Strain Name:

B6.A-(D8Mit113)/Pgn

Stock Number:

007835

Availability:

Repository-Cryopreserved

Description

Strain Information

Type Congenic;
Specieslaboratory mouse
Background Strain C57BL/6J
Donor Strain C57BL/6J-Chr 8A/J/NaJ
H2 Haplotypeb

Description
This congenic interval includes the QTL Hdlq50. Mice heterozygous for Hdlq50A/J/Hdlq50C57BL/6J exhibit increased plasma high density lipoprotein (HDL) cholesterol levels.

Development
Using a marker assisted series of backcrosses, this congenic interval, defined by D8Mit113, was introgressed into C57BL/6J using the donor strain C57BL/6J-Chr 8A/J/NaJ (004386). The donor strain is a consomic carrying the A/J Chromosome 6 on a C57BL/6J background. The consomic was backcrossed in the laboratory of Dr. Beverly Paigen. This strain was donated to The Jackson Laboratory Repository in 2007 and was cryopreserved using sperm. Mice recovered from cryopreservation will be heterozyous for the congenic interval.

Related Strains

Strains carrying   Hdlq50A/J allele
007817   B6.A-(D8Mit236-D8Mit113)/Pgn
007839   B6.A-(D8Mit261-D8Mit211)/Pgn
007814   B6.A-(D8Mit65-D8Mit47)/Pgn
View Strains carrying   Hdlq50A/J     (3 strains)

Additional Web Information

Congenic Nomenclature

Phenotype

Phenotype Information

Research Applications

This mouse can be used to support research in many areas including:

Cardiovascular Research

Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)

Genes & Alleles

Gene & Allele Information

Gene Symbol and Name D8Mit113, DNA segment, Chr 8, Massachusetts Institute of Technology 113
Chromosome 8
Allele Symbol Hdlq50A/J
Allele Name A/J
Strain of OriginC57BL/6J-Chr 8/Na
Gene Symbol and Name Hdlq50, HDL QTL 50
Chromosome 8

Genotyping

Genotyping Information

This strain will not have a genotyping protocol or one is not currently available.

Helpful Links

Optimizing PCR Protocols

References

References

Additional References

Hdlq50A/J related

Stylianou IM; Tsaih SW; DiPetrillo K; Ishimori N; Li R; Paigen B; Churchill G. 2006. Complex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and F2 crosses. Genetics 174(2):999-1007. [PubMed: 16951076]  [MGI Ref ID J:114073]

Health & husbandry

Health & Colony Maintenance Information

Currently there no information available for this strain. This may be due to the supply level of this strain.

Purchasing information

Pricing, Supply Level & Notes, Controls, General Terms & Conditions

Pricing

Pricing for USA, Canada and Mexico shipping destinations             View   International   Pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $1900.00
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

Pricing for International shipping destinations             View   USA, Canada and Mexico   Pricing
Weeks of AgePrice*Gender
Cryorecovery Fee $2470.00
*Price(s) in US dollars ($)

Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes
  • Cryorecovery - Standard.
    The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
    One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 or 1-207-288-5845.

General Terms and Conditions

View JAX® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
Ordering and Purchasing Information

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Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
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