Strain Name:

BXSB.129P2(Cg)-Tcratm1Mjo/TheoJ

Stock Number:

007848

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Availability:

Cryopreserved - Ready for recovery

BXSB-Tcrα-/- homozygotes lack αβ+ T cells and do not develop the spontaneous lupus symptoms normally associated with the BXSB recombinant inbred genetic background. These BXSB-Tcrα-/- mice may be useful for adoptive transfer experiments for studying the role of T cells in systemic autoimmunity and lupus.

Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Type Congenic; Mutant Strain; Targeted Mutation;
Additional information on Genetically Engineered and Mutant Mice.
Visit our online Nomenclature tutorial.
Additional information on Congenic nomenclature.
Specieslaboratory mouse
 
Donating Investigator Argyrios N Theofilopoulos,   The Scripps Research Institute

Description
Male mice on the BXSB recombinant inbred genetic background (see Stock No. 000740) develop spontaneous autoimmune disease closely resembling the human disease systemic lupus erythematosus (SLE), including moderate lymph node and spleen enlargement, hemolytic anemia, hypergammaglobulinemia, and immune complex glomerulonephritis. This autoimmune phenotype is associated with at least six non-MHC loci (the Y chromosome linked Yaa, Bxs1-4 on chromosome 1 and Bxs6 on chromosome 13) and defined by increased homeostatic proliferation of self-reactive T cells. Because these BXSB-Tcrα-/- mice are homozygous for the Tcrα targeted mutation, they lack αβ+ T cells and do not develop spontaneous lupus symptoms. These BXSB-Tcrα-/- mice may be useful for adoptive transfer experiments for studying the role of T cells in systemic autoimmunity and lupus.

Development
A targeting vector (isolated from a genomic library of embryonic BALB/c DNA) was designed to disrupt the Tcrα-C element C1 constant region of the gene with a neomycin cassette. This construct was electroporated into 129P2/OlaHsd-derived GK129 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric founders were bred to BALB/c to generate mutant mice. These mice were then crossed with C57BL/6 inbred mice in the laboratory of Dr. Michael J. Owen (Imperial Cancer Research Fund). Mice were then sent to Dr. Argyrios N. Theofilopoulos (The Scripps Research Institute) and subsequently backcrossed to their stocks of the BXSB recombinant inbred strain (BXSB/MpScr) for at least 6 generations prior to arrival at The Jackson Laboratory. Upon arrival, mutant mice were bred with the BXSB/MpJ recombinant inbred strain (Stock No. 000740) for at least one generation to establish the mutant colony.

Control Information

  Control
   000740 BXSB/MpJ
 
  Considerations for Choosing Controls

Related Strains

Strains carrying   Tcratm1Mjo allele
004444   NOD.129P2(C)-Tcratm1Mjo/DoiJ
View Strains carrying   Tcratm1Mjo     (1 strain)

Strains carrying other alleles of Tcra
005308   B10.Cg-H2d Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005895   B10.Cg-Thy1a H2d Tg(TcraCl1,TcrbCl1)1Shrm/J
002761   B10.Cg-Tg(TcrAND)53Hed/J
003147   B10.D2-Hc1 H2d H2-T18c/nSnJ-Tg(DO11.10)10Dlo/J
003199   B10.PL-H2u H2-T18a/(73NS)Sn-Tg(TCRA)B1Jg/J
002116   B6.129S2-Tcratm1Mom/J
022073   B6.Cg-Rag1tm1Mom Thy1a Tg(Tcra2C,Tcrb2C)1Dlo/J
008684   B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest/J
014550   B6.Cg-Thy1a Tg(TcraCWM5,TcrbCWM5)1807Wuth/J
005023   B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J
005655   B6.Cg-Tg(Tcra,Tcrb)3Ayr/J
008428   B6.Cg-Tg(Tcra,Tcrb)HRCAll/J
008429   B6.Cg-Tg(Tcra,Tcrb)HRVAll/J
008006   B6.Cg-Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/J
004194   B6.Cg-Tg(TcraTcrb)425Cbn/J
005236   B6.Cg-Tg(TcraY1,TcrbY1)416Tev/J
004554   B6.NOD-(D17Mit21-D17Mit10) Tg(TCRaAI4)1Dvs/DvsJ
002115   B6;129S2-Tcratm1Mom/J
004694   B6;D2-Tg(TcrLCMV)327Sdz/JDvsJ
002408   B6;SJL-Tg(TcrAND)53Hed/J
021880   BXSB.B6-Tg(TcraTcrb)1100Mjb/DcrJ
004364   C.Cg-Tcratm1Mom Tcrbtm1Mom/J
003303   C.Cg-Tg(DO11.10)10Dlo/J
002045   C.SJL-Tcrac/SlkJ
002047   C.SJL-Tcrba Tcrac/SlkJ
014639   C57BL/6-Tg(Cd4-TcraDN32D3)1Aben/J
011005   C57BL/6-Tg(H2-Kb-Tcra,-Tcrb)P25Ktk/J
006912   C57BL/6-Tg(Tcra2D2,Tcrb2D2)1Kuch/J
003831   C57BL/6-Tg(TcraTcrb)1100Mjb/J
005307   CBy.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
005922   CBy.Cg-Thy1a Tg(TcraCl1,TcrbCl1)1Shrm/J
005694   D1Lac.Cg-Tg(Tcra,Tcrb)24Efro/J
017314   NOD-Tg(TcraTcrb)2H6Lwn/J
006436   NOD.Cg-(Gpi1-D7Mit346)C57BL/6J Tg(TcraAI4)1Dvs/DvsJ
004257   NOD.Cg-Prkdcscid Tg(TcrLCMV)327Sdz/Dvs
004347   NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs/DvsJ
009377   NOD.Cg-Rag1tm1Mom Tg(TcraBDC12-4.1)10Jos Tg(TcrbBDC12-4.1)82Gse/J
005686   NOD.Cg-Thy1a Tg(TcraCl4,TcrbCl4)1Shrm/ShrmJ
004696   NOD.Cg-Tg(TcrLCMV)327Sdz/DvsJ
004460   NOD.Cg-Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/DoiJ
010526   NOD.Cg-Tg(TcraTcrbNY4.1)1Pesa/DvsJ
005868   NOD.Cg-Tg(TcraTcrbNY8.3)1Pesa/DvsJ
006303   NOD.FVB-Tg(TcraBDC12-4.1)10Jos/GseJ
004334   NOD/ShiLt-Tg(TcraAI4)1Dvs
018030   SJL.Cg-Tg(TcraTcrbVP2)1Bkim/J
002597   STOCK Tg(TcrHEL3A9)1Mmd/J
View Strains carrying other alleles of Tcra     (46 strains)

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI
      assigned by genotype

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Tcratm1Mjo/Tcra+

        NOD.129P2-Tcratm1Mjo
  • immune system phenotype
  • abnormal T cell physiology
    • unlike in wild-type controls no dual TCRA expressing cells are present   (MGI Ref ID J:108590)
  • decreased susceptibility to autoimmune diabetes
    • males and females are significantly protected from cyclophosphamide induced diabetes compared to wild-type controls   (MGI Ref ID J:108590)
    • marker analysis confirms that multiple susceptibility loci are entirely NOD derived   (MGI Ref ID J:108590)
  • hematopoietic system phenotype
  • abnormal T cell physiology
    • unlike in wild-type controls no dual TCRA expressing cells are present   (MGI Ref ID J:108590)

Tcratm1Mjo/Tcra+

        SJL.129P2-Tcratm1Mjo
  • immune system phenotype
  • *normal* immune system phenotype
    • no difference in the susceptibility to experimental autoimmune encephalomyelitis is detected compared to wild-type controls   (MGI Ref ID J:108590)

Tcratm1Mjo/Tcratm1Mjo

        involves: 129P2/OlaHsd * BALB/c
  • immune system phenotype
  • abnormal T cell morphology
    • alphabeta+ T cells are completely absent   (MGI Ref ID J:1292)
    • increased activated T cell number
      • on average 27% of the gamma-delta T cells are activated   (MGI Ref ID J:111129)
  • abnormal immune system organ morphology   (MGI Ref ID J:1292)
    • abnormal splenic cell ratio
      • elimination of alphabeta+ T cells is compensated for by an increase in splenic immunoglobulin positive cells (B cells) positive for IgM and IgD   (MGI Ref ID J:1292)
    • abnormal thymus cortex morphology
      • the cortices of thymi in nulls are greatly expanded and tightly packed with CD4+CD8+ cells   (MGI Ref ID J:1292)
    • abnormal thymus medulla morphology
      • no medullae anre discernible in mutant thymi   (MGI Ref ID J:1292)
    • small Peyer's patches
      • in mutants, these are smaller and shriveled in appearance compared to wild-type, being approximately half the size of controls   (MGI Ref ID J:1292)
  • increased B cell number
    • in spleens compared to heterozygous controls   (MGI Ref ID J:111129)
  • increased autoantibody level
    • about 50% of sera are reactive for mammalian cell proteins compared to only about 11% of sera from heterozygous controls   (MGI Ref ID J:111129)
    • reactivity in some mice is primarily against small nuclear ribonucleoproteins   (MGI Ref ID J:111129)
    • by 5 weeks of age about 50% of mice show IgG autoantibodies in more than one assay (anti-dsDNA, anti-nuclear antigens, and immunoblotting for antibodies to mammalian cell proteins)   (MGI Ref ID J:111129)
    • increased anti-nuclear antigen antibody level
      • more than 80% of sera are positive for anti-nuclear antigens although the degree of reactivity varies   (MGI Ref ID J:111129)
      • increased anti-double stranded DNA antibody level   (MGI Ref ID J:111129)
  • increased immunoglobulin level   (MGI Ref ID J:111129)
    • increased IgE level
      • in some mice compared to heterozygous controls   (MGI Ref ID J:111129)
    • increased IgG1 level
      • in some mice compared to heterozygous controls   (MGI Ref ID J:111129)
  • hematopoietic system phenotype
  • abnormal T cell morphology
    • alphabeta+ T cells are completely absent   (MGI Ref ID J:1292)
    • increased activated T cell number
      • on average 27% of the gamma-delta T cells are activated   (MGI Ref ID J:111129)
  • abnormal splenic cell ratio
    • elimination of alphabeta+ T cells is compensated for by an increase in splenic immunoglobulin positive cells (B cells) positive for IgM and IgD   (MGI Ref ID J:1292)
  • abnormal thymus cortex morphology
    • the cortices of thymi in nulls are greatly expanded and tightly packed with CD4+CD8+ cells   (MGI Ref ID J:1292)
  • abnormal thymus medulla morphology
    • no medullae anre discernible in mutant thymi   (MGI Ref ID J:1292)
  • increased B cell number
    • in spleens compared to heterozygous controls   (MGI Ref ID J:111129)
  • increased immunoglobulin level   (MGI Ref ID J:111129)
    • increased IgE level
      • in some mice compared to heterozygous controls   (MGI Ref ID J:111129)
    • increased IgG1 level
      • in some mice compared to heterozygous controls   (MGI Ref ID J:111129)

Tcratm1Mjo/Tcratm1Mjo

        involves: 129P2/OlaHsd
  • immune system phenotype
  • colitis
    • in specific pathogen free mice areas of the colonic mucosa with architectural disturbances also show marked neutrophilic infiltration   (MGI Ref ID J:37699)
    • inflammation is not detected in germ free or gnotobiotic mice   (MGI Ref ID J:37699)
  • decreased T cell proliferation
    • proliferation in response to stimulation with the mitogen Con A is reduced compared to heterozygous controls   (MGI Ref ID J:110898)
  • enlarged mesenteric lymph nodes
    • in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls   (MGI Ref ID J:110898)
  • enlarged spleen
    • in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls   (MGI Ref ID J:110898)
    • spleen hyperplasia
      • increase mean cell yield in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls   (MGI Ref ID J:110898)
  • increased T cell number
    • increase in the abundance of TCRB+ TCRA- cells in mice exposed to environmental antigens   (MGI Ref ID J:110898)
    • increased activated T cell number
      • a substantial proportion of the gamma-delta T cells in lymph organs of mice exposed to environmental antigens are activated   (MGI Ref ID J:110898)
    • increased gamma-delta T cell number
      • increase in gamma-delta T cells in the spleen, mesenteric lymph nodes, Peyer's patch lymph nodes and peripheral lymph nodes in mice exposed to environmental antigens compared to heterozygous controls   (MGI Ref ID J:110898)
      • a substantial proportion of the gamma-delta T cells are activated   (MGI Ref ID J:110898)
  • digestive/alimentary phenotype
  • abnormal colon morphology
    • in specific pathogen free mice areas of the colonic mucosa show hyperplasia, an increase in crypt fusion and crowding of the glands   (MGI Ref ID J:37699)
  • abnormal intestinal mucosa morphology
    • in specific pathogen free mice areas of the colonic mucosa show hyperplasia, an increase in crypt fusion and crowding of the glands   (MGI Ref ID J:37699)
    • however, colon morphology is similar to wild-type controls in germ free or gnotobiotic mice   (MGI Ref ID J:37699)
  • colitis
    • in specific pathogen free mice areas of the colonic mucosa with architectural disturbances also show marked neutrophilic infiltration   (MGI Ref ID J:37699)
    • inflammation is not detected in germ free or gnotobiotic mice   (MGI Ref ID J:37699)
  • diarrhea
    • occasionally seen in specific pathogen free mice   (MGI Ref ID J:37699)
  • rectal prolapse
    • occasionally seen in specific pathogen free mice   (MGI Ref ID J:37699)
  • nervous system phenotype
  • abnormal neuron proliferation
    • decrease in hippocampal neurogenesis   (MGI Ref ID J:170591)
  • hematopoietic system phenotype
  • decreased T cell proliferation
    • proliferation in response to stimulation with the mitogen Con A is reduced compared to heterozygous controls   (MGI Ref ID J:110898)
  • enlarged spleen
    • in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls   (MGI Ref ID J:110898)
    • spleen hyperplasia
      • increase mean cell yield in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls   (MGI Ref ID J:110898)
  • increased T cell number
    • increase in the abundance of TCRB+ TCRA- cells in mice exposed to environmental antigens   (MGI Ref ID J:110898)
    • increased activated T cell number
      • a substantial proportion of the gamma-delta T cells in lymph organs of mice exposed to environmental antigens are activated   (MGI Ref ID J:110898)
    • increased gamma-delta T cell number
      • increase in gamma-delta T cells in the spleen, mesenteric lymph nodes, Peyer's patch lymph nodes and peripheral lymph nodes in mice exposed to environmental antigens compared to heterozygous controls   (MGI Ref ID J:110898)
      • a substantial proportion of the gamma-delta T cells are activated   (MGI Ref ID J:110898)
  • cellular phenotype
  • abnormal neuron proliferation
    • decrease in hippocampal neurogenesis   (MGI Ref ID J:170591)

Tcratm1Mjo/Tcratm1Mjo

        involves: 129P2/OlaHsd * MRL
  • renal/urinary system phenotype
  • abnormal kidney morphology
    • develop glomerular, interstitial and sometimes perivascular lesions   (MGI Ref ID J:45448)
  • increased urine protein level
    • compared to age-matched B10.A mice   (MGI Ref ID J:45448)
  • homeostasis/metabolism phenotype
  • increased urine protein level
    • compared to age-matched B10.A mice   (MGI Ref ID J:45448)
View Research Applications

Research Applications
This mouse can be used to support research in many areas including:

Cancer Research
Toxicology
      xenograft/transplant host

Cell Biology Research
Signal Transduction

Immunology, Inflammation and Autoimmunity Research
Autoimmunity
      lupus erythematosus
      lupus erythematosus, control
Immunodeficiency
      T cell deficiency
      specific T cell deficiency
Immunodeficiency Associated with Other Defects
Intracellular Signaling Molecules
T Cell Receptor Signaling Defects

Research Tools
Cancer Research
      xenograft/transplant host
Genetics Research
      Tissue/Cell Markers
      Tissue/Cell Markers: transplantation marker for embryonic and adult tissue
Immunology, Inflammation and Autoimmunity Research
      T Cell Receptor Deficiency
      T cell deficiency
      T cell deficiency, xenograft/transplant host
Toxicology Research
      xenograft/transplant host

Tcratm1Mjo related

Hematological Research
Immunological Defects

Immunology, Inflammation and Autoimmunity Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers
Immunodeficiency
Inflammation
T Cell Receptor Signaling Defects

Research Tools
Cancer Research
      specific T cell deficiency

Genes & Alleles

Gene & Allele Information provided by MGI

 
Allele Symbol Tcratm1Mjo
Allele Name targeted mutation 1, Michael J Owen
Allele Type Targeted (knock-out)
Common Name(s) Calpha-; TCRalpha; TCRalpha KO; TCRalphae-; Tcralpha-;
Mutation Made By Michael Owen,   Imperial Cancer Research Fund
Strain of Origin129P2/OlaHsd
ES Cell Line NameGK129
ES Cell Line Strain129P2/OlaHsd
Gene Symbol and Name Tcra, T cell receptor alpha chain
Chromosome 14
Gene Common Name(s) Tcr alpha; Tcralpha;
Molecular Note The Tcra-C element C1 was disrupted by the insertion of a neomycin selection cassette. [MGI Ref ID J:1292]

Genotyping

Genotyping Information

Genotyping Protocols

Tcratm1Mjo STD PCR, Standard PCR


Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Lawson BR; Koundouris SI; Barnhouse M; Dummer W; Baccala R; Kono DH; Theofilopoulos AN. 2001. The role of alpha beta+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus. J Immunol 167(4):2354-60. [PubMed: 11490025]  [MGI Ref ID J:120153]

Additional References

Tcratm1Mjo related

Au-Yeung BB; Katzman SD; Fowell DJ. 2006. Cutting edge: Itk-dependent signals required for CD4+ T cells to exert, but not gain, Th2 effector function. J Immunol 176(7):3895-9. [PubMed: 16547221]  [MGI Ref ID J:129883]

Binstadt BA; Hebert JL; Ortiz-Lopez A; Bronson R; Benoist C; Mathis D. 2009. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A 106(39):16758-63. [PubMed: 19805369]  [MGI Ref ID J:153217]

Blyth K; Vaillant F; Hanlon L; Mackay N; Bell M; Jenkins A; Neil JC; Cameron ER. 2006. Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Res 66(4):2195-201. [PubMed: 16489021]  [MGI Ref ID J:106649]

Bosco N; Hung HC; Pasqual N; Jouvin-Marche E; Marche PN; Gascoigne NR; Ceredig R. 2006. Role of the T cell receptor alpha chain in the development and phenotype of naturally arising CD4+CD25+ T cells. Mol Immunol 43(3):246-54. [PubMed: 16199261]  [MGI Ref ID J:104864]

Bour-Jordan H; Salomon BL; Thompson HL; Santos R; Abbas AK; Bluestone JA. 2007. Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. J Immunol 179(2):1004-12. [PubMed: 17617592]  [MGI Ref ID J:131077]

Capone M; Cantarella D; Schumann J; Naidenko OV; Garavaglia C; Beermann F; Kronenberg M; Dellabona P; MacDonald HR; Casorati G. 2003. Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice. J Immunol 170(5):2390-8. [PubMed: 12594262]  [MGI Ref ID J:82014]

Cobaleda C; Jochum W; Busslinger M. 2007. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature 449(7161):473-7. [PubMed: 17851532]  [MGI Ref ID J:126362]

Coles MC; Veiga-Fernandes H; Foster KE; Norton T; Pagakis SN; Seddon B; Kioussis D. 2006. Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes. Proc Natl Acad Sci U S A 103(36):13457-62. [PubMed: 16938836]  [MGI Ref ID J:112903]

Correia-Neves M; Mathis D; Benoist C. 2001. A molecular chart of thymocyte positive selection. Eur J Immunol 31(9):2583-92. [PubMed: 11536156]  [MGI Ref ID J:115618]

Correia-Neves M; Waltzinger C; Mathis D; Benoist C. 2001. The shaping of the T cell repertoire. Immunity 14(1):21-32. [PubMed: 11163227]  [MGI Ref ID J:132246]

Corthay A; Nandakumar KS; Holmdahl R. 2001. Evaluation of the Percentage of Peripheral T Cells with Two Different T Cell Receptor alpha-Chains and of their Potential Role in Autoimmunity. J Autoimmun 16(4):423-9. [PubMed: 11437490]  [MGI Ref ID J:70152]

Crompton T; Gilmour KC; Owen MJ. 1996. The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86(2):243-51. [PubMed: 8706129]  [MGI Ref ID J:34462]

Di Santo JP; Aifantis I; Rosmaraki E; Garcia C; Feinberg J; Fehling HJ; Fischer A; von Boehmer H; Rocha B. 1999. The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development. J Exp Med 189(3):563-74. [PubMed: 9927518]  [MGI Ref ID J:52569]

Dianda L; Hanby AM; Wright NA; Sebesteny A; Hayday AC; Owen MJ. 1997. T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol 150(1):91-7. [PubMed: 9006326]  [MGI Ref ID J:37699]

Elliott JI. 1998. Selection of dual Valpha T cells. Eur J Immunol 28(7):2115-23. [PubMed: 9692880]  [MGI Ref ID J:49315]

Elliott JI; Altmann DM. 1995. Dual T cell receptor alpha chain T cells in autoimmunity. J Exp Med 182(4):953-9. [PubMed: 7561698]  [MGI Ref ID J:108590]

Elliott JI; Altmann DM. 1996. Non-obese diabetic mice hemizygous at the T cell receptor alpha locus are susceptible to diabetes and sialitis. Eur J Immunol 26(4):953-956. [PubMed: 8625995]  [MGI Ref ID J:32586]

Faulkner L; Cooper A; Fantino C; Altmann DM; Sriskandan S. 2005. The mechanism of superantigen-mediated toxic shock: not a simple Th1 cytokine storm. J Immunol 175(10):6870-7. [PubMed: 16272345]  [MGI Ref ID J:119695]

Feuerer M; Herrero L; Cipolletta D; Naaz A; Wong J; Nayer A; Lee J; Goldfine AB; Benoist C; Shoelson S; Mathis D. 2009. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15(8):930-9. [PubMed: 19633656]  [MGI Ref ID J:152186]

Fowell DJ; Shinkai K; Liao XC; Beebe AM; Coffman RL; Littman DR; Locksley RM. 1999. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity 11(4):399-409. [PubMed: 10549622]  [MGI Ref ID J:109489]

Furmanski AL; Saldana JI; Rowbotham NJ; Ross SE; Crompton T. 2012. Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte. Eur J Immunol 42(2):489-99. [PubMed: 22101858]  [MGI Ref ID J:179819]

Granucci F; Di Tota FP; Raimondi G; Citterio S; Rescigno M; Ricciardi-Castagnoli P. 2001. Autoreactive isotype-specific T cells determine B cell frequency. Eur J Immunol 31(1):215-24. [PubMed: 11265637]  [MGI Ref ID J:118406]

Hadeiba H; Locksley RM. 2003. Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity. J Immunol 170(11):5502-10. [PubMed: 12759427]  [MGI Ref ID J:109990]

He Q; Morillon YM 2nd; Spidale NA; Kroger CJ; Liu B; Sartor RB; Wang B; Tisch R. 2013. Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. J Immunol 191(12):5858-66. [PubMed: 24198282]  [MGI Ref ID J:207147]

Herlands RA; Christensen SR; Sweet RA; Hershberg U; Shlomchik MJ. 2008. T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells. Immunity 29(2):249-60. [PubMed: 18691914]  [MGI Ref ID J:139567]

Hirota K; Turner JE; Villa M; Duarte JH; Demengeot J; Steinmetz OM; Stockinger B. 2013. Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol 14(4):372-9. [PubMed: 23475182]  [MGI Ref ID J:194909]

Hoglund P; Mintern J; Waltzinger C; Heath W; Benoist C; Mathis D. 1999. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med 189(2):331-9. [PubMed: 9892615]  [MGI Ref ID J:52940]

Holland SJ; Bartok I; Attaf M; Genolet R; Luescher IF; Kotsiou E; Richard A; Wang E; White M; Coe DJ; Chai JG; Ferreira C; Dyson J. 2012. The T-cell receptor is not hardwired to engage MHC ligands. Proc Natl Acad Sci U S A 109(45):E3111-8. [PubMed: 23077253]  [MGI Ref ID J:191243]

Huang GJ; Smith AL; Gray DH; Cosgrove C; Singer BH; Edwards A; Sim S; Parent JM; Johnsen A; Mott R; Mathis D; Klenerman P; Benoist C; Flint J. 2010. A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. PLoS Biol 8(12):e1000561. [PubMed: 21179499]  [MGI Ref ID J:170591]

Hughes DP; Hayday A; Craft JE; Owen MJ; Crispe IN. 1995. T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice. J Exp Med 182(1):233-41. [PubMed: 7540652]  [MGI Ref ID J:26250]

Irla M; Hugues S; Gill J; Nitta T; Hikosaka Y; Williams IR; Hubert FX; Scott HS; Takahama Y; Hollander GA; Reith W. 2008. Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 29(3):451-63. [PubMed: 18799151]  [MGI Ref ID J:139647]

Jenkinson SR; Williams JA; Jeon H; Zhang J; Nitta T; Ohigashi I; Kruhlak M; Zuklys S; Sharrow S; Adams A; Granger L; Choi Y; Siebenlist U; Bishop GA; Hollander GA; Takahama Y; Hodes RJ. 2013. TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development. Proc Natl Acad Sci U S A 110(52):21107-12. [PubMed: 24324158]  [MGI Ref ID J:206133]

Karnowski A; Chevrier S; Belz GT; Mount A; Emslie D; D'Costa K; Tarlinton DM; Kallies A; Corcoran LM. 2012. B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1. J Exp Med 209(11):2049-64. [PubMed: 23045607]  [MGI Ref ID J:190912]

Katayama M; Ohmura K; Yukawa N; Terao C; Hashimoto M; Yoshifuji H; Kawabata D; Fujii T; Iwakura Y; Mimori T. 2013. Neutrophils are essential as a source of IL-17 in the effector phase of arthritis. PLoS One 8(5):e62231. [PubMed: 23671588]  [MGI Ref ID J:200527]

Kirberg J; Baron A; Jakob S; Rolink A; Karjalainen K; von Boehmer H. 1994. Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor. J Exp Med 180(1):25-34. [PubMed: 8006585]  [MGI Ref ID J:86429]

Kouskoff V; Korganow AS; Duchatelle V; Degott C; Benoist C; Mathis D. 1996. Organ-specific disease provoked by systemic autoimmunity. Cell 87(5):811-22. [PubMed: 8945509]  [MGI Ref ID J:36815]

LaBranche TP; Hickman-Brecks CL; Meyer DM; Storer CE; Jesson MI; Shevlin KM; Happa FA; Barve RA; Weiss DJ; Minnerly JC; Racz JL; Allen PM. 2010. Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse. Am J Pathol 177(3):1388-96. [PubMed: 20696780]  [MGI Ref ID J:163689]

Labrecque N; Whitfield LS; Obst R; Waltzinger C; Benoist C; Mathis D. 2001. How much TCR does a T cell need? Immunity 15(1):71-82. [PubMed: 11485739]  [MGI Ref ID J:70595]

Le Campion A; Gagnerault MC; Auffray C; Becourt C; Poitrasson-Riviere M; Lallemand E; Bienvenu B; Martin B; Lepault F; Lucas B. 2009. Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development. Blood 114(9):1784-93. [PubMed: 19561321]  [MGI Ref ID J:152255]

Luhder F; Chambers C; Allison JP; Benoist C; Mathis D. 2000. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc Natl Acad Sci U S A 97(22):12204-9. [PubMed: 11035773]  [MGI Ref ID J:109887]

Luhder F; Katz J; Benoist C; Mathis D. 1998. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med 187(3):379-87. [PubMed: 9449718]  [MGI Ref ID J:108722]

Maloy KJ; Burkhart C; Freer G; Rulicke T; Pircher H; Kono DH; Theofilopoulos AN; Ludewig B; Hoffmann-Rohrer U; Zinkernagel RM; Hengartner H. 1999. Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection. J Immunol 162(5):2867-74. [PubMed: 10072535]  [MGI Ref ID J:114743]

McPhee CG; Bubier JA; Sproule TJ; Park G; Steinbuck MP; Schott WH; Christianson GJ; Morse HC 3rd; Roopenian DC. 2013. IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol 191(9):4581-8. [PubMed: 24078696]  [MGI Ref ID J:206236]

Napolitano A; Pittoni P; Beaudoin L; Lehuen A; Voehringer D; Macdonald HR; Dellabona P; Casorati G. 2013. Functional Education of Invariant NKT Cells by Dendritic Cell Tuning of SHP-1. J Immunol 190(7):3299-308. [PubMed: 23427253]  [MGI Ref ID J:194522]

Peng SL; Cappadona J; McNiff JM; Madaio MP; Owen MJ; Hayday AC; Craft J. 1998. Pathogenesis of autoimmunity in alphabeta T cell-deficient lupus-prone mice. Clin Exp Immunol 111(1):107-16. [PubMed: 9472669]  [MGI Ref ID J:45448]

Peng SL; Madaio MP; Hughes DP; Crispe IN; Owen MJ; Wen L; Hayday AC; Craft J. 1996. Murine lupus in the absence of alpha beta T cells. J Immunol 156(10):4041-9. [PubMed: 8621947]  [MGI Ref ID J:32944]

Peng SL; McNiff JM; Madaio MP; Ma J; Owen MJ; Flavell RA; Hayday AC ; Craft J. 1997. alpha beta T cell regulation and CD40 ligand dependence in murine systemic autoimmunity. J Immunol 158(5):2464-70. [PubMed: 9036998]  [MGI Ref ID J:38492]

Pennington DJ; Silva-Santos B; Shires J; Theodoridis E; Pollitt C; Wise EL; Tigelaar RE; Owen MJ; Hayday AC. 2003. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol 4(10):991-8. [PubMed: 14502287]  [MGI Ref ID J:125582]

Pennington DJ; Silva-Santos B; Silberzahn T; Escorcio-Correia M; Woodward MJ; Roberts SJ; Smith AL; Dyson PJ; Hayday AC. 2006. Early events in the thymus affect the balance of effector and regulatory T cells. Nature 444(7122):1073-7. [PubMed: 17190001]  [MGI Ref ID J:117487]

Perona-Wright G; Mohrs K; Mayer KD; Mohrs M. 2010. Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J Immunol 184(2):615-23. [PubMed: 20018622]  [MGI Ref ID J:159399]

Philpott KL; Viney JL; Kay G; Rastan S; Gardiner EM; Chae S; Hayday AC; Owen MJ. 1992. Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science 256(5062):1448-52. [PubMed: 1604321]  [MGI Ref ID J:1292]

Ploquin MJ; Eksmond U; Kassiotis G. 2011. B cells and TCR avidity determine distinct functions of CD4+ T cells in retroviral infection. J Immunol 187(6):3321-30. [PubMed: 21841129]  [MGI Ref ID J:179252]

Raimondi G; Zanoni I; Citterio S; Ricciardi-Castagnoli P; Granucci F. 2006. Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence. J Immunol 176(7):4012-20. [PubMed: 16547236]  [MGI Ref ID J:129897]

Raimondi G; Zanoni I; Citterio S; Ricciardi-Castagnoli P; Granucci F. 2006. Induction of peripheral T cell tolerance by antigen-presenting B cells. II. Chronic antigen presentation overrules antigen-presenting B cell activation. J Immunol 176(7):4021-8. [PubMed: 16547237]  [MGI Ref ID J:129896]

Sant'Angelo DB; Janeway CA Jr. 2002. Negative selection of thymocytes expressing the D10 TCR. Proc Natl Acad Sci U S A 99(10):6931-6. [PubMed: 12011450]  [MGI Ref ID J:76534]

Scheu S; Stetson DB; Reinhardt RL; Leber JH; Mohrs M; Locksley RM. 2006. Activation of the integrated stress response during T helper cell differentiation. Nat Immunol 7(6):644-51. [PubMed: 16680145]  [MGI Ref ID J:112676]

Schmid CD; Stienekemeier M; Oehen S; Bootz F; Zielasek J; Gold R; Toyka KV; Schachner M; Martini R. 2000. Immune deficiency in mouse models for inherited peripheral neuropathies leads to improved myelin maintenance. J Neurosci 20(2):729-35. [PubMed: 10632602]  [MGI Ref ID J:59319]

Schumann J; Mycko MP; Dellabona P; Casorati G; MacDonald HR. 2006. Cutting edge: influence of the TCR Vbeta domain on the selection of semi-invariant NKT cells by endogenous ligands. J Immunol 176(4):2064-8. [PubMed: 16455960]  [MGI Ref ID J:129129]

Seach N; Guerri L; Le Bourhis L; Mburu Y; Cui Y; Bessoles S; Soudais C; Lantz O. 2013. Double-positive thymocytes select mucosal-associated invariant T cells. J Immunol 191(12):6002-9. [PubMed: 24244014]  [MGI Ref ID J:207116]

Shameli A; Clemente-Casares X; Wang J; Santamaria P. 2011. Development of memory-like autoregulatory CD8+ T cells is CD4+ T cell dependent. J Immunol 187(6):2859-66. [PubMed: 21824864]  [MGI Ref ID J:179264]

Solomon S; Kolb C; Mohanty S; Jeisy-Walder E; Preyer R; Schollhorn V; Illges H. 2002. Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35). Eur J Immunol 32(3):644-51. [PubMed: 11857338]  [MGI Ref ID J:115361]

Tritt M; Sgouroudis E; d'Hennezel E; Albanese A; Piccirillo CA. 2008. Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes 57(1):113-23. [PubMed: 17928397]  [MGI Ref ID J:132415]

Ueno A; Cho S; Cheng L; Wang J; Hou S; Nakano H; Santamaria P; Yang Y. 2007. Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. Diabetes 56(6):1686-93. [PubMed: 17360980]  [MGI Ref ID J:126514]

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Wallberg M; Wong FS; Green EA. 2011. An islet-specific pulse of TGF-(beta) abrogates CTL function and promotes (beta) cell survival independent of Foxp3+ T cells. J Immunol 186(4):2543-51. [PubMed: 21217013]  [MGI Ref ID J:169173]

Wang J; Tsai S; Han B; Tailor P; Santamaria P. 2012. Autoantigen recognition is required for recruitment of IGRP(206-214)-autoreactive CD8+ T cells but is dispensable for tolerance. J Immunol 189(6):2975-84. [PubMed: 22908330]  [MGI Ref ID J:190235]

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Health & husbandry

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Colony Maintenance

Breeding & HusbandryWhen maintaining a live colony, homozygous mice may be bred together. The appropriate strain control for these mice is BXSB/MpJ (Stock No. 000740).

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls


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Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2085.00
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

Pricing for International shipping destinations View USA Canada and Mexico Pricing

Cryopreserved

Cryopreserved Mice - Ready for Recovery

Price (US dollars $)
Cryorecovery* $2710.50
Animals Provided

At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Supply Notes

  • Cryorecovery - Standard.
    Progeny testing is not required.
    The average number of mice provided from recovery of our cryopreserved strains is 10. The total number of animals provided, their gender and genotype will vary. We will fulfill your order by providing at least two pair of mice, at least one animal of each pair carrying the mutation of interest. Please inquire if larger numbers of animals with specific genotype and genders are needed. Animals typically ship between 11 and 14 weeks from the date of your order. If a second cryorecovery is needed in order to provide the minimum number of animals, animals will ship within 25 weeks. IMPORTANT NOTE: The genotypes of animals provided may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation, or that discussed in the strain description. Please inquire about possible genotypes which will be recovered for this specific strain. The Jackson Laboratory cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

    Cryorecovery to establish a Dedicated Supply for greater quantities of mice
    Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services, Tel: 1-800-422-6423 (from U.S.A., Canada or Puerto Rico only) or 1-207-288-5845 (from any location).

View USA Canada and Mexico Pricing View International Pricing

Standard Supply

Cryopreserved. Ready for recovery. Please refer to pricing and supply notes on the strain data sheet for further information.

Control Information

  Control
   000740 BXSB/MpJ
 
  Considerations for Choosing Controls
  Control Pricing Information for Genetically Engineered Mutant Strains.
 

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCTS" means biological materials supplied by JACKSON, and their derivatives. "RECIPIENT" means each recipient of MICE, PRODUCTS, or services provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than the internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE or PRODUCTS from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON's prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.


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