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- Description
- Phenotype
- Genes & alleles
- Genotyping
- Health & husbandry
- References
- Purchasing information
- Terms of Use
Description
Strain Information
Type Coisogenic; Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered Mutant Mice. Species laboratory mouse Generation +F2 (07-DEC-07) Development
The reeler 7 Jackson mutation arose spontaneously on the C57BL/6J inbred background at The Jackson Laboratory in 2006 and has been maintained on this background.
Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Related Strains
Strains carrying other alleles of Reln
005250 B6;129S2-Relnrl-4J/J 000235 B6C3Fe a/a-Relnrl/J 005744 C57BL/6J-Relnrl-6J/J View Strains carrying other alleles of Reln (3 strains)
Phenotype
Phenotype Information
assigned by genotype
Relnrl-7J/Relnrl-7J
C57BL/6J-Relnrl-7J/J
- nervous system phenotype
- abnormal cerebellar Purkinje cell layer (MGI Ref ID J:125130)
- the cerebellum is small with scrambled Purkinjie and granule cells
- abnormal cerebral cortex morphology (MGI Ref ID J:125130)
- abnormal stratification in cerebral cortex (MGI Ref ID J:125130)
- scrambled layering in the cortex
- abnormal hippocampus morphology (MGI Ref ID J:125130)
- neurons of the hippocamnpal gyrus are scattered in irregular wavy layers
- small cerebellum (MGI Ref ID J:125130)
- behavior/neurological phenotype
- abnormal gait (MGI Ref ID J:125130)
- ataxia (MGI Ref ID J:125130)
- by 2 weeks of age honozygotes lean side-to-side as they walk
- impaired balance (MGI Ref ID J:125130)
- honozygotes are unable to keep their hindquarters upright and they frequently fall on their side
- life span-post-weaning/aging
- premature death (MGI Ref ID J:125130)
- homozygotes have not lived to adulthood
This mouse can be used to support research in many areas including:Relnrl-7J related
Mouse/Human Gene Homologs
autosomal recessive lissencephaly
Neurobiology Research
Ataxia (Movement) Defects
Cerebellar Defects
Cortical Defects
Genes & Alleles
Gene & Allele Information
| Allele Symbol | Relnrl-7J | ||
|---|---|---|---|
| Allele Name | reeler 7 Jackson | ||
| Allele Type | Spontaneous | ||
| Strain of Origin | C57BL/6J | ||
| Gene Symbol and Name | Reln, reelin | ||
| Chromosome | 5 | ||
| Gene Common Name(s) | PRO1598; RL; Reelen; reeler; rl; | ||
| Molecular Note | This mutation was shown to be an allele of this gene by complementation testing to the original reeler mutation. | ||
Genotyping
Genotyping Information
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
References
References
Selected Reference(s)
Harris B; Ward-Bailey P; Johnson K; Bronson R. 2007. Reeler 7 Jackson, a new mutation in the reelin gene MGI Direct Data Submission :. [MGI Ref ID J:125130]
Purchasing information
Pricing, Supply Level & Notes, Controls, General Terms & Conditions
Pricing
| Pricing for USA, Canada and Mexico shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $164.70 Female or Male Heterozygous for Relnrl-7J $203.30 Female or Male Homozygous for Relnrl-7J *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $329.40 Heterozygous for Relnrl-7J x Heterozygous for Relnrl-7J tested $284.00 Heterozygous or Wild-type for Relnrl-7J - +/? x Heterozygous or Wild-type for Relnrl-7J - +/? untested
Additional Supply Details
| Supply Notes |
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| Pricing for International shipping destinations |
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Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $214.20 Female or Male Heterozygous for Relnrl-7J $264.30 Female or Male Homozygous for Relnrl-7J *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $428.30 Heterozygous for Relnrl-7J x Heterozygous for Relnrl-7J tested $369.20 Heterozygous or Wild-type for Relnrl-7J - +/? x Heterozygous or Wild-type for Relnrl-7J - +/? untested
Additional Supply Details
| Supply Notes |
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Supply Details
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
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| Supply Notes |
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Control Information
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
General Terms and Conditions
See Terms of Use
The Jackson Laboratory's Genotype Promise
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.Ordering and Purchasing Information
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JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form
Terms of Use
Terms of Use
General Terms and Conditions
Contact information
General inquiries
Contracts Administration
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
JAX® Mice & Services Conditions of Use
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