Description

The genotypes of the animals provided may not reflect those discussed in the strain description or the mating scheme utilized by The Jackson Laboratory prior to cryopreservation. Please inquire for possible genotypes for this specific strain.

Strain Information

Former Names B6(V)-Bhrd/J    (Changed: 22-JUN-09 ) B6(V)-Pafl/J    (Changed: 04-MAR-08 ) Type Mutant Strain; Spontaneous Mutation; Additional information on Genetically Engineered and Mutant Mice. Visit our online Nomenclature tutorial. Species laboratory mouse Generation N35+N2F6pN1 Generation Definitions

Description
Females heterozygous for the bad hair day mutation have patches of fur missing from the coat, male hemizygotes are almost bald, and female homozygotes are nearly as bald as hemizygous males. Hairs from heterozygous females are morphologically normal, while those from hemizygous males are short and thin. There is increased pigment in the hairs of both hemizygotes and heterozygotes.

Development
The bad hair day mutation arose spontaneously at The Jackson Laboratory in 2004 in the B6.V-Lep^ob/J strain when that strain was at generation N34. Two backcrosses were done to C57BL/6J and this strain has been maintained by sibling inbreeding heterozygous females and wildtype males or widltype females and hemizygous males since then.

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls

Phenotype

Phenotype Information

View Mammalian Phenotype Terms

Mammalian Phenotype Terms provided by MGI

      assigned by genotype

Bhrd/Bhrd

        B6(V)-Bhrd/GrsrJ

• integument phenotype
• abnormal hair growth   (MGI Ref ID J:127794)
• • sparse hair
    • homozygous females are almost as bald as hemizygous males   (MGI Ref ID J:127794)

Bhrd/Bhrd⁺

        B6(V)-Bhrd/GrsrJ

• integument phenotype
• abnormal coat appearance   (MGI Ref ID J:127794)
• • abnormal hair growth   (MGI Ref ID J:127794)
  • • focal hair loss
      • heterozygous females have patches of fur missing in the coat   (MGI Ref ID J:127794)

Bhrd/Y

        B6(V)-Bhrd/GrsrJ

• integument phenotype
• abnormal coat appearance   (MGI Ref ID J:127794)
• • abnormal hair growth   (MGI Ref ID J:127794)
  • • sparse hair
      • males appear almost bald   (MGI Ref ID J:127794)

View Research Applications

Research Applications

This mouse can be used to support research in many areas including:

Bhrd related

Dermatology Research
Skin and Hair Texture Defects

Developmental Biology Research
Skin and Hair Texture Defects

Genes & Alleles

Gene & Allele Information provided by MGI

Allele Symbol		Bhrd
Allele Name		bad hair day
Allele Type		Spontaneous
Strain of Origin		B6.Cg-Lepob/J
Gene Symbol and Name		Bhrd, bad hair day
Chromosome		X
Gene Common Name(s)		Pafl; patchy fur-like;
Molecular Note		This spontaneous mutation arose at The Jackson Laboratory in 2004.

Genotyping

Genotyping Information

Helpful Links

Genotyping resources and troubleshooting

References

References provided by MGI

Selected Reference(s)

Son Yong Karst; Patricia F. Ward-Bailey; Richard Samples; Kenneth R. Johnson; Leah Rae Donahue; Muriel T. Davisson. 2007. Bad hair day: a semidominant X-linked mutation affecting skin and hair. MGI Direct Data Submission :.  [MGI Ref ID J:127794]

Health & husbandry

Health & Colony Maintenance Information

Animal Health Reports

Production of mice from cryopreserved embryos or sperm occurs in a maximum barrier room, G200.

Pricing and Purchasing

Pricing, Supply Level & Notes, Controls

General Supply Notes

• View the complete collection of spontaneous mutants in the Mouse Mutant Resource.
• Genomic DNA is available for this strain from the Mouse DNA Resource.

Control Information

	Control
	Wild-type from the colony
Considerations for Choosing Controls
Control Pricing Information for Genetically Engineered Mutant Strains.

Important Note

Although this line has been backcrossed twice to select against the Lep^ob mutation that was in the founder, there is a small chance that the recessive Lep^ob mutation might still be segregating in this strain.

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

See Terms of Use tab for General Terms and Conditions

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX^® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX^® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX^® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

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