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| These mT/mG mice are useful as a Cre reporter strain; expressing red fluorescence prior to, and green fluorescence following, Cre-mediated recombination in widespread cell and tissue types. | |||||||||||||||||||
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Description
Strain Information
Type Mutant Stock; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Mating System Homozygote x Homozygote (Female x Male) 09-APR-08 Species laboratory mouse Generation ?+1F10 (18-JUN-12)
Generation DefinitionsDonating Investigator Dr. Liqun Luo, Stanford University, HHMI Description
Mice homozygous for this mT/mG mutation are viable and fertile. These mice possess loxP sites on either side of a membrane-targeted tdTomato (mT) cassette and express strong red fluorescence in all tissues and cell types examined. Tail or whole body epifluorescence is sufficient to identify mT/mG homozygotes. When bred to Cre recombinase expressing mice, the resulting offspring have the mT cassette deleted in the cre expressing tissue(s), allowing expression of the membrane-targeted EGFP (mG) cassette located just downstream. The donating investigator reports that the ACTB promoter allows stronger and persistent expression of the fluorescent proteins (especially in adult cells) compared to the endogenous Gt(ROSA) locus alone. This double-fluorescent system allows direct live visualization of both recombined and non-recombined cells at single cell resolution, offering an internal control for phenotypic analysis of Cre-induced mosaic mutants and providing a second marker for lineage tracing applications. In addition, the localization of fluorescent proteins to membrane structures outlines cell morphology and allows resolution of fine cellular processes. These mT/mG mice are useful as a Cre reporter strain; expressing red fluorescence prior to, and green fluorescence following, Cre-mediated recombination in widespread cell and tissue types.Development
The mT/mG (membrane-Tomato/membrane-Green) targeting vector was designed with a CMV enhancer/chicken beta-actin core promoter (pCA) driving expression of a loxP-flanked, N-terminal membrane-tagged, tdTomato protein sequence followed by a polyadenylation signal (tdTomato is a non-oligomerizing DsRed variant with a 12 residue linker fusing two copies of the protein (tandem dimer)). Immediately distal to the second loxP site is an N-terminal membrane-tagged, enhanced green fluorescent protein (EGFP) sequence itself followed by a polyadenylation signal. An frt-flanked neo cassette was also located distal to the expression vector. This entire mT/mG construct was inserted into the Gt(ROSA)26Sor locus via electroporation of (129X1/SvJ x 129S1/Sv)F1-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were microinjected in C57BL/6J blastocysts. Chimeric progeny were bred to outbred CD-1 mice. The resulting mutant mice were interbred to generate homozygotes prior to arrival at The Jackson Laboratory. Upon arrival, mice were bred to 129X1/SvJ (Stock No. 000691) for at least one generation to establish the colony.
Control Information
| Control | ||
|---|---|---|
| 000691 129X1/SvJ | (approximate) | |
| Considerations for Choosing Controls | ||
Related Strains
Fluorescent Protein Strains
View Fluorescent Protein Strains (357 strains)
007676 B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/J
Additional Web Information
Fluorescent Proteins/lacZ Systems
Introduction to Cre-lox technology
Phenotype
Phenotype Information
assigned by genotype
The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
involves: 129S1/Sv * 129X1/SvJ
- normal phenotype
- no abnormal phenotype detected
- mice are viable and fertile, with no observable adverse phenotypes (MGI Ref ID J:124702)
This mouse can be used to support research in many areas including:
GFP relatedNeurobiology Research
Cre-lox System
loxP-flanked Sequences
loxP-flanked Sequences: Test/Reporter
Research Tools
Cre-lox System
loxP-flanked Sequences
loxP-flanked Sequences: Test/Reporter
Fluorescent Proteins
Genetics Research
Mutagenesis and Transgenesis
Mutagenesis and Transgenesis: Cre-lox System
Tissue/Cell Markers
Tissue/Cell Markers: Cre-lox System
Tissue/Cell Markers: multiple
Research Tools
Fluorescent Proteins
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo | ||
|---|---|---|---|
| Allele Name | targeted mutation 4, Liqun Luo | ||
| Allele Type | Targeted (Reporter) | ||
| Common Name(s) | Gt(ROSA26)ACTB-tdTomato-EGFP; R26-X; R26-mR/mG; R26TG; ROSA-R/G; ROSA-mT/mG; Rosa26flox-mTRed-Stop-flox-mGFP; Rosa26mTmGflox; TomatoGFP+; mT/mG; mTmG; | ||
| Mutation Made By | Dr. Liqun Luo, Stanford University, HHMI | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| ES Cell Line Name | R1 | ||
| ES Cell Line Strain | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Site of Expression | Membrane-targeted tdTomato (mT) is expressed in all tissues and cell types examined. When bred to Cre recombinase expressing mice, the mT cassette is deleted in the cre expressing tissue(s), allowing expression of the membrane-targeted EGFP (mG). | ||
| Expressed Gene | RFP, Red Fluorescent Protein, coral | ||
| Red Fluorescent Protein (RFP), derived from marine invertebrate organisms such as the soft coral Discosoma spp and reef coral, Heteractis crispa, is a versatile reporter molecule which has found use in many biological applications. The wild type protein, which is an obligate tetramer, is not well tolerated in mammalian systems. The original molecule has been modified in order to optimize expression to mammalian physiology (examples include monomeric RFP, mRFP1, DsRed, etc). | |||
| Expressed Gene | GFP, Green Fluorescent Protein, jellyfish | ||
| Green Fluorescent Protein (GFP), derived from the jellyfish Aequorea victoria, is a versatile reporter molecule which has found use in many biological applications. In some constructs the original molecule has been modified in order to enhance its fluorescence intensity (EGFP, enhanced GFP). When utilized in a transgenic construct, tissue expressing sufficient amounts of GFP will fluoresce when exposed to a 488 nm light source. | |||
| Molecular Note | The targeting vector was designed with a CMV enhancer/chicken beta-actin core promoter (pCA) driving expression of a loxP-flanked, N-terminal membrane-tagged, optimized DsRed fluorescent protein variant (called tandem-dimer-Tomato or tdTomato) sequence followed by a polyadenylation signal. Immediately distal to the second loxP site is an N-terminal membrane-tagged, enhanced green fluorescent protein (EGFP) sequence itself followed by a polyadenylation signal. An frt-flanked neo cassette was also located distal to the expression vector. Red fluorescence is detected in all tissues tested. When mice are bred to Cre expressing mice, the floxed region is excised in Cre-expressing tissue and this allows expression of the EGFP cassette. [MGI Ref ID J:123053] [MGI Ref ID J:124702] | ||
| Gene Symbol and Name | Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano | ||
| Chromosome | 6 | ||
| Gene Common Name(s) | AV258896; Gtrgeo26; Gtrosa26; R26; ROSA26; beta geo; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Gt(ROSA)26Sor(Luo),Separated MCA
Gt(ROSA)26Sortm1Luo, tm2Luo, tm3Luo, tm4ACTB-tdTomato,-EGFP)Luo, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Muzumdar MD; Tasic B; Miyamichi K; Li L; Luo L. 2007. A global double-fluorescent Cre reporter mouse. Genesis 45(9):593-605. [PubMed: 17868096] [MGI Ref ID J:124702]
Additional References
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo relatedAgarwal A; Dibaj P; Kassmann CM; Goebbels S; Nave KA; Schwab MH. 2011. In Vivo Imaging and Noninvasive Ablation of Pyramidal Neurons in Adult NEX-CreERT2 Mice. Cereb Cortex :. [PubMed: 21880656] [MGI Ref ID J:181084]
Ahrens MJ; Romereim S; Dudley AT. 2011. A re-evaluation of two key reagents for in vivo studies of Wnt signaling. Dev Dyn :. [PubMed: 21793100] [MGI Ref ID J:174609]
Angus-Hill ML; Elbert KM; Hidalgo J; Capecchi MR. 2011. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. Proc Natl Acad Sci U S A 108(12):4914-9. [PubMed: 21383188] [MGI Ref ID J:170088]
Armour EA; Carson RP; Ess KC. 2012. Cystogenesis and elongated primary cilia in Tsc1-deficient distal convoluted tubules. Am J Physiol Renal Physiol 303(4):F584-92. [PubMed: 22674026] [MGI Ref ID J:188431]
Asahina K; Zhou B; Pu WT; Tsukamoto H. 2011. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 53(3):983-95. [PubMed: 21294146] [MGI Ref ID J:170930]
Banga A; Akinci E; Greder LV; Dutton JR; Slack JM. 2012. In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts. Proc Natl Acad Sci U S A 109(38):15336-41. [PubMed: 22949652] [MGI Ref ID J:190153]
Berry R; Rodeheffer MS. 2013. Characterization of the adipocyte cellular lineage in vivo. Nat Cell Biol 15(3):302-8. [PubMed: 23434825] [MGI Ref ID J:195198]
Bonegio RG; Beck LH; Kahlon RK; Lu W; Salant DJ. 2011. The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int 79(10):1099-112. [PubMed: 21270765] [MGI Ref ID J:186872]
Booth AJ; Wood SC; Cornett AM; Dreffs AA; Lu G; Muro AF; White ES; Bishop DK. 2012. Recipient-derived EDA fibronectin promotes cardiac allograft fibrosis. J Pathol 226(4):609-18. [PubMed: 21960174] [MGI Ref ID J:181815]
Boyer SW; Schroeder AV; Smith-Berdan S; Forsberg EC. 2011. All Hematopoietic Cells Develop from Hematopoietic Stem Cells through Flk2/Flt3-Positive Progenitor Cells. Cell Stem Cell 9(1):64-73. [PubMed: 21726834] [MGI Ref ID J:174372]
Brzezinski JA 4th; Kim EJ; Johnson JE; Reh TA. 2011. Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development 138(16):3519-31. [PubMed: 21771810] [MGI Ref ID J:175804]
Carson RP; Van Nielen DL; Winzenburger PA; Ess KC. 2012. Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin. Neurobiol Dis 45(1):369-80. [PubMed: 21907282] [MGI Ref ID J:179842]
Chan AC; Drakos SG; Ruiz OE; Smith AC; Gibson CC; Ling J; Passi SF; Stratman AN; Sacharidou A; Revelo MP; Grossmann AH; Diakos NA; Davis GE; Metzstein MM; Whitehead KJ; Li DY. 2011. Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest 121(5):1871-81. [PubMed: 21490399] [MGI Ref ID J:173947]
Chapman HA; Li X; Alexander JP; Brumwell A; Lorizio W; Tan K; Sonnenberg A; Wei Y; Vu TH. 2011. Integrin alpha6beta4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest 121(7):2855-62. [PubMed: 21701069] [MGI Ref ID J:175915]
Chen C; Kudo M; Rutaganira F; Takano H; Lee C; Atakilit A; Robinett KS; Uede T; Wolters PJ; Shokat KM; Huang X; Sheppard D. 2012. Integrin alpha9beta1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest 122(8):2916-27. [PubMed: 22772469] [MGI Ref ID J:190074]
Chen H; Matsumoto K; Brockway BL; Rackley CR; Liang J; Lee JH; Jiang D; Noble PW; Randell SH; Kim CF; Stripp BR. 2012. Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. Stem Cells 30(9):1948-60. [PubMed: 22696116] [MGI Ref ID J:194655]
Cho H; Zhao X; Hatori M; Yu RT; Barish GD; Lam MT; Chong LW; DiTacchio L; Atkins AR; Glass CK; Liddle C; Auwerx J; Downes M; Panda S; Evans RM. 2012. Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485(7396):123-7. [PubMed: 22460952] [MGI Ref ID J:183855]
Choi DC; Maguschak KA; Ye K; Jang SW; Myers KM; Ressler KJ. 2010. Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci U S A 107(6):2675-80. [PubMed: 20133801] [MGI Ref ID J:157538]
Choi N; Zhang B; Zhang L; Ittmann M; Xin L. 2012. Adult Murine Prostate Basal and Luminal Cells Are Self-Sustained Lineages that Can Both Serve as Targets for Prostate Cancer Initiation. Cancer Cell 21(2):253-65. [PubMed: 22340597] [MGI Ref ID J:181459]
Croyle MJ; Lehman JM; O'Connor AK; Wong SY; Malarkey EB; Iribarne D; Dowdle WE; Schoeb TR; Verney ZM; Athar M; Michaud EJ; Reiter JF; Yoder BK. 2011. Role of epidermal primary cilia in the homeostasis of skin and hair follicles. Development 138(9):1675-85. [PubMed: 21429982] [MGI Ref ID J:171221]
Davis J; Piatigorsky J. 2011. Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation. Invest Ophthalmol Vis Sci 52(7):4158-68. [PubMed: 21447684] [MGI Ref ID J:181429]
Ding M; Carrao AC; Wagner RJ; Xie Y; Jin Y; Rzucidlo EM; Yu J; Li W; Tellides G; Hwa J; Aprahamian TR; Martin KA. 2012. Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype. J Mol Cell Cardiol 52(2):474-84. [PubMed: 21952104] [MGI Ref ID J:183565]
Dy P; Wang W; Bhattaram P; Wang Q; Wang L; Ballock RT; Lefebvre V. 2012. Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell 22(3):597-609. [PubMed: 22421045] [MGI Ref ID J:183084]
Evers B; Speksnijder EN; Schut E; Ciampricotti M; Smalley MJ; Derksen PW; Jonkers J; de Visser KE. 2010. A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis. J Pathol 220(1):34-44. [PubMed: 19927317] [MGI Ref ID J:155546]
Flodby P; Borok Z; Banfalvi A; Zhou B; Gao D; Minoo P; Ann DK; Morrisey EE; Crandall ED. 2010. Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol 43(2):173-8. [PubMed: 19767448] [MGI Ref ID J:174124]
Fre S; Hannezo E; Sale S; Huyghe M; Lafkas D; Kissel H; Louvi A; Greve J; Louvard D; Artavanis-Tsakonas S. 2011. Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One 6(10):e25785. [PubMed: 21991352] [MGI Ref ID J:179632]
Gaudreau MC; Heyd F; Bastien R; Wilhelm B; Moroy T. 2012. Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells. J Immunol 188(11):5377-88. [PubMed: 22523384] [MGI Ref ID J:188749]
Ghosh S; Lau H; Simons BW; Powell JD; Meyers DJ; De Marzo AM; Berman DM; Lotan TL. 2011. PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol 360(2):329-42. [PubMed: 22015718] [MGI Ref ID J:178714]
Godel M; Hartleben B; Herbach N; Liu S; Zschiedrich S; Lu S; Debreczeni-Mor A; Lindenmeyer MT; Rastaldi MP; Hartleben G; Wiech T; Fornoni A; Nelson RG; Kretzler M; Wanke R; Pavenstadt H; Kerjaschki D; Cohen CD; Hall MN; Ruegg MA; Inoki K; Walz G; Huber TB. 2011. Role of mTOR in podocyte function and diabetic nephropathy in humans and mice. J Clin Invest 121(6):2197-209. [PubMed: 21606591] [MGI Ref ID J:174021]
Greder LV; Gupta S; Li S; Abedin MJ; Sajini A; Segal Y; Slack JM; Dutton JR. 2012. Analysis of endogenous Oct4 activation during induced pluripotent stem cell reprogramming using an inducible Oct4 lineage label. Stem Cells 30(11):2596-601. [PubMed: 22948941] [MGI Ref ID J:194647]
Greenbaum AM; Revollo LD; Woloszynek JR; Civitelli R; Link DC. 2012. N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. Blood 120(2):295-302. [PubMed: 22323481] [MGI Ref ID J:188098]
Grieskamp T; Rudat C; Ludtke TH; Norden J; Kispert A. 2011. Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res 108(7):813-23. [PubMed: 21252157] [MGI Ref ID J:183603]
Grosse AS; Pressprich MF; Curley LB; Hamilton KL; Margolis B; Hildebrand JD; Gumucio DL. 2011. Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. Development 138(20):4423-32. [PubMed: 21880782] [MGI Ref ID J:178336]
Hartman BH; Reh TA; Bermingham-McDonogh O. 2010. Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear. Proc Natl Acad Sci U S A 107(36):15792-7. [PubMed: 20798046] [MGI Ref ID J:164376]
He Y; Zhang H; Yu L; Gunel M; Boggon TJ; Chen H; Min W. 2010. Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal 3(116):ra26. [PubMed: 20371769] [MGI Ref ID J:171969]
Hohne M; Ising C; Hagmann H; Volker LA; Brahler S; Schermer B; Brinkkoetter PT; Benzing T. 2013. Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions. Am J Pathol 182(2):332-8. [PubMed: 23246153] [MGI Ref ID J:193169]
Hu H; Li J; Gagen CS; Gray NW; Zhang Z; Qi Y; Zhang P. 2011. Conditional knockout of protein O-mannosyltransferase 2 reveals tissue-specific roles of O-mannosyl glycosylation in brain development. J Comp Neurol 519(7):1320-37. [PubMed: 21452199] [MGI Ref ID J:179356]
Huang X; Liu J; Ketova T; Fleming JT; Grover VK; Cooper MK; Litingtung Y; Chiang C. 2010. Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc Natl Acad Sci U S A 107(18):8422-7. [PubMed: 20400693] [MGI Ref ID J:160335]
Ichise T; Yoshida N; Ichise H. 2010. H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice. Development 137(6):1003-13. [PubMed: 20179099] [MGI Ref ID J:159024]
Jan TA; Chai R; Sayyid ZN; van Amerongen R; Xia A; Wang T; Sinkkonen ST; Zeng YA; Levin JR; Heller S; Nusse R; Cheng AG. 2013. Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Development 140(6):1196-206. [PubMed: 23444352] [MGI Ref ID J:194845]
Kang SH; Fukaya M; Yang JK; Rothstein JD; Bergles DE. 2010. NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron 68(4):668-81. [PubMed: 21092857] [MGI Ref ID J:167748]
King P; Paul A; Laufer E. 2009. Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A 106(50):21185-90. [PubMed: 19955443] [MGI Ref ID J:155826]
Kisseleva T; Cong M; Paik Y; Scholten D; Jiang C; Benner C; Iwaisako K; Moore-Morris T; Scott B; Tsukamoto H; Evans SM; Dillmann W; Glass CK; Brenner DA. 2012. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A 109(24):9448-53. [PubMed: 22566629] [MGI Ref ID J:185556]
Kobayashi H; Gilbert V; Liu Q; Kapitsinou PP; Unger TL; Rha J; Rivella S; Schlondorff D; Haase VH. 2012. Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury. J Immunol 188(10):5106-15. [PubMed: 22490864] [MGI Ref ID J:188688]
Kurihara T; Westenskow PD; Krohne TU; Aguilar E; Johnson RS; Friedlander M. 2011. Astrocyte pVHL and HIF-alpha isoforms are required for embryonic-to-adult vascular transition in the eye. J Cell Biol 195(4):689-701. [PubMed: 22084310] [MGI Ref ID J:178823]
Lallemand Y; Moreau J; Cloment CS; Vives FL; Robert B. 2013. Generation and characterization of a tamoxifen inducible Msx1(CreERT2) knock-in allele. Genesis 51(2):110-9. [PubMed: 23090744] [MGI Ref ID J:194129]
Lange SS; Bedford E; Reh S; Wittschieben JP; Carbajal S; Kusewitt DF; DiGiovanni J; Wood RD. 2013. Dual role for mammalian DNA polymerase zeta in maintaining genome stability and proliferative responses. Proc Natl Acad Sci U S A 110(8):E687-96. [PubMed: 23386725] [MGI Ref ID J:194536]
Le Bouffant R; Souquet B; Duval N; Duquenne C; Herve R; Frydman N; Robert B; Habert R; Livera G. 2011. Msx1 and Msx2 promote meiosis initiation. Development 138(24):5393-402. [PubMed: 22071108] [MGI Ref ID J:178676]
Le Garrec JF; Ragni CV; Pop S; Dufour A; Olivo-Marin JC; Buckingham ME; Meilhac SM. 2013. Quantitative analysis of polarity in 3D reveals local cell coordination in the embryonic mouse heart. Development 140(2):395-404. [PubMed: 23250213] [MGI Ref ID J:191715]
Leshan RL; Greenwald-Yarnell M; Patterson CM; Gonzalez IE; Myers MG Jr. 2012. Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance. Nat Med :. [PubMed: 22522563] [MGI Ref ID J:183754]
Li Y; Wang J; Asahina K. 2013. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A 110(6):2324-9. [PubMed: 23345421] [MGI Ref ID J:194339]
Lilla JN; Chen CC; Mukai K; Benbarak MJ; Franco CB; Kalesnikoff J; Yu M; Tsai M; Piliponsky AM; Galli SJ. 2011. Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood 118(26):6930-8. [PubMed: 22001390] [MGI Ref ID J:179080]
Lin C; Song H; Huang C; Yao E; Gacayan R; Xu SM; Chuang PT. 2012. Alveolar type II cells possess the capability of initiating lung tumor development. PLoS One 7(12):e53817. [PubMed: 23285300] [MGI Ref ID J:195738]
Lopes M; Gooupille O; Saint Cloment C; Robert B. 2012. Msx1 is expressed in retina endothelial cells at artery branching sites Biol Open :376-384. [MGI Ref ID J:184582]
Lopes M; Goupille O; Cloment CS; Lallemand Y; Cumano A; Robert B. 2011. Msx genes define a population of mural cell precursors required for head blood vessel maturation. Development 138(14):3055-66. [PubMed: 21693521] [MGI Ref ID J:173525]
Luo J; Elwood F; Britschgi M; Villeda S; Zhang H; Ding Z; Zhu L; Alabsi H; Getachew R; Narasimhan R; Wabl R; Fainberg N; James ML; Wong G; Relton J; Gambhir SS; Pollard JW; Wyss-Coray T. 2013. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med 210(1):157-72. [PubMed: 23296467] [MGI Ref ID J:194761]
Lyndaker AM; Lim PX; Mleczko JM; Diggins CE; Holloway JK; Holmes RJ; Kan R; Schlafer DH; Freire R; Cohen PE; Weiss RS. 2013. Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance. PLoS Genet 9(2):e1003320. [PubMed: 23468651] [MGI Ref ID J:195191]
Ma CY; Shi GY; Shi CS; Kao YC; Lin SW; Wu HL. 2012. Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response. J Immunol 188(12):6328-37. [PubMed: 22573811] [MGI Ref ID J:188879]
Ma S; Kwon HJ; Huang Z. 2012. Ric-8a, a guanine nucleotide exchange factor for heterotrimeric G proteins, regulates bergmann glia-basement membrane adhesion during cerebellar foliation. J Neurosci 32(43):14979-93. [PubMed: 23100420] [MGI Ref ID J:191222]
Martin EI; Ressler KJ; Jasnow AM; Dabrowska J; Hazra R; Rainnie DG; Nemeroff CB; Owens MJ. 2010. A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor. Biol Psychiatry 67(12):1212-6. [PubMed: 20303068] [MGI Ref ID J:162037]
Massarwa R; Niswander L. 2013. In toto live imaging of mouse morphogenesis and new insights into neural tube closure. Development 140(1):226-36. [PubMed: 23175632] [MGI Ref ID J:191070]
Mathew SJ; Hansen JM; Merrell AJ; Murphy MM; Lawson JA; Hutcheson DA; Hansen MS; Angus-Hill M; Kardon G. 2011. Connective tissue fibroblasts and Tcf4 regulate myogenesis. Development 138(2):371-84. [PubMed: 21177349] [MGI Ref ID J:167712]
Michalski JP; Anderson C; Beauvais A; De Repentigny Y; Kothary R. 2011. The Proteolipid Protein Promoter Drives Expression outside of the Oligodendrocyte Lineage during Embryonic and Early Postnatal Development. PLoS One 6(5):e19772. [PubMed: 21572962] [MGI Ref ID J:172435]
Moriyama M; Fukuhara T; Britschgi M; He Y; Narasimhan R; Villeda S; Molina H; Huber BT; Holers M; Wyss-Coray T. 2011. Complement Receptor 2 Is Expressed in Neural Progenitor Cells and Regulates Adult Hippocampal Neurogenesis. J Neurosci 31(11):3981-3989. [PubMed: 21411641] [MGI Ref ID J:170456]
Mourikis P; Gopalakrishnan S; Sambasivan R; Tajbakhsh S. 2012. Cell-autonomous Notch activity maintains the temporal specification potential of skeletal muscle stem cells. Development 139(24):4536-48. [PubMed: 23136394] [MGI Ref ID J:189959]
Mourikis P; Sambasivan R; Castel D; Rocheteau P; Bizzarro V; Tajbakhsh S. 2012. A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state. Stem Cells 30(2):243-52. [PubMed: 22069237] [MGI Ref ID J:190192]
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Murphy PA; Kim TN; Lu G; Bollen AW; Schaffer CB; Wang RA. 2012. Notch4 normalization reduces blood vessel size in arteriovenous malformations. Sci Transl Med 4(117):117ra8. [PubMed: 22261032] [MGI Ref ID J:183703]
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Song R; Hennig GW; Wu Q; Jose C; Zheng H; Yan W. 2011. Male germ cells express abundant endogenous siRNAs. Proc Natl Acad Sci U S A 108(32):13159-64. [PubMed: 21788498] [MGI Ref ID J:175627]
Soudja SM; Ruiz AL; Marie JC; Lauvau G. 2012. Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion. Immunity 37(3):549-62. [PubMed: 22940097] [MGI Ref ID J:187687]
Srinivasan RS; Oliver G. 2011. Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev 25(20):2187-97. [PubMed: 22012621] [MGI Ref ID J:177488]
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Toh B; Wang X; Keeble J; Sim WJ; Khoo K; Wong WC; Kato M; Prevost-Blondel A; Thiery JP; Abastado JP. 2011. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol 9(9):e1001162. [PubMed: 21980263] [MGI Ref ID J:184038]
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Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Room Number AX11
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice are bred as homozygotes. Mating System Homozygote x Homozygote (Female x Male) 09-APR-08 Diet Information LabDiet® 5K52/5K67
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $177.00 Female or Male Homozygous for Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Price per Pair (US dollars $) Pair Genotype $354.00 Homozygous for Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo x Homozygous for Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
| Pricing for International shipping destinations |
|
Live Mice
Price per mouse (US dollars $) Gender Genotypes Provided Individual Mouse $230.10 Female or Male Homozygous for Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo
Price per Pair (US dollars $) Pair Genotype $460.20 Homozygous for Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo x Homozygous for Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
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|
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Standard Supply
Repository-Live. Repository-Live represents an exclusive set of over 1500 unique mouse models maintained at The Jackson Laboratory to support a vast array of research areas. The breeding colonies for Repository Strains provide mice for both large and small orders and fluctuate in size depending on current demand for each strain. Repository-live orders are treated as custom orders. Within 2 business days, we respond to each availability inquiry or order with various delivery options. Repository Strains typically are delivered at 4 to 8 weeks of age and will not exceed 12 weeks of age on the day of shipping.
General Supply Notes
- Genomic DNA is available for this strain from the Mouse DNA Resource.
Control Information
| Control | ||
|---|---|---|
| 000691 129X1/SvJ | (approximate) | |
| Considerations for Choosing Controls | ||
| Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Payment Terms and Conditions
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
See Terms of Use tab for General Terms and Conditions
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
JAX® Mice
Surgical and Preconditioning Services
JAX® Services
Customer Services and Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
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Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Strain(s) not available to companies or for-profit entities.
- Strain(s) not available to companies or for-profit entities.
Contact information
General inquiries regarding Terms of UseContracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.