Strain Name: |
B6.A-(D8Mit261-D8Mit211)/Pgn |
|---|---|
Stock Number: |
007839 |
Availability: | Repository-Cryopreserved |
General Terms and Conditions |
| Genes & Alleles | D8Mit211; D8Mit261; Hdlq44; Hdlq44A/J; Hdlq50; Hdlq50A/J; ; |
Product Information
Strain Details
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Species laboratory mouse Background Strain C57BL/6J Donor Strain C57BL/6J-Chr 8A/J/NaJ H2 Haplotype b Strain Description
This congenic interval includes the QTL Hdlq44 and Hdlq50. A/J derived alleles at Hdlq44 and Hdlq50 affect plasma high density lipoprotein (HDL) cholesterol levels.Strain Development
Using a marker assisted series of backcrosses, this congenic interval, defined by D8Mit261-D8Mit211, was introgressed into C57BL/6J using the donor strain C57BL/6J-Chr 8A/J/NaJ (004386). The donor strain is a consomic carrying the A/J Chromosome 6 on a C57BL/6J background. The consomic was backcrossed in the laboratory of Dr. Beverly Paigen. This strain was donated to The Jackson Laboratory Repository in 2007 and was cryopreserved using sperm. Mice recovered from cryopreservation will be heterozyous for the congenic interval.
Gene & Allele Details
| Gene Symbol and Name | D8Mit211, DNA segment, Chr 8, Massachusetts Institute of Technology 211 | ||
|---|---|---|---|
| Chromosome | 8 | ||
| Gene Symbol and Name | D8Mit261, DNA segment, Chr 8, Massachusetts Institute of Technology 261 | ||
| Chromosome | 8 | ||
| Allele Symbol | Hdlq44A/J | ||
| Allele Name | A/J | ||
| Strain of Origin | A/J | ||
| Gene Symbol and Name | Hdlq44, HDL QTL 44 | ||
| Chromosome | 8 | ||
| Allele Symbol | Hdlq50A/J | ||
| Allele Name | A/J | ||
| Strain of Origin | C57BL/6J-Chr 8/Na | ||
| Gene Symbol and Name | Hdlq50, HDL QTL 50 | ||
| Chromosome | 8 | ||
Related Strains
Strains carrying Hdlq44A/J allele
007817 B6.A-(D8Mit236-D8Mit113)/Pgn 007836 B6.A-(D8Mit261-D8Mit236)/Pgn 007838 B6.A-(D8Mit65-D8Mit132)/Pgn 007814 B6.A-(D8Mit65-D8Mit47)/Pgn View Strains carrying Hdlq44A/J (4 strains)
007835 B6.A-(D8Mit113)/Pgn 007817 B6.A-(D8Mit236-D8Mit113)/Pgn 007814 B6.A-(D8Mit65-D8Mit47)/Pgn
Additional Web Information
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:
Cardiovascular Research
Research Tools
Genetics Research (Gene Mapping: Tools for QTL Mapping, Segregation and Linkage Analysis)
References
Additional ReferencesPrice and Supply Information
| Strain Name: | B6.A-(D8Mit261-D8Mit211)/Pgn |
| Stock Number: | 007839 |
Price Details
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Supply Details
| Standard Supply | Repository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
Cryorecovery - Standard. The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery. Cryorecovery to establish a Dedicated Supply for greater quantities of mice. |
| Licensing | See General Terms and Conditions below |
General Terms and Conditions
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The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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