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General Terms and Conditions

Strain Common Names	B6.K2;
Genes & Alleles	H2;   Ped;   ;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Major Histocompatibility Congenic Type JAX® GEMM® Strain - Mutant Strain Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Background Strain C57BL/6J Donor Strain B6.AK-H2k; B6.A-H2-T18a H2 Haplotype b4 Generation N20+F?+F1 (27-FEB-08)

Appearance
black
Related Genotype: a/a

Important Note
This C57BL/6 strain is homozygous for the age related hearing loss mutation Cdh23^ahl, which on this background causes progressive hearing loss with onset after 10 months of age.

Strain Description
The Qa2 or Ped complex includes four similar genes. The functional (Qa2^positive) and null (Qa2^negative) alleles correlate with the rate of preimplantation embryo development such that Qa2^positive mice are characterized by the fast Ped phenotype and Qa2^negative mice, which do not express the QA2 antigen, are characterized by the slow Ped phenotype. This strain, commonly known as B6.K2, is fast Ped or Qa2^positive. B6.K2 mice were developed to provide a control for B6.K1 mice (Stock No. 007958). (Warner CM, 1993; Watkins A, 2006)

Strain Development
This H2 congenic was developed in the mid-1970s by Dr. Lorraine Flaherty through intercross and backcross of the congenic strains, B6.A-H2-T18^a and B6.AK-H2^k. The H2^b4 haplotype, commonly described as B6.K2, consists of K^b, D^b, Qa2^positive and Tla^b. This strain serves as a control for (Stock No. 007958) B6.Cg-H2^b3/FlaCmwJ (B6.K1) which is Qa2^negative. Both strains have been backcrossed to C57BL/6 for more than 20 generations. Mice from Dr. Flaherty's colony were sent to Dr. Carol Warner at Northeastern University in 1985 and maintained as sibling matings. The colony was donated to the Repository in 2007.

Gene & Allele Details

Gene Symbol and Name		H2, histocompatibility-2, MHC
Chromosome		17
Gene Common Name(s)		H-2; MHC-II;
Gene Symbol and Name		Ped, preimplantation embryo development
Chromosome		17
Gene Common Name(s)		Qa-2 antigen;

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Additional Web Information

Congenic Nomenclature

Animal Health Reports

Room Number           AX12

Research Applications

This mouse can be used to support research in many areas including:

Immunology and Inflammation Research
CD Antigens, Antigen Receptors, and Histocompatibility Markers

Reproductive Biology Research

References

Selected Reference(s)

Flaherty L. 1976. The Tla region of the mouse: identification of a new serologically defined locus, Qa-2. Immunogenetics 3:533-539.  [MGI Ref ID J:12074]

Watkins A; Wilkins A; Osmond C; Warner CM; Comiskey M; Hanson M; Fleming TP. 2006. The influence of mouse Ped gene expression on postnatal development. J Physiol 571(Pt 1):211-20. [PubMed: 16269433]  [MGI Ref ID J:125255]

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Price and Supply Information

Strain Name:	B6.Cg-H2b4/FlaCmwJ
Stock Number:	007959

Price Details

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Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Mouse Mutant Resource collection. Genomic DNA is available for this strain from the Mouse DNA Resource.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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