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| When crossed with a Cre recombinase-expressing strain, this strain carrying a floxed allele is useful in eliminating tissue-specific expression of the gene. This mutant mouse strain may be useful in studies of fetal and neonatal hematopoietic stem cells and hematopoiesis. | |||||||||||||||
- Description
- Disease & phenotype
- Genes & alleles
- Genotyping
- Health & care
- References
- Pricing & purchasing
- Terms of use
Description
The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.
Strain Information
Type Congenic; Mutant Strain; Targeted Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Donating Investigator Sean J Morrison, UT Southwestern Description
These mice possess loxP sites on either side of the exon 3-5 region of the targeted gene. Mice homozygous for this allele are viable and fertile and do not display any gross physical or behavioral abnormalities. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene.When the floxed allele is excised by crosses with a Tie2 (endothelial-specific receptor tyrosine kinase)-Cre mouse (Stock No. 004128) and the Sox17 targeted mutant EGFP reporter strain (Stock No. 007687), mutants are embryonic lethal around E13.5. Mutant embryos have severe hematopoietic failure and lack definitive hematopoietic stem cells.
When the floxed allele is excised by Mx1 (myxovirus (influenza virus) resistance 1)-Cre (Stock No. 003556) and the Sox17 targeted mutant EGFP reporter strain (Stock No. 007687), neonatal mutant mice die after one week, showing hematopoietic defects. This mutant mouse strain may be useful in studies of fetal and neonatal hematopoietic stem cells and hematopoiesis.
Development
A targeting vector was designed to flank the exon 3-5 region with loxP sites and place an FRT-flanked neomycin resistance cassette in intron 5. Exons 4 and 5 contain the coding sequence. The construct was electroporated into (129X1/SvJ x 129S1/Sv)F1-Kitl+-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/Ka CD45.2:Thy1.1 (Ptprcb Thy1a) mice. A cross to a C57BL/6-background Actb-FLP strain was then carried out to remove the FRT-flanked neomycin cassette. The line was then backcrossed to the C57BL/Ka CD45.2:Thy1.1 line for 8 generations by the donating laboratory.
Related Strains
Strains carrying Thy1a allele
005895 B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J 001317 B6.Cg-Igha Thy1a Gpi1a/J 014550 B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J 005023 B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J 000406 B6.PL-Thy1a/CyJ 000983 B6.PL/(84NS)CyJ 017351 BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J 007687 BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J 005307 CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 005922 CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J 005443 CBy.PL(B6)-Thy1a/ScrJ 005686 NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ 004483 NOD.NON-Thy1a/1LtJ 002721 NOD.NON-Thy1a/J 005651 SJL.AK-Thy1a/TseJ 003961 SJL.Cg Thy1a-Noxo1hslt/J View Strains carrying Thy1a (16 strains)
007172 129S6.129X1(B6)-Ptprctm1Weis/J 002725 B6.129-Ptprctm1Holm/J 008451 B6.129P(Cg)-Ptprca Cx3cr1tm1Litt/LittJ 007594 B6.129P2-Ptrpca Ightm1Mnz/J 007171 B6.129X1-Ptprctm1Weis/J 006259 B6.Cg-Pepcb Ptprca Tg(UBC-scFv)2Nemz/J 013198 B6.Cg-Ptprca Mir223tm1Fcam/J 002014 B6.SJL-Ptprca Pepcb/BoyJ 017351 BKa.Cg-Ptprcb Bmi1tm1Ilw Thy1a/J 007687 BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J 018869 C.129S4(Cg)-Il13tm2.1Lky/J 007173 C.129X1(B6)-Ptprctm1Weis/J 016091 C57BL/6-Ptprcltng/J 006584 CBy.SJL(B6)-Ptprca/J 014149 NOD.B6-Ptprcb/6908MrkTacJ 005616 NOD.C-(Ptprc-D1Mit262)/WehiJ
007687 BKa.Cg-Sox17tm1Sjm Ptprcb Thy1a/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
- Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested. Vesicoureteral Reflux 3; VUR3 (SOX17)
assigned by genotype
The following phenotype relates to a compound genotype created using this strain.
Contact JAX® Services jaxservices@jax.org for customized breeding options.Sox17tm1Sjm/Sox17tm2Sjm Tg(Mx1-cre)1Cgn/0
involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA (conditional)
- mortality/aging
- complete postnatal lethality
- death of all mice by 14 days after birth (MGI Ref ID J:123050)
- hematopoietic system phenotype
- decreased bone marrow cell number
- when sacrificed 4-5 days after end of poly(I:C) treatment, reduced bone marrow cellularity is observed (MGI Ref ID J:123050)
- decreased hematopoietic stem cell number
- HSCs are reduced in bone marrow and spleen (MGI Ref ID J:123050)
- decreased leukocyte cell number
- numbers are significantly reduce compared to controls following cre induction (MGI Ref ID J:123050)
- decreased platelet cell number
- numbers are significantly reduce compared to controls following cre induction (MGI Ref ID J:123050)
- spleen hypoplasia
- when sacrificed 4-5 days after end of poly(I:C) treatment, reduced spleen cellularity is observed (MGI Ref ID J:123050)
- thymus hypoplasia
- mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment (MGI Ref ID J:123050)
- immune system phenotype
- decreased leukocyte cell number
- numbers are significantly reduce compared to controls following cre induction (MGI Ref ID J:123050)
- spleen hypoplasia
- when sacrificed 4-5 days after end of poly(I:C) treatment, reduced spleen cellularity is observed (MGI Ref ID J:123050)
- thymus hypoplasia
- mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment (MGI Ref ID J:123050)
Sox17tm1Sjm/Sox17tm2Sjm Tg(Tek-cre)12Flv/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * C57BL/Ka (conditional)
- mortality/aging
- complete embryonic lethality during organogenesis
- expected numbers of homozygotes are found at E12.5, but complete lethality is observed by E13.5 (MGI Ref ID J:123050)
- embryogenesis phenotype
- abnormal embryonic hematopoiesis
- no hematopoiesis is visible in the yolk sac or embryo at E12.5 (MGI Ref ID J:123050)
- embryonic growth retardation
- at E12.5, mutants are growth retarded (MGI Ref ID J:123050)
- growth/size phenotype
- embryonic growth retardation
- at E12.5, mutants are growth retarded (MGI Ref ID J:123050)
- hematopoietic system phenotype
- abnormal embryonic hematopoiesis
- no hematopoiesis is visible in the yolk sac or embryo at E12.5 (MGI Ref ID J:123050)
This mouse can be used to support research in many areas including:
Thy1a relatedHematological Research
Hematopoietic Defects
Research Tools
Cre-lox System
loxP-flanked Sequences
Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Research Tools
Genetics Research
Tissue/Cell Markers
Tissue/Cell Markers: T cell specific surface marker
Immunology and Inflammation Research
T cell specific surface marker
Genes & Alleles
Gene & Allele Information provided by MGI
| Allele Symbol | Sox17tm2Sjm | ||
|---|---|---|---|
| Allele Name | targeted mutation 2, Sean J Morrison | ||
| Allele Type | Targeted (Floxed/Frt) | ||
| Common Name(s) | Sox17cKO; Sox17fl; | ||
| Mutation Made By | Sean Morrison, UT Southwestern | ||
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| ES Cell Line Name | R1 | ||
| ES Cell Line Strain | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> | ||
| Gene Symbol and Name | Sox17, SRY-box containing gene 17 | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | VUR3; | ||
| Molecular Note | LoxP sites were inserted on either side of the exon 3-5 region of the Sox17 gene. Mice homozygous for this allele are viable and fertile and do not display any gross physical or behavioral abnormalities. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. [MGI Ref ID J:123050] | ||
| Allele Symbol | Thy1a | ||
| Allele Name | a variant | ||
| Allele Type | Not Applicable | ||
| Common Name(s) | Thy-1.1; Thy1.1; Thy1a; theta-AKR; thetaAKR; | ||
| Site of Expression | The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. | ||
| Gene Symbol and Name | Thy1, thymus cell antigen 1, theta | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | CD7; CD90; T25; Thy 1.2; Thy-1; Thy-1.2; Thy1.1; Thy1.2; theta; | ||
| General Note |
The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experiments designed to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that isthe same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900). | ||
| Molecular Note | The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains. | ||
| Gene Symbol and Name | Ptprc, protein tyrosine phosphatase, receptor type, C | ||
| Chromosome | 1 | ||
| Gene Common Name(s) | B220; CD45; CD45 antigen; CD45R; Cd45; GP180; L-CA; LCA; LY5; Ly-5; Lyt-4; RT7; T-lymphocyte antigen 4; T200; lymphocyte antigen 5; | ||
Genotyping
Genotyping Information
Genotyping Protocols
Sox17tm2Sjm, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
References
References provided by MGI
Selected Reference(s)
Kim I; Saunders TL; Morrison SJ. 2007. Sox17 dependence distingushes the transcriptional regulation of fetal from adult hematopoietic stem cells Cell 130(3):470-83. [PubMed: 17655922] [MGI Ref ID J:123050]
Additional References
Sox17tm2Sjm relatedThy1a relatedArtus J; Piliszek A; Hadjantonakis AK. 2011. The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol 350(2):393-404. [PubMed: 21146513] [MGI Ref ID J:170416]
Viotti M; Niu L; Shi SH; Hadjantonakis AK. 2012. Role of the gut endoderm in relaying left-right patterning in mice. PLoS Biol 10(3):e1001276. [PubMed: 22412348] [MGI Ref ID J:184721]
Yang H; Lee S; Lee S; Kim K; Yang Y; Kim JH; Adams RH; Wells JM; Morrison SJ; Koh GY; Kim I. 2013. Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. J Clin Invest 123(1):418-31. [PubMed: 23241958] [MGI Ref ID J:194296]
Beck PL; Li Y; Wong J; Chen CW; Keenan CM; Sharkey KA; McCafferty DM. 2007. Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation. Gastroenterology 132(5):1778-90. [PubMed: 17449036] [MGI Ref ID J:128325]
Chen TT; Li L; Chung DH; Allen CD; Torti SV; Torti FM; Cyster JG; Chen CY; Brodsky FM; Niemi EC; Nakamura MC; Seaman WE; Daws MR. 2005. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med 202(7):955-65. [PubMed: 16203866] [MGI Ref ID J:107466]
Cuda CM; Wan S; Sobel ES; Croker BP; Morel L. 2007. Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms. J Immunol 179(11):7439-47. [PubMed: 18025188] [MGI Ref ID J:154964]
D'Eustachio P; Owens GC; Edelman GM; Cunningham BA. 1985. Chromosomal location of the gene encoding the neural cell adhesion molecule (N-CAM) in the mouse. Proc Natl Acad Sci U S A 82(22):7631-5. [PubMed: 3865183] [MGI Ref ID J:8111]
Dewals B; Hoving JC; Horsnell WG; Brombacher F. 2010. Control of Schistosoma mansoni egg-induced inflammation by IL-4-responsive CD4(+)CD25(-)CD103(+)Foxp3(-) cells is IL-10-dependent. Eur J Immunol 40(10):2837-47. [PubMed: 20821727] [MGI Ref ID J:165816]
Divangahi M; Desjardins D; Nunes-Alves C; Remold HG; Behar SM. 2010. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol 11(8):751-8. [PubMed: 20622882] [MGI Ref ID J:162390]
Dolfi DV; Duttagupta PA; Boesteanu AC; Mueller YM; Oliai CH; Borowski AB; Katsikis PD. 2011. Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo. J Immunol 186(8):4599-608. [PubMed: 21389258] [MGI Ref ID J:172460]
Fife BT; Griffin MD; Abbas AK; Locksley RM; Bluestone JA. 2006. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. J Clin Invest 116(8):2252-61. [PubMed: 16886063] [MGI Ref ID J:113109]
Green MC; Sweet HO. 1975. [Hx - Hm - W.] Mouse News Lett 52:38. [MGI Ref ID J:13675]
Inlay MA; Bhattacharya D; Sahoo D; Serwold T; Seita J; Karsunky H; Plevritis SK; Dill DL; Weissman IL. 2009. Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev 23(20):2376-81. [PubMed: 19833765] [MGI Ref ID J:154864]
Kelly LM; Pereira JP; Yi T; Xu Y; Cyster JG. 2011. EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues. J Immunol 187(6):3026-32. [PubMed: 21844396] [MGI Ref ID J:179238]
Krieg C; Letourneau S; Pantaleo G; Boyman O. 2010. Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc Natl Acad Sci U S A 107(26):11906-11. [PubMed: 20547866] [MGI Ref ID J:161365]
Leiter EH. 1998. NOD Mice and Related Strains: Origins, Husbandry and Biology Introduction. In: NOD Mice and Related Strains: Research Applications in Diabetes, AIDS, Cancer, and Other Diseases. RG Landes, Austin. [MGI Ref ID J:110093]
REIF AE; ALLEN JM. 1964. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med 120:413-33. [PubMed: 14207060] [MGI Ref ID J:24839]
Ranheim EA; Tarbell KV; Krogsgaard M; Mallet-Designe V; Teyton L; McDevitt HO; Weissman IL. 2004. Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgene. Autoimmunity 37(8):555-67. [PubMed: 15763918] [MGI Ref ID J:128250]
Read S; Hogan TV; Zwar TD; Gleeson PA; Van Driel IR. 2007. Prevention of autoimmune gastritis in mice requires extra-thymic T-cell deletion and suppression by regulatory T cells. Gastroenterology 133(2):547-58. [PubMed: 17603058] [MGI Ref ID J:128303]
Reif AE; Allen JM. 1966. Mouse thymic iso-antigens. Nature 209(22):521-3. [PubMed: 5919593] [MGI Ref ID J:5012]
Sercan O; Stoycheva D; Hammerling GJ; Arnold B; Schuler T. 2010. IFN-gamma receptor signaling regulates memory CD8+ T cell differentiation. J Immunol 184(6):2855-62. [PubMed: 20164422] [MGI Ref ID J:160112]
Uhl M; Kepp O; Jusforgues-Saklani H; Vicencio JM; Kroemer G; Albert ML. 2009. Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells. Cell Death Differ 16(7):991-1005. [PubMed: 19229247] [MGI Ref ID J:164191]
Voehringer D; Liang HE; Locksley RM. 2008. Homeostasis and effector function of lymphopenia-induced 'memory-like' T cells in constitutively T cell-depleted mice. J Immunol 180(7):4742-53. [PubMed: 18354198] [MGI Ref ID J:133382]
Wang L; Jameson SC; Hogquist KA. 2009. Epidermal Langerhans cells are not required for UV-induced immunosuppression. J Immunol 183(9):5548-53. [PubMed: 19843938] [MGI Ref ID J:156799]
Wuthrich M; Ersland K; Pick-Jacobs JC; Gern BH; Frye CA; Sullivan TD; Brennan MB; Filutowicz HI; O'Brien K; Korthauer KD; Schultz-Cherry S; Klein BS. 2012. Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall. Infect Immun 80(2):787-97. [PubMed: 22124658] [MGI Ref ID J:180817]
Wuthrich M; Warner T; Klein BS. 2005. IL-12 is required for induction but not maintenance of protective, memory responses to Blastomyces dermatitidis: implications for vaccine development in immune-deficient hosts. J Immunol 175(8):5288-97. [PubMed: 16210634] [MGI Ref ID J:119110]
Xiao Z; Mescher MF; Jameson SC. 2007. Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J Exp Med 204(11):2667-77. [PubMed: 17954566] [MGI Ref ID J:126126]
Yu Y; Cho HI; Wang D; Kaosaard K; Anasetti C; Celis E; Yu XZ. 2013. Adoptive Transfer of Tc1 or Tc17 Cells Elicits Antitumor Immunity against Established Melanoma through Distinct Mechanisms. J Immunol 190(4):1873-81. [PubMed: 23315072] [MGI Ref ID J:193239]
Zaleski M; Klein J. 1974. Immune response of mice to Thy-1. 1 antigen: genetic control by alleles at the Ir-5 locus loosely linked to the H-2 complex. J Immunol 113(4):1170-7. [PubMed: 4606643] [MGI Ref ID J:5487]
Zaleski MB. 1975. Immune response of mice to the Thy-1.1 antigen: effect of the Ir-5 alleles studies in 129/J and B10.129(6M) mice Immunogenetics 2:241-8. [MGI Ref ID J:30773]
Zecher D; Li Q; Oberbarnscheidt MH; Demetris AJ; Shlomchik WD; Rothstein DM; Lakkis FG. 2010. NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells. J Immunol 184(12):6649-57. [PubMed: 20483732] [MGI Ref ID J:161405]
Health & husbandry
Health & Colony Maintenance Information
Animal Health Reports
Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.
Pricing and Purchasing
Pricing, Supply Level & Notes, Controls
| Pricing for USA, Canada and Mexico shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2250.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
| Pricing for International shipping destinations |
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Cryopreserved
Cryopreserved Mice - Ready for Recovery
Animals Provided
Price (US dollars $) Cryorecovery* $2925.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
Supply Notes
- Cryorecovery - Standard.
Progeny testing is not required.
The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).
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Standard Supply
Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering Information
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MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.