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Price and Supply Information
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Genes & Alleles

Hr;   Hrtm1Cct;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Mutant Strain Type JAX® GEMM® Strain - Targeted Mutation Mating System Heterozygote x Heterozygote         (Female x Male) Species laboratory mouse Donating Investigator Catherine Thompson,   Wyeth Research Generation N8+F1 (20-DEC-07)

Strain Description
Homozygotes are viable and fertile, but optimal breeding is done with heterozygotes. The mice appear normal at birth and for about two weeks postnatally. Once the animals begin to shed, the hair is lost and does not grow back. They remain bald and over time, the skin becomes thicker and progressively more wrinkled. The degree of wrinkling is variable but can be severe; frequently the skin protrudes over the eyes and off the sides of the animals. Wrinkling is more severe than in the hairless rhino allele. Northern analysis of mRNA from back skin confirmed the absence of expression. This strain maybe be useful in studies of skin and hair.

Strain Development
A targeting vector was designed to replace exons 8-10 and a portion of exon 7 with a loxP-flanked PGKneo neomycin resistance cassette. The targeting vector was introduced to a 129S6/SvEvTac-derived embryonic stem (ES) cell line. Germline chimeras were crossed to C57BL/6 for seven generations by the donating laboratory.

Mammalian Phenotype Terms assigned by genotype The following phenotype information may relate to a genetic background differing from this JAX® Mice strain. Hrtm1Cct/Hrtm1Cct         involves: 129/Sv * C57BL/6 skin/coat/nails phenotype abnormal hair follicle structure (MGI Ref ID J:92053) by day 12, pilary canal widens to form a utricle abnormal skin morphology (MGI Ref ID J:92053) dermal cysts (MGI Ref ID J:92053) small dermal cysts appear as hair is lost; these cysts increase in size with age due to cell proliferation and secretion of sebum into sealed compartments while utricle size remains constant skin hyperplasia (MGI Ref ID J:92053) increased cell proliferation in epidermis and utricles alopecia (MGI Ref ID J:92053) first postnatal hair coat grows normally hair loss begins around age 18 and starts at the head, proceeding caudally in a scattered pattern hair follicles fail to regenerate wrinkled skin (MGI Ref ID J:92053) skin becomes progressively more wrinkled with age Hrtm1Cct/Hrtm1Cct         involves: 129/Sv skin/coat/nails phenotype abnormal skin morphology (MGI Ref ID J:102493) abnormal epidermal structures (utricles) form by P22; skin is grossly abnormal alopecia (MGI Ref ID J:102493) BY P22, mice exhibit hair loss

Gene & Allele Details

Allele Symbol		Hrtm1Cct
Allele Name		targeted mutation 1, Catherine C Thompson
Common Name(s)		Hr-;
Mutation Made By		Catherine Thompson,   Wyeth Research
Strain of Origin		129/Sv
ES Cell Line Strain		129
Gene Symbol and Name		Hr, hairless
Chromosome		14
Gene Common Name(s)		ALUNC; AU; HSA277165; N; ba; baldy; bldy; rh; rh-bmh; rhino-bald Mill Hill;
Molecular Note		Homologous recombination was used to replace exons 8-10 with a floxed PGK-neo. Southern blot confirmed recombination in mutant mice. Northern blot of mutant skin indicated lack of full-length mRNA and Western blot showed a lack of full-length protein in the skin of mutants. [MGI Ref ID J:92053]

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls
Control Pricing Information for JAX® GEMM® Strains

Genotyping Protocols

Hr^tm1Cct

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Related Strains

Strains carrying other alleles of Hr

001737	B6.A-H2-T18a.HRS-Hrhr/J
007622	B6;SJL-Tg(KRT14-Hr)551Cct/J
000758	C57BL/6J-Hbbp Hrrh-7J/J
002922	D2.HRS-Hrhr/J
000673	HRS/J
001103	HRS/J-Hrhr Esdb/+ Esdb/J
000266	RHJ/Le
001591	RHJ/LeJ
002335	SKH2/J
000147	WLHR/LeJ

View Strains carrying other alleles of Hr     (10 strains)

Additional Web Information

Congenic Nomenclature

Animal Health Reports

Room Number           AX11

Research Applications

This mouse can be used to support research in many areas including:

Dermatology Research
Skin and Hair Texture Defects

References

Selected Reference(s)

Zarach JM; Beaudoin GM rd; Coulombe PA; Thompson CC. 2004. The co-repressor hairless has a role in epithelial cell differentiation in the skin. Development 131(17):4189-200. [PubMed: 15280217]  [MGI Ref ID J:92053]

Additional References

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Price and Supply Information

Strain Name:	B6.129S6-Hrtm1Cct/J
Stock Number:	007621

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. The shipping destinations are:

• USA, Canada and Mexico
• International

*Pricing for Shipping Destination selected:

        International

Price(s) in US dollars ($)		Genotype(s) Provided
Individual Mouse Price	$307.40	Heterozygous for Hrtm1Cct
Individual Mouse Price	$379.50	Homozygous for Hrtm1Cct
Pair	$614.70	Heterozygous for Hrtm1Cct x Heterozygous for Hrtm1Cct

Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Histology and Tissue Collection Services are available for all JAX® Mice strains. For more information, please contact Customer Service at orderquest@jax.org or 1-207-288-5845. Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions
Control Information	View Control Information in Strain Details. View Control Pricing Information for JAX® Strains.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

Effective September 26, 2007: License Requirements for Strains using Cre-lox Technology only apply in Canada, see Licenses for Strains using Cre-lox Technology.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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