Strain Name:

B6.129P2-Mecp2tm1Bird/J

Stock Number:

007177

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Availability:

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Mice with this X-linked floxed mutation of the methyl CpG binding protein 2 gene may be useful in neurological and developmental studies of Rett syndrome.

Description

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
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Additional information on Congenic nomenclature.
Mating SystemHomozygote x Hemizygote         (Female x Male)   26-JUL-10
Specieslaboratory mouse
GenerationN5F10 (12-DEC-13)
Generation Definitions
 
Donating Investigator Adrian Bird,   University of Edinburgh

Description
These mice possess two functional loxP sites flanking exons 3-4 of the targeted gene on the X chromosome (the donating investigator reports that the middle loxP site is non-functional). Homozygous females and hemizygous males are viable and fertile. Northern blot analysis showed the expected mature transcript from the Mecp2lox locus as well as a transcript in which the beta-globin intron was unspliced. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 3-4 deleted in the cre-expressing tissue(s). Mice with this X-linked floxed mutation may be useful in neurological and developmental studies of Rett syndrome.

For example, when crossed to a strain expressing Cre recombinase in nervous tissue (see Stock No. 003771), this mutant mouse strain develops a neurological phenotype that mimics Rett syndrome.

When crossed to a strain expressing Cre recombinase in GABAergic neurons (see Stock No. 017535), these mice exhibit behaviors common to those seen in Rett Syndrome and Autism Spectrum Disorders.

In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Mecp2tm1Bird allele
006847   B6;129P2-Mecp2tm1Bird/J
View Strains carrying   Mecp2tm1Bird     (1 strain)

View Strains carrying other alleles of Mecp2     (9 strains)

Additional Web Information

Introduction to Cre-lox technology

Phenotype

Phenotype Information

View Related Disease (OMIM) Terms

Related Disease (OMIM) Terms provided by MGI
- Model with phenotypic similarity to human disease where etiologies involve orthologs. Human genes are associated with this disease. Orthologs of those genes appear in the mouse genotype(s).
Rett Syndrome; RTT
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Angelman Syndrome; AS   (MECP2)
Autism, Susceptibility to, X-Linked 3; AUTSX3   (MECP2)
Encephalopathy, Neonatal Severe, Due to Mecp2 Mutations   (MECP2)
Lubs X-Linked Mental Retardation Syndrome; MRXSL   (MECP2)
Mental Retardation, X-Linked, Syndromic 13; MRXS13   (MECP2)
View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain.

Mecp2tm1Bird/Y

        (129S6.129P2-Mecp2tm1Bird x C57BL/6)F1
  • mortality/aging
  • *normal* mortality/aging
    • no early mortality is observed in contrast to Mecp2-null animals   (MGI Ref ID J:135825)
  • growth/size/body phenotype
  • increased body weight
    • a mild increase (animals are about 1 gram heavier) is observed relative to wild-type or F1 mutants from an FVB/N cross   (MGI Ref ID J:135825)
  • behavior/neurological phenotype
  • abnormal nest building behavior
    • mice show deficits in nest-building relative to wild-type, with fewer animals building or completing nests than wild-type animals over the same time period   (MGI Ref ID J:135825)
  • abnormal social investigation
    • mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage   (MGI Ref ID J:135825)
  • abnormal touch/ nociception
    • mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity   (MGI Ref ID J:135825)
    • increased thermal nociceptive threshold
      • mice show increased latency in the hot plate assay   (MGI Ref ID J:135825)
  • decreased startle reflex
    • mice have a decreased startle response relative to wild-type   (MGI Ref ID J:135825)
  • impaired coordination
    • mice display impaired performance in coordination tasks like the rotating rod, hanging wire, and dowel walking tests   (MGI Ref ID J:135825)
  • nervous system phenotype
  • decreased prepulse inhibition
    • mice show decreased prepulse inhibition at 74 and 82 decibels compared to wild-type   (MGI Ref ID J:135825)
  • integument phenotype
  • abnormal touch/ nociception
    • mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity   (MGI Ref ID J:135825)
    • increased thermal nociceptive threshold
      • mice show increased latency in the hot plate assay   (MGI Ref ID J:135825)

Mecp2tm1Bird/Y

        (129S6.129P2-Mecp2tm1Bird x FVB/N)F1
  • mortality/aging
  • *normal* mortality/aging
    • no early mortality is observed in contrast to Mecp2-null animals   (MGI Ref ID J:135825)
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • no overt abnormalities are observed; mutants do not exhibit impaired coordination in a variety of tests measured   (MGI Ref ID J:135825)
    • mice do not show overt abnormalities like tremor or limb grasping   (MGI Ref ID J:135825)
    • abnormal contextual conditioning behavior
      • percentage of time spent freezing is elevated relative to wild-type when placed back into the conditioning chamber   (MGI Ref ID J:135825)
    • abnormal cued conditioning behavior
      • percentage of time spent freezing is elevated relative to wild-type when re-exposure to a previously experienced cue   (MGI Ref ID J:135825)
    • abnormal social investigation
      • mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage   (MGI Ref ID J:135825)
    • abnormal touch/ nociception
      • mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity   (MGI Ref ID J:135825)
    • decreased anxiety-related response
      • mice show decrease anxiety-related behavior in open field assays than wild-type mice   (MGI Ref ID J:135825)
    • increased vertical activity
      • increased number of vertical explorations is observed compared to wild-type; this is indicative of reduced anxiety   (MGI Ref ID J:135825)
  • nervous system phenotype
  • decreased prepulse inhibition
    • mice show decreased prepulse inhibition compared to wild-type   (MGI Ref ID J:135825)
  • respiratory system phenotype
  • abnormal breathing pattern
    • at 4 months, respiratory pattern is qualitatively different than in wild-type; coefficient of variability of the respiratory rhythm is higher than in wild-type   (MGI Ref ID J:135825)
    • apnea
      • increase in apnea incidence (39.5/hour) is observed compared to wild-type (5.8/hour)   (MGI Ref ID J:135825)
  • growth/size/body phenotype
  • *normal* growth/size/body phenotype
    • no size difference is detected relative to wild-type, unlike mice on the C57BL/6 background   (MGI Ref ID J:135825)
  • integument phenotype
  • abnormal touch/ nociception
    • mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity   (MGI Ref ID J:135825)

Mecp2tm1Bird/Y

        involves: 129P2/OlaHsd * C57BL/6J * FVB/N
  • mortality/aging
  • *normal* mortality/aging
    • mice do not show premature lethality   (MGI Ref ID J:166851)
  • respiratory system phenotype
  • *normal* respiratory system phenotype
    • mice do not exhibit apneas   (MGI Ref ID J:166851)

The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.

Mecp2tm1Bird/Y Tg(Nes-cre)1Kln/0

        involves: 129P2/OlaHsd * C57BL/6 * SJL   (conditional)
  • mortality/aging
  • premature death   (MGI Ref ID J:67910)
  • behavior/neurological phenotype
  • abnormal gait
    • develop a stiff, uncoordinated gait   (MGI Ref ID J:67910)
  • hypoactivity   (MGI Ref ID J:67910)
  • limb grasping   (MGI Ref ID J:67910)
  • craniofacial phenotype
  • abnormal tooth morphology
    • frequently exhibit uneven wearing of the teeth   (MGI Ref ID J:67910)
  • endocrine/exocrine gland phenotype
  • cryptorchism   (MGI Ref ID J:67910)
  • growth/size/body phenotype
  • abnormal tooth morphology
    • frequently exhibit uneven wearing of the teeth   (MGI Ref ID J:67910)
  • decreased body weight   (MGI Ref ID J:67910)
  • reproductive system phenotype
  • cryptorchism   (MGI Ref ID J:67910)

Mecp2tm1Bird/Y Tg(Slc32a1-cre)2.1Hzo/0

        involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB   (conditional)
  • mortality/aging
  • premature death
    • around 50% of mutant mice die by 26 weeks   (MGI Ref ID J:166851)
  • growth/size/body phenotype
  • weight loss
    • mice exhibit a period of rapid weight loss preceding death; initial weight gain is normal   (MGI Ref ID J:166851)
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • at 12 weeks of age, mice show similar responses to controls in thermal nociception assays, indicating that the self-injury observed is not due to impaired nociception   (MGI Ref ID J:166851)
    • mice display no anxiety-like phenotypes, indicating that hypoactivity or altered social behavior does not result from increased anxiety   (MGI Ref ID J:166851)
    • animals show no increased interest in a novel object than controls at 11-12 weeks   (MGI Ref ID J:166851)
    • mice recognize and habituate to a novel vanilla odorant; mutants did spend more time sniffing the novel scent than controls (possible manifestation of repetitive behavior) on the first day, but show no differences on the second day   (MGI Ref ID J:166851)
    • abnormal nest building behavior
      • mice are poor nest builders, possibly due to social behavior alterations or to forelimb apraxia at 13 weeks   (MGI Ref ID J:166851)
    • abnormal social investigation
      • mice spend more time showing directed interest (sniffing, pawing, rearing) near the novel partner mouse than displayed by controls in a 3-chamber assay of social interaction at 12-13 weeks   (MGI Ref ID J:166851)
    • abnormal spatial learning
      • in a Morris water maze paradigm, animals show a similar rate of learning to control during the 4 training days, but have difficulty locating the platform during the probe trial   (MGI Ref ID J:166851)
    • decreased grip strength
      • at 9 weeks, mice show decreased time wire hang time prior to falling and reduce forelimb grip strength compared to controls   (MGI Ref ID J:166851)
    • decreased startle reflex
      • mice have impaired maximum acoustic startle response than controls to 120 dB at 8 weeks   (MGI Ref ID J:166851)
    • hypoactivity
      • there is a trend to reduced activity observed at 12 weeks, while 19-week old mice are hypoactive   (MGI Ref ID J:166851)
    • impaired coordination
      • at 5 weeks, mice show increased numbers of footslips on a wire grid and impaired dowel walk at 9 weeks   (MGI Ref ID J:166851)
      • mice have a shorter latency to fall on an accelerating rotarod at 19 weeks   (MGI Ref ID J:166851)
    • increased grooming behavior
      • time spent grooming is 300% greater than in control mice; excessive grooming leads to fur loss and epidermal lesions in group- and single-housed mice   (MGI Ref ID J:166851)
    • increased stereotypic behavior
      • male mice begin to show repetitive behaviors after 5 weeks of age such as forelimb stereotypies similar to the mid-line hand-wringing that characterizes Rett syndrome in humans   (MGI Ref ID J:166851)
      • animals display a greater tendency to place their nose in the same hole 2 or more sequential times in a holeboard assay for head-dipping stereotypy   (MGI Ref ID J:166851)
    • limb grasping
      • after 5 weeks of age, mice show repetitive behavior such as hindlimb clasping   (MGI Ref ID J:166851)
  • nervous system phenotype
  • *normal* nervous system phenotype
    • miniature excitatory postsynaptic current quantal size and frequency are similar to controls   (MGI Ref ID J:166851)
    • paired pulse ratio is not significantly altered in neurons   (MGI Ref ID J:166851)
    • abnormal miniature inhibitory postsynaptic currents
      • amplitude and charge of mIPSCs from layer 2/3 pyramidal neurons of the somatosensory cortex are reduced; no change in frequency is observed   (MGI Ref ID J:166851)
      • similar results are observed in autaptic GABAergic striatal neurons   (MGI Ref ID J:166851)
    • abnormal nervous system electrophysiology
      • non-seizure hyperexcitability discharges are frequently observed in cultured neurons, but no electrographic seizures are seen   (MGI Ref ID J:166851)
    • increased prepulse inhibition
      • mice show an increased prepulse inhibition at 78 and 82 dB prepulses at 8 weeks   (MGI Ref ID J:166851)
    • reduced long term potentiation
      • impaired LTP induced by theta-burst stimulation of Schaffer collaterals is detected   (MGI Ref ID J:166851)
  • respiratory system phenotype
  • abnormal respiratory function
    • severe respiratory dysfunction is coincident with weight loss   (MGI Ref ID J:166851)
    • abnormal breathing pattern   (MGI Ref ID J:166851)
      • apnea
        • mice display frequent apneas of greater than 0.4 second durations, coincident with weight loss   (MGI Ref ID J:166851)
      • respiratory distress   (MGI Ref ID J:166851)
  • decreased tidal volume
    • coinciding with weight loss, mice display a 42% reduction in tidal volume (and 45% reduction in minute volume)   (MGI Ref ID J:166851)

Mecp2tm1Bird/Y Tg(dlx6a-cre)1Mekk/0

        involves: 129P2/OlaHsd * 129S6/SvEvTac * CD-1 * FVB   (conditional)
  • mortality/aging
  • *normal* mortality/aging
    • mice survive to at least 80 weeks of age   (MGI Ref ID J:166851)
  • behavior/neurological phenotype
  • *normal* behavior/neurological phenotype
    • mice show similar grooming times to controls   (MGI Ref ID J:166851)
    • mice have a nonsignificant trend to reduced total distance traveled   (MGI Ref ID J:166851)
    • time exhibiting aggressive behavior such as wrestling, tail-rattling, boxing, and mounting is similar to controls   (MGI Ref ID J:166851)
    • mice exhibit intact olfactory recognition and habituation in response to a novel odorant at 11 weeks of age   (MGI Ref ID J:166851)
    • at 12 weeks, mice have intact nociception demonstrated by a hot-plate or tail-flick assay   (MGI Ref ID J:166851)
    • abnormal nest building behavior
      • nest building is impaired   (MGI Ref ID J:166851)
    • abnormal social investigation
      • mice show increased social interaction with novel and familiar partners; time spent with novel partners is 60% higher than in controls in a 3-chamber assay   (MGI Ref ID J:166851)
    • decreased startle reflex
      • mice show impaired maximum acoustic startle response to 120dB   (MGI Ref ID J:166851)
    • impaired coordination
      • mice display more footslips, shorter latency to fall on wire, reduced number of side touches on dowel and shorter latency to fall from rotarod compared to controls   (MGI Ref ID J:166851)
    • increased stereotypic behavior
      • mice show a 200% increase relative to control in number of holes explored with 2 or more sequential nose pokes in a holeboard assay   (MGI Ref ID J:166851)
  • nervous system phenotype
  • increased prepulse inhibition
    • 24 week-old mice show increased prepulse inhibition at 74 dB   (MGI Ref ID J:166851)
  • respiratory system phenotype
  • *normal* respiratory system phenotype
    • mice show no alterations in tidal volume or minute volume, and display no apneas   (MGI Ref ID J:166851)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Neurobiology Research
Behavioral and Learning Defects
Neurodevelopmental Defects
      Rett's syndrome

Research Tools
Cre-lox System
      loxP-flanked Sequences
Developmental Biology Research
      Cre-lox System

Mecp2tm1Bird related

Neurobiology Research
Ataxia (Movement) Defects

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Mecp2tm1Bird
Allele Name targeted mutation 1, Adrian Bird
Allele Type Targeted (Conditional ready (e.g. floxed), No functional change)
Common Name(s) Mecp2lox;
Mutation Made By Adrian Bird,   University of Edinburgh
Strain of Origin129P2/OlaHsd
ES Cell Line NameE14TG2a
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Mecp2, methyl CpG binding protein 2
Chromosome X
Gene Common Name(s) 1500041B07Rik; AUTSX3; BB130002; D630021H01Rik; MRX16; MRX79; MRXS13; MRXSL; Mbd5; PPMX; RIKEN cDNA 1500041B07 gene; RIKEN cDNA D630021H01 gene; RS; RTS; RTT; WBP10; expressed sequence BB130002;
Molecular Note Insertion of a neomycin resistance cassette into the gene introduced loxP sites that flank exons 3 and 4, and added an intron and polyadenylation signal from the human beta globin gene. From the mutated allele, Northern blot analysis detected the wild type mature transcript and also a transcript in which the beta globin intron was unspliced. [MGI Ref ID J:67910]

Genotyping

Genotyping Information

Genotyping Protocols

Mecp2tm1Bird, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Guy J; Hendrich B; Holmes M; Martin JE; Bird A. 2001. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27(3):322-6. [PubMed: 11242117]  [MGI Ref ID J:67910]

Additional References

Mecp2tm1Bird related

Chao HT; Chen H; Samaco RC; Xue M; Chahrour M; Yoo J; Neul JL; Gong S; Lu HC; Heintz N; Ekker M; Rubenstein JL; Noebels JL; Rosenmund C; Zoghbi HY. 2010. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468(7321):263-9. [PubMed: 21068835]  [MGI Ref ID J:166851]

Cheval H; Guy J; Merusi C; De Sousa D; Selfridge J; Bird A. 2012. Postnatal inactivation reveals enhanced requirement for MeCP2 at distinct age windows. Hum Mol Genet 21(17):3806-14. [PubMed: 22653753]  [MGI Ref ID J:185982]

Fyffe SL; Neul JL; Samaco RC; Chao HT; Ben-Shachar S; Moretti P; McGill BE; Goulding EH; Sullivan E; Tecott LH; Zoghbi HY. 2008. Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. Neuron 59(6):947-58. [PubMed: 18817733]  [MGI Ref ID J:143360]

Li C; Jiang S; Liu SQ; Lykken E; Zhao LT; Sevilla J; Zhu B; Li QJ. 2014. MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation. Proc Natl Acad Sci U S A 111(27):E2807-16. [PubMed: 24958888]  [MGI Ref ID J:212167]

Maliszewska-Cyna E; Bawa D; Eubanks JH. 2010. Diminished prevalence but preserved synaptic distribution of N-methyl-d-aspartate receptor subunits in the methyl CpG binding protein 2(MeCP2)-null mouse brain. Neuroscience 168(3):624-32. [PubMed: 20381590]  [MGI Ref ID J:161478]

McCauley MD; Wang T; Mike E; Herrera J; Beavers DL; Huang TW; Ward CS; Skinner S; Percy AK; Glaze DG; Wehrens XH; Neul JL. 2011. Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med 3(113):113ra125. [PubMed: 22174313]  [MGI Ref ID J:183640]

McGraw CM; Samaco RC; Zoghbi HY. 2011. Adult neural function requires MeCP2. Science 333(6039):186. [PubMed: 21636743]  [MGI Ref ID J:173307]

Nguyen MV; Du F; Felice CA; Shan X; Nigam A; Mandel G; Robinson JK; Ballas N. 2012. MeCP2 Is Critical for Maintaining Mature Neuronal Networks and Global Brain Anatomy during Late Stages of Postnatal Brain Development and in the Mature Adult Brain. J Neurosci 32(29):10021-34. [PubMed: 22815516]  [MGI Ref ID J:186548]

Peddada S; Yasui DH; LaSalle JM. 2006. Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet 15(12):2003-14. [PubMed: 16682435]  [MGI Ref ID J:112064]

Samaco RC; Fryer JD; Ren J; Fyffe S; Chao HT; Sun Y; Greer JJ; Zoghbi HY; Neul JL. 2008. A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Hum Mol Genet 17(12):1718-27. [PubMed: 18321864]  [MGI Ref ID J:135825]

Samaco RC; Mandel-Brehm C; Chao HT; Ward CS; Fyffe-Maricich SL; Ren J; Hyland K; Thaller C; Maricich SM; Humphreys P; Greer JJ; Percy A; Glaze DG; Zoghbi HY; Neul JL. 2009. Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities. Proc Natl Acad Sci U S A :. [PubMed: 20007372]  [MGI Ref ID J:155808]

Wang X; Lacza Z; Sun YE; Han W. 2014. Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons. Diabetologia 57(1):236-45. [PubMed: 24078059]  [MGI Ref ID J:206489]

Ward CS; Arvide EM; Huang TW; Yoo J; Noebels JL; Neul JL. 2011. MeCP2 Is Critical within HoxB1-Derived Tissues of Mice for Normal Lifespan. J Neurosci 31(28):10359-70. [PubMed: 21753013]  [MGI Ref ID J:174516]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Breeding & HusbandryMutant mice were bred to C57BL/6J mice to generate this congenic strain. When maintaining the live congenic colony, females homozygous for this X-linked mutation can be bred with males hemizygous for this X-linked mutation.
Mating SystemHomozygote x Hemizygote         (Female x Male)   26-JUL-10
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $239.00MaleHemizygous for Mecp2tm1Bird  
$239.00FemaleHomozygous for Mecp2tm1Bird  
Price per Pair (US dollars $)Pair Genotype
$478.00Homozygous for Mecp2tm1Bird x Hemizygous for Mecp2tm1Bird  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)GenderGenotypes Provided
Individual Mouse $310.70MaleHemizygous for Mecp2tm1Bird  
$310.70FemaleHomozygous for Mecp2tm1Bird  
Price per Pair (US dollars $)Pair Genotype
$621.40Homozygous for Mecp2tm1Bird x Hemizygous for Mecp2tm1Bird  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Control Information

  Control
   000664 C57BL/6J
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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