Strain Name:

C57BL/6JEi-Chr YAKR/J/Ei

Stock Number:

007250

Availability:

Repository-Cryopreserved

Description

Strain Information

Type Consomic;
Additional information on Consomic Mice.
Specieslaboratory mouse
Background Strain C57BL/6JEiJ
Donor Strain AKR/J
H2 Haplotypeb
GenerationN73pN1
 
Donating Investigator Eva Eicher,   The Jackson Laboratory

Appearance
black

Related Genotype: a/a

Description
This consomic is valuable in the study of sex determination. The TOrl /+ XYAKR/J offspring, from the cross of B6.Cg-TOrl /+ females with C57BL/6JEi-Chr YAKR/J/EiJ males, are sex reversed, with ovarian tissue development.

Development
The Y Chromosome was backcrossed from AKR/J onto C57BL/6JEi through repeated backcrossing. In 2007 sperm were cryopreserved from males at generation N73.

Related Strains

View Strains carrying other alleles of Sry     (6 strains)

Phenotype

Phenotype Information

View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Developmental Biology Research
Internal/Organ Defects (gonads)

Reproductive Biology Research
Developmental Defects Affecting Gonads

Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)
Reproductive Biology Research

Genes & Alleles

Gene & Allele Information

Allele Symbol SryAKR/J
Allele Name sex-determining region of Chr Y- AKR/J
Allele Type Spontaneous
Common Name(s) AKR Y; YAKR;
Strain of OriginAKR/J
Gene Symbol and Name Sry, sex determining region of Chr Y
Chromosome Y
Gene Common Name(s) SRYGENE; TDF; TDY; Tdf; Tdy; testis determining factor; testis determining-Y;
Molecular Note This allele contains all the information necessary and sufficient to initiate normal testis development but is conditionally dysfunctional on the C57BL/6 background. [MGI Ref ID J:44538]

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Selected Reference(s)

Albrecht KH; Eicher EM. 1997. DNA sequence analysis of Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL/6J-Y(POS) sex reversal and defines the SRY functional unit. Genetics 147(3):1267-77. [PubMed: 9383069]  [MGI Ref ID J:44538]

Washburn LL; Albrecht KH; Eicher EM. 2001. C57BL/6J-T-Associated Sex Reversal in Mice Is Caused by Reduced Expression of a Mus domesticus Sry Allele. Genetics 158(4):1675-81. [PubMed: 11514455]  [MGI Ref ID J:71077]

Washburn LL; Eicher EM. 1989. Normal testis determination in the mouse depends on genetic interaction of a locus on chromosome 17 and the Y chromosome. Genetics 123(1):173-9. [PubMed: 2806881]  [MGI Ref ID J:10075]

Additional References

SryAKR/J related

Cattanach BM; Raspberry C; Beechey CV. 1995. XY sex reversal associated with autosomal deletions Mouse Genome 93:426.  [MGI Ref ID J:133266]

Nagamine CM; Carlisle C. 1996. The dominant white spotting oncogene allele Kit(W-42J) exacerbates XY(DOM) sex reversal. Development 122(11):3597-605. [PubMed: 8951075]  [MGI Ref ID J:36829]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations View International pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Additional Supply Details

Pricing for International shipping destinations View USA Canada and Mexico pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Additional Supply Details

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

General Terms and Conditions


See Terms of Use


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General Terms and Conditions


Contact information

General inquiries

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phone:207-288-6470
fax:207-288-6655

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