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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Spontaneous Mutation; Transgenic; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Donating Investigator Eva Eicher, The Jackson Laboratory Appearance
albino female
Related Genotype: a/a Tyrc-2J/Tyrc-2J +/+albino male
Related Genotype: a/a Tyrc-2J/Tyrc-2J +/Ymottled gray-black female
Related Genotype: a/a Tyrc-2J/Tyrc-2J Tg(Tyr)3412ARpw/+dark gray-black male
Related Genotype: a/a Tyrc-2J/Tyrc-2J Tg(Tyr)3412ARpw/YView images of coat colors for this strain.
Description
On an albino background Tg(Tyr)3412ARpw permits the identification of gender as early as embryonic day 10.5. This strain is segregating for Tg(Tyr)3412ARpw and homozygous for Tyrc-2J so the individuals not carrying Tg(Tyr3412)ARpw are albino. Because Tg(Tyr)3412ARpw inserted into the X Chromosome, breeding a carrier male with a noncarrier (wild-type) female results in embryos in which all XX individuals develop eye pigment, due to the Tg(Tyr)3412ARpw inherited from their father, while all XY individuals have non-pigmented eyes, having inherited a wild-type X Chromosome from their mother.This strain is also homozygous for Tg(SryEGFP)92Ei. This reporter transgene consists of a 5 prime regulatory segment of the Sry gene driving EGFP. This transgene is expressed in the pre-support cell lineage (pre-sertoli and pre-granulosa cells) of the fetal genital ridge (Albrecht and Eicher, 2001) and in discrete areas the adult male but not female brain (Dewing et al., 2006). Specifically, Sry has been found expressed in tyrosine hydroxylase expressing neurons in all regions of the male substantial nigra, most strongly in the pars compacta. The expression of EGFP from this transgene is stronger in homozygotes than in heterozygotes. This strain is maintained homozygous for Tg(SryEGFP)92Ei.
Development
Tg(Tyr)3412ARpw was generated by microinjection into FVB/N fertilized eggs and integrated into the X Chromosome. Tg(Tyr)3412ARpw was backcrossed onto the B6(Cg)-Tyrc-2J/J albino background, where carriers of the transgene can be detected by coat color. Tg(Sry-EGFP)92Ei was generated by microinjection into C57BL/6J fertilized eggs. C57BL/6J-Tg(Sry-EGFP)92Ei was bred with the C57BL/6J congenic strain bearing both Tyrc-2J and Tg(Tyr)3412ARpw and the resulting offspring were intercrossed to generate this strain, which is homozygous for Tyrc-2J, Tg(Sry-EGFP)92Ei, and segregating for Tg(Tyr)3412ARpw.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (170 strains)
000058 B6(Cg)-Tyrc-2J/J
007265 C57BL/6-Tg(Sry-EGFP)92Ei Chr YAKR/J/EiJ 007264 C57BL/6-Tg(Sry-EGFP)92Ei Tg(Sry)4Ei Chr YPOS/EiJ 003927 C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ 007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
007250 C57BL/6JEi-Chr YAKR/J/Ei 001543 C57BL/6JEi-Chr YCB/EiJ
Additional Web Information
Congenic Nomenclature
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Tyr)3412ARpw/Tg(Tyr)3412ARpw
FVB/NJ-Tg(Tyr)3412ARpw
- pigmentation phenotype
- abnormal coat color (MGI Ref ID J:120431)
- on this albino background expression of this tyrosinase transgene yields a gray-toned agouti coat color in homozygous females and hemizygous males
- skin/coat/nails phenotype
- abnormal coat color (MGI Ref ID J:120431)
- on this albino background expression of this tyrosinase transgene yields a gray-toned agouti coat color in homozygous females and hemizygous males
Tg(Tyr)3412ARpw/Y
FVB/NJ-Tg(Tyr)3412ARpw
- pigmentation phenotype
- variegated coat color (MGI Ref ID J:120431)
- females hemizygous for this tyrosinase trangene on this albino background display a mosaic agouti and albino coat color
- skin/coat/nails phenotype
- variegated coat color (MGI Ref ID J:120431)
- females hemizygous for this tyrosinase trangene on this albino background display a mosaic agouti and albino coat color
Tg(Tyr)3412ARpw/Y
FVB/NJ-Tg(Tyr)3412ARpw
- pigmentation phenotype
- abnormal coat color (MGI Ref ID J:120431)
- on this albino background expression of this tyrosonase transgene yields a gray-toned agouti coat color in hemizygous males and homozygous females
- skin/coat/nails phenotype
- abnormal coat color (MGI Ref ID J:120431)
- on this albino background expression of this tyrosonase transgene yields a gray-toned agouti coat color in hemizygous males and homozygous females
This mouse can be used to support research in many areas including:
Tyrc-2J relatedResearch Tools
Developmental Biology Research
Fluorescent Proteins
Genetics Research (Tissue/Cell Markers)
Reproductive Biology Research
Tg(Sry-EGFP)92Ei relatedDermatology Research
Color and White Spotting Defects
Mouse/Human Gene Homologs
albinism, tyrosine negative
Sensorineural Research
Retinal Degeneration
Developmental Biology Research
Neurobiology Research
Research Tools
Fluorescent Proteins
Reproductive Biology Research
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Sry-EGFP)92Ei | ||
|---|---|---|---|
| Allele Name | transgene insertion 92, Eva M Eicher | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | Tg92Ei; | ||
| Strain of Origin | C57BL/6J | ||
| Site of Expression | Fluorescence is detected in pre-sertoli and pre-granulosa cells of the genital ridge, expression is stronger in homozygotes. Expression is also detected in tyrosine hydroxylase-expressing neurons of the substantia nigra of the midbrain and the medial mammillary bodies of the hypothalamus in males but not females. | ||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Promoter | Sry, sex determining region of Chr Y, mouse, laboratory | ||
| Molecular Note | The transgenic vector was composed of the Sry promoter region from bp 542-8304 inserted upstream of the EGFP-1 coding region. The construct contains two SV40 early mRNA polyadenylation signal in place of the endogenous Sry 3' UTR. Expression of EGFP indicates that the spatial expression of EGFP mRNA and protein is similar to endogenous Sry . [MGI Ref ID J:73280] | ||
| Allele Symbol | Tg(Tyr)3412ARpw | ||
| Allele Name | transgene insertion 3412A, Richard P Woychick | ||
| Allele Type | Transgenic (random, expressed) | ||
| Site of Expression | Fluorescence is detected in pre-sertoli and pre-granulosa cells of the genital ridge, expression is stronger in homozygotes. Expression is also detected in tyrosine hydroxylase-expressing neurons of the substantia nigra of the midbrain and the medial mammillary bodies of the hypothalamus in males but not females. | ||
| Expressed Gene | Tyr, tyrosinase, mouse, laboratory | ||
| Promoter | Tyr, tyrosinase, mouse, laboratory | ||
| Allele Symbol | Tyrc-2J | ||
| Allele Name | albino 2 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | B6.Cg-Tyrp1 Hps1 | ||
| Molecular Note | This mutation has a G to T base change at nucleotide 291 resulting in an amino acid change from arginine to leucine at residue 77 which lies in the highly conserved DDRE sequence. Nucleotide 291 is at the alternative 5' splice donor site for exon 1 and this allele does not produce the 1a or 1b subset of tyrosinase transcripts but does produce a significant increase in 1c and 1d transcripts. Western blots of homozygous mutant skin extracts demostrate the nearly complete absence of the broad 76-84 kDa bandof glycosylated wild-type tyrosinase. No tyrosinase activity was found in hairbulb extracts from homozygous mice. [MGI Ref ID J:36008] [MGI Ref ID J:6611] | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Albrecht KH; Eicher EM. 2001. Evidence that sry is expressed in pre-sertoli cells and sertoli and granulosa cells have a common precursor. Dev Biol 240(1):92-107. [PubMed: 11784049] [MGI Ref ID J:73280]
Dewing P; Chiang CW; Sinchak K; Sim H; Fernagut PO; Kelly S; Chesselet MF; Micevych PE; Albrecht KH; Harley VR; Vilain E. 2006. Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol 16(4):415-20. [PubMed: 16488877] [MGI Ref ID J:123875]
Additional References
Tyrc-2J relatedTg(Tyr)3412ARpw relatedAnderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234] [MGI Ref ID J:141035]
Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. [PubMed: 16827931] [MGI Ref ID J:128215]
Balkema GW; Cusick K; Nguyen TH. 2001. Diurnal variation in synaptic ribbon length and visual threshold. Vis Neurosci 18(5):789-97. [PubMed: 11925014] [MGI Ref ID J:99554]
Bravo-Nuevo A; Walsh N; Stone J. 2004. Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse. Invest Ophthalmol Vis Sci 45(6):2005-12. [PubMed: 15161869] [MGI Ref ID J:92276]
Cohen-Solal KA; Crespo-Carbone SM; Namkoong J; Mackason KR; Roberts KG; Reuhl KR; Chen S. 2002. Progressive appearance of pigmentation in amelanotic melanoma lesions. Pigment Cell Res 15(4):282-9. [PubMed: 12100494] [MGI Ref ID J:77989]
Cortese K; Giordano F; Surace EM; Venturi C; Ballabio A; Tacchetti C; Marigo V. 2005. The ocular albinism type 1 (OA1) gene controls melanosome maturation and size. Invest Ophthalmol Vis Sci 46(12):4358-64. [PubMed: 16303920] [MGI Ref ID J:103788]
D'Orazio JA; Nobuhisa T; Cui R; Arya M; Spry M; Wakamatsu K; Igras V; Kunisada T; Granter SR; Nishimura EK; Ito S; Fisher DE. 2006. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature 443(7109):340-4. [PubMed: 16988713] [MGI Ref ID J:112959]
Danciger M; Ogando D; Yang H; Matthes MT; Yu N; Ahern K; Yasumura D; Williams RW; Lavail MM. 2008. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci 49(7):2863-9. [PubMed: 18344445] [MGI Ref ID J:136923]
Dentin R; Liu Y; Koo SH; Hedrick S; Vargas T; Heredia J; Yates J rd; Montminy M. 2007. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449(7160):366-9. [PubMed: 17805301] [MGI Ref ID J:126351]
Eisenhofer G; Tian H; Holmes C; Matsunaga J; Roffler-Tarlov S; Hearing VJ. 2003. Tyrosinase: a developmentally specific major determinant of peripheral dopamine. FASEB J 17(10):1248-55. [PubMed: 12832289] [MGI Ref ID J:119178]
Green EL. 1973. Albino-2J (c<2J>) Mouse News Lett 49:31. [MGI Ref ID J:27522]
Katz ML; Wendt KD; Sanders DN. 2005. RPE65 gene mutation prevents development of autofluorescence in retinal pigment epithelial phagosomes. Mech Ageing Dev 126(4):513-21. [PubMed: 15722110] [MGI Ref ID J:98275]
Kitamoto J; Libby RT; Gibbs D; Steel KP; Williams DS. 2005. Myosin VI is required for normal retinal function. Exp Eye Res 81(1):116-20. [PubMed: 15978262] [MGI Ref ID J:134368]
LaVail MM; Gorrin GM; Repaci MA; Thomas LA; Ginsberg HM. 1987. Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci 28(7):1043-8. [PubMed: 3596986] [MGI Ref ID J:99553]
Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491] [MGI Ref ID J:103803]
Le Fur N; Kelsall SR; Mintz B. 1996. Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics 37(2):245-8. [PubMed: 8921397] [MGI Ref ID J:36008]
Lehman AL; Silvers WK; Puri N; Wakamatsu K; Ito S; Brilliant MH. 2000. The underwhite (uw) locus acts autonomously and reduces the production of melanin J Invest Dermatol 115(4):601-6. [PubMed: 10998130] [MGI Ref ID J:64978]
Libby RT; Smith RS; Savinova OV; Zabaleta A; Martin JE; Gonzalez FJ; John SW. 2003. Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Science 299(5612):1578-81. [PubMed: 12624268] [MGI Ref ID J:82280]
Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20. [PubMed: 7852195] [MGI Ref ID J:21682]
Nishimura EK; Granter SR; Fisher DE. 2005. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307(5710):720-4. [PubMed: 15618488] [MGI Ref ID J:96016]
Rachel RA; Dolen G; Hayes NL; Lu A; Erskine L; Nowakowski RS; Mason CA. 2002. Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina. J Neurosci 22(11):4249-63. [PubMed: 12040030] [MGI Ref ID J:77026]
Raven MA; Reese BE. 2002. Horizontal cell density and mosaic regularity in pigmented and albino mouse retina. J Comp Neurol 454(2):168-76. [PubMed: 12412141] [MGI Ref ID J:126185]
Rikke BA; Simpson VJ; Montoliu L; Johnson TE. 2001. No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics. Alcohol Clin Exp Res 25(2):171-6. [PubMed: 11236829] [MGI Ref ID J:68230]
Rizvi TA; Huang Y; Sidani A; Atit R; Largaespada DA; Boissy RE; Ratner N. 2002. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. J Neurosci 22(22):9831-40. [PubMed: 12427839] [MGI Ref ID J:109211]
Robison WG Jr; Kuwabara T. 1976. Light-induced alterations of retinal pigment epithelium in black, albino, and beige mice. Exp Eye Res 22(5):549-57. [PubMed: 1278263] [MGI Ref ID J:5656]
Rosenzweig HL; Martin TM; Jann MM; Planck SR; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci 49(4):1518-24. [PubMed: 18385071] [MGI Ref ID J:136140]
Savinova OV; Sugiyama F; Martin JE; Tomarev SI; Paigen BJ; Smith RS; John SW. 2001. Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet 2(1):12. [PubMed: 11532192] [MGI Ref ID J:82879]
Schwesinger C; Yee C; Rohan RM; Joussen AM; Fernandez A; Meyer TN; Poulaki V; Ma JJ; Redmond TM; Liu S; Adamis AP; D'Amato RJ. 2001. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol 158(3):1161-72. [PubMed: 11238064] [MGI Ref ID J:133002]
Takeuchi S; Zhang W; Wakamatsu K; Ito S; Hearing VJ; Kraemer KH; Brash DE. 2004. Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci U S A 101(42):15076-81. [PubMed: 15477596] [MGI Ref ID J:93542]
Thiels E; Hoffman EK; Gorin MB. 2008. A reliable behavioral assay for the assessment of sustained photophobia in mice. Curr Eye Res 33(5):483-91. [PubMed: 18568886] [MGI Ref ID J:139747]
Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688] [MGI Ref ID J:6611]
Young A; Powelson EB; Whitney IE; Raven MA; Nusinowitz S; Jiang M; Birnbaumer L; Reese BE; Farber DB. 2008. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci 49(7):3245-52. [PubMed: 18378571] [MGI Ref ID J:136897]
Woychik RP. 2007. Tyrosinase Minigene insertion in Chromosome X MGI Direct Data Submission :. [MGI Ref ID J:120431]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A2A
Colony Maintenance
Breeding & Husbandry Carriers of Tg(Tyr)3412ARpw on this Tyrc-2J homozygous background are pigmented while non-carriers are albino. This strain is maintained at The Jackson Laboratory by sibling breeding mice homozygous for Tg(Sry-EGFP)92Ei and Tyrc-2J and segregating for Tg(Tyr)3412ARpw. A female or male pigmented mouse, therefore an obligate carrier of Tg(Tyr)3412ARpw, is bred with an albino non-carrier. For experimental purposes a pigmented male bred with an albino female will generate albino male and pigmented female offspring.
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
|
Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $124.10 Female or Male Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei $124.10 Female or Male Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $248.20 Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei x Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei $248.20 Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei x Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $161.40 Female or Male Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei $161.40 Female or Male Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $322.70 Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei x Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei $322.70 Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei x Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
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