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| Mice homozygous for the NZM2410 lupus susceptibility QTL (Sle1, Sle2, Sle3) on the C57BL/6J background develop a systemic autoimmunity with fatal glomerulonephritis. In comparison to NZM2410 (see Stock No. 002676), disease onset in this strain is slightly delayed however, breeding and survival are improved. This strain may used in autoimmunity and lupus research. | ||||||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
Strain Information
Former Names BcN/LmoJ (Changed: 17-APR-13 ) Type Recombinant Congenic (RC); Additional information on Recombinant Congenic Mice. Visit our online Nomenclature tutorial. Mating System Sibling x Sibling (Female x Male) 21-JAN-08 Species laboratory mouse Background Strain C57BL/6J Donor Strain NZM2410/J H2 Haplotype b Generation N?+F10 (13-JUL-11)
Generation DefinitionsAppearance
Appearance: tan
Related Genotype: a/a Tyrp1b/Tyrp1b Oca2p/Oca2pDescription
Mice homozygous for three NZM2410-derived lupus susceptibility QTLs (Sle1, Sle2, Sle3) on the C57BL/6J background develop a systemic autoimmunity with fatal glomerulonephritis. One hundred percent of mice die by 12 months of age. Death occurs within days of kidney failure. In the days between kidney failure and death, the mice exhibit heavy proteinuria, elevated blood urea nitrogen and generalized edema. In comparison to NZM2410 (see Stock No. 002676), disease onset in this strain is slightly delayed. With about 6% of the NZM2410 genome, BcN/LmoJ is phenotypically similar to NZM2410, but breeding and survival are improved.Development
Individual congenic strains for three NZM2410/J lupus susceptibility QTL (Sle1, Sle2 and Sle3) were generated by six sucessive backcrosses to C57BL/6J and genotyped using SSLP markers located at the terminal ends of the interval and one internal marker closely linked to the susceptibility locus for each QTL. Additional markers were used to screen each chromosome, and contaminating intervals were identified and selectively eliminated at N3, N4 and N7. Two double congenics, Sle1/Sle2 and Sle1/Sle3, were created by intercross and selection for homozygosity along both congenic intervals. The double congenics then were intercrossed and selected for homozygosity at each QTL to produce this recombinant congenic. This strain was donated to The Jackson Laboratory Repository in 2007 by Dr. Laurence Morel.
Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
Phenotype
Phenotype Information
View Mammalian Phenotype Terms
Mammalian Phenotype Terms provided by MGI
assigned by genotype
Sle1NZM2410/Aeg/Sle1NZM2410/Aeg Sle2NZM2410/Aeg/Sle2NZM2410/Aeg Sle3NZM2410/Aeg/Sle3NZM2410/Aeg
B6.NZM-Sle1NZM2410/Aeg Sle2NZM2410/Aeg Sle3NZM2410/Aeg/LmoJ
- hematopoietic system phenotype
- increased marginal zone B cell number
- increased proportion of B220+ CD1dhi splenic B cells (MGI Ref ID J:138314)
- immune system phenotype
- abnormal marginal zone B cell physiology
- increased marginal zone B cell number
- increased proportion of B220+ CD1dhi splenic B cells (MGI Ref ID J:138314)
This mouse can be used to support research in many areas including:
Immunology, Inflammation and Autoimmunity Research
Autoimmunity
lupus erythematosus
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Sle1NZM2410/Aeg | ||
|---|---|---|---|
| Allele Name | NZM2410/Aeg | ||
| Allele Type | QTL | ||
| Common Name(s) | Sle1NZM2410; | ||
| Strain of Origin | NZM2410/Aeg | ||
| Gene Symbol and Name | Sle1, systemic lupus erythmatosus susceptibility 1 | ||
| Chromosome | 1 | ||
| Allele Symbol | Sle2NZM2410/Aeg | ||
| Allele Name | NZM2410/Aeg | ||
| Allele Type | QTL | ||
| Common Name(s) | Sle.1.2.3; Sle2NZM2410; Sle2z; | ||
| Strain of Origin | NZM2410/Aeg | ||
| Gene Symbol and Name | Sle2, systemic lupus erythmatosus susceptibility 2 | ||
| Chromosome | 4 | ||
| Molecular Note | This allele confers susceptibility to glomerulonephritis compared to C57BL/6J. [MGI Ref ID J:25006] | ||
| Allele Symbol | Sle3NZM2410/Aeg | ||
| Allele Name | NZM2410/Aeg | ||
| Allele Type | QTL | ||
| Common Name(s) | Sle3NZM2410; | ||
| Strain of Origin | NZM2410/Aeg | ||
| Gene Symbol and Name | Sle3, systemic lupus erythmatosus susceptibility 3 | ||
| Chromosome | 7 | ||
| Molecular Note | This allele confers increased serum IgM and IgG Ab levels and severe glomerulonephritis compared to C57BL/6J. [MGI Ref ID J:52863] | ||
References
References provided by MGI
Selected Reference(s)
Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565] [MGI Ref ID J:62719]
Additional References
Stanic AK; Stein CM; Morgan AC; Fazio S; Linton MF; Wakeland EK; Olsen NJ; Major AS. 2006. Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc Natl Acad Sci U S A 103(18):7018-23. [PubMed: 16636270] [MGI Ref ID J:109461]
Xu Z; Duan B; Croker BP; Wakeland EK; Morel L. 2005. Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci. J Immunol 175(2):936-43. [PubMed: 16002692] [MGI Ref ID J:100703]
Sle1NZM2410/Aeg relatedSle2NZM2410/Aeg relatedCuda CM; Li S; Liang S; Yin Y; Potula HH; Xu Z; Sengupta M; Chen Y; Butfiloski E; Baker H; Chang LJ; Dozmorov I; Sobel ES; Morel L. 2012. Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans. J Immunol 188(2):604-14. [PubMed: 22180614] [MGI Ref ID J:180778]
Cuda CM; Wan S; Sobel ES; Croker BP; Morel L. 2007. Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms. J Immunol 179(11):7439-47. [PubMed: 18025188] [MGI Ref ID J:154964]
Duan B; Niu H; Xu Z; Sharpe AH; Croker BP; Sobel ES; Morel L. 2008. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 88(9):1008-20. [PubMed: 18607347] [MGI Ref ID J:138314]
Erickson LD; Lin LL; Duan B; Morel L; Noelle RJ. 2003. A genetic lesion that arrests plasma cell homing to the bone marrow. Proc Natl Acad Sci U S A 100(22):12905-10. [PubMed: 14555759] [MGI Ref ID J:99737]
Jacob CO; Zhu J; Armstrong DL; Yan M; Han J; Zhou XJ; Thomas JA; Reiff A; Myones BL; Ojwang JO; Kaufman KM; Klein-Gitelman M; McCurdy D; Wagner-Weiner L; Silverman E; Ziegler J; Kelly JA; Merrill JT; Harley JB; Ramsey-Goldman R; Vila LM; Bae SC; Vyse TJ;Gilkeson GS; Gaffney PM; Moser KL; Langefeld CD; Zidovetzki R; Mohan C. 2009. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A 106(15):6256-61. [PubMed: 19329491] [MGI Ref ID J:147757]
Kumar KR; Li L; Yan M; Bhaskarabhatla M; Mobley AB; Nguyen C; Mooney JM; Schatzle JD; Wakeland EK; Mohan C. 2006. Regulation of B cell tolerance by the lupus susceptibility gene Ly108. Science 312(5780):1665-9. [PubMed: 16778059] [MGI Ref ID J:109640]
Mehrad B; Park SJ; Akangire G; Standiford TJ; Wu T; Zhu J; Mohan C. 2006. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol 176(5):3233-9. [PubMed: 16493084] [MGI Ref ID J:129410]
Mohan C; Alas E; Morel L; Yang P; Wakeland EK. 1998. Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes. J Clin Invest 101(6):1362-72. [PubMed: 9502778] [MGI Ref ID J:47099]
Mohan C; Morel L; Yang P; Wakeland EK. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 159(1):454-65. [PubMed: 9200486] [MGI Ref ID J:41076]
Morel L; Mohan C; Yu Y; Schiffenbauer J; Rudofsky UH; Tian N ; Longmate JA ; Wakeland EK. 1999. Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome 10(2):176-81. [PubMed: 9922399] [MGI Ref ID J:52863]
Morel L; Yu Y; Blenman KR; Caldwell RA; Wakeland EK. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome 7(5):335-9. [PubMed: 8661718] [MGI Ref ID J:33173]
Panchanathan R; Liu H; Liu H; Fang CM; Erickson LD; Pitha PM; Choubey D. 2012. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. J Immunol 188(1):270-8. [PubMed: 22116829] [MGI Ref ID J:180587]
Sriram U; Varghese L; Bennett HL; Jog NR; Shivers DK; Ning Y; Behrens EM; Caricchio R; Gallucci S. 2012. Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset. J Immunol 189(1):80-91. [PubMed: 22661089] [MGI Ref ID J:188939]
Subramanian S; Tus K; Li QZ; Wang A; Tian XH; Zhou J; Liang C; Bartov G; McDaniel LD; Zhou XJ; Schultz RA; Wakeland EK. 2006. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci U S A 103(26):9970-5. [PubMed: 16777955] [MGI Ref ID J:111064]
Xu Z; Duan B; Croker BP; Morel L. 2006. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 120(2):189-98. [PubMed: 16713741] [MGI Ref ID J:113234]
Sle3NZM2410/Aeg relatedDuan B; Niu H; Xu Z; Sharpe AH; Croker BP; Sobel ES; Morel L. 2008. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 88(9):1008-20. [PubMed: 18607347] [MGI Ref ID J:138314]
Erickson LD; Lin LL; Duan B; Morel L; Noelle RJ. 2003. A genetic lesion that arrests plasma cell homing to the bone marrow. Proc Natl Acad Sci U S A 100(22):12905-10. [PubMed: 14555759] [MGI Ref ID J:99737]
Gabriel CL; Smith PB; Mendez-Fernandez YV; Wilhelm AJ; Ye AM; Major AS. 2012. Autoimmune-mediated glucose intolerance in a mouse model of systemic lupus erythematosus. Am J Physiol Endocrinol Metab 303(11):E1313-24. [PubMed: 23032686] [MGI Ref ID J:192117]
Liu Y; Li L; Kumar KR; Xie C; Lightfoot S; Zhou XJ; Kearney JF; Weigert M; Mohan C. 2007. Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells. J Immunol 179(2):1340-52. [PubMed: 17617627] [MGI Ref ID J:143003]
Mehrad B; Park SJ; Akangire G; Standiford TJ; Wu T; Zhu J; Mohan C. 2006. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol 176(5):3233-9. [PubMed: 16493084] [MGI Ref ID J:129410]
Mohan C; Morel L; Yang P; Wakeland EK. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 159(1):454-65. [PubMed: 9200486] [MGI Ref ID J:41076]
Morel L; Rudofsky UH; Longmate JA; Schiffenbauer J; Wakeland EK. 1994. Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1(3):219-29. [PubMed: 7889410] [MGI Ref ID J:25006]
Morel L; Yu Y; Blenman KR; Caldwell RA; Wakeland EK. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome 7(5):335-9. [PubMed: 8661718] [MGI Ref ID J:33173]
Panchanathan R; Liu H; Liu H; Fang CM; Erickson LD; Pitha PM; Choubey D. 2012. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. J Immunol 188(1):270-8. [PubMed: 22116829] [MGI Ref ID J:180587]
Sriram U; Varghese L; Bennett HL; Jog NR; Shivers DK; Ning Y; Behrens EM; Caricchio R; Gallucci S. 2012. Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset. J Immunol 189(1):80-91. [PubMed: 22661089] [MGI Ref ID J:188939]
Xu Z; Butfiloski EJ; Sobel ES; Morel L. 2004. Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2. J Immunol 173(10):6050-8. [PubMed: 15528340] [MGI Ref ID J:132281]
Xu Z; Duan B; Croker BP; Morel L. 2006. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 120(2):189-98. [PubMed: 16713741] [MGI Ref ID J:113234]
Xu Z; Vallurupalli A; Fuhrman C; Ostrov D; Morel L. 2011. A New Zealand Black-Derived Locus Suppresses Chronic Graft-versus-Host Disease and Autoantibody Production through Nonlymphoid Bone Marrow-Derived Cells. J Immunol 186(7):4130-9. [PubMed: 21335485] [MGI Ref ID J:170470]
Duan B; Niu H; Xu Z; Sharpe AH; Croker BP; Sobel ES; Morel L. 2008. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest 88(9):1008-20. [PubMed: 18607347] [MGI Ref ID J:138314]
Erickson LD; Lin LL; Duan B; Morel L; Noelle RJ. 2003. A genetic lesion that arrests plasma cell homing to the bone marrow. Proc Natl Acad Sci U S A 100(22):12905-10. [PubMed: 14555759] [MGI Ref ID J:99737]
Jacob CO; Zhu J; Armstrong DL; Yan M; Han J; Zhou XJ; Thomas JA; Reiff A; Myones BL; Ojwang JO; Kaufman KM; Klein-Gitelman M; McCurdy D; Wagner-Weiner L; Silverman E; Ziegler J; Kelly JA; Merrill JT; Harley JB; Ramsey-Goldman R; Vila LM; Bae SC; Vyse TJ;Gilkeson GS; Gaffney PM; Moser KL; Langefeld CD; Zidovetzki R; Mohan C. 2009. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A 106(15):6256-61. [PubMed: 19329491] [MGI Ref ID J:147757]
Mehrad B; Park SJ; Akangire G; Standiford TJ; Wu T; Zhu J; Mohan C. 2006. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol 176(5):3233-9. [PubMed: 16493084] [MGI Ref ID J:129410]
Mohan C; Morel L; Yang P; Wakeland EK. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J Immunol 159(1):454-65. [PubMed: 9200486] [MGI Ref ID J:41076]
Mohan C; Yu Y; Morel L; Yang P; Wakeland EK. 1999. Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death. J Immunol 162(11):6492-502. [PubMed: 10352264] [MGI Ref ID J:55031]
Morel L; Mohan C; Yu Y; Schiffenbauer J; Rudofsky UH; Tian N ; Longmate JA ; Wakeland EK. 1999. Multiplex inheritance of component phenotypes in a murine model of lupus. Mamm Genome 10(2):176-81. [PubMed: 9922399] [MGI Ref ID J:52863]
Morel L; Yu Y; Blenman KR; Caldwell RA; Wakeland EK. 1996. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome 7(5):335-9. [PubMed: 8661718] [MGI Ref ID J:33173]
Panchanathan R; Liu H; Liu H; Fang CM; Erickson LD; Pitha PM; Choubey D. 2012. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. J Immunol 188(1):270-8. [PubMed: 22116829] [MGI Ref ID J:180587]
Peeva E; Gonzalez J; Hicks R; Diamond B. 2006. Cutting edge: lupus susceptibility interval Sle3/5 confers responsiveness to prolactin in C57BL/6 mice. J Immunol 177(3):1401-5. [PubMed: 16849443] [MGI Ref ID J:137982]
Sriram U; Varghese L; Bennett HL; Jog NR; Shivers DK; Ning Y; Behrens EM; Caricchio R; Gallucci S. 2012. Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset. J Immunol 189(1):80-91. [PubMed: 22661089] [MGI Ref ID J:188939]
Xu Z; Duan B; Croker BP; Morel L. 2006. STAT4 deficiency reduces autoantibody production and glomerulonephritis in a mouse model of lupus. Clin Immunol 120(2):189-98. [PubMed: 16713741] [MGI Ref ID J:113234]
Zhu J; Liu X; Xie C; Yan M; Yu Y; Sobel ES; Wakeland EK; Mohan C. 2005. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J Clin Invest 115(7):1869-78. [PubMed: 15951839] [MGI Ref ID J:99643]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Mating System Sibling x Sibling (Female x Male) 21-JAN-08 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Individual Mouse $110.00 Female or Male Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Individual Mouse $143.00 Female or Male Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
|
|
|
Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Special Mutant Stock Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| None Available | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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