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Former Name	129S4-Park2tm1Rpa/J    (Changed: 11-JUL-07 )
Genes & Alleles	Park2;   Park2tm1Rpa;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Coisogenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Donating Investigator Richard Palmiter,   University of Washington

Strain Description
Mice carrying this mutation are viable, fertile, and display no apparent defects or abnormalities. Mutations in the human homolog of this gene are associated with autosomal juvenile parkinsonism, a heritable form of Parkinson's disease.

Strain Development
A targeting vector was designed to replace approximately 4 kb of the gene, including exon 2, with a neomycin gene driven by a Polr2a gene promoter. The vector was introduced to 129S4/SvJaeSor-derived AK18.1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. Chimeric animals were crossed with 129S4/SvJaeSor.

Mammalian Phenotype Terms assigned by genotype The following phenotype information may relate to a genetic background differing from this JAX® Mice strain. Park2tm1Rpa/Park2tm1Rpa         involves: 129S4/SvJaeSor * C57BL/6 behavior/neurological phenotype *normal* behavior/neurological phenotype (MGI Ref ID J:95204) no significant differences were found, after controlling the false discovery rate, in any of 25 different behavioral tests examining general neurological function, motor function, emotionality, and learning and memory homeostasis/metabolism phenotype *normal* homeostasis/metabolism phenotype (MGI Ref ID J:95204) no significant difference in body temperature or in response to a 2 hour cold challenge was seen nervous system phenotype *normal* nervous system phenotype (MGI Ref ID J:95204) dopamine levels in the striatum and norepinephrine levels in the olfactory bulb and spinal cord are normal and histopathological analysis failed to detect any defects in the brains of aged mice

Gene & Allele Details

Allele Symbol		Park2tm1Rpa
Allele Name		targeted mutation 1, Richard D Palmiter
Strain of Origin		129S4/SvJaeSor
ES Cell Line Name		Other (see notes)
Gene Symbol and Name		Park2, parkin
Chromosome		17
Gene Common Name(s)		AR-JP; LPRS2; PDJ; PRKN; Park;
General Note		ES cell line = AK18.1.
Molecular Note		Approximately 4 kb of the genomic sequence containing exon 2 were replaced with a construct containing the neor gene, driven by the polymerase (RNA) II (DNA directed) polypeptide A gene promoter, and the negative selection markers HSV-TK and PGK-DTA. [MGI Ref ID J:95204]

Control Information

	Control
	002448 129S1/SvImJ
Considerations for Choosing Controls

Genotyping Protocols

Park2^tm1Rpa

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony, these mice may be bred as homozygotes.
Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying other alleles of Park2

006582

B6.129S4-Park2tm1Shn/J

View Strains carrying other alleles of Park2     (1 strain)

Animal Health Reports

Room Number           AX11

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Parkinson's Disease (Park2 (parkin) mutants)
Parkinson's Disease

References

Selected Reference(s)

Perez FA; Palmiter RD. 2005. Parkin-deficient mice are not a robust model of parkinsonism. Proc Natl Acad Sci U S A 102(6):2174-9. [PubMed: 15684050]  [MGI Ref ID J:95204]

Additional References

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Price and Supply Information

Strain Name:	129S-Park2tm1Rpa/J
Stock Number:	007587

Price Details

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Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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