Strain Name: |
B6.129S6-Hrtm1Cct/J |
|---|---|
Stock Number: |
007621 |
Availability: | Repository- Live |
General Terms and Conditions |
| Genes & Alleles | Hr; Hrtm1Cct; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Mating System Heterozygote x Heterozygote (Female x Male) Species laboratory mouse Donating Investigator Catherine Thompson, Wyeth Research Generation N8+F1 (20-DEC-07) Strain Description
Homozygotes are viable and fertile, but optimal breeding is done with heterozygotes. The mice appear normal at birth and for about two weeks postnatally. Once the animals begin to shed, the hair is lost and does not grow back. They remain bald and over time, the skin becomes thicker and progressively more wrinkled. The degree of wrinkling is variable but can be severe; frequently the skin protrudes over the eyes and off the sides of the animals. Wrinkling is more severe than in the hairless rhino allele. Northern analysis of mRNA from back skin confirmed the absence of expression. This strain maybe be useful in studies of skin and hair.Strain Development
A targeting vector was designed to replace exons 8-10 and a portion of exon 7 with a loxP-flanked PGKneo neomycin resistance cassette. The targeting vector was introduced to a 129S6/SvEvTac-derived embryonic stem (ES) cell line. Germline chimeras were crossed to C57BL/6 for seven generations by the donating laboratory.
Mammalian Phenotype Terms assigned by genotype |
Gene & Allele Details
| Allele Symbol | Hrtm1Cct | ||
|---|---|---|---|
| Allele Name | targeted mutation 1, Catherine C Thompson | ||
| Common Name(s) | Hr-; | ||
| Mutation Made By | Catherine Thompson, Wyeth Research | ||
| Strain of Origin | 129/Sv | ||
| ES Cell Line Strain | 129 | ||
| Gene Symbol and Name | Hr, hairless | ||
| Chromosome | 14 | ||
| Gene Common Name(s) | ALUNC; AU; HSA277165; N; ba; baldy; bldy; rh; rh-bmh; rhino-bald Mill Hill; | ||
| Molecular Note | Homologous recombination was used to replace exons 8-10 with a floxed PGK-neo. Southern blot confirmed recombination in mutant mice. Northern blot of mutant skin indicated lack of full-length mRNA and Western blot showed a lack of full-length protein in the skin of mutants. [MGI Ref ID J:92053] | ||
Control Information
| Control | ||
|---|---|---|
| Wild-type from the colony | ||
| Considerations for Choosing Controls | ||
Genotyping Protocols
Hrtm1Cct
Colony Maintenance
| Diet Information | LabDiet® 5K52/5K67 |
|---|
Related Strains
Strains carrying other alleles of Hr
001737 B6.A-H2-T18a.HRS-Hrhr/J 007622 B6;SJL-Tg(KRT14-Hr)551Cct/J 000758 C57BL/6J-Hbbp Hrrh-7J/J 002922 D2.HRS-Hrhr/J 000673 HRS/J 001103 HRS/J-Hrhr Esdb/+ Esdb/J 000266 RHJ/Le 001591 RHJ/LeJ 002335 SKH2/J 000147 WLHR/LeJ View Strains carrying other alleles of Hr (10 strains)
Additional Web Information
Congenic Nomenclature
Animal Health Reports
Room Number AX11
Research Applications
This mouse can be used to support research in many areas including:
Dermatology Research
Skin and Hair Texture Defects
References
Selected Reference(s)
Additional ReferencesZarach JM; Beaudoin GM rd; Coulombe PA; Thompson CC. 2004. The co-repressor hairless has a role in epithelial cell differentiation in the skin. Development 131(17):4189-200. [PubMed: 15280217] [MGI Ref ID J:92053]
Price and Supply Information
| Strain Name: | B6.129S6-Hrtm1Cct/J |
| Stock Number: | 007621 |
Price Details
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection. |
| Licensing | See General Terms and Conditions below for Licensing and Use Restrictions |
| Control Information | View Control Information in Strain Details. |
General Terms and Conditions
View JAX® Mice & Services Conditions of Use.
Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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