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Strain Name:

B6;SJL-Tg(KRT14-Hr)551Cct/J

Stock Number:

007622

Availability:

Repository- Live

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General Terms and Conditions

Former Name      B6SJL-Tg(KRT14-Hr)551Cct/J    (Changed: 20-JUL-07 )
Genes & Alleles   Hr;   KRT14;   Tg(KRT14-Hr)551Cct;

Product Information

Strain Details

Type JAX® GEMM® Strain - Mutant Stock
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Transgenic
Mating SystemNoncarrier x Hemizygote         (Female x Male)
Specieslaboratory mouse
Donating Investigator Catherine Thompson,   Wyeth Research
Generation?N2+F0 (08-JAN-08)

Strain Description
Hemizygous mice are viable and fertile. When young, these mice look similar to wildtype mice, but as they age, their coats become shorter and more sparse. Molecular analysis shows delayed development of sebaceous glands, accelerated hair cycle and less-differentiated epidermis. RNA and protein expressed from the transgene are detected in skin as determined by Western and Northern analysis. This strain may be useful as a model for skin and hair development studies.

Strain Development
A 3.5 kb fragment containing the coding sequence of the rat Hr cDNA was inserted between the human keratin 14 (KRT14) promoter/rabbit beta-globin intron and the KRT14 5' UTR/polyadenylation signal. The linearized transgene was microinjected into B6SJLF2 embryos. Transgenic mice were crossed with C57BL/6 one time by the donating laboratory.

Mammalian Phenotype Terms assigned by genotype

Tg(KRT14-Hr)551Cct/?

        involves: C57BL/6 * SJL
  • skin/coat/nails phenotype
  • abnormal hair follicle root sheath (MGI Ref ID J:102493)
    • the matrix cells associated with the hair follicle root sheath are proliferating at a slower rate compared to non-transgenic controls
  • abnormal sebaceous gland morphology (MGI Ref ID J:102493)
    • sebaceous gland development is delayed in these mice with no glands present in the hair follicles at 9 days of age but are visible in some hair follicles by 12 days of age
  • short hair (MGI Ref ID J:102493)
    • hairs found in follicles at 9 days of age are shorter than those found in non-transgenic controls
  • thickened epidermis (MGI Ref ID J:102493)
    • the back skin of 9 day old mice is thicker than in non-transgenic controls due to an increase in undifferentiated skin cells and a decrease in terminally-differentiated keratinocytes
  • endocrine/exocrine gland phenotype
  • abnormal sebaceous gland morphology (MGI Ref ID J:102493)
    • sebaceous gland development is delayed in these mice with no glands present in the hair follicles at 9 days of age but are visible in some hair follicles by 12 days of age

Gene & Allele Details

Allele Symbol Tg(KRT14-Hr)551Cct
Allele Name transgene insertion 551, Catherine C Thompson
Common Name(s) K14-rHr;
Strain of Origin(C57BL/6 x SJL)F2
Expressed Gene Hr, hairless, mouse, laboratory
Promoter KRT14, keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner), human
Molecular Note A 3.5 kb fragment containing the coding sequence of the rat Hr cDNA was inserted between the human keratin 14 (KRT14) promoter/rabbit beta-globin intron and the KRT14 5' UTR/polyadenylation signal.Hr protein expression is high in the skin in early postnatal development, and remains above wild-type levels as development proceeds. [MGI Ref ID J:102493]

Control Information

  Control
   Noncarrier
 
  Considerations for Choosing Controls

Genotyping Protocols

Tg(KRT14-Hr)551Cct

Colony Maintenance

Diet Information LabDiet® 5K52/5K67

Related Strains

Strains carrying other alleles of Hr
007621   B6.129S6-Hrtm1Cct/J
001737   B6.A-H2-T18a.HRS-Hrhr/J
000758   C57BL/6J-Hbbp Hrrh-7J/J
002922   D2.HRS-Hrhr/J
000673   HRS/J
001103   HRS/J-Hrhr Esdb/+ Esdb/J
000266   RHJ/Le
001591   RHJ/LeJ
002335   SKH2/J
000147   WLHR/LeJ
View Strains carrying other alleles of Hr     (10 strains)

View Strains carrying other alleles of KRT14     (10 strains)

Animal Health Reports

Room Number           AX11

Research Applications

This mouse can be used to support research in many areas including:

Dermatology Research
Skin and Hair Texture Defects

References

Selected Reference(s)

Beaudoin GM rd; Sisk JM; Coulombe PA; Thompson CC. 2005. Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A 102(41):14653-8. [PubMed: 16195376]  [MGI Ref ID J:102493]

Price and Supply Information

Strain Name: B6;SJL-Tg(KRT14-Hr)551Cct/J
Stock Number: 007622

Price Details

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Supply Details

Standard SupplyRepository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes Usually shipped between four and eight weeks of age.
This strain is included in the Induced Mutant Resource Colony collection.
LicensingSee General Terms and Conditions below  
Control InformationView Control Information in Strain Details.

General Terms and Conditions

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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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