Strain Name:

B6.NZM-Sle1NZM2410/Aeg Sle2NZM2410/Aeg Sle3NZM2410/Aeg/LmoJ

Stock Number:

007228

Order this mouse

Availability:

Repository- Live

Other products are available, see Purchasing Information for Cryopreserved Embryos

Use Restrictions Apply, see Terms of Use
Common Names: B6.NZMSle1/Sle2/Sle3;    
Mice homozygous for the NZM2410 lupus susceptibility QTL (Sle1, Sle2 and Sle3) develop a systemic autoimmunity with fatal glomerulonephritis. Mice from this strain differ from those of NZM2410/J (Stock No. 002676) in that disease onset is slightly delayed with improved breeding and survival. This strain may used in autoimmunity and lupus research.

Description

Strain Information

Former Names BcN/LmoJ    (Changed: 17-APR-13 )
Type Recombinant Congenic (RC);
Additional information on Recombinant Congenic Mice.
Visit our online Nomenclature tutorial.
Mating SystemSibling x Sibling         (Female x Male)   21-JAN-08
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain NZM2410/J
H2 Haplotypeb
GenerationN?+F15 (13-JUL-11)
Generation Definitions

Appearance
Appearance: tan
Related Genotype: a/a Tyrp1b/Tyrp1b Oca2p/Oca2p

Description
Mice homozygous for three NZM2410-derived lupus susceptibility QTLs (Sle1, Sle2, Sle3) on the C57BL/6J background develop a systemic autoimmunity with fatal glomerulonephritis. One hundred percent of mice die by 12 months of age. Death occurs within days of kidney failure. In the days between kidney failure and death, the mice exhibit heavy proteinuria, elevated blood urea nitrogen and generalized edema. In comparison to NZM2410 (see Stock No. 002676), disease onset in this strain is slightly delayed. With about 6% of the NZM2410 genome, BcN/LmoJ is phenotypically similar to NZM2410, but breeding and survival are improved.

Development
Individual congenic strains for three NZM2410/J lupus susceptibility QTL (Sle1, Sle2 and Sle3) were generated by six sucessive backcrosses to C57BL/6J and genotyped using SSLP markers located at the terminal ends of the interval and one internal marker closely linked to the susceptibility locus for each QTL. Additional markers were used to screen each chromosome, and contaminating intervals were identified and selectively eliminated at N3, N4 and N7. Two double congenics, Sle1/Sle2 and Sle1/Sle3, were created by intercross and selection for homozygosity along both congenic intervals. The double congenics then were intercrossed and selected for homozygosity at each QTL to produce this recombinant congenic. This strain was donated to The Jackson Laboratory Repository in 2007 by Dr. Laurence Morel.

In 2013, a SNP (single nucleotide polymorphism) panel analysis, using 16 markers that distinguish C57BL/6 allele-type from NZM2410/J allele-type, was performed on the living colony at The Jackson Laboratory Repository. This showed 12/16 markers were homozygous for C57BL/6 allele-type (one marker each on chromosomes 1 [~52.0 cM], 3, 4 [~10.9 cM], 6, 8, 9, 16, and 19; two markers each on chromosomes 13 and 17). 4/16 markers were homozygous for NZM2410/J allele-type (one marker on chromosome 2 [~27.3 cM], two markers on chromosome 11 [~2.0 cM and ~9.8 cM] and one marker on chromosome 12 [~9.8 cM]). These regions of NZM2410/J are in addition to the Sle1 [chr1; ~76 cM], Sle2 [chr4; ~39 cM] and Sle3 [chr7; ~15 cM] regions selected for during backcrossing onto C57BL/6. Of note, this SNP pattern is identical to all previous SNP test results performed on the living colony at The Jackson Laboratory Repository (2011 and 2012).

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Sle1NZM2410/Aeg allele
021569   B6.Cg-Sle1NZM2410/Aeg Yaa/DcrJ
View Strains carrying   Sle1NZM2410/Aeg     (1 strain)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

Sle1NZM2410/Aeg/Sle1NZM2410/Aeg Sle2NZM2410/Aeg/Sle2NZM2410/Aeg Sle3NZM2410/Aeg/Sle3NZM2410/Aeg

        B6.NZM-Sle1NZM2410/Aeg Sle2NZM2410/Aeg Sle3NZM2410/Aeg/LmoJ
  • hematopoietic system phenotype
  • abnormal marginal zone B cell physiology
    • impaired TI-2 antigen binding capacity   (MGI Ref ID J:138314)
    • increased intrafollicular localization of IgM+ CD1dhi B cells   (MGI Ref ID J:138314)
  • increased marginal zone B cell number
    • increased proportion of B220+ CD1dhi splenic B cells   (MGI Ref ID J:138314)
  • immune system phenotype
  • abnormal marginal zone B cell physiology
    • impaired TI-2 antigen binding capacity   (MGI Ref ID J:138314)
    • increased intrafollicular localization of IgM+ CD1dhi B cells   (MGI Ref ID J:138314)
  • increased marginal zone B cell number
    • increased proportion of B220+ CD1dhi splenic B cells   (MGI Ref ID J:138314)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Sle1NZM2410/Aeg
Allele Name NZM2410/Aeg
Allele Type QTL
Common Name(s) Sle1NZM2410;
Strain of OriginNZM2410/Aeg
Gene Symbol and Name Sle1, systemic lupus erythmatosus susceptibility 1
Chromosome 1
 
Allele Symbol Sle2NZM2410/Aeg
Allele Name NZM2410/Aeg
Allele Type QTL
Common Name(s) Sle.1.2.3; Sle2NZM2410; Sle2z;
Strain of OriginNZM2410/Aeg
Gene Symbol and Name Sle2, systemic lupus erythmatosus susceptibility 2
Chromosome 4
Molecular Note This allele confers susceptibility to glomerulonephritis compared to C57BL/6J. [MGI Ref ID J:25006]
 
Allele Symbol Sle3NZM2410/Aeg
Allele Name NZM2410/Aeg
Allele Type QTL
Common Name(s) Sle3NZM2410;
Strain of OriginNZM2410/Aeg
Gene Symbol and Name Sle3, systemic lupus erythmatosus susceptibility 3
Chromosome 7
Molecular Note This allele confers increased serum IgM and IgG Ab levels and severe glomerulonephritis compared to C57BL/6J. [MGI Ref ID J:52863]

Genotyping

Genotyping Information


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Additional References

Sle1NZM2410/Aeg related

Cuda CM; Li S; Liang S; Yin Y; Potula HH; Xu Z; Sengupta M; Chen Y; Butfiloski E; Baker H; Chang LJ; Dozmorov I; Sobel ES; Morel L. 2012. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol 188(2):604-14. [PubMed: 22180614]  [MGI Ref ID J:180778]

Cuda CM; Wan S; Sobel ES; Croker BP; Morel L. 2007. Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms. J Immunol 179(11):7439-47. [PubMed: 18025188]  [MGI Ref ID J:154964]

Duan B; Niu H; Xu Z; Sharpe AH; Croker BP; Sobel ES; Morel L. 2008. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 88(9):1008-20. [PubMed: 18607347]  [MGI Ref ID J:138314]

Erickson LD; Lin LL; Duan B; Morel L; Noelle RJ. 2003. A genetic lesion that arrests plasma cell homing to the bone marrow. Proc Natl Acad Sci U S A 100(22):12905-10. [PubMed: 14555759]  [MGI Ref ID J:99737]

Jacob CO; Zhu J; Armstrong DL; Yan M; Han J; Zhou XJ; Thomas JA; Reiff A; Myones BL; Ojwang JO; Kaufman KM; Klein-Gitelman M; McCurdy D; Wagner-Weiner L; Silverman E; Ziegler J; Kelly JA; Merrill JT; Harley JB; Ramsey-Goldman R; Vila LM; Bae SC; Vyse TJ;Gilkeson GS; Gaffney PM; Moser KL; Langefeld CD; Zidovetzki R; Mohan C. 2009. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A 106(15):6256-61. [PubMed: 19329491]  [MGI Ref ID J:147757]

Kumar KR; Li L; Yan M; Bhaskarabhatla M; Mobley AB; Nguyen C; Mooney JM; Schatzle JD; Wakeland EK; Mohan C. 2006. Regulation of B cell tolerance by the lupus susceptibility gene Ly108. Science 312(5780):1665-9. [PubMed: 16778059]  [MGI Ref ID J:109640]

Mehrad B; Park SJ; Akangire G; Standiford TJ; Wu T; Zhu J; Mohan C. 2006. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol 176(5):3233-9. [PubMed: 16493084]  [MGI Ref ID J:129410]

Mohan C; Alas E; Morel L; Yang P; Wakeland EK. 1998. Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes. J Clin Invest 101(6):1362-72. [PubMed: 9502778]  [MGI Ref ID J:47099]

Mohan C; Morel L; Yang P; Wakeland EK. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 159(1):454-65. [PubMed: 9200486]  [MGI Ref ID J:41076]

Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565]  [MGI Ref ID J:62719]

Morel L; Mohan C; Yu Y; Schiffenbauer J; Rudofsky UH; Tian N ; Longmate JA ; Wakeland EK. 1999. Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome 10(2):176-81. [PubMed: 9922399]  [MGI Ref ID J:52863]

Morel L; Yu Y; Blenman KR; Caldwell RA; Wakeland EK. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome 7(5):335-9. [PubMed: 8661718]  [MGI Ref ID J:33173]

Panchanathan R; Liu H; Liu H; Fang CM; Erickson LD; Pitha PM; Choubey D. 2012. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. J Immunol 188(1):270-8. [PubMed: 22116829]  [MGI Ref ID J:180587]

Sriram U; Varghese L; Bennett HL; Jog NR; Shivers DK; Ning Y; Behrens EM; Caricchio R; Gallucci S. 2012. Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset. J Immunol 189(1):80-91. [PubMed: 22661089]  [MGI Ref ID J:188939]

Subramanian S; Tus K; Li QZ; Wang A; Tian XH; Zhou J; Liang C; Bartov G; McDaniel LD; Zhou XJ; Schultz RA; Wakeland EK. 2006. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A 103(26):9970-5. [PubMed: 16777955]  [MGI Ref ID J:111064]

Xu Z; Duan B; Croker BP; Morel L. 2006. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 120(2):189-98. [PubMed: 16713741]  [MGI Ref ID J:113234]

Sle2NZM2410/Aeg related

Duan B; Niu H; Xu Z; Sharpe AH; Croker BP; Sobel ES; Morel L. 2008. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 88(9):1008-20. [PubMed: 18607347]  [MGI Ref ID J:138314]

Erickson LD; Lin LL; Duan B; Morel L; Noelle RJ. 2003. A genetic lesion that arrests plasma cell homing to the bone marrow. Proc Natl Acad Sci U S A 100(22):12905-10. [PubMed: 14555759]  [MGI Ref ID J:99737]

Gabriel CL; Smith PB; Mendez-Fernandez YV; Wilhelm AJ; Ye AM; Major AS. 2012. Autoimmune-mediated glucose intolerance in a mouse model of systemic lupus erythematosus. Am J Physiol Endocrinol Metab 303(11):E1313-24. [PubMed: 23032686]  [MGI Ref ID J:192117]

Liu Y; Li L; Kumar KR; Xie C; Lightfoot S; Zhou XJ; Kearney JF; Weigert M; Mohan C. 2007. Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells. J Immunol 179(2):1340-52. [PubMed: 17617627]  [MGI Ref ID J:143003]

Mehrad B; Park SJ; Akangire G; Standiford TJ; Wu T; Zhu J; Mohan C. 2006. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol 176(5):3233-9. [PubMed: 16493084]  [MGI Ref ID J:129410]

Mohan C; Morel L; Yang P; Wakeland EK. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 159(1):454-65. [PubMed: 9200486]  [MGI Ref ID J:41076]

Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565]  [MGI Ref ID J:62719]

Morel L; Rudofsky UH; Longmate JA; Schiffenbauer J; Wakeland EK. 1994. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1(3):219-29. [PubMed: 7889410]  [MGI Ref ID J:25006]

Morel L; Yu Y; Blenman KR; Caldwell RA; Wakeland EK. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome 7(5):335-9. [PubMed: 8661718]  [MGI Ref ID J:33173]

Panchanathan R; Liu H; Liu H; Fang CM; Erickson LD; Pitha PM; Choubey D. 2012. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. J Immunol 188(1):270-8. [PubMed: 22116829]  [MGI Ref ID J:180587]

Sriram U; Varghese L; Bennett HL; Jog NR; Shivers DK; Ning Y; Behrens EM; Caricchio R; Gallucci S. 2012. Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset. J Immunol 189(1):80-91. [PubMed: 22661089]  [MGI Ref ID J:188939]

Xu Z; Butfiloski EJ; Sobel ES; Morel L. 2004. Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2. J Immunol 173(10):6050-8. [PubMed: 15528340]  [MGI Ref ID J:132281]

Xu Z; Duan B; Croker BP; Morel L. 2006. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 120(2):189-98. [PubMed: 16713741]  [MGI Ref ID J:113234]

Xu Z; Vallurupalli A; Fuhrman C; Ostrov D; Morel L. 2011. A New Zealand Black-Derived Locus Suppresses Chronic Graft-versus-Host Disease and Autoantibody Production through Nonlymphoid Bone Marrow-Derived Cells. J Immunol 186(7):4130-9. [PubMed: 21335485]  [MGI Ref ID J:170470]

Sle3NZM2410/Aeg related

Duan B; Niu H; Xu Z; Sharpe AH; Croker BP; Sobel ES; Morel L. 2008. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 88(9):1008-20. [PubMed: 18607347]  [MGI Ref ID J:138314]

Erickson LD; Lin LL; Duan B; Morel L; Noelle RJ. 2003. A genetic lesion that arrests plasma cell homing to the bone marrow. Proc Natl Acad Sci U S A 100(22):12905-10. [PubMed: 14555759]  [MGI Ref ID J:99737]

Jacob CO; Zhu J; Armstrong DL; Yan M; Han J; Zhou XJ; Thomas JA; Reiff A; Myones BL; Ojwang JO; Kaufman KM; Klein-Gitelman M; McCurdy D; Wagner-Weiner L; Silverman E; Ziegler J; Kelly JA; Merrill JT; Harley JB; Ramsey-Goldman R; Vila LM; Bae SC; Vyse TJ;Gilkeson GS; Gaffney PM; Moser KL; Langefeld CD; Zidovetzki R; Mohan C. 2009. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A 106(15):6256-61. [PubMed: 19329491]  [MGI Ref ID J:147757]

Mehrad B; Park SJ; Akangire G; Standiford TJ; Wu T; Zhu J; Mohan C. 2006. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol 176(5):3233-9. [PubMed: 16493084]  [MGI Ref ID J:129410]

Mohan C; Morel L; Yang P; Wakeland EK. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 159(1):454-65. [PubMed: 9200486]  [MGI Ref ID J:41076]

Mohan C; Yu Y; Morel L; Yang P; Wakeland EK. 1999. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J Immunol 162(11):6492-502. [PubMed: 10352264]  [MGI Ref ID J:55031]

Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565]  [MGI Ref ID J:62719]

Morel L; Mohan C; Yu Y; Schiffenbauer J; Rudofsky UH; Tian N ; Longmate JA ; Wakeland EK. 1999. Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome 10(2):176-81. [PubMed: 9922399]  [MGI Ref ID J:52863]

Morel L; Yu Y; Blenman KR; Caldwell RA; Wakeland EK. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome 7(5):335-9. [PubMed: 8661718]  [MGI Ref ID J:33173]

Panchanathan R; Liu H; Liu H; Fang CM; Erickson LD; Pitha PM; Choubey D. 2012. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. J Immunol 188(1):270-8. [PubMed: 22116829]  [MGI Ref ID J:180587]

Peeva E; Gonzalez J; Hicks R; Diamond B. 2006. Cutting edge: lupus susceptibility interval Sle3/5 confers responsiveness to prolactin in C57BL/6 mice. J Immunol 177(3):1401-5. [PubMed: 16849443]  [MGI Ref ID J:137982]

Sriram U; Varghese L; Bennett HL; Jog NR; Shivers DK; Ning Y; Behrens EM; Caricchio R; Gallucci S. 2012. Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset. J Immunol 189(1):80-91. [PubMed: 22661089]  [MGI Ref ID J:188939]

Xu Z; Duan B; Croker BP; Morel L. 2006. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 120(2):189-98. [PubMed: 16713741]  [MGI Ref ID J:113234]

Zhu J; Liu X; Xie C; Yan M; Yu Y; Sobel ES; Wakeland EK; Mohan C. 2005. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J Clin Invest 115(7):1869-78. [PubMed: 15951839]  [MGI Ref ID J:99643]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Room Number           AX10

Colony Maintenance

Mating SystemSibling x Sibling         (Female x Male)   21-JAN-08
Diet Information LabDiet® 5K52/5K67

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


Pricing for USA, Canada and Mexico shipping destinations View International Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $135.00Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $1650.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
Pricing for International shipping destinations View USA Canada and Mexico Pricing

Live Mice

Price per mouse (US dollars $)Gender
Individual Mouse $175.50Female or Male  

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Cryopreserved

Frozen Products

Price (US dollars $)
Frozen Embryo $2145.00

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

Supply Notes

  • Cryopreserved Embryos
    Available to most shipping destinations1
    This strain is also available as cryopreserved embryos2. Orders for cryopreserved embryos may be placed with our Customer Service Department. Experienced technicians at The Jackson Laboratory have recovered frozen embryos of this strain successfully. We will provide you enough embryos to perform two embryo transfers. The Jackson Laboratory does not guarantee successful recovery at your facility. For complete information on purchasing embryos, please visit our Cryopreserved Embryos web page.

    1 Shipments cannot be made to Australia due to Australian government import restrictions.
    2 Embryos for most strains are cryopreserved at the two cell stage while some strains are cryopreserved at the eight cell stage. If this information is important to you, please contact Customer Service.
View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Repository-Live.
Repository-Live represents an exclusive set of over 1800 unique mouse models across a vast array of research areas. Breeding colonies provide mice for large and small orders and fluctuate in size depending on current research demand. If a strain is not immediately available, you will receive an estimated availability timeframe for your inquiry or order in 2-3 business days. Repository strains typically are delivered at 4 to 8 weeks of age. Requests for specific ages will be noted but not guaranteed and we do not accept age requests for breeder pairs. However, if cohorts of mice (5 or more of one gender) are needed at a specific age range for experiments, we will do our best to accommodate your age request.

General Supply Notes

  • This strain is included in the Special Mutant Stock Resource collection.

Control Information

  Control
   None Available
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.


See Terms of Use tab for General Terms and Conditions


The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form

Terms of Use

Terms of Use


General Terms and Conditions


For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

Contact information

General inquiries regarding Terms of Use

Contracts Administration

phone:207-288-6470

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


(6.8)