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| This strain expresses Cre-recombinase in the male germ line. | |||||||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
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Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Former Names B6Ei.129-Tg(Prm-cre)58Og/EiJ (Changed: 10-MAR-08 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N15F2pN1
Generation DefinitionsDescription
Embryonic stem cells containing recombinase transgenes that are expressed in the male germ line, but not in other tissues or in the embryonic stem cells themselves, substantially simplify the production of subtle or conditional mutations in mice. This strain shows that transgenes comprised of the mouse protamine 1 promoter and the Cre recombinase coding sequence mediate the efficient recombination of a Cre target transgene in the male germ line, but not in other tissues. This system can be used for reducing the time, effort, and resources required to produce homologously recombined alleles in mice that have been secondarily rearranged by site-specific recombinase.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
The PrmCre transgene was designed with the mouse protamine 1 promoter upstream of a modified Cre recombinase coding sequence (modified to contain a consensus translation start site, 11 codons for a human c-myc epitope, 7 codons for a minimal simian virus 40 nuclear localization signal, and a polyadenylation signal). This transgene was microinjected into pronuclei of fertilized 129/SvJae oocytes, and the resulting transgenic offspring were bred to 129/SvJae mice. Founder line 58 mice (with a single copy of the transgene) were backcrossed to 129Sv/Jae for many generations prior to arrival at The Jackson Laboratory (as Stock No. 003328. Upon arrival, some mice were backcrossed to C57BL/6EiJ (Stock No. 000924) to generate this congenic colony.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Wild-type from the colony | ||
| 000924 C57BL/6JEiJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Prm-cre)58Og allele
003328 129S/Sv-Tg(Prm-cre)58Og/J View Strains carrying Tg(Prm-cre)58Og (1 strain)
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedResearch Tools
Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Prm-cre)58Og | ||
|---|---|---|---|
| Allele Name | transgene insertion 58, Stephen O'Gorman | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Prm-cre; Prm1cre; PrmCre; TgNPro:Cre; | ||
| Strain of Origin | 129S4/SvJae | ||
| Site of Expression | male germ line | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Prm1, protamine 1, mouse, laboratory | ||
| Gene Symbol and Name | Tg(Prm-cre)58Og, transgene insertion 58, Stephen O'Gorman | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Prm-cre; Prm1cre; PrmCre; | ||
| Driver Note | Prm1 | ||
| Molecular Note | This transgene expresses Cre recombinase under the control of the mouse protamine (Prm1) promoter. The transgene directs expression of Cre recombinase in the male germ cells and not in other tissues. [MGI Ref ID J:67932] | ||
Genotyping
Genotyping Information
Genotyping Protocols
Generic Cre Melt Curve Analysis, Melt Curve Analysis
Generic Cre, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Additional References
Tg(Prm-cre)58Og relatedAdams JW; Wang J; Davis JR; Liaw C; Gaidarov I; Gatlin J; Dalton ND; Gu Y; Ross J Jr; Behan D; Chien K; Connolly D. 2008. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Am J Physiol Heart Circ Physiol 295(2):H509-21. [PubMed: 18539757] [MGI Ref ID J:138227]
An W; Han JS; Schrum CM; Maitra A; Koentgen F; Boeke JD. 2008. Conditional activation of a single-copy L1 transgene in mice by Cre. Genesis 46(7):373-83. [PubMed: 18615728] [MGI Ref ID J:138548]
Atasoy D; Schoch S; Ho A; Nadasy KA; Liu X; Zhang W; Mukherjee K; Nosyreva ED; Fernandez-Chacon R; Missler M; Kavalali ET; Sudhof TC. 2007. Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A 104(7):2525-30. [PubMed: 17287346] [MGI Ref ID J:117978]
Baek WY; de Crombrugghe B; Kim JE. 2010. Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance. Bone 46(4):920-8. [PubMed: 20026264] [MGI Ref ID J:162059]
Bark C; Bellinger FP; Kaushal A; Mathews JR; Partridge LD; Wilson MC. 2004. Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission. J Neurosci 24(40):8796-805. [PubMed: 15470145] [MGI Ref ID J:94005]
Batista F; Lu L; Williams SA; Stanley P. 2012. Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis. Biol Reprod 86(6):179. [PubMed: 22492969] [MGI Ref ID J:185823]
Bharti K; Gasper M; Ou J; Brucato M; Clore-Gronenborn K; Pickel J; Amheiter H. 2012. A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development PLoS Genet :1-59. [MGI Ref ID J:182723]
Bhattaram P; Penzo-Mendez A; Sock E; Colmenares C; Kaneko KJ; Vassilev A; Depamphilis ML; Wegner M; Lefebvre V. 2010. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1:9. [PubMed: 20596238] [MGI Ref ID J:175338]
Brade T; Kumar S; Cunningham TJ; Chatzi C; Zhao X; Cavallero S; Li P; Sucov HM; Ruiz-Lozano P; Duester G. 2011. Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development 138(1):139-48. [PubMed: 21138976] [MGI Ref ID J:167039]
Brenner S; Drewel D; Steinbart T; Weisel F; Hartel E; Potzsch S; Welzel H; Brandl A; Yu P; Mudde GC; Schweizer A; Nitschke L; Winkler TH. 2011. A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing. EMBO J 30(13):2705-18. [PubMed: 21623346] [MGI Ref ID J:174233]
Cai CL; Zhou W; Yang L; Bu L; Qyang Y; Zhang X; Li X; Rosenfeld MG; Chen J; Evans S. 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132(10):2475-87. [PubMed: 15843407] [MGI Ref ID J:98516]
Chaboissier MC; Kobayashi A; Vidal VI; Lutzkendorf S; van de Kant HJ; Wegner M; de Rooij DG; Behringer RR; Schedl A. 2004. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131(9):1891-901. [PubMed: 15056615] [MGI Ref ID J:89368]
Chandra S; Fornai F; Kwon HB; Yazdani U; Atasoy D; Liu X; Hammer RE; Battaglia G; German DC; Castillo PE; Sudhof TC. 2004. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A 101(41):14966-71. [PubMed: 15465911] [MGI Ref ID J:93544]
Chang YF; Lee-Chang JS; Harris KY; Sinha-Hikim AP; Rao MK. 2011. Role of beta-catenin in post-meiotic male germ cell differentiation. PLoS One 6(11):e28039. [PubMed: 22125654] [MGI Ref ID J:180951]
Chang YF; Lee-Chang JS; Imam JS; Buddavarapu KC; Subaran SS; Sinha-Hikim AP; Gorospe M; Rao MK. 2012. Interaction between microRNAs and actin-associated protein Arpc5 regulates translational suppression during male germ cell differentiation. Proc Natl Acad Sci U S A 109(15):5750-5. [PubMed: 22447776] [MGI Ref ID J:183553]
Chau BN; Borges HL; Chen TT; Masselli A; Hunton IC; Wang JY. 2002. Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol 4(10):757-65. [PubMed: 12360286] [MGI Ref ID J:80087]
Chen JW; Zhou B; Yu QC; Shin SJ; Jiao K; Schneider MD; Baldwin HS; Bergelson JM. 2006. Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves. Circ Res 98(7):923-30. [PubMed: 16543498] [MGI Ref ID J:121400]
Cheng A; Arumugam TV; Liu D; Khatri RG; Mustafa K; Kwak S; Ling HP; Gonzales C; Xin O; Jo DG; Guo Z; Mark RJ; Mattson MP. 2007. Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. J Neurosci 27(7):1519-28. [PubMed: 17301160] [MGI Ref ID J:118333]
Cheng H; Zheng M; Peter AK; Kimura K; Li X; Ouyang K; Shen T; Cui L; Frank D; Dalton ND; Gu Y; Frey N; Peterson KL; Evans SM; Knowlton KU; Sheikh F; Chen J. 2011. Selective deletion of long but not short Cypher isoforms leads to late-onset dilated cardiomyopathy. Hum Mol Genet 20(9):1751-62. [PubMed: 21303826] [MGI Ref ID J:170494]
Crone SA; Quinlan KA; Zagoraiou L; Droho S; Restrepo CE; Lundfald L; Endo T; Setlak J; Jessell TM; Kiehn O; Sharma K. 2008. Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron 60(1):70-83. [PubMed: 18940589] [MGI Ref ID J:145621]
Crone SA; Viemari JC; Droho S; Mrejeru A; Ramirez JM; Sharma K. 2012. Irregular Breathing in Mice following Genetic Ablation of V2a Neurons. J Neurosci 32(23):7895-906. [PubMed: 22674265] [MGI Ref ID J:185186]
Debbache J; Zaidi MR; Davis S; Guo T; Bismuth K; Wang X; Skuntz S; Maric D; Pickel J; Meltzer P; Merlino G; Arnheiter H. 2012. In vivo Role of Alternative Splicing and Serine Phosphorylation of the Microphthalmia-associated Transcription Factor MITF. Genetics :. [PubMed: 22367038] [MGI Ref ID J:182722]
Debruyne JP; Noton E; Lambert CM; Maywood ES; Weaver DR; Reppert SM. 2006. A clock shock: mouse CLOCK is not required for circadian oscillator function. Neuron 50(3):465-77. [PubMed: 16675400] [MGI Ref ID J:109634]
Dendouga N; Gao H; Moechars D; Janicot M; Vialard J; McGowan CH. 2005. Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. Mol Cell Biol 25(17):7569-79. [PubMed: 16107704] [MGI Ref ID J:100407]
Dickendesher TL; Baldwin KT; Mironova YA; Koriyama Y; Raiker SJ; Askew KL; Wood A; Geoffroy CG; Zheng B; Liepmann CD; Katagiri Y; Benowitz LI; Geller HM; Giger RJ. 2012. NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci 15(5):703-12. [PubMed: 22406547] [MGI Ref ID J:191258]
Dominguez D; Tournoy J; Hartmann D; Huth T; Cryns K; Deforce S; Serneels L; Camacho IE; Marjaux E; Craessaerts K; Roebroek AJ; Schwake M; D'Hooge R; Bach P; Kalinke U; Moechars D; Alzheimer C; Reiss K; Saftig P; De Strooper B. 2005. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem 280(35):30797-806. [PubMed: 15987683] [MGI Ref ID J:100925]
Dy P; Han Y; Lefebvre V. 2008. Generation of mice harboring a Sox5 conditional null allele. Genesis 46(6):294-9. [PubMed: 18543318] [MGI Ref ID J:137217]
Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 341(2):346-59. [PubMed: 20206616] [MGI Ref ID J:160493]
Fernandes HB; Catches JS; Petralia RS; Copits BA; Xu J; Russell TA; Swanson GT; Contractor A. 2009. High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. Neuron 63(6):818-29. [PubMed: 19778510] [MGI Ref ID J:155003]
Francis SM; Bergsied J; Isaac CE; Coschi CH; Martens AL; Hojilla CV; Chakrabarti S; Dimattia GE; Khoka R; Wang JY; Dick FA. 2009. A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol 29(16):4455-66. [PubMed: 19506017] [MGI Ref ID J:151417]
Gao X; Tate P; Hu P; Tjian R; Skarnes WC; Wang Z. 2008. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A 105(18):6656-61. [PubMed: 18448678] [MGI Ref ID J:134633]
Gao Z; Huang Z; Olivey HE; Gurbuxani S; Crispino JD; Svensson EC. 2010. FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis. EMBO J 29(2):457-68. [PubMed: 20010697] [MGI Ref ID J:156475]
Garcia-Galiano D; van Ingen Schenau D; Leon S; Krajnc-Franken MA; Manfredi-Lozano M; Romero-Ruiz A; Navarro VM; Gaytan F; van Noort PI; Pinilla L; Blomenrohr M; Tena-Sempere M. 2012. Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology 153(1):316-28. [PubMed: 22067321] [MGI Ref ID J:181650]
Gazit R; Gruda R; Elboim M; Arnon TI; Katz G; Achdout H; Hanna J; Qimron U; Landau G; Greenbaum E; Zakay-Rones Z; Porgador A; Mandelboim O. 2006. Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1. Nat Immunol 7(5):517-23. [PubMed: 16565719] [MGI Ref ID J:112394]
Guan X; Shi X; Li X; Chang B; Wang Y; Li D; Chan L. 2012. GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab 303(7):E853-64. [PubMed: 22829581] [MGI Ref ID J:189593]
Harada K; Truong AB; Cai T; Khavari PA. 2005. The class II phosphoinositide 3-kinase C2beta is not essential for epidermal differentiation. Mol Cell Biol 25(24):11122-30. [PubMed: 16314532] [MGI Ref ID J:103754]
Hartman HB; Lai K; Evans MJ. 2009. Loss of small heterodimer partner expression in the liver protects against dyslipidemia. J Lipid Res 50(2):193-203. [PubMed: 18820241] [MGI Ref ID J:149005]
Hellsten E; Evans JP; Bernard DJ; Janne PA; Nussbaum RL. 2001. Disrupted sperm function and fertilin beta processing in mice deficient in the inositol polyphosphate 5-phosphatase Inpp5b. Dev Biol 240(2):641-53. [PubMed: 11784089] [MGI Ref ID J:73678]
Hodges CA; Cotton CU; Palmert MR; Drumm ML. 2008. Generation of a conditional null allele for Cftr in mice. Genesis 46(10):546-52. [PubMed: 18802965] [MGI Ref ID J:142723]
Howng SY; Avila RL; Emery B; Traka M; Lin W; Watkins T; Cook S; Bronson R; Davisson M; Barres BA; Popko B. 2010. ZFP191 is required by oligodendrocytes for CNS myelination. Genes Dev 24(3):301-11. [PubMed: 20080941] [MGI Ref ID J:156938]
Hu X; Atzler D; Xu X; Zhang P; Guo H; Lu Z; Fassett J; Schwedhelm E; Boger RH; Bache RJ; Chen Y. 2011. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol 31(7):1540-6. [PubMed: 21493890] [MGI Ref ID J:182373]
Izvolsky KI; Lu J; Martin G; Albrecht KH; Cardoso WV. 2008. Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis. Genesis 46(1):8-18. [PubMed: 18196599] [MGI Ref ID J:135241]
Johansson JU; Ericsson J; Janson J; Beraki S; Stanic D; Mandic SA; Wikstrom MA; Hokfelt T; Ogren SO; Rozell B; Berggren PO; Bark C. 2008. An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet 4(11):e1000278. [PubMed: 19043548] [MGI Ref ID J:142096]
Jonassen JA; San Agustin J; Follit JA; Pazour GJ. 2008. Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 183(3):377-84. [PubMed: 18981227] [MGI Ref ID J:141071]
Jones-Mason ME; Zhao X; Kappes D; Lasorella A; Iavarone A; Zhuang Y. 2012. E protein transcription factors are required for the development of CD4(+) lineage T cells. Immunity 36(3):348-61. [PubMed: 22425249] [MGI Ref ID J:187334]
Kaeser PS; Deng L; Chavez AE; Liu X; Castillo PE; Sudhof TC. 2009. ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron 64(2):227-39. [PubMed: 19874790] [MGI Ref ID J:155764]
Kaeser PS; Kwon HB; Chiu CQ; Deng L; Castillo PE; Sudhof TC. 2008. RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. J Neurosci 28(50):13435-47. [PubMed: 19074017] [MGI Ref ID J:143053]
Karamitros D; Kotantaki P; Lygerou Z; Veiga-Fernandes H; Pachnis V; Kioussis D; Taraviras S. 2010. Differential geminin requirement for proliferation of thymocytes and mature T cells. J Immunol 184(5):2432-41. [PubMed: 20107189] [MGI Ref ID J:159657]
Kim IS; Lee M; Park KC; Jeon Y; Park JH; Hwang EJ; Jeon TI; Ko S; Lee H; Baek SH; Kim KI. 2012. Roles of Mis18alpha in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell 46(3):260-73. [PubMed: 22516971] [MGI Ref ID J:188023]
Kim JD; Kang K; Kim J. 2009. YY1's role in DNA methylation of Peg3 and Xist. Nucleic Acids Res 37(17):5656-64. [PubMed: 19628663] [MGI Ref ID J:173022]
Kim Y; Kobayashi A; Sekido R; DiNapoli L; Brennan J; Chaboissier MC; Poulat F; Behringer RR; Lovell-Badge R; Capel B. 2006. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4(6):e187. [PubMed: 16700629] [MGI Ref ID J:110252]
Kimura H; Kwan KM; Zhang Z; Deng JM; Darnay BG; Behringer RR; Nakamura T; de Crombrugghe B; Akiyama H. 2008. Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS ONE 3(9):e3174. [PubMed: 18779865] [MGI Ref ID J:143940]
Kobuke K; Piccolo F; Garringer KW; Moore SA; Sweezer E; Yang B; Campbell KP. 2008. A Common Disease-Associated Missense Mutation in Alpha-Sarcoglycan Fails to Cause Muscular Dystrophy in Mice. Hum Mol Genet :. [PubMed: 18252746] [MGI Ref ID J:130252]
Kostetskii I; Li J; Xiong Y; Zhou R; Ferrari VA; Patel VV; Molkentin JD; Radice GL. 2005. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res 96(3):346-54. [PubMed: 15662031] [MGI Ref ID J:98828]
Lee S; Lee DK; Dou Y; Lee J; Lee B; Kwak E; Kong YY; Lee SK; Roeder RG; Lee JW. 2006. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A 103(42):15392-7. [PubMed: 17021013] [MGI Ref ID J:116064]
Leland S; Nagarajan P; Polyzos A; Thomas S; Samaan G; Donnell R; Marchetti F; Venkatachalam S. 2009. Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice. Proc Natl Acad Sci U S A 106(31):12776-81. [PubMed: 19617567] [MGI Ref ID J:151880]
Li H; Wang D; Singh LS; Berk M; Tan H; Zhao Z; Steinmetz R; Kirmani K; Wei G; Xu Y. 2009. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 4(5):e5705. [PubMed: 19479052] [MGI Ref ID J:149315]
Li H; Wang Z; Wang B; Guo Q; Dolios G; Tabuchi K; Hammer RE; Sudhof TC; Wang R; Zheng H. 2010. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem 285(40):30598-605. [PubMed: 20693289] [MGI Ref ID J:166379]
Li X; Zima AV; Sheikh F; Blatter LA; Chen J. 2005. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice. Circ Res 96(12):1274-81. [PubMed: 15933266] [MGI Ref ID J:110271]
Li Z; Cai X; Cai CL; Wang J; Zhang W; Petersen BE; Yang FC; Xu M. 2011. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 118(17):4509-18. [PubMed: 21803851] [MGI Ref ID J:178415]
Liang X; Sun Y; Ye M; Scimia MC; Cheng H; Martin J; Wang G; Rearden A; Wu C; Peterson KL; Powell HC; Evans SM; Chen J. 2009. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation 120(7):568-76. [PubMed: 19652092] [MGI Ref ID J:167114]
Liang X; Zhou Q; Li X; Sun Y; Lu M; Dalton N; Ross J Jr; Chen J. 2005. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol 25(8):3056-62. [PubMed: 15798193] [MGI Ref ID J:97635]
Ling H; Zhang T; Pereira L; Means CK; Cheng H; Gu Y; Dalton ND; Peterson KL; Chen J; Bers D; Heller Brown J. 2009. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest 119(5):1230-40. [PubMed: 19381018] [MGI Ref ID J:149675]
Liodis P; Denaxa M; Grigoriou M; Akufo-Addo C; Yanagawa Y; Pachnis V. 2007. Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci 27(12):3078-89. [PubMed: 17376969] [MGI Ref ID J:119476]
Lou Y; Javed A; Hussain S; Colby J; Frederick D; Pratap J; Xie R; Gaur T; van Wijnen AJ; Jones SN; Stein GS; Lian JB; Stein JL. 2009. A Runx2 threshold for the cleidocranial dysplasia phenotype. Hum Mol Genet 18(3):556-68. [PubMed: 19028669] [MGI Ref ID J:143532]
Lozovatsky L; Abayasekara N; Piawah S; Walther Z. 2009. CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. Mol Biol Cell 20(21):4489-99. [PubMed: 19726564] [MGI Ref ID J:164479]
Lyu YL; Wang JC. 2003. Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A 100(12):7123-8. [PubMed: 12773624] [MGI Ref ID J:94879]
Marchlik E; Thakker P; Carlson T; Jiang Z; Ryan M; Marusic S; Goutagny N; Kuang W; Askew GR; Roberts V; Benoit S; Zhou T; Ling V; Pfeifer R; Stedman N; Fitzgerald KA; Lin LL; Hall JP. 2010. Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality. J Leukoc Biol 88(6):1171-80. [PubMed: 20651301] [MGI Ref ID J:166476]
Mark MD; Maejima T; Kuckelsberg D; Yoo JW; Hyde RA; Shah V; Gutierrez D; Moreno RL; Kruse W; Noebels JL; Herlitze S. 2011. Delayed Postnatal Loss of P/Q-Type Calcium Channels Recapitulates the Absence Epilepsy, Dyskinesia, and Ataxia Phenotypes of Genomic Cacna1A Mutations. J Neurosci 31(11):4311-26. [PubMed: 21411672] [MGI Ref ID J:170451]
Masubuchi S; Gao T; O'Neill A; Eckel-Mahan K; Newton AC; Sassone-Corsi P. 2010. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proc Natl Acad Sci U S A :. [PubMed: 20080691] [MGI Ref ID J:156530]
Morabito MV; Abbas AI; Hood JL; Kesterson RA; Jacobs MM; Kump DS; Hachey DL; Roth BL; Emeson RB. 2010. Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome. Neurobiol Dis 39(2):169-80. [PubMed: 20394819] [MGI Ref ID J:163043]
O'Donnell N; Zachara NE; Hart GW; Marth JD. 2004. Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol 24(4):1680-90. [PubMed: 14749383] [MGI Ref ID J:93112]
O'Gorman S; Dagenais NA; Qian M; Marchuk Y. 1997. Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc Natl Acad Sci U S A 94(26):14602-7. [PubMed: 9405659] [MGI Ref ID J:67932]
Olive KP; Tuveson DA; Ruhe ZC; Yin B; Willis NA; Bronson RT; Crowley D; Jacks T. 2004. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119(6):847-60. [PubMed: 15607980] [MGI Ref ID J:95316]
Paulusma CC; Van der Kruijssen CM; Van den Eijnden-Van Raaij AJ. 1994. Localization of activin subunits in early murine development determined by subunit-specific antibodies. J Immunol Methods 169(2):143-52. [PubMed: 8133077] [MGI Ref ID J:17302]
Penzo-Mendez A; Dy P; Pallavi B; Lefebvre V. 2007. Generation of mice harboring a Sox4 conditional null allele. Genesis 45(12):776-80. [PubMed: 18064674] [MGI Ref ID J:130461]
Potter KA; Kern MJ; Fullbright G; Bielawski J; Scherer SS; Yum SW; Li JJ; Cheng H; Han X; Venkata JK; Akbar Ali Khan P; Rohrer B; Hama H. 2011. Central nervous system dysfunction in a mouse model of Fa2h deficiency. Glia 59(7):1009-21. [PubMed: 21491498] [MGI Ref ID J:171655]
Puckelwartz MJ; Kessler E; Zhang Y; Hodzic D; Randles KN; Morris G; Earley JU; Hadhazy M; Holaska JM; Mewborn SK; Pytel P; McNally EM. 2009. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum Mol Genet 18(4):607-20. [PubMed: 19008300] [MGI Ref ID J:144757]
Puschendorf M; Terranova R; Boutsma E; Mao X; Isono K; Brykczynska U; Kolb C; Otte AP; Koseki H; Orkin SH; van Lohuizen M; Peters AH. 2008. PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet 40(4):411-20. [PubMed: 18311137] [MGI Ref ID J:134477]
Rajan I; Read R; Small DL; Perrard J; Vogel P. 2011. An alternative splicing variant in Clcn7-/- mice prevents osteopetrosis but not neural and retinal degeneration. Vet Pathol 48(3):663-75. [PubMed: 20448277] [MGI Ref ID J:186049]
Reginensi A; Clarkson M; Neirijnck Y; Lu B; Ohyama T; Groves AK; Sock E; Wegner M; Costantini F; Chaboissier MC; Schedl A. 2011. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet 20(6):1143-53. [PubMed: 21212101] [MGI Ref ID J:168845]
Ricke RM; Jeganathan KB; Malureanu L; Harrison AM; van Deursen JM. 2012. Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol 199(6):931-49. [PubMed: 23209306] [MGI Ref ID J:195237]
Schaff UY; Shih HH; Lorenz M; Sako D; Kriz R; Milarski K; Bates B; Tchernychev B; Shaw GD; Simon SI. 2008. SLIC-1/sorting nexin 20: A novel sorting nexin that directs subcellular distribution of PSGL-1. Eur J Immunol 38(2):550-64. [PubMed: 18196517] [MGI Ref ID J:131282]
Schoch S; Mittelstaedt T; Kaeser PS; Padgett D; Feldmann N; Chevaleyre V; Castillo PE; Hammer RE; Han W; Schmitz F; Lin W; Sudhof TC. 2006. Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J 25(24):5852-63. [PubMed: 17124501] [MGI Ref ID J:119934]
Seidler B; Schmidt A; Mayr U; Nakhai H; Schmid RM; Schneider G; Saur D. 2008. A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. Proc Natl Acad Sci U S A 105(29):10137-42. [PubMed: 18621715] [MGI Ref ID J:140423]
Seifert EL; Caron AZ; Morin K; Coulombe J; Hong He X; Jardine K; Dewar-Darch D; Boekelheide K; Harper ME; McBurney MW. 2012. SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice. FASEB J 26(2):555-66. [PubMed: 22006156] [MGI Ref ID J:180628]
Seymour PA; Freude KK; Dubois CL; Shih HP; Patel NA; Sander M. 2008. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol 323(1):19-30. [PubMed: 18723011] [MGI Ref ID J:141017]
Sharma K; Leonard AE; Lettieri K; Pfaff SL. 2000. Genetic and epigenetic mechanisms contribute to motor neuron pathfinding. Nature 406(6795):515-9. [PubMed: 10952312] [MGI Ref ID J:63774]
Shaw AT; Meissner A; Dowdle JA; Crowley D; Magendantz M; Ouyang C; Parisi T; Rajagopal J; Blank LJ; Bronson RT; Stone JR; Tuveson DA; Jaenisch R; Jacks T. 2007. Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis. Genes Dev 21(6):694-707. [PubMed: 17369402] [MGI Ref ID J:119477]
St Amand TR; Lu JT; Zamora M; Gu Y; Stricker J; Hoshijima M; Epstein JA; Ross JJ Jr; Ruiz-Lozano P; Chien KR. 2006. Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development. Dev Biol 291(2):208-17. [PubMed: 16430881] [MGI Ref ID J:107057]
Stark KL; Xu B; Bagchi A; Lai WS; Liu H; Hsu R; Wan X; Pavlidis P; Mills AA; Karayiorgou M; Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40(6):751-60. [PubMed: 18469815] [MGI Ref ID J:136969]
Starremans PG; Li X; Finnerty PE; Guo L; Takakura A; Neilson EG; Zhou J. 2008. A mouse model for polycystic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1. Kidney Int 73(12):1394-405. [PubMed: 18385665] [MGI Ref ID J:140012]
Stewart R; Flechner L; Montminy M; Berdeaux R. 2011. CREB is activated by muscle injury and promotes muscle regeneration. PLoS One 6(9):e24714. [PubMed: 21931825] [MGI Ref ID J:177923]
Su X; Paris M; Gi YJ; Tsai KY; Cho MS; Lin YL; Biernaskie JA; Sinha S; Prives C; Pevny LH; Miller FD; Flores ER. 2009. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75. [PubMed: 19570515] [MGI Ref ID J:151638]
Sumara G; Formentini I; Collins S; Sumara I; Windak R; Bodenmiller B; Ramracheya R; Caille D; Jiang H; Platt KA; Meda P; Aebersold R; Rorsman P; Ricci R. 2009. Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell 136(2):235-48. [PubMed: 19135240] [MGI Ref ID J:146185]
Tadjali M; Zhou S; Rehg J; Sorrentino BP. 2006. Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele. Stem Cells 24(6):1556-63. [PubMed: 16484343] [MGI Ref ID J:128682]
Takagi Y; Mitsui A; Nishiyama A; Nozaki K; Sono H; Gon Y; Hashimoto N; Yodoi J. 1999. Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage. Proc Natl Acad Sci U S A 96(7):4131-6. [PubMed: 10097175] [MGI Ref ID J:108918]
Teves ME; Jha KN; Song J; Nagarkatti-Gude DR; Herr JC; Foster JA; Strauss JF 3rd; Zhang Z. 2013. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. Andrology 1(1):37-46. [PubMed: 23258628] [MGI Ref ID J:194944]
Usdin TB; Paciga M; Riordan T; Kuo J; Parmelee A; Petukova G; Camerini-Otero RD; Mezey E. 2008. Tuberoinfundibular Peptide of 39 residues is required for germ cell development. Endocrinology 149(9):4292-300. [PubMed: 18483145] [MGI Ref ID J:138142]
Verhulst PJ; De Smet B; Saels I; Thijs T; Ver Donck L; Moechars D; Peeters TL; Depoortere I. 2008. Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice. Gastroenterology 135(4):1267-76. [PubMed: 18657539] [MGI Ref ID J:141985]
Vidal VP; Chaboissier MC; Lutzkendorf S; Cotsarelis G; Mill P; Hui CC; Ortonne N; Ortonne JP; Schedl A. 2005. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol 15(15):1340-51. [PubMed: 16085486] [MGI Ref ID J:100131]
Vincent SD; Dunn NR; Hayashi S; Norris DP; Robertson EJ. 2003. Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev 17(13):1646-62. [PubMed: 12842913] [MGI Ref ID J:84300]
Vissel B; Royle GA; Christie BR; Schiffer HH; Ghetti A; Tritto T; Perez-Otano I; Radcliffe RA; Seamans J; Sejnowski T; Wehner JM; Collins AC; O'Gorman S; Heinemann SF. 2001. The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 29(1):217-27. [PubMed: 11182093] [MGI Ref ID J:107698]
Vogel P; Donoviel MS; Read R; Hansen GM; Hazlewood J; Anderson SJ; Sun W; Swaffield J; Oravecz T. 2009. Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS ONE 4(1):e4112. [PubMed: 19119317] [MGI Ref ID J:145159]
Von Coelln R; Thomas B; Savitt JM; Lim KL; Sasaki M; Hess EJ; Dawson VL; Dawson TM. 2004. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci U S A 101(29):10744-9. [PubMed: 15249681] [MGI Ref ID J:91487]
Wang C; Lee JE; Cho YW; Xiao Y; Jin Q; Liu C; Ge K. 2012. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A 109(38):15324-9. [PubMed: 22949634] [MGI Ref ID J:190157]
Wang CC; Held RG; Chang SC; Yang L; Delpire E; Ghosh A; Hall BJ. 2011. A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function. Neuron 72(5):789-805. [PubMed: 22153375] [MGI Ref ID J:178913]
Weinert S; Bergmann N; Luo X; Erdmann B; Gotthardt M. 2006. M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol 173(4):559-70. [PubMed: 16702235] [MGI Ref ID J:111284]
Wijshake T; Malureanu LA; Baker DJ; Jeganathan KB; van de Sluis B; van Deursen JM. 2012. Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. PLoS Genet 8(12):e1003138. [PubMed: 23300461] [MGI Ref ID J:194926]
Williams G; Wood A; Williams EJ; Gao Y; Mercado ML; Katz A; Joseph-McCarthy D; Bates B; Ling HP; Aulabaugh A; Zaccardi J; Xie Y; Pangalos MN; Walsh FS; Doherty P. 2008. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem 283(24):16641-52. [PubMed: 18411262] [MGI Ref ID J:138580]
Winden KD; Oldham MC; Mirnics K; Ebert PJ; Swan CH; Levitt P; Rubenstein JL; Horvath S; Geschwind DH. 2009. The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol 5:291. [PubMed: 19638972] [MGI Ref ID J:160728]
Xiao G; Cheng H; Cao H; Chen K; Tu Y; Yu S; Jiao H; Yang S; Im HJ; Chen D; Chen J; Wu C. 2012. Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling. J Biol Chem 287(25):21450-60. [PubMed: 22556421] [MGI Ref ID J:186501]
Yamamoto K; Wang Y; Jiang W; Liu X; Dubois RL; Lin CS; Ludwig T; Bakkenist CJ; Zha S. 2012. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J Cell Biol 198(3):305-13. [PubMed: 22869596] [MGI Ref ID J:191288]
Yang J; Goldstein JL; Hammer RE; Moon YA; Brown MS; Horton JD. 2001. Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci U S A 98(24):13607-12. [PubMed: 11717426] [MGI Ref ID J:72930]
Yang L; Cai CL; Lin L; Qyang Y; Chung C; Monteiro RM; Mummery CL; Fishman GI; Cogen A; Evans S. 2006. Isl1Cre reveals a common Bmp pathway in heart and limb development. Development 133(8):1575-85. [PubMed: 16556916] [MGI Ref ID J:107396]
Yao J; Le TC; Kos CH; Henderson JM; Allen PG; Denker BM; Pollak MR. 2004. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol 2(6):787-94. [PubMed: 15208719] [MGI Ref ID J:90755]
Yin Y; Lin C; Kim ST; Roig I; Chen H; Liu L; Veith GM; Jin RU; Keeney S; Jasin M; Moley K; Zhou P; Ma L. 2011. The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol 356(1):51-62. [PubMed: 21624359] [MGI Ref ID J:175255]
Zhang J; Felder A; Liu Y; Guo LT; Lange S; Dalton ND; Gu Y; Peterson KL; Mizisin AP; Shelton GD; Lieber RL; Chen J. 2010. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet 19(2):329-41. [PubMed: 19864491] [MGI Ref ID J:155342]
Zhang J; Wang Y; Chi Z; Keuss MJ; Pai YM; Kang HC; Shin JH; Bugayenko A; Wang H; Xiong Y; Pletnikov MV; Mattson MP; Dawson TM; Dawson VL. 2011. The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. Cell 145(2):284-99. [PubMed: 21496646] [MGI Ref ID J:173768]
Zhang X; Heaney S; Maas RL. 2003. Cre-loxp fate-mapping of Pax6 enhancer active retinal and pancreatic progenitors. Genesis 35(1):22-30. [PubMed: 12481295] [MGI Ref ID J:81626]
Zhang Y; Foreman O; Wigle DA; Kosari F; Vasmatzis G; Salisbury JL; van Deursen J; Galardy PJ. 2012. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest 122(12):4362-74. [PubMed: 23187126] [MGI Ref ID J:193965]
Zhao F; Edwards R; Dizon D; Afrasiabi K; Mastroianni JR; Geyfman M; Ouellette AJ; Andersen B; Lipkin SM. 2010. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol 338(2):270-9. [PubMed: 20025862] [MGI Ref ID J:156704]
Zheng K; Wang PJ. 2012. Blockade of pachytene piRNA biogenesis reveals a novel requirement for maintaining post-meiotic germline genome integrity. PLoS Genet 8(11):e1003038. [PubMed: 23166510] [MGI Ref ID J:194084]
Health & husbandry
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.Colony Maintenance
Breeding & Husbandry When maintaining a live colony, hemizygous mice may be bred to wildtype (non-carrier) mice or C57BL/6EiJ inbred mice (Stock No. 000924).
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2450.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
|
Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $3185.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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|
|
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Wild-type from the colony | ||
| 000924 C57BL/6JEiJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
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JAX® Services
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Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.