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Strain Common Names	DR3f;      NOD.Lc11f;
Genes & Alleles	D11Mit314;   D11Mit33;   Idd4;   ;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Background Strain NOD/ShiLtJ Donor Strain C57L/J Donating Investigator Marcia McDuffie,   U. of Virginia School of Medicine H2 Haplotype g7 Generation N6F10+F1 (30-JAN-08)

Appearance
albino
Related Genotype: A/A Tyr^c/Tyr^c

Strain Description
This NOD congenic strain, commonly referred to as NOD.Lc11f or DR3f, carries a small C57L/J derived congenic interval on Chromosome 11, D11Mit314 (51Mb) through D11Mit33 (81Mb) that encodes C57L/J derived Csf2 and part of Idd4 down to the overlap of Idd4.1 and Idd4.2. Stat5a, Stat5b, Stat3, candidate genes in the Idd4.4 region along with Idd4.1, 4.2 and Idd4.5 regions are of NOD origin. Csf2 production by macrophages is significantly lower than in macrophages of NOD mice. Stat5 phosphorylation levels from macrophages of NOD.Lc11f mice were significantly higher than the levels seen in C57L/J mice (Litherland et al, 2005). Diabetes incidence in females is reported to be about 44% compared to 70% in NOD control mice. (Davoodi-Semiromi et al, 2007).

This strain is useful to further study the role of Csf2 and to identify other Idd4 candidate genes and their role in autoimmune diabetes.

Strain Development
This NOD congenic stock (NOD.Lc11f, DR3f) contains a genomic segment from C57L/J introgressed into Chr. 11. Seven additional stocks (Stock No's 008054, 008055, 008056, 008057, 008058, 008059, and 008060) were developed from Stock No. 008053 through backcrossing to NOD once and selective breeding. This model, Stock No. 008057, contains a C57L/J congenic interval D11Mit314 (51Mb) through D11Mit33 (81Mb) encoding C57L/J derived Csf2 and part of the Idd4 down to the overlap of Idd4.1 and Idd4.2, while retaining NOD derived Stat5a/Stat5b/Stat3 alleles. In 2008, the Type 1 Diabetes Resource received this stock at N6F10.

Gene & Allele Details

Gene Symbol and Name		D11Mit314, DNA Segment, Chr 11, Massachusetts Institute of Technology 314
Chromosome		11
Gene Symbol and Name		D11Mit33, DNA segment, Chr 11, Massachusetts Institute of Technology 33
Chromosome		11
Gene Symbol and Name		Idd4, insulin dependent diabetes susceptibility 4
Chromosome		11
Gene Common Name(s)		Idd-4;

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ Non-MHC Congenics)

Immunology and Inflammation Research
Autoimmunity (Type 1 Diabetes)

Research Tools
Immunology and Inflammation Research

References

Selected Reference(s)

Davoodi-Semiromi A; McDuffie M; Litherland S; Clare-Salzler M. 2007. Truncated pStat5B is associated with the Idd4 locus in NOD mice. Biochem Biophys Res Commun 356(3):655-61. [PubMed: 17382905]  [MGI Ref ID J:121519]

Laloraya M; Davoodi-Semiromi A; Kumar GP; McDuffie M; She JX. 2006. Impaired Crkl expression contributes to the defective DNA binding of Stat5b in nonobese diabetic mice. Diabetes 55(3):734-41. [PubMed: 16505237]  [MGI Ref ID J:106850]

Litherland SA; Grebe KM; Belkin NS; Paek E; Elf J; Atkinson M; Morel L; Clare-Salzler MJ; McDuffie M. 2005. Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction. J Immunol 175(7):4561-5. [PubMed: 16177100]  [MGI Ref ID J:118951]

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Price and Supply Information

Strain Name:	NOD.L-(D11Mit314-D11Mit33)/McdfJ
Stock Number:	008057

 

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

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Supply Details

Standard Supply	Under Development for Distribution Colony
Supply Notes	This strain is included in the Type 1 Diabetes Repository collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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