • the glomeruli exhibited increase cellularity, thickened capillary loops, and an increase in mesangial matrix   (MGI Ref ID J:66501)
    • karyorrhexis was noted in a segmental pattern   (MGI Ref ID J:66501)
    • numerous subendothelial and mesangial deposits of immunoglobulin proteins are visible, along with widespread epithelial cell foot process effacement   (MGI Ref ID J:66501)
  • increased urine protein level
    • proteinura greater than 30 mg/dl is observed at 6 weeks of age   (MGI Ref ID J:66501)
    • by 22 weeks of age, 54% of mice exhibit abnormal proteinura   (MGI Ref ID J:66501)
  • kidney failure
    • some mice suffer from oliguria shortly before dying suggesting kidney failure   (MGI Ref ID J:66501)
  • oliguria
    • some mice suffer from oliguria shortly before dying   (MGI Ref ID J:66501)
  • digestive/alimentary phenotype
  • abnormal digestion
    • some female mice with kidney problems have extended stomachs full of undigested food   (MGI Ref ID J:66501)
    • these mice appear extremely thin and lethargic   (MGI Ref ID J:66501)
  • hematopoietic system phenotype
  • abnormal B cell activation
    • B cells expressing activation markers are increased 26% in wild-type to 62% and 70%, in mild and severe lymphadenopathy, respectively   (MGI Ref ID J:66501)
  • abnormal T cell activation
    • T cells expressing activation markers are increased from 21% in wild-type to 34% in mice with mild lymphadenopathy, and 57% in mice with severe lymphadenopathy   (MGI Ref ID J:66501)
  • abnormal erythropoiesis
    • erythropoiesis in the bone marrow is decreased   (MGI Ref ID J:66501)
  • abnormal granulocyte differentiation
    • granulopoiesis is increased in the bone marrow   (MGI Ref ID J:66501)
  • abnormal leukocyte cell number   (MGI Ref ID J:66501)
    • increased B cell number
      • B cell numbers are increased in older mice 2- to 8- fold   (MGI Ref ID J:66501)
    • increased T cell number
      • T cell numbers are increased in older mice 2- to 8- fold   (MGI Ref ID J:66501)
    • increased plasmacytoid dendritic cell number
      • increased plasmacytoid cells are found in the lymph nodes   (MGI Ref ID J:66501)
  • enlarged spleen
    • spleens of mice over 15 weeks of age weigh 3-10 times as much as controls   (MGI Ref ID J:66501)
  • extramedullary hematopoiesis
    • along with numerous megakaryocytes, islands of erythropoiesis and granulopoiesis are observed throughout the enlarged spleens   (MGI Ref ID J:66501)
  • increased IgA level
    • mean IgA levels are 35-fold higher than controls by 14 weeks of age   (MGI Ref ID J:66501)
  • increased IgG2a level
    • there is a 12-fold increase in IgG2a levels over controls in 14 week old mice   (MGI Ref ID J:66501)
  • increased spleen red pulp amount
    • expansion of the red pulp is noted in mice over 15 weeks of age   (MGI Ref ID J:66501)
  • increased spleen white pulp amount
    • expansion of the white pulp is noted in mice over 15 weeks of age   (MGI Ref ID J:66501)
  • homeostasis/metabolism phenotype
  • increased urine protein level
    • proteinura greater than 30 mg/dl is observed at 6 weeks of age   (MGI Ref ID J:66501)
    • by 22 weeks of age, 54% of mice exhibit abnormal proteinura   (MGI Ref ID J:66501)
  • cellular phenotype
  • abnormal granulocyte differentiation
    • granulopoiesis is increased in the bone marrow   (MGI Ref ID J:66501)

Ptprctm1Weis/Ptprctm1Weis

        B6.129X1-Ptprctm1Weis
  • immune system phenotype
  • *normal* immune system phenotype
    • immunoreceptor tyrosine-based activation motif-mediated cytokine secretion in NK cells is normal   (MGI Ref ID J:109462)
    • abnormal B cell activation
      • a slightly increased percentage of B cells express the activation marker at 6 months of age   (MGI Ref ID J:147129)
    • abnormal T cell activation
      • the activation marker CD69 is slightly upregulated on both CD4 and CD8 T cells in vivo   (MGI Ref ID J:147129)
      • na?ve CD8 T cells are hyper-response to in vitro stimulation   (MGI Ref ID J:147129)
      • abnormal thymocyte activation
        • double-positive thymocytes are more responsive to in vitro stimulation than controls   (MGI Ref ID J:147129)
    • abnormal T cell subpopulation ratio
      • the CD4:CD8 T cell ratio in the periphery is over 1.5 at six months of age   (MGI Ref ID J:147129)
    • abnormal double-positive T cell morphology
      • double-positive thymocytes have CD5 and CD69 slighlty upregulated and are more responsive to in vitro stimulation   (MGI Ref ID J:147129)
    • abnormal follicular B cell physiology
      • follicular B cells are hyper-responsive to stimulation in vitro   (MGI Ref ID J:147129)
    • decreased follicular B cell number
      • follicular B cells are hyper-responsive to stimulation in vitro   (MGI Ref ID J:147129)
    • enlarged lymph nodes
      • mild lymphadenopathy is observed in these mice   (MGI Ref ID J:147129)
    • increased memory T cell number
      • CD44hi CD62Llo memory T cells are increased about 2-fold at 6 months of age compared to controls   (MGI Ref ID J:147129)
      • differences are noticeable at 3 months of age with increases progressing with age   (MGI Ref ID J:147129)
    • increased plasma cell number
      • plasma cell numbers in the spleen is increased 4-fold at 3 months of age compared to controls   (MGI Ref ID J:147129)
    • increased transitional stage B cell number
      • T1 and T2 B cell numbers are increased in the spleen   (MGI Ref ID J:147129)
    • liver inflammation
      • perivascular infiltrates occur in the liver of mice over 12 months of age   (MGI Ref ID J:147129)
    • lung inflammation
      • perivascular infiltrates occur in the lung of mice over 12 months of age   (MGI Ref ID J:147129)
  • respiratory system phenotype
  • lung inflammation
    • perivascular infiltrates occur in the lung of mice over 12 months of age   (MGI Ref ID J:147129)
  • liver/biliary system phenotype
  • liver inflammation
    • perivascular infiltrates occur in the liver of mice over 12 months of age   (MGI Ref ID J:147129)
  • hematopoietic system phenotype
  • abnormal B cell activation
    • a slightly increased percentage of B cells express the activation marker at 6 months of age   (MGI Ref ID J:147129)
  • abnormal T cell activation
    • the activation marker CD69 is slightly upregulated on both CD4 and CD8 T cells in vivo   (MGI Ref ID J:147129)
    • na?ve CD8 T cells are hyper-response to in vitro stimulation   (MGI Ref ID J:147129)
    • abnormal thymocyte activation
      • double-positive thymocytes are more responsive to in vitro stimulation than controls   (MGI Ref ID J:147129)
  • abnormal T cell subpopulation ratio
    • the CD4:CD8 T cell ratio in the periphery is over 1.5 at six months of age   (MGI Ref ID J:147129)
  • abnormal double-positive T cell morphology
    • double-positive thymocytes have CD5 and CD69 slighlty upregulated and are more responsive to in vitro stimulation   (MGI Ref ID J:147129)
  • abnormal follicular B cell physiology
    • follicular B cells are hyper-responsive to stimulation in vitro   (MGI Ref ID J:147129)
  • decreased follicular B cell number
    • follicular B cells are hyper-responsive to stimulation in vitro   (MGI Ref ID J:147129)
  • increased memory T cell number
    • CD44hi CD62Llo memory T cells are increased about 2-fold at 6 months of age compared to controls   (MGI Ref ID J:147129)
    • differences are noticeable at 3 months of age with increases progressing with age   (MGI Ref ID J:147129)
  • increased plasma cell number
    • plasma cell numbers in the spleen is increased 4-fold at 3 months of age compared to controls   (MGI Ref ID J:147129)
  • increased transitional stage B cell number
    • T1 and T2 B cell numbers are increased in the spleen   (MGI Ref ID J:147129)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      anti-dsDNA antibodies
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Lymphoid Tissue Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Ptprctm1Weis
Allele Name targeted mutation 1, Arthur Weiss
Allele Type Targeted (knock-in)
Common Name(s) CD45 E613R; Cd45w; Wedge;
Mutation Made ByDr. Arthur Weiss,   University of California, San Francisco
Strain of Origin129X1/SvJ
ES Cell Line NameJM-1
ES Cell Line Strain129X1/SvJ
Promoter Ptprc, protein tyrosine phosphatase, receptor type, C, mouse, laboratory
Molecular Note To recapitulate a mutation in the orthologous human gene that disrupts the inhibitory wedge, a glutamate to arginine substitution at codon 613 (E613R) was engineered in exon 18 and incorporated at the endogenous locus via homolgous recombination. A single loxP site remained in intron 18 after the floxed neo cassette was excised. [MGI Ref ID J:66501]

Genotyping

Genotyping Information

Genotyping Protocols

Ptprctm1Weis, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Majeti R; Xu Z; Parslow TG; Olson JL; Daikh DI; Killeen N; Weiss A. 2000. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 103(7):1059-70. [PubMed: 11163182]  [MGI Ref ID J:66501]

Additional References

Ptprctm1Weis related

Bermejo DA; Jackson SW; Gorosito-Serran M; Acosta-Rodriguez EV; Amezcua-Vesely MC; Sather BD; Singh AK; Khim S; Mucci J; Liggitt D; Campetella O; Oukka M; Gruppi A; Rawlings DJ. 2013. Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORgammat and Ahr that leads to IL-17 production by activated B cells. Nat Immunol 14(5):514-22. [PubMed: 23563688]  [MGI Ref ID J:196434]

Hermiston ML; Zikherman J; Tan AL; Lam VC; Cresalia NM; Oksenberg N; Goren N; Brassat D; Oksenberg JR; Weiss A. 2009. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A 106(2):546-51. [PubMed: 19129486]  [MGI Ref ID J:143867]

Hesslein DG; Takaki R; Hermiston ML; Weiss A; Lanier LL. 2006. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc Natl Acad Sci U S A 103(18):7012-7. [PubMed: 16627620]  [MGI Ref ID J:109462]

Hsu LY; Tan YX; Xiao Z; Malissen M; Weiss A. 2009. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J Exp Med 206(11):2527-41. [PubMed: 19841086]  [MGI Ref ID J:154166]

Zikherman J; Hermiston M; Steiner D; Hasegawa K; Chan A; Weiss A. 2009. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol 182(7):4093-106. [PubMed: 19299707]  [MGI Ref ID J:147129]

Zikherman J; Parameswaran R; Hermiston M; Weiss A. 2013. The Structural Wedge Domain of the Receptor-like Tyrosine Phosphatase CD45 Enforces B Cell Tolerance by Regulating Substrate Specificity. J Immunol 190(6):2527-35. [PubMed: 23396948]  [MGI Ref ID J:193596]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2450.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $3185.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.5)