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| Stock No.'s 008053, 008054, 008055, 008056, 008057, 008058, 008059 and 008060, are viable, fertile and diabetes resistant. These NOD congenic strains are the result of crossing segments of C57L/J derived Chromosome 11 into the NOD/Bdc background. These strains are useful for identifying candidate genes within the Idd4 subloci. | |||||||||||
Type Congenic; Mutant Strain; Mating System Homozygote x Homozygote (Female x Male) Species laboratory mouse Background Strain NOD/ShiLtJ Donor Strain C57L/J H2 Haplotype g7 Generation N6F8+F1 (30-JAN-08) Donating Investigator Marcia McDuffie, U. of Virginia School of Medicine Appearance
albino
Related Genotype: A/A Tyrc/TyrcDescription
This NOD congenic strain, commonly referred to as NOD.Lc11j or DR3j carries Chromosome 11 alleles, D11Mit314 (51Mb) through D11Mit339 (63Mb) and D11Mit132 (86Mb) through D11Mit42 (113Mb) derived from C57L/J, which includes candidate gene Csf2 and Stat5a, Stat5b and Stat3. Diabetes incidence in this strain is reported to be about 12% in females compared to 70% in female NOD control mice. (Davoodi-Semiromi et al. 2007). This strain is useful to further study the role of Csf2, Stat5a, Stat5b and Stat3 in autoimmune diabetes; to identify additional candidate diabetes resistant genes and to positionally clone the Idd4 diabetes resistant loci.Development
This NOD congenic stock (NOD.Lc11j, DR3j) contains a genomic segment from C57L/J introgressed into Chr 11. Seven additional stocks (Stock No's 008054, 008055, 008056, 008057, 008058, 008059, and 008060) were developed from Stock No. 008053 through backcrossing to NOD once followed by selective breeding. This model, Stock No. 008060, is a double congenic containing C57L/J congenic intervals D11Mit314 (51Mb) through D11Mit339 (63Mb) and D11Mit132 (86Mb) through DllMit42 (113Mb) encoding C57L/J derived Csf2 and Stat5a/Stat5b/Stat3 while retaining NOD derived Idd4.1 and Idd4.2 alleles. In 2008, the Type 1 Diabetes Resource received this stock at N6F3.
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
Congenic Nomenclature
Research Applications
This mouse can be used to support research in many areas including:
Diabetes and Obesity Research
Type 1 Diabetes (IDDM) Analysis Strains (NOD/ShiLtJ Non-MHC Congenics)
Immunology and Inflammation Research
Autoimmunity (Type 1 Diabetes)
Inflammation
| Gene Symbol and Name | D11Mit42, DNA segment, Chr 11, Massachusetts Institute of Technology 42 | ||
|---|---|---|---|
| Chromosome | 11 | ||
| Gene Symbol and Name | D11Mit314, DNA Segment, Chr 11, Massachusetts Institute of Technology 314 | ||
| Chromosome | 11 | ||
| Gene Symbol and Name | D11Mit339, DNA Segment, Chr 11, Massachusetts Institute of Technology 339 | ||
| Chromosome | 11 | ||
| Gene Symbol and Name | D11Mit132, DNA segment, Chr 11, Massachusetts Institute of Technology 132 | ||
| Chromosome | 11 | ||
| Gene Symbol and Name | Idd4, insulin dependent diabetes susceptibility 4 | ||
| Chromosome | 11 | ||
| Gene Common Name(s) | Idd-4; | ||
This strain will not have a genotyping protocol or one is not currently available.
Helpful Links
Optimizing PCR Protocols
Davoodi-Semiromi A; McDuffie M; Litherland S; Clare-Salzler M. 2007. Truncated pStat5B is associated with the Idd4 locus in NOD mice. Biochem Biophys Res Commun 356(3):655-61. [PubMed: 17382905] [MGI Ref ID J:121519]
Animal Health Reports
Room Number AX11
Colony Maintenance
Diet Information LabDiet® 5K52/5K67
Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $54.00 Female or Male Homozygous *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $108.00 Homozygous x Homozygous
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
|
Weeks of Age Price* Gender Genotypes Provided Individual Mouse Price $70.20 Female or Male Homozygous *Price(s) in US dollars ($)
Pairs /Price* Pair Genotype $140.40 Homozygous x Homozygous
| Standard Supply | Repository-Live. A collection of over 1000 strains maintained as live colonies. Individual colonies are sized to meet current customer demand. Delivery for orders of 10 mice or less ranges on average from one to eight weeks; mice are generally shipped between four to six weeks of age with a maximum shipping age of ~nine weeks. Colony sizes do not generally support stringent age specifications for large volumes of mice; however custom orders and larger quantities of mice are easily arranged. Estimated ship dates for all orders provided within 48 hours of order placement. |
|---|---|
| Supply Notes |
|
| Control | ||
|---|---|---|
| 001976 NOD/ShiLtJ | ||
| Considerations for Choosing Controls | ||
| USA, Canada and Mexico - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
| International - Control Pricing Information for Genetically Engineered Mutant Strains. | ||
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