| |||||||||||
| Mice homozygous for this gene trapped allele exhibit a higher incidence of diffuse immunoreactive beta-amyloid deposits when compared to wildtype controls. This mutant mouse strain may be useful in studies of Alzheimer's disease. | |||||||||||
Former Names B6.129P2-Sorl1Gt(pGT1tfr)1Ucd/J (Changed: 22-AUG-08 ) Type Congenic; Gene Trap; Mutant Strain; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Additional information on Congenic nomenclature. Species laboratory mouse Generation N7+F1pN1 Donating Investigator David Hui, University of Cincinnati - GRI Description
Mice that are homozygous for the gene-trapped allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The gene trap contains the reporter gene beta-geo and has been inserted into exon 47. The donating investigator reports that one year old mutant mice exhibit a higher incidence of diffuse immunoreactive beta-amyloid deposits when compared to wildtype littermate controls. This mutant mouse strain may be useful in studies of Alzheimer's disease.Development
A gene trap vector, pGT1tfr, was electroporated into 129P2/OlaHsd derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice for 6 generations before arriving at The Jackson Laboratory. The mice were then backcrossed to C57BL/6J for one generation.
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.
View Mammalian Phenotype Terms
Mammalian Phenotype Terms
assigned by genotype
Sorl1Gt(Ex255)Byg/Sorl1Gt(Ex255)Byg
B6.129P2-Sorl1Gt(Ex255)Byg
- nervous system phenotype
- amyloid beta deposits (MGI Ref ID J:125747)
- at 1 year, mutants show higher incidence of diffuse beta-amyloid deposits in brain than found in wild-type littermates
- other phenotype
- amyloid beta deposits (MGI Ref ID J:125747)
- at 1 year, mutants show higher incidence of diffuse beta-amyloid deposits in brain than found in wild-type littermates
View Research Applications
Research Applications
This mouse can be used to support research in many areas including:
Neurobiology Research
Alzheimer's Disease
| Allele Symbol | Sorl1Gt(Ex255)Byg | ||
|---|---|---|---|
| Allele Name | gene trap Ex255, BayGenomics | ||
| Allele Type | Gene trapped | ||
| Common Name(s) | LR-11; Sorl1Gt(pGT1tfr)1Ucd; | ||
| Strain of Origin | 129P2/OlaHsd | ||
| ES Cell Line Strain | 129 | ||
| Gene Symbol and Name | Sorl1, sortilin-related receptor, LDLR class A repeats-containing | ||
| Chromosome | 9 | ||
| Gene Common Name(s) | 2900010L19Rik; AI596264; AW261561; C11orf32; FLJ21930; FLJ39258; LR11; LRP9; RGD619914; RIKEN cDNA 2900010L19 gene; SORLA; SorLA-1; expressed sequence AI596264; expressed sequence AW261561; gp250; mSorLA; | ||
| Molecular Note | A gene trap vector, pGT1tfr, was electroporated into 129P2/OlaHsd derived embryonic stem (ES) cells. [MGI Ref ID J:125747] | ||
Genotyping Protocols
Sorl1Gt(pGT1tfr)1Ucd, Standard PCR
Helpful Links
Genotyping resources and troubleshooting
Hui D; Greer T; Kodvawala A. 2007. Generation and description of gene trap mutation of Sorl1 MGI Direct Data Submission :. [MGI Ref ID J:125747]
Sorl1Gt(Ex255)Byg relatedRohe M; Carlo AS; Breyhan H; Sporbert A; Militz D; Schmidt V; Wozny C; Harmeier A; Erdmann B; Bales KR; Wolf S; Kempermann G; Paul SM; Schmitz D; Bayer TA; Willnow TE; Andersen OM. 2008. Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. J Biol Chem 283(21):14826-34. [PubMed: 18362153] [MGI Ref ID J:137577]
Stryke D; Kawamoto M; Huang CC; Johns SJ; King LA; Harper CA; Meng EC; Lee RE; Yee A; L'Italien L; Chuang PT; Young SG; Skarnes WC; Babbitt PC; Ferrin TE. 2003. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res 31(1):278-81. [PubMed: 12520002] [MGI Ref ID J:91812]
Colony Maintenance
Breeding & Husbandry When maintaining a live colony, these mice can be bred as homozygotes.
| Pricing for USA, Canada and Mexico shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $1900.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Pricing for International shipping destinations |
|
Animals Provided
Price (US dollars $) Cryorecovery Fee $2470.00 At least two mice that carry the mutation (if it is a mutant strain) will be provided. Their genotypes may not reflect those discussed in the strain description. Please inquire for possible genotypes and see additional details below.
| Standard Supply | Cryopreserved. Ready for recovery. Please refer to pricing and supply notes for further information. |
|---|---|
| Supply Notes |
|
| Control | ||
|---|---|---|
| 000664 C57BL/6J | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
Purchasing Information
JAX® Mice Orders
Surgical Services
Contact Information
Orders & Technical Support
Tel: 1-800-422-6423 or 1-207-288-5845
Fax: 1-207-288-6150
Technical Support Email Form
| phone: | 207-288-6470 |
| fax: | 207-288-6655 |
MICE, PRODUCTS AND SERVICES ARE PROVIDED “AS IS”. JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of mice, products or services, JACKSON will, at its option, provide credit or replacement for the mice or product received or the services provided.
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS or services, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. In purchasing or receiving MICE, PRODUCTS or services from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE and PRODUCTS are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or services. In addition, special terms and conditions of sale of certain MICE, PRODUCTS or services may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and services by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or services shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or services by JACKSON.