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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Congenic; Mutant Strain; Spontaneous Mutation; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation +F10 (12-NOV-10)
Generation DefinitionsDonating Investigator Eva Eicher, The Jackson Laboratory Appearance
albino female
Related Genotype: a/a Tyrc-2J/Tyrc-2J +/+albino male
Related Genotype: a/a Tyrc-2J/Tyrc-2J +/Ymottled gray-black female
Related Genotype: a/a Tyrc-2J/Tyrc-2J Tg(Tyr)3412ARpw/+dark gray-black male
Related Genotype: a/a Tyrc-2J/Tyrc-2J Tg(Tyr)3412ARpw/YView images of coat colors for this strain.
Description
On an albino background the X-linked transgene Tg(Tyr)3412ARpw permits visual identification of XX versus XY as early as embryonic day 10.5. This strain is segregating for Tg(Tyr)3412ARpw and homozygous for Tyrc-2J so the individuals not carrying Tg(Tyr3412)ARpw are albino. Because Tg(Tyr)3412ARpw inserted into the X Chromosome, breeding a carrier male with a noncarrier (wild-type) female results in embryos in which all XX individuals develop eye pigment, due to the Tg(Tyr)3412ARpw inherited from their father, while all XY individuals have non-pigmented eyes, having inherited a wild-type X Chromosome from their mother.This strain is also homozygous for Tg(SryEGFP)92Ei. This reporter transgene consists of a 5 prime regulatory segment of the Sry gene driving EGFP. This transgene is expressed in the pre-support cell lineage (pre-sertoli and pre-granulosa cells) of the fetal genital ridge (Albrecht and Eicher, 2001) and in discrete areas the adult male but not female brain (Dewing et al., 2006). Specifically, Sry has been found expressed in tyrosine hydroxylase expressing neurons in all regions of the male substantial nigra, most strongly in the pars compacta. The expression of EGFP from this transgene is stronger in homozygotes than in heterozygotes. This strain is maintained homozygous for Tg(SryEGFP)92Ei.
Development
Tg(Tyr)3412ARpw was generated by microinjection into FVB/N fertilized eggs and integrated into the X Chromosome. Tg(Tyr)3412ARpw was backcrossed onto the B6(Cg)-Tyrc-2J/J albino background, where carriers of the transgene can be detected by coat color. Tg(Sry-EGFP)92Ei was generated by microinjection into C57BL/6J fertilized eggs. C57BL/6J-Tg(Sry-EGFP)92Ei was bred with the C57BL/6J congenic strain bearing both Tyrc-2J and Tg(Tyr)3412ARpw and the resulting offspring were intercrossed to generate this strain, which is homozygous for Tyrc-2J, Tg(Sry-EGFP)92Ei, and segregating for Tg(Tyr)3412ARpw.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (345 strains)
017614 B6(Cg)-Tyrc-2J Tg(UBC-mCherry)1Phbs/J 000058 B6(Cg)-Tyrc-2J/J 008647 B6.129P2(Cg)-Trpa1tm1Kykw Tyrc-2J/J 014173 STOCK Tyrc-2J Omptm1.1(COP4*/EYFP)Tboz/J
007265 C57BL/6-Tg(Sry-EGFP)92Ei Chr YAKR/J/EiJ 007264 C57BL/6-Tg(Sry-EGFP)92Ei Tg(Sry)4Ei Chr YPOS/EiJ 003927 C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ 007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
007265 C57BL/6-Tg(Sry-EGFP)92Ei Chr YAKR/J/EiJ 007264 C57BL/6-Tg(Sry-EGFP)92Ei Tg(Sry)4Ei Chr YPOS/EiJ 003927 C57BL/6J-Tg(Sry-EGFP)92Ei/EiJ 007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
007483 FVB.Cg-Tg(Tyr)3412ARpw Tg(Sry-EGFP)92Ei/EiJ
Additional Web Information
Fluorescent Proteins/lacZ Systems
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Tg(Tyr)3412ARpw/Tg(Tyr)3412ARpw
FVB/NJ-Tg(Tyr)3412ARpw
- pigmentation phenotype
- abnormal coat/hair pigmentation
- on this albino background expression of this tyrosinase transgene yields a gray-toned agouti coat color in homozygous females and hemizygous males (MGI Ref ID J:120431)
- integument phenotype
- abnormal coat/hair pigmentation
- on this albino background expression of this tyrosinase transgene yields a gray-toned agouti coat color in homozygous females and hemizygous males (MGI Ref ID J:120431)
Tg(Tyr)3412ARpw/Y
FVB/NJ-Tg(Tyr)3412ARpw
- pigmentation phenotype
- variegated coat color
- females hemizygous for this tyrosinase trangene on this albino background display a mosaic agouti and albino coat color (MGI Ref ID J:120431)
- integument phenotype
- variegated coat color
- females hemizygous for this tyrosinase trangene on this albino background display a mosaic agouti and albino coat color (MGI Ref ID J:120431)
Tg(Tyr)3412ARpw/Y
FVB/NJ-Tg(Tyr)3412ARpw
- pigmentation phenotype
- abnormal coat/hair pigmentation
- on this albino background expression of this tyrosonase transgene yields a gray-toned agouti coat color in hemizygous males and homozygous females (MGI Ref ID J:120431)
- integument phenotype
- abnormal coat/hair pigmentation
- on this albino background expression of this tyrosonase transgene yields a gray-toned agouti coat color in hemizygous males and homozygous females (MGI Ref ID J:120431)
This mouse can be used to support research in many areas including:
Tyrc-2J relatedResearch Tools
Developmental Biology Research
Fluorescent Proteins
Genetics Research
Tissue/Cell Markers
Reproductive Biology Research
Tg(Sry-EGFP)92Ei relatedDermatology Research
Color and White Spotting Defects
Mouse/Human Gene Homologs
albinism, tyrosine negative
Sensorineural Research
Retinal Degeneration
Developmental Biology Research
Neurobiology Research
Research Tools
Fluorescent Proteins
Reproductive Biology Research
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Tg(Sry-EGFP)92Ei | ||
|---|---|---|---|
| Allele Name | transgene insertion 92, Eva M Eicher | ||
| Allele Type | Transgenic (Reporter) | ||
| Common Name(s) | Tg92Ei; | ||
| Strain of Origin | C57BL/6J | ||
| Site of Expression | Fluorescence is detected in pre-sertoli and pre-granulosa cells of the genital ridge, expression is stronger in homozygotes. Expression is also detected in tyrosine hydroxylase-expressing neurons of the substantia nigra of the midbrain and the medial mammillary bodies of the hypothalamus in males but not females. | ||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Promoter | Sry, sex determining region of Chr Y, mouse, laboratory | ||
| Molecular Note | The transgenic vector was composed of the Sry promoter region from bp 542-8304 inserted upstream of the EGFP-1 coding region. The construct contains two SV40 early mRNA polyadenylation signal in place of the endogenous Sry 3' UTR. Expression of EGFP indicates that the spatial expression of EGFP mRNA and protein is similar to endogenous Sry. [MGI Ref ID J:73280] | ||
| Gene Symbol and Name | Tg(Sry-EGFP)92Ei, transgene insertion 92, Eva M Eicher | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Tg92Ei; | ||
| Allele Symbol | Tg(Tyr)3412ARpw | ||
| Allele Name | transgene insertion 3412A, Richard P Woychick | ||
| Allele Type | Transgenic (random, expressed) | ||
| Common Name(s) | Tg3412A; | ||
| Site of Expression | Fluorescence is detected in pre-sertoli and pre-granulosa cells of the genital ridge, expression is stronger in homozygotes. Expression is also detected in tyrosine hydroxylase-expressing neurons of the substantia nigra of the midbrain and the medial mammillary bodies of the hypothalamus in males but not females. | ||
| Expressed Gene | Tyr, tyrosinase, mouse, laboratory | ||
| Promoter | Tyr, tyrosinase, mouse, laboratory | ||
| Allele Symbol | Tyrc-2J | ||
| Allele Name | albino 2 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | B6.Cg-Tyrp1 Hps1 | ||
| Molecular Note | This mutation has a G to T base change at nucleotide 291 resulting in an amino acid change from arginine to leucine at residue 77 which lies in the highly conserved DDRE sequence. Nucleotide 291 is at the alternative 5' splice donor site for exon 1 and this allele does not produce the 1a or 1b subset of tyrosinase transcripts but does produce a significant increase in 1c and 1d transcripts. Western blots of homozygous mutant skin extracts demostrate the nearly complete absence of the broad 76-84 kDa bandof glycosylated wild-type tyrosinase. No tyrosinase activity was found in hairbulb extracts from homozygous mice. [MGI Ref ID J:36008] [MGI Ref ID J:6611] | ||
References
References provided by MGI
Selected Reference(s)
Albrecht KH; Eicher EM. 2001. Evidence that sry is expressed in pre-sertoli cells and sertoli and granulosa cells have a common precursor. Dev Biol 240(1):92-107. [PubMed: 11784049] [MGI Ref ID J:73280]
Dewing P; Chiang CW; Sinchak K; Sim H; Fernagut PO; Kelly S; Chesselet MF; Micevych PE; Albrecht KH; Harley VR; Vilain E. 2006. Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol 16(4):415-20. [PubMed: 16488877] [MGI Ref ID J:123875]
Additional References
Bouma GJ; Hudson QJ; Washburn LL; Eicher EM. 2010. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biol Reprod 82(2):380-9. [PubMed: 19864314] [MGI Ref ID J:156788]
Tyrc-2J relatedTg(Sry-EGFP)92Ei relatedAlur RP; Cox TA; Crawford MA; Gong X; Brooks BP. 2008. Optic nerve axon number in mouse is regulated by PAX2. J AAPOS 12(2):117-21. [PubMed: 18083586] [MGI Ref ID J:172973]
Anderson MG; Hawes NL; Trantow CM; Chang B; John SW. 2008. Iris phenotypes and pigment dispersion caused by genes influencing pigmentation. Pigment Cell Melanoma Res 21(5):565-78. [PubMed: 18715234] [MGI Ref ID J:141035]
Anderson MG; Libby RT; Mao M; Cosma IM; Wilson LA; Smith RS; John SW. 2006. Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma. BMC Biol 4:20. [PubMed: 16827931] [MGI Ref ID J:128215]
Balkema GW; Cusick K; Nguyen TH. 2001. Diurnal variation in synaptic ribbon length and visual threshold. Vis Neurosci 18(5):789-97. [PubMed: 11925014] [MGI Ref ID J:99554]
Bravo-Nuevo A; Walsh N; Stone J. 2004. Photoreceptor degeneration and loss of retinal function in the C57BL/6-C2J mouse. Invest Ophthalmol Vis Sci 45(6):2005-12. [PubMed: 15161869] [MGI Ref ID J:92276]
Cohen-Solal KA; Crespo-Carbone SM; Namkoong J; Mackason KR; Roberts KG; Reuhl KR; Chen S. 2002. Progressive appearance of pigmentation in amelanotic melanoma lesions. Pigment Cell Res 15(4):282-9. [PubMed: 12100494] [MGI Ref ID J:77989]
Cortese K; Giordano F; Surace EM; Venturi C; Ballabio A; Tacchetti C; Marigo V. 2005. The ocular albinism type 1 (OA1) gene controls melanosome maturation and size. Invest Ophthalmol Vis Sci 46(12):4358-64. [PubMed: 16303920] [MGI Ref ID J:103788]
D'Orazio JA; Nobuhisa T; Cui R; Arya M; Spry M; Wakamatsu K; Igras V; Kunisada T; Granter SR; Nishimura EK; Ito S; Fisher DE. 2006. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning. Nature 443(7109):340-4. [PubMed: 16988713] [MGI Ref ID J:112959]
Danciger M; Ogando D; Yang H; Matthes MT; Yu N; Ahern K; Yasumura D; Williams RW; Lavail MM. 2008. Genetic modifiers of retinal degeneration in the rd3 mouse. Invest Ophthalmol Vis Sci 49(7):2863-9. [PubMed: 18344445] [MGI Ref ID J:136923]
Dentin R; Liu Y; Koo SH; Hedrick S; Vargas T; Heredia J; Yates J rd; Montminy M. 2007. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449(7160):366-9. [PubMed: 17805301] [MGI Ref ID J:126351]
Eisenhofer G; Tian H; Holmes C; Matsunaga J; Roffler-Tarlov S; Hearing VJ. 2003. Tyrosinase: a developmentally specific major determinant of peripheral dopamine. FASEB J 17(10):1248-55. [PubMed: 12832289] [MGI Ref ID J:119178]
Gibbs D; Cideciyan AV; Jacobson SG; Williams DS. 2009. Retinal pigment epithelium defects in humans and mice with mutations in MYO7A: imaging melanosome-specific autofluorescence. Invest Ophthalmol Vis Sci 50(9):4386-93. [PubMed: 19324852] [MGI Ref ID J:154563]
Green EL. 1973. Albino-2J (c<2J>) Mouse News Lett 49:31. [MGI Ref ID J:27522]
Iacovelli J; Zhao C; Wolkow N; Veldman P; Gollomp K; Ojha P; Lukinova N; King A; Feiner L; Esumi N; Zack DJ; Pierce EA; Vollrath D; Dunaief JL. 2011. Generation of Cre Transgenic Mice with Postnatal RPE-Specific Ocular Expression. Invest Ophthalmol Vis Sci 52(3):1378-83. [PubMed: 21212186] [MGI Ref ID J:170522]
Imanishi Y; Sun W; Maeda T; Maeda A; Palczewski K. 2008. Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem 283(36):25091-102. [PubMed: 18606814] [MGI Ref ID J:142021]
Johnson BA; Cole BS; Geisert EE; Ikeda S; Ikeda A. 2010. Tyrosinase is the modifier of retinoschisis in mice. Genetics 186(4):1337-44. [PubMed: 20876567] [MGI Ref ID J:166949]
Katz ML; Wendt KD; Sanders DN. 2005. RPE65 gene mutation prevents development of autofluorescence in retinal pigment epithelial phagosomes. Mech Ageing Dev 126(4):513-21. [PubMed: 15722110] [MGI Ref ID J:98275]
Kitamoto J; Libby RT; Gibbs D; Steel KP; Williams DS. 2005. Myosin VI is required for normal retinal function. Exp Eye Res 81(1):116-20. [PubMed: 15978262] [MGI Ref ID J:134368]
LaVail MM; Gorrin GM; Repaci MA; Thomas LA; Ginsberg HM. 1987. Genetic regulation of light damage to photoreceptors. Invest Ophthalmol Vis Sci 28(7):1043-8. [PubMed: 3596986] [MGI Ref ID J:99553]
Lamoreux ML; Wakamatsu K; Ito S. 2001. Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin. Pigment Cell Res 14(1):23-31. [PubMed: 11277491] [MGI Ref ID J:103803]
Le Fur N; Kelsall SR; Mintz B. 1996. Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics 37(2):245-8. [PubMed: 8921397] [MGI Ref ID J:36008]
Lehman AL; Silvers WK; Puri N; Wakamatsu K; Ito S; Brilliant MH. 2000. The underwhite (uw) locus acts autonomously and reduces the production of melanin J Invest Dermatol 115(4):601-6. [PubMed: 10998130] [MGI Ref ID J:64978]
Libby RT; Smith RS; Savinova OV; Zabaleta A; Martin JE; Gonzalez FJ; John SW. 2003. Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. Science 299(5612):1578-81. [PubMed: 12624268] [MGI Ref ID J:82280]
Motohashi H; Hozawa K; Oshima T; Takeuchi T; Takasaka T. 1994. Dysgenesis of melanocytes and cochlear dysfunction in mutant microphthalmia (mi) mice. Hear Res 80(1):10-20. [PubMed: 7852195] [MGI Ref ID J:21682]
Nishimura EK; Granter SR; Fisher DE. 2005. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307(5710):720-4. [PubMed: 15618488] [MGI Ref ID J:96016]
Ohlemiller KK; Rice ME; Lett JM; Gagnon PM. 2009. Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline. Hear Res 249(1-2):1-14. [PubMed: 19141317] [MGI Ref ID J:145863]
Rachel RA; Dolen G; Hayes NL; Lu A; Erskine L; Nowakowski RS; Mason CA. 2002. Spatiotemporal features of early neuronogenesis differ in wild-type and albino mouse retina. J Neurosci 22(11):4249-63. [PubMed: 12040030] [MGI Ref ID J:77026]
Raven MA; Reese BE. 2002. Horizontal cell density and mosaic regularity in pigmented and albino mouse retina. J Comp Neurol 454(2):168-76. [PubMed: 12412141] [MGI Ref ID J:126185]
Rikke BA; Simpson VJ; Montoliu L; Johnson TE. 2001. No effect of albinism on sedative-hypnotic sensitivity to ethanol and anesthetics. Alcohol Clin Exp Res 25(2):171-6. [PubMed: 11236829] [MGI Ref ID J:68230]
Rizvi TA; Huang Y; Sidani A; Atit R; Largaespada DA; Boissy RE; Ratner N. 2002. A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. J Neurosci 22(22):9831-40. [PubMed: 12427839] [MGI Ref ID J:109211]
Robison WG Jr; Kuwabara T. 1976. Light-induced alterations of retinal pigment epithelium in black, albino, and beige mice. Exp Eye Res 22(5):549-57. [PubMed: 1278263] [MGI Ref ID J:5656]
Rosenzweig HL; Kawaguchi T; Martin TM; Planck SR; Davey MP; Rosenbaum JT. 2009. Nucleotide oligomerization domain-2 (NOD2)-induced uveitis: dependence on IFN-gamma. Invest Ophthalmol Vis Sci 50(4):1739-45. [PubMed: 19098321] [MGI Ref ID J:146921]
Rosenzweig HL; Martin TM; Jann MM; Planck SR; Davey MP; Kobayashi K; Flavell RA; Rosenbaum JT. 2008. NOD2, the gene responsible for familial granulomatous uveitis, in a mouse model of uveitis. Invest Ophthalmol Vis Sci 49(4):1518-24. [PubMed: 18385071] [MGI Ref ID J:136140]
Savinova OV; Sugiyama F; Martin JE; Tomarev SI; Paigen BJ; Smith RS; John SW. 2001. Intraocular pressure in genetically distinct mice: an update and strain survey. BMC Genet 2(1):12. [PubMed: 11532192] [MGI Ref ID J:82879]
Schuster-Gossler K; Lee AW; Lerner CP; Parker HJ; Dyer VW; Scott VE; Gossler A; Conover JC. 2001. Use of coisogenic host blastocysts for efficient establishment of germline chimeras with C57BL/6J ES cell lines. Biotechniques 31(5):1022-4, 1026. [PubMed: 11730008] [MGI Ref ID J:144015]
Schwesinger C; Yee C; Rohan RM; Joussen AM; Fernandez A; Meyer TN; Poulaki V; Ma JJ; Redmond TM; Liu S; Adamis AP; D'Amato RJ. 2001. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol 158(3):1161-72. [PubMed: 11238064] [MGI Ref ID J:133002]
Solodova E; Jablonska J; Weiss S; Lienenklaus S. 2011. Production of IFN-beta during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage. PLoS One 6(4):e18543. [PubMed: 21494554] [MGI Ref ID J:172226]
Svensson RU; Haverkamp JM; Thedens DR; Cohen MB; Ratliff TL; Henry MD. 2011. Slow disease progression in a C57BL/6 pten-deficient mouse model of prostate cancer. Am J Pathol 179(1):502-12. [PubMed: 21703427] [MGI Ref ID J:173997]
Takeuchi S; Zhang W; Wakamatsu K; Ito S; Hearing VJ; Kraemer KH; Brash DE. 2004. Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci U S A 101(42):15076-81. [PubMed: 15477596] [MGI Ref ID J:93542]
Thiels E; Hoffman EK; Gorin MB. 2008. A reliable behavioral assay for the assessment of sustained photophobia in mice. Curr Eye Res 33(5):483-91. [PubMed: 18568886] [MGI Ref ID J:139747]
Tinkum KL; Marpegan L; White LS; Sun J; Herzog ED; Piwnica-Worms D; Piwnica-Worms H. 2011. Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells. Mol Cell Biol 31(18):3759-72. [PubMed: 21791610] [MGI Ref ID J:175772]
Townsend D; Witkop CJ Jr; Mattson J. 1981. Tyrosinase subcellular distribution and kinetic parameters in wild type and C-locus mutant C57BL/6J mice. J Exp Zool 216(1):113-9. [PubMed: 6793688] [MGI Ref ID J:6611]
Whitney IE; Raven MA; Ciobanu DC; Williams RW; Reese BE. 2009. Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Invest Ophthalmol Vis Sci 50(5):1996-2003. [PubMed: 19168892] [MGI Ref ID J:149703]
Xie T; Nguyen T; Hupe M; Wei ML. 2009. Multidrug resistance decreases with mutations of melanosomal regulatory genes. Cancer Res 69(3):992-9. [PubMed: 19155314] [MGI Ref ID J:144973]
Young A; Powelson EB; Whitney IE; Raven MA; Nusinowitz S; Jiang M; Birnbaumer L; Reese BE; Farber DB. 2008. Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. Invest Ophthalmol Vis Sci 49(7):3245-52. [PubMed: 18378571] [MGI Ref ID J:136897]
Tg(Tyr)3412ARpw relatedBouma GJ; Hudson QJ; Washburn LL; Eicher EM. 2010. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biol Reprod 82(2):380-9. [PubMed: 19864314] [MGI Ref ID J:156788]
Bouma GJ; Hudson QJ; Washburn LL; Eicher EM. 2010. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biol Reprod 82(2):380-9. [PubMed: 19864314] [MGI Ref ID J:156788]
Woychik RP. 2007. Tyrosinase Minigene insertion in Chromosome X MGI Direct Data Submission :. [MGI Ref ID J:120431]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number A2A
Colony Maintenance
Breeding & Husbandry Carriers of Tg(Tyr)3412ARpw on this Tyrc-2J homozygous background are pigmented while non-carriers are albino. This strain is maintained at The Jackson Laboratory by sibling breeding mice homozygous for Tg(Sry-EGFP)92Ei and Tyrc-2J and segregating for Tg(Tyr)3412ARpw. A female or male pigmented mouse, therefore an obligate carrier of Tg(Tyr)3412ARpw, is bred with an albino non-carrier. For experimental purposes a pigmented male bred with an albino female will generate albino male and pigmented female offspring.
Purchasing information
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $155.00 Female or Male Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei $155.00 Female or Male Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei
Pairs /Price (US dollars $) Pair Genotype $310.00 Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei x Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei $310.00 Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei x Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
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Live Mice
Price (US dollars $) Gender Genotypes Provided Individual Mouse $201.50 Female or Male Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei $201.50 Female or Male Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei
Pairs /Price (US dollars $) Pair Genotype $403.00 Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei x Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei $403.00 Homozygous for Tyrc-2J, Noncarrier, Homozygous for Tg(Sry-EGFP)92Ei x Homozygous for Tyrc-2J, Hemizygous for Tg(Tyr)3412ARpw, Homozygous for Tg(Sry-EGFP)92Ei Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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Standard Supply
Repository-Live. The Repository Strains represent an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. We treat orders for these strains as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- This strain is included in the Mouse Mutant Resource collection.
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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| phone: | 207-288-6470 |
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JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.