Strain Name: |
BcN/LmoJ |
|---|---|
Stock Number: |
007228 |
Availability: | Repository- Live |
General Terms and Conditions |
| Strain Common Names | B6.NZMSle1/Sle2/Sle3; |
| Genes & Alleles | Sle1; Sle1NZM2410/Aeg; Sle2; Sle2NZM2410/Aeg; Sle3; Sle3NZM2410/Aeg; |
Type Recombinant Congenic (Rc) Additional information on Recombinant Congenic Mice. Mating System Sibling x Sibling (Female x Male) Species laboratory mouse RI progenitor C57BL/6J NZM2410/J H2 Haplotype b Appearance
Appearance: tan
Related Genotype: a/a Tyrp1b/Tyrp1b Oca2p/Oca2pStrain Description
Mice homozygous for three NZM2410-derived lupus susceptibility QTLs (Sle1, Sle2, Sle3) on the C57BL/6J background develop a systemic autoimmunity with fatal glomerulonephritis. One hundred percent of mice die by 12 months of age. Death occurs within days of kidney failure. In the days between kidney failure and death, the mice exhibit heavy proteinuria, elevated blood urea nitrogen and generalized edema. In comparison to NZM2410 (see Stock No. 002676), disease onset in this strain is slightly delayed. With about 6% of the NZM2410 genome, BcN/LmoJ is phenotypically similar to NZM2410, but breeding and survival are improved.Strain Development
Individual congenic strains for three NZM2410/J lupus susceptibility QTL (Sle1, Sle2 and Sle3) were generated by six sucessive backcrosses to C57BL/6J and genotyped using SSLP markers located at the terminal ends of the interval and one internal marker closely linked to the susceptibility locus for each QTL. Additional markers were used to screen each chromosome, and contaminating intervals were identified and selectively eliminated at N3, N4 and N7. Two double congenics, Sle1/Sle2 and Sle1/Sle3, were created by intercross and selection for homozygosity along both congenic intervals. The double congenics then were intercrossed and selected for homozygosity at each QTL to produce this recombinant congenic. This strain was donated to The Jackson Laboratory Repository in 2007 by Dr. Laurence Morel.
| Allele Symbol | Sle1NZM2410/Aeg | ||
|---|---|---|---|
| Allele Name | NZM2410/Aeg | ||
| Common Name(s) | Sle1NZM2410; | ||
| Strain of Origin | NZM2410/Aeg | ||
| Gene Symbol and Name | Sle1, systemic lupus erythmatosus susceptibility 1 | ||
| Chromosome | 1 | ||
| Allele Symbol | Sle2NZM2410/Aeg | ||
| Allele Name | NZM2410/Aeg | ||
| Common Name(s) | Sle2NZM2410; | ||
| Strain of Origin | NZM2410/Aeg | ||
| Gene Symbol and Name | Sle2, systemic lupus erythmatosus susceptibility 2 | ||
| Chromosome | 4 | ||
| Molecular Note | This allele confers susceptibility to glomerulonephritis compared to C57BL/6J. [MGI Ref ID J:25006] | ||
| Allele Symbol | Sle3NZM2410/Aeg | ||
| Allele Name | NZM2410/Aeg | ||
| Common Name(s) | Sle3NZM2410; | ||
| Strain of Origin | NZM2410/Aeg | ||
| Gene Symbol and Name | Sle3, systemic lupus erythmatosus susceptibility 3 | ||
| Chromosome | 7 | ||
| Molecular Note | This allele confers increased serum IgM and IgG Ab levels and severe glomerulonephritis compared to C57BL/6J. [MGI Ref ID J:52863] | ||
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Room Number AX11
Immunology and Inflammation Research
Autoimmunity (lupus erythematosus)
Selected Reference(s)
Additional ReferencesMorel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565] [MGI Ref ID J:62719]
| Strain Name: | BcN/LmoJ |
| Stock Number: | 007228 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and six weeks of age. This strain is included in the Special Mutant Stock Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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