Go to JAX^® Mice Query Form

General Terms and Conditions	Additional Licensing and Use Restrictions

Genes & Alleles

Bmper;   Bmpertm1Emdr;

---

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Targeted Mutation Species laboratory mouse Donating Investigator Edward De Robertis,   University of California, Los Angeles

Strain Description
Homozygous mutant mice die at birth due to respiratory failure. They display extensive skeletal abnormalities. At a lower penetrance, mutants show microphthalmia and exencephaly. RT-PCR was used to confirm expression in mouse embyronic fibroblasts.

Strain Development
A targeting vector was used to place an in-frame lacZ reporter gene in the first exon of the gene at the initiator methionine and insert a neomycin resistance cassette downstream of lacZ. The targeting vector was introduced to LW1 129S4/SvJae-derived embryonic stem (ES) cells. This line has been backcrossed to B6SJLF1/J for 17 generations by the donating laboratory.

Mammalian Phenotype Terms assigned by genotype Bmpertm1Emdr/Bmpertm1Emdr         B6SJL-Bmpertm1Emdr lethality-prenatal/perinatal neonatal lethality (MGI Ref ID J:121684) mice die at birth nervous system phenotype exencephaly (MGI Ref ID J:121684) exhibited at low penetrance respiratory system phenotype respiratory failure (MGI Ref ID J:121684) mice display respiratory failure at birth skeleton phenotype abnormal skeleton morphology (MGI Ref ID J:121684) mice show extensive skeletal abnormalities vision/eye phenotype microphthalmia (MGI Ref ID J:121684) exhibited at low penetrance

Gene & Allele Details

Allele Symbol		Bmpertm1Emdr
Allele Name		targeted mutation 1, E M de Robertis
Common Name(s)		CV-2;
Mutation Made By		Edward De Robertis,   University of California, Los Angeles
Strain of Origin		129S4/SvJae
ES Cell Line Name		LW1
ES Cell Line Strain		129S4/SvJae
Gene Symbol and Name		Bmper, BMP-binding endothelial regulator
Chromosome		9
Gene Common Name(s)		3110056H04Rik; CRIM3; CV-2; CV2; RGD1563373; RIKEN cDNA 3110056H04 gene; crossveinless-2;
Molecular Note		A targeting vector was used to place an in-frame LacZ reporter gene in the first exon of the gene at the initiator methionine and insert a neomycin resistance cassette downstream of LacZ. [MGI Ref ID J:121684]

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony, these mice are bred as heterozygotes. Homozygotes have a perinatal lethal phenotype.

Research Applications

This mouse can be used to support research in many areas including:

Developmental Biology Research
Neurodevelopmental Defects
Postnatal Mortality
Skeletal Defects

References

Selected Reference(s)

de Robertis EM. 2007. A targeted mutation of Bmper MGI Direct Data Submission :.  [MGI Ref ID J:121684]

---

Price and Supply Information

Strain Name:	B6SJL-Bmpertm1Emdr/J
Stock Number:	007554

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

• USA, Canada and Mexico
• International

*NO Shipping Destination selected!

 

Supply Details

Standard Supply	Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes	Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org. This strain is included in the Induced Mutant Resource Colony collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

---

Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Go to JAX^® Mice Query Form