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Strain Common Names	NOD.DR3i;      NOD.Lc11i;
Genes & Alleles	D11Mit314;   D11Mit325;   D11Mit339;   D11Mit42;   Idd4;   ;

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Product Information

Strain Details

Type JAX® GEMM® Strain - Congenic Additional information on JAX® GEMM® Strains. Mating System Homozygote x Homozygote         (Female x Male) Species laboratory mouse Donor Strain C57L/J Donating Investigator Marcia McDuffie,   U. of Virginia School of Medicine Generation N6F7+F1 (30-JAN-08)

Strain Description
This NOD congenic strain, commonly referred to as NOD.Lc11i or DR3i, carries two C57L/J derived congenic intervals on Chromosome 11, D11Mit314 (51Mb) through D11Mit339 (63Mb) and D11Mit325 ((86Mb) through D11Mit42 (112Mb) that encodes C57L/J derived Csf2 and Stat5a, Stat5b, Stat3. The donating investigator reports diabetes incidence in females to be 4% compared to 70% in NOD control mice (Davoodi-Semiromi et al. 2007).

This strain is useful to further study the roles of Csf2 and Stat5a, Stat5b, Stat3 in autoimmune diabetes.

Strain Development
This NOD congenic stock (NOD.Lc11i, DR3i) contains a genomic segment from C57L/J introgressed into Chr. 11. Seven additional stocks (Stock No's 008054, 008055, 008056, 008057, 008058, 008059, and 008060) were developed from Stock No. 008053 through backcrossing to NOD once followed by selective breeding. This model, Stock No. 008059, is a double congenic containing C57L/J congenic intervals D11Mit314 (51Mb) through D11Mit339 (63Mb) and D11Mit325 (99Mb) through DllMit42 (113Mb) encoding C57L/J derived Csf2 and from the Idd4.1 and Idd4.2 overlap through Stat5a/Stat5b/Stat3 alleles. In 2008, the Type 1 Diabetes Resource received this stock at N6F7.

Gene & Allele Details

Gene Symbol and Name		D11Mit42, DNA segment, Chr 11, Massachusetts Institute of Technology 42
Chromosome		11
Gene Symbol and Name		D11Mit314, DNA Segment, Chr 11, Massachusetts Institute of Technology 314
Chromosome		11
Gene Symbol and Name		D11Mit339, DNA Segment, Chr 11, Massachusetts Institute of Technology 339
Chromosome		11
Gene Symbol and Name		D11Mit325, DNA Segment, Chr 11, Massachusetts Institute of Technology 325
Chromosome		11
Gene Symbol and Name		Idd4, insulin dependent diabetes susceptibility 4
Chromosome		11
Gene Common Name(s)		Idd-4;

Control Information

	Control
	001976 NOD/ShiLtJ
Considerations for Choosing Controls

Colony Maintenance

Diet Information	LabDiet® 5K52/5K67

Additional Web Information

Congenic Nomenclature

Research Applications

This mouse can be used to support research in many areas including:

Diabetes and Obesity Research
Type 1 Diabetes (IDDM) (resistant)
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ Non-MHC Congenics)

Immunology and Inflammation Research
Autoimmunity (Type 1 Diabetes)

Research Tools
Immunology and Inflammation Research

References

Selected Reference(s)

Davoodi-Semiromi A; McDuffie M; Litherland S; Clare-Salzler M. 2007. Truncated pStat5B is associated with the Idd4 locus in NOD mice. Biochem Biophys Res Commun 356(3):655-61. [PubMed: 17382905]  [MGI Ref ID J:121519]

Laloraya M; Davoodi-Semiromi A; Kumar GP; McDuffie M; She JX. 2006. Impaired Crkl expression contributes to the defective DNA binding of Stat5b in nonobese diabetic mice. Diabetes 55(3):734-41. [PubMed: 16505237]  [MGI Ref ID J:106850]

McDuffie M. 2000. Derivation of diabetes-resistant congenic lines from the nonobese diabetic mouse. Clin Immunol 96(2):119-30. [PubMed: 10900159]  [MGI Ref ID J:63736]

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Price and Supply Information

Strain Name:	NOD.L-(D11Mit314-D11Mit339)(D11Mit325-D11Mit42)/McdfJ
Stock Number:	008059

 

This strain is currently Under Development for Distribution Colony.
To register your interest in this strain go to the Strain Interest Form.

Estimated Available for Sale Date:

Please note: Estimated available for sale dates are provided to keep customers better informed on strains under development. Please note that our Colony Managers routinely monitor the target date and edit it based on breeding performance and other factors. The length of time it takes to make a new strain available for sale depends on genotype, age, number of animals sent by the Donating Investigator, breeding performance, additional strain development (backcrossing, making homozygous), and anticipated demand for the strain/interest registered.

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Supply Details

Standard Supply	Under Development for Distribution Colony
Supply Notes	This strain is included in the Type 1 Diabetes Repository collection.
Licensing	See General Terms and Conditions below for Licensing and Use Restrictions
Control Information	View Control Information in Strain Details.

General Terms and Conditions

View JAX^® Mice & Services Conditions of Use.

For additional Licensing and Use Restrictions view the link(s) below:
- Use of MICE by companies or for-profit entities requires a license prior to shipping.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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