Go to JAX^® Mice Query Form

General Terms and Conditions

Former Name	B6.129P2-Sorl1Gt(pGT1tfr)1Ucd/J    (Changed: 22-AUG-08 )
Genes & Alleles	Sorl1;   Sorl1Gt(Ex255)Byg;

---

Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Type JAX® GEMM® Strain - Gene Trap Type JAX® GEMM® Strain - Mutant Strain Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Donating Investigator David Hui,   University of Cincinnati Generation N7+F1 (27-APR-08)

Strain Description
Mice that are homozygous for the gene-trapped allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. The gene trap contains the reporter gene beta-geo and has been inserted into exon 47. The donating investigator reports that one year old mutant mice exhibit a higher incidence of diffuse immunoreactive beta-amyloid deposits when compared to wildtype littermate controls. This mutant mouse strain may be useful in studies of Alzheimer's disease.

Strain Development
A gene trap vector, pGT1tfr, was electroporated into 129P2/OlaHsd derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice for 6 generations before arriving at The Jackson Laboratory. The mice were then backcrossed to C57BL/6J for one generation.

Mammalian Phenotype Terms assigned by genotype Sorl1Gt(Ex255)Byg/Sorl1Gt(Ex255)Byg         B6.129P2-Sorl1Gt(Ex255)Byg nervous system phenotype amyloid beta deposits (MGI Ref ID J:125747) at 1 year, mutants show higher incidence of diffuse beta-amyloid deposits in brain than found in wild-type littermates other phenotype amyloid beta deposits (MGI Ref ID J:125747) at 1 year, mutants show higher incidence of diffuse beta-amyloid deposits in brain than found in wild-type littermates

Gene & Allele Details

Allele Symbol		Sorl1Gt(Ex255)Byg
Allele Name		gene trap Ex255, BayGenomics
Common Name(s)		LR-11; Sorl1Gt(pGT1tfr)1Ucd;
Strain of Origin		129P2/OlaHsd
ES Cell Line Strain		129
Gene Symbol and Name		Sorl1, sortilin-related receptor, LDLR class A repeats-containing
Chromosome		9
Gene Common Name(s)		2900010L19Rik; AI596264; AW261561; C11orf32; FLJ21930; FLJ39258; LR11; LRP9; RGD619914; RIKEN cDNA 2900010L19 gene; SORLA; SorLA-1; expressed sequence AI596264; expressed sequence AW261561; gp250; mSorLA;
Molecular Note		A gene trap vector, pGT1tfr, was electroporated into 129P2/OlaHsd derived embryonic stem (ES) cells. [MGI Ref ID J:125747]

Control Information

	Control
	000664 C57BL/6J
Considerations for Choosing Controls

Genotyping Protocols

Sorl1^{Gt(pGT1tfr)1Ucd}

Colony Maintenance

Breeding & Husbandry	When maintaining a live colony, these mice can be bred as homozygotes.
Diet Information	LabDiet® 5K52/5K67

Additional Web Information

Congenic Nomenclature
Visit the Alzheimer's Disease Mouse Model Resource site for helpful information on Alzheimer's Disease and research resources.

Animal Health Reports

Room Number           AX12

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Alzheimer's Disease

References

Selected Reference(s)

Hui D; Greer T; Kodvawala A. 2007. Generation and description of gene trap mutation of Sorl1 MGI Direct Data Submission :.  [MGI Ref ID J:125747]

Additional References

---

Price and Supply Information

Strain Name:	B6.129P2-Sorl1Gt(Ex255)Byg/J
Stock Number:	007999

Price Details

IMPORTANT NOTE: Prices are based on shipping destination. To view prices, select your shipping destination.

• USA, Canada and Mexico
• International

*NO Shipping Destination selected!

 

Supply Details

Standard Supply	Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement.
Supply Notes	Usually shipped between four and eight weeks of age. This strain is included in the Induced Mutant Resource Colony collection.
Licensing	See General Terms and Conditions below
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

---

Ordering and Purchasing Information

      Purchasing Information
      JAX^® Mice Orders
      Surgical Services

Contact Information
Orders & Technical Support
Tel: 800.422.6423 or 207.288.5845
Fax: 207.288.6150
Technical Support Email Form

Go to JAX^® Mice Query Form