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Strain Common Names	B6.NZMSle1/Sle2/Sle3;
Genes & Alleles	Sle1;   Sle1NZM2410/Aeg;   Sle2;   Sle2NZM2410/Aeg;   Sle3;   Sle3NZM2410/Aeg;

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Product Information

Strain Details

Type Recombinant Congenic (Rc) Additional information on Recombinant Congenic Mice. Mating System Sibling x Sibling         (Female x Male) Species laboratory mouse RI progenitor C57BL/6J NZM2410/J H2 Haplotype b

Appearance
Appearance: tan
Related Genotype: a/a Tyrp1^b/Tyrp1^b Oca2^p/Oca2^p

Strain Description
Mice homozygous for three NZM2410-derived lupus susceptibility QTLs (Sle1, Sle2, Sle3) on the C57BL/6J background develop a systemic autoimmunity with fatal glomerulonephritis. One hundred percent of mice die by 12 months of age. Death occurs within days of kidney failure. In the days between kidney failure and death, the mice exhibit heavy proteinuria, elevated blood urea nitrogen and generalized edema. In comparison to NZM2410 (see Stock No. 002676), disease onset in this strain is slightly delayed. With about 6% of the NZM2410 genome, BcN/LmoJ is phenotypically similar to NZM2410, but breeding and survival are improved.

Strain Development
Individual congenic strains for three NZM2410/J lupus susceptibility QTL (Sle1, Sle2 and Sle3) were generated by six sucessive backcrosses to C57BL/6J and genotyped using SSLP markers located at the terminal ends of the interval and one internal marker closely linked to the susceptibility locus for each QTL. Additional markers were used to screen each chromosome, and contaminating intervals were identified and selectively eliminated at N3, N4 and N7. Two double congenics, Sle1/Sle2 and Sle1/Sle3, were created by intercross and selection for homozygosity along both congenic intervals. The double congenics then were intercrossed and selected for homozygosity at each QTL to produce this recombinant congenic. This strain was donated to The Jackson Laboratory Repository in 2007 by Dr. Laurence Morel.

Gene & Allele Details

Allele Symbol		Sle1NZM2410/Aeg
Allele Name		NZM2410/Aeg
Common Name(s)		Sle1NZM2410;
Strain of Origin		NZM2410/Aeg
Gene Symbol and Name		Sle1, systemic lupus erythmatosus susceptibility 1
Chromosome		1
Allele Symbol		Sle2NZM2410/Aeg
Allele Name		NZM2410/Aeg
Common Name(s)		Sle2NZM2410;
Strain of Origin		NZM2410/Aeg
Gene Symbol and Name		Sle2, systemic lupus erythmatosus susceptibility 2
Chromosome		4
Molecular Note		This allele confers susceptibility to glomerulonephritis compared to C57BL/6J. [MGI Ref ID J:25006]
Allele Symbol		Sle3NZM2410/Aeg
Allele Name		NZM2410/Aeg
Common Name(s)		Sle3NZM2410;
Strain of Origin		NZM2410/Aeg
Gene Symbol and Name		Sle3, systemic lupus erythmatosus susceptibility 3
Chromosome		7
Molecular Note		This allele confers increased serum IgM and IgG Ab levels and severe glomerulonephritis compared to C57BL/6J. [MGI Ref ID J:52863]

Control Information

	Control
	None Available
Considerations for Choosing Controls

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Animal Health Reports

Room Number           AX11

Research Applications

This mouse can be used to support research in many areas including:

Immunology and Inflammation Research
Autoimmunity (lupus erythematosus)

References

Selected Reference(s)

Morel L; Croker BP; Blenman KR; Mohan C; Huang G; Gilkeson G; Wakeland EK. 2000. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci U S A 97(12):6670-5. [PubMed: 10841565]  [MGI Ref ID J:62719]

Additional References

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Price and Supply Information

Strain Name:	BcN/LmoJ
Stock Number:	007228

Price Details

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Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and six weeks of age. This strain is included in the Special Mutant Stock Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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