Strain Name: |
B6.129P2-Sorl1Gt(Ex255)Byg/J |
|---|---|
Stock Number: |
007999 |
Availability: | Repository- Live |
General Terms and Conditions |
| Former Name |
B6.129P2-Sorl1Gt(pGT1tfr)1Ucd/J (Changed: 22-AUG-08
) |
| Genes & Alleles | Sorl1; Sorl1Gt(Ex255)Byg; |
Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Gene Trap Type JAX® GEMM® Strain - Mutant Strain Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Donating Investigator David Hui, University of Cincinnati Generation N7+F1 (27-APR-08) Strain Description
Mice that are homozygous for the gene-trapped allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The gene trap contains the reporter gene beta-geo and has been inserted into exon 47. The donating investigator reports that one year old mutant mice exhibit a higher incidence of diffuse immunoreactive beta-amyloid deposits when compared to wildtype littermate controls. This mutant mouse strain may be useful in studies of Alzheimer's disease.Strain Development
A gene trap vector, pGT1tfr, was electroporated into 129P2/OlaHsd derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice for 6 generations before arriving at The Jackson Laboratory. The mice were then backcrossed to C57BL/6J for one generation.
Mammalian Phenotype Terms assigned by genotype |
| Allele Symbol | Sorl1Gt(Ex255)Byg | ||
|---|---|---|---|
| Allele Name | gene trap Ex255, BayGenomics | ||
| Common Name(s) | LR-11; Sorl1Gt(pGT1tfr)1Ucd; | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Strain | 129 | ||
| Gene Symbol and Name | Sorl1, sortilin-related receptor, LDLR class A repeats-containing | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | 2900010L19Rik; AI596264; AW261561; C11orf32; FLJ21930; FLJ39258; LR11; LRP9; RGD619914; RIKEN cDNA 2900010L19 gene; SORLA; SorLA-1; expressed sequence AI596264; expressed sequence AW261561; gp250; mSorLA; | ||
| Molecular Note | A gene trap vector, pGT1tfr, was electroporated into 129P2/OlaHsd derived embryonic stem (ES) cells. [MGI Ref ID J:125747] | ||
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Sorl1Gt(pGT1tfr)1Ucd
| Breeding & Husbandry | When maintaining a live colony, these mice can be bred as homozygotes. |
|---|---|
| Diet Information | LabDiet® 5K52/5K67 |
Congenic Nomenclature
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
Room Number AX12
Neurobiology Research
Alzheimer's Disease
Selected Reference(s)
Additional ReferencesHui D; Greer T; Kodvawala A. 2007. Generation and description of gene trap mutation of Sorl1 MGI Direct Data Submission :. [MGI Ref ID J:125747]
| Strain Name: | B6.129P2-Sorl1Gt(Ex255)Byg/J |
| Stock Number: | 007999 |
IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection. |
| Licensing | See General Terms and Conditions below |
| Control Information | View Control Information in Strain Details. |
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