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| These Wnt1-Cre transgenic mice express Cre recombinase under the control of the wingless-related MMTV integration site 1 (Wnt1) promoter. When crossed with a strain containing loxP site-flanked sequences, Cre-mediated recombination results in deletion of the flanked sequences in the developing neural tube. | |||||||||||||||||||
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Description
Strain Information
Former Names B6.Cg-Tg(Wnt1-cre)11Rth/J (Changed: 18-JUN-09 ) Type Congenic; Mutant Strain; Transgenic; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Mating System Noncarrier x Hemizygote (Female x Male) 22-SEP-09 Species laboratory mouse Generation N3F?+ (21-SEP-09) Donating Investigator David Rowitch, Dana-Farber Cancer Institute Description
These Wnt1-Cre transgenic mice express Cre recombinase under the control of the wingless-related MMTV integration site 1 (Wnt1) promoter. Cre recombinase activity is detected in the Wnt1 pattern of expression: in the midbrain by 8.5 dpc and after neural tube closure, in the dorsal and ventral midlines of the midbrain and caudal diencephalon, midbrain-hindbrain junction and dorsal spinal cord. When crossed with a strain containing loxP site-flanked sequences, Cre-mediated recombination results in deletion of the flanked sequences in the developing neural tube tissues of the resulting offspring. The donating investigator reports that homozygous mice may be lethal as some offspring from transgenic carrier parents die around two months of age.In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
The Wnt1-Cre transgene, created by Dr. David H. Rowitch and Andrew P. McMahon (Harvard University), was designed to place a Cre recombinase cDNA under the control of the mouse Wnt1 promoter/enhancer elements. Specifically, the Wnt1-Cre transgene was created by inserting the Cre recombinase cDNA into a 10 kb modified mouse Wnt1 genomic sequence at the polylinker site between the promoter and enhancer (the Wnt1 genomic sequence spans from approximately 1 kb upstream of the translation initiation codon to approximately 5.5 kb downstream of the polyA signal, and is modified with a polylinker that disrupts the translational start site and a reverse-oriented neo cassette in 3' UTR of exon 4). This transgene was injected into the male pronucleus of B6CBAF1/J (C57BL/6JxCBA/J) zygotes. Founder mice were established. These Wnt1-Cre transgenic mice, reported to be C57BL/6J genetic background (although they were white), were then obtained by Dr. Miles Epstein (University of Wisconsin - Madison). Wnt1-Cre mice were bred together for many generations (and are now brown) prior to sending to The Jackson Laboratory. Upon arrival, mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.
Control Information
| Control | ||
|---|---|---|
| Noncarrier | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying Tg(Wnt1-cre)11Rth allele
003829 STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J View Strains carrying Tg(Wnt1-cre)11Rth (1 strain)
000243 B6C3Fe a/a-Wnt1sw/J 002865 B6CBA-Tg(Wnt1-lacZ)206Amc/J 002870 B6SJL-Tg(Wnt1)1Hev/J 002934 FVB.Cg-Tg(Wnt1)1Hev/J 003829 STOCK Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J
Additional Web Information
Introduction to Cre-lox technology
Phenotype
Phenotype Information
This mouse can be used to support research in many areas including:
cre relatedNeurobiology Research
Cre-lox System
Cre Recombinase expression in neural tissue
Research Tools
Cre-lox System
Cre Recombinase Expression
Developmental Biology Research
Cre-lox System
Research Tools
Cre-lox System
Genetics Research
Mutagenesis and Transgenesis: Cre-lox System
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Tg(Wnt1-cre)11Rth | ||
|---|---|---|---|
| Allele Name | transgene insertion 11, David H Rowitch | ||
| Allele Type | Transgenic (Cre/Flp) | ||
| Common Name(s) | Wnt1-Cre; Wnt1::Cre; Wnt1cre; | ||
| Mutation Made By | David Rowitch, Dana-Farber Cancer Institute | ||
| Strain of Origin | (C57BL/6J x CBA/J)F1/J | ||
| Site of Expression | embryonic neural tube, midbrain, dorsal and ventral midlines of the midbrain and caudal diencephalon, the mid-hindbrain junction and dorsal spinal cord | ||
| Expressed Gene | cre, cre recombinase, bacteriophage P1 | ||
| Cre recombinase is an enzyme derived from the bacteriophage P1 that specifically recognizes loxP sites. Cre has been shown to effectively mediate the excision of DNA located between loxP sites. After the excision event, the DNA ends recombine leaving a single loxP site in place of the intervening sequence. | |||
| Promoter | Wnt1, wingless-related MMTV integration site 1, mouse, laboratory | ||
| Driver Note | Wnt1 | ||
| General Note | Homozygous transgenic mice that are also homozygous for Tg(Wnt1-GAL4)11Rth are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. | ||
| Molecular Note | The Wnt1 promoter preceded the cre recombinase coding sequence which was followed downstream by the Wnt1 enhancer. The Wnt1 regulatory sequences initially direct expression in the midbrain. After neural tube closure, expression occurs in the dorsal and ventral midlines of the midbrain and caudal diencephalon, the midbrain-hindbrain junction and in the dorsal spinal cord. [MGI Ref ID J:69326] | ||
| Gene Symbol and Name | Tg(Wnt1-cre)11Rth, transgene insertion 11, David H Rowitch | ||
| Chromosome | UN | ||
| Gene Common Name(s) | Wnt1-Cre; Wnt1::Cre; Wnt1cre; | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Genotyping resources and troubleshooting
References
References
Selected Reference(s)
Danielian PS; Muccino D; Rowitch DH; Michael SK; McMahon AP. 1998. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr Biol 8(24):1323-6. [PubMed: 9843687] [MGI Ref ID J:69326]
Druckenbrod NR; Powers PA; Bartley CR; Walker JW; Epstein ML. 2008. Targeting of endothelin receptor-B to the neural crest. Genesis 46(8):396-400. [PubMed: 18693272] [MGI Ref ID J:140320]
Additional References
Tg(Wnt1-cre)11Rth relatedAnderson RM; Stottmann RW; Choi M; Klingensmith J. 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Dev Dyn 235(9):2507-2520. [PubMed: 16894609] [MGI Ref ID J:111609]
Anthwal N; Chai Y; Tucker AS. 2008. The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn 237(6):1604-13. [PubMed: 18498113] [MGI Ref ID J:136394]
Araki T; Chan G; Newbigging S; Morikawa L; Bronson RT; Neel BG. 2009. Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation. Proc Natl Acad Sci U S A 106(12):4736-41. [PubMed: 19251646] [MGI Ref ID J:147154]
Arenkiel BR; Tvrdik P; Gaufo GO; Capecchi MR. 2004. Hoxb1 functions in both motoneurons and in tissues of the periphery to establish and maintain the proper neuronal circuitry. Genes Dev 18(13):1539-52. [PubMed: 15198977] [MGI Ref ID J:91364]
Baquet ZC; Bickford PC; Jones KR. 2005. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J Neurosci 25(26):6251-9. [PubMed: 15987955] [MGI Ref ID J:99291]
Barbosa AC; Funato N; Chapman S; McKee MD; Richardson JA; Olson EN; Yanagisawa H. 2007. Hand transcription factors cooperatively regulate development of the distal midline mesenchyme. Dev Biol 310(1):154-68. [PubMed: 17764670] [MGI Ref ID J:128020]
Beppu H; Malhotra R; Beppu Y; Lepore JJ; Parmacek MS; Bloch KD. 2009. BMP type II receptor regulates positioning of outflow tract and remodeling of atrioventricular cushion during cardiogenesis. Dev Biol 331(2):167-75. [PubMed: 19409885] [MGI Ref ID J:150767]
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Chai Y; Jiang X; Ito Y; Bringas P; Han J; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis Development 127(8):1671-9. [PubMed: 10725243] [MGI Ref ID J:61091]
Chang CP; Stankunas K; Shang C; Kao SC; Twu KY; Cleary ML. 2008. Pbx1 functions in distinct regulatory networks to pattern the great arteries and cardiac outflow tract. Development 135(21):3577-86. [PubMed: 18849531] [MGI Ref ID J:141111]
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Chen CL; Broom DC; Liu Y; de Nooij JC; Li Z; Cen C; Samad OA; Jessell TM; Woolf CJ; Ma Q. 2006. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron 49(3):365-77. [PubMed: 16446141] [MGI Ref ID J:106971]
Chen H; McCaffery JM; Chan DC. 2007. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130(3):548-62. [PubMed: 17693261] [MGI Ref ID J:132329]
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Choi M; Stottmann RW; Yang YP; Meyers EN; Klingensmith J. 2007. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circ Res 100(2):220-8. [PubMed: 17218603] [MGI Ref ID J:133691]
Choudhary B; Ito Y; Makita T; Sasaki T; Chai Y; Sucov HM. 2006. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol 289(2):420-9. [PubMed: 16332365] [MGI Ref ID J:104325]
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Dietrich P; Shanmugasundaram R; Shuyu E; Dragatsis I. 2009. Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages. Hum Mol Genet 18(1):142-50. [PubMed: 18838463] [MGI Ref ID J:143295]
Druckenbrod NR; Epstein ML. 2009. Age-dependent changes in the gut environment restrict the invasion of the hindgut by enteric neural progenitors. Development 136(18):3195-203. [PubMed: 19700623] [MGI Ref ID J:152317]
Dudas M; Kim J; Li WY; Nagy A; Larsson J; Karlsson S; Chai Y; Kaartinen V. 2006. Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol 296(2):298-314. [PubMed: 16806156] [MGI Ref ID J:119289]
Dudas M; Sridurongrit S; Nagy A; Okazaki K; Kaartinen V. 2004. Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells. Mech Dev 121(2):173-82. [PubMed: 15037318] [MGI Ref ID J:90453]
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Foster K; Sheridan J; Veiga-Fernandes H; Roderick K; Pachnis V; Adams R; Blackburn C; Kioussis D; Coles M. 2008. Contribution of neural crest-derived cells in the embryonic and adult thymus. J Immunol 180(5):3183-9. [PubMed: 18292542] [MGI Ref ID J:131558]
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Gitler AD; Zhu Y; Ismat FA; Lu MM; Yamauchi Y; Parada LF; Epstein JA. 2003. Nf1 has an essential role in endothelial cells. Nat Genet 33(1):75-9. [PubMed: 12469121] [MGI Ref ID J:80323]
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Guo C; Qiu HY; Huang Y; Chen H; Yang RQ; Chen SD; Johnson RL; Chen ZF; Ding YQ. 2007. Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice. Development 134(2):317-25. [PubMed: 17166916] [MGI Ref ID J:117035]
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Huang X; Goudy SL; Ketova T; Litingtung Y; Chiang C. 2008. Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn 237(10):3079-3087. [PubMed: 18816854] [MGI Ref ID J:139635]
Huang X; Ketova T; Fleming JT; Wang H; Dey SK; Litingtung Y; Chiang C. 2009. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development 136(15):2535-43. [PubMed: 19570847] [MGI Ref ID J:152851]
Ito Y; Yeo JY; Chytil A; Han J; Bringas P Jr; Nakajima A; Shuler CF; Moses HL; Chai Y. 2003. Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development 130(21):5269-80. [PubMed: 12975342] [MGI Ref ID J:86042]
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Ivanova A; Signore M; Caro N; Greene ND; Copp AJ; Martinez-Barbera JP. 2005. In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A. Genesis 43(3):129-35. [PubMed: 16267821] [MGI Ref ID J:103417]
Iwao K; Inatani M; Matsumoto Y; Ogata-Iwao M; Takihara Y; Irie F; Yamaguchi Y; Okinami S; Tanihara H. 2009. Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling. J Clin Invest 119(7):1997-2008. [PubMed: 19509472] [MGI Ref ID J:152572]
Jacob J; Ferri AL; Milton C; Prin F; Pla P; Lin W; Gavalas A; Ang SL; Briscoe J. 2007. Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci 10(11):1433-9. [PubMed: 17922007] [MGI Ref ID J:128441]
Jaskoll T; Zhou YM; Chai Y; Makarenkova HP; Collinson JM; West JD; Hajihosseini MK; Lee J; Melnick M. 2002. Embryonic Submandibular Gland Morphogenesis: Stage-Specific Protein Localization of FGFs, BMPs, Pax6 and Pax9 in Normal Mice and Abnormal SMG Phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) Mice. Cells Tissues Organs 170(2-3):83-98. [PubMed: 11731698] [MGI Ref ID J:74539]
Jeong J; Mao J; Tenzen T; Kottmann AH; McMahon AP. 2004. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 18(8):937-51. [PubMed: 15107405] [MGI Ref ID J:89445]
Jia Q; McDill BW; Li SZ; Deng C; Chang CP; Chen F. 2007. Smad signaling in the neural crest regulates cardiac outflow tract remodeling through cell autonomous and non-cell autonomous effects. Dev Biol 311(1):172-84. [PubMed: 17916348] [MGI Ref ID J:126324]
Jiang X; Rowitch DH; Soriano P; McMahon AP; Sucov HM. 2000. Fate of the mammalian cardiac neural crest. Development 127(8):1607-16. [PubMed: 10725237] [MGI Ref ID J:129696]
Johnson EM; Craig ET; Yeh HH. 2007. TrkB is necessary for pruning at the climbing fibre-Purkinje cell synapse in the developing murine cerebellum. J Physiol 582(Pt 2):629-46. [PubMed: 17463037] [MGI Ref ID J:140836]
Joseph NM; Mosher JT; Buchstaller J; Snider P; McKeever PE; Lim M; Conway SJ; Parada LF; Zhu Y; Morrison SJ. 2008. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 13(2):129-40. [PubMed: 18242513] [MGI Ref ID J:131914]
Kaartinen V; Dudas M; Nagy A; Sridurongrit S; Lu MM; Epstein JA. 2004. Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development 131(14):3481-90. [PubMed: 15226263] [MGI Ref ID J:90988]
Kao SC; Wu H; Xie J; Chang CP; Ranish JA; Graef IA; Crabtree GR. 2009. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science 323(5914):651-4. [PubMed: 19179536] [MGI Ref ID J:144171]
Katz SG; Williams A; Yang J; Fujiwara Y; Tsang AP; Epstein JA; Orkin SH. 2003. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc Natl Acad Sci U S A 100(24):14030-5. [PubMed: 14614148] [MGI Ref ID J:99745]
Kist R; Greally E; Peters H. 2007. Derivation of a mouse model for conditional inactivation of Pax9. Genesis 45(7):460-4. [PubMed: 17610273] [MGI Ref ID J:125026]
Klein OD; Lyons DB; Balooch G; Marshall GW; Basson MA; Peterka M; Boran T; Peterkova R; Martin GR. 2008. An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development 135(2):377-85. [PubMed: 18077585] [MGI Ref ID J:130572]
Ko SO; Chung IH; Xu X; Oka S; Zhao H; Cho ES; Deng C; Chai Y. 2007. Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol 312(1):435-47. [PubMed: 17964566] [MGI Ref ID J:128941]
Kolpakova-Hart E; Jinnin M; Hou B; Fukai N; Olsen BR. 2007. Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms. Dev Biol 309(2):273-84. [PubMed: 17698054] [MGI Ref ID J:124871]
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Luo Y; High FA; Epstein JA; Radice GL. 2006. N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev Biol 299(2):517-28. [PubMed: 17014840] [MGI Ref ID J:115264]
MacDonald ST; Bamforth SD; Chen CM; Farthing CR; Franklyn A; Broadbent C; Schneider JE; Saga Y; Lewandoski M; Bhattacharya S. 2008. Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res 79(3):448-57. [PubMed: 18440989] [MGI Ref ID J:137951]
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Matsumoto Y; Irie F; Inatani M; Tessier-Lavigne M; Yamaguchi Y. 2007. Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. J Neurosci 27(16):4342-50. [PubMed: 17442818] [MGI Ref ID J:121105]
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Merki E; Zamora M; Raya A; Kawakami Y; Wang J; Zhang X; Burch J; Kubalak SW; Kaliman P; Belmonte JC; Chien KR; Ruiz-Lozano P. 2005. Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A 102(51):18455-60. [PubMed: 16352730] [MGI Ref ID J:104700]
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Moenning A; Jager R; Egert A; Kress W; Wardelmann E; Schorle H. 2009. Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Mol Cell Biol 29(3):881-91. [PubMed: 19047372] [MGI Ref ID J:145520]
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Ting MC; Wu NL; Roybal PG; Sun J; Liu L; Yen Y; Maxson RE Jr. 2009. EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis. Development 136(5):855-64. [PubMed: 19201948] [MGI Ref ID J:146459]
Trokovic N; Trokovic R; Mai P; Partanen J. 2003. Fgfr1 regulates patterning of the pharyngeal region. Genes Dev 17(1):141-53. [PubMed: 12514106] [MGI Ref ID J:81179]
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Breeding & Husbandry When maintaining a live colony, these transgenic carriers may be bred to noncarrier (wildtype) siblings. The donating investigator reports that homozygous mice may be lethal as some offspring from transgenic carrier parents die around two months of age. Mating System Noncarrier x Hemizygote (Female x Male) 22-SEP-09 Diet Information LabDiet® 5K52/5K67
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
For Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice, Products & Services Conditions of Use
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.No Warranty
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
No Liability
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.