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Strain Name:

C57BL/6J-Brunol4Ff/Frk

Stock Number:

008131

Availability:

Repository-Cryopreserved

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General Terms and Conditions

Genes & Alleles   Brunol4;   Brunol4Ff;

Product Information

Strain Details

Type JAX® GEMM® Strain - Coisogenic
Additional information on JAX® GEMM® Strains.
Type JAX® GEMM® Strain - Transgenic
Specieslaboratory mouse
Mammalian Phenotype Terms assigned by genotype

Brunol4Ff/Brunol4+

        involves: C57BL/6J
  • behavior/neurological phenotype
  • hyperactivity (MGI Ref ID J:123744)
    • mice are slightly hyperactive
  • seizures (MGI Ref ID J:123744)
    • at 3 months of age, mice exhibit seizures
    • seizures range in severity from milder muscle twitching in the face and neck, forelimb clonus, and salivation to rearing and falling, myoclonic jerks, and arching of the back and tail
    • seizures are often followed by running-bouncing phase with occasional tonic-clonic hinbdlimb extension
    • incidence of seizures decrease with age
    • electrically induced seizures (MGI Ref ID J:123744)
      • at 7 weeks, mice have a reduce threshold to electroconvulsive seizure
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:123744)
    • mice are slightly smaller at weaning
  • increased body weight (MGI Ref ID J:123744)
    • by week 35 mice are 10% heavier than wild type mice
    • increased weight gain (MGI Ref ID J:123744)
      • mice exhibit a late-onset weight gain resulting in 10% heavier weight compared to wild type mice
  • nervous system phenotype
  • seizures (MGI Ref ID J:123744)
    • at 3 months of age, mice exhibit seizures
    • seizures range in severity from milder muscle twitching in the face and neck, forelimb clonus, and salivation to rearing and falling, myoclonic jerks, and arching of the back and tail
    • seizures are often followed by running-bouncing phase with occasional tonic-clonic hinbdlimb extension
    • incidence of seizures decrease with age
    • electrically induced seizures (MGI Ref ID J:123744)
      • at 7 weeks, mice have a reduce threshold to electroconvulsive seizure

Brunol4Ff/Brunol4Ff

        involves: C57BL/6J
  • lethality-prenatal/perinatal
  • neonatal lethality (MGI Ref ID J:123744)
    • most mice die within the first day of birth
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:123744)
    • only 1.1% of mice survive until 4 weeks on a C57BL/6 background
  • behavior/neurological phenotype
  • tonic-clonic seizures (MGI Ref ID J:123744)
    • mice that survive for more than 6 months exhibit limbic and tonic-clonic seizures
  • growth/size phenotype
  • decreased body size (MGI Ref ID J:123744)
    • mice that survive for more than 6 months are smaller in size compared to wild type mice
  • nervous system phenotype
  • tonic-clonic seizures (MGI Ref ID J:123744)
    • mice that survive for more than 6 months exhibit limbic and tonic-clonic seizures

The following phenotype information may relate to a genetic background differing from this JAX® Mice strain.

Brunol4Ff/Brunol4Ff

        involves: C3H/HeJ * C57BL/6J
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:123744)
    • only 2.2% of mice survive until 4 weeks on a C3H/HeJ, C57BL/6 mixed background

Brunol4Ff/Brunol4Ff

        involves: C57BL/6J * EL/EFrkJ
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:123744)
    • only 3.6% of mice survive until 4 weeks on a EL/EFrkJ, C57BL/6 mixed background

Brunol4Ff/Brunol4Ff

        involves: C57BL/6J * FVB/NJ
  • behavior/neurological phenotype
  • absence seizures (MGI Ref ID J:123744)
    • mice experience exhibit spike-wave discharges on a FVB/NJ, C57BL/6 background but not a 129S1, C57BL/6 mixed background
  • nervous system phenotype
  • absence seizures (MGI Ref ID J:123744)
    • mice experience exhibit spike-wave discharges on a FVB/NJ, C57BL/6 background but not a 129S1, C57BL/6 mixed background
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:123744)
    • only 5.6% of mice survive until 4 weeks on a FVB/NJ, C57BL/6 mixed background

Brunol4Ff/Brunol4Ff

        involves: A/J * C57BL/6J
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:123744)
    • only 5.8% of mice survive until 4 weeks on a A/J, C57BL/6 mixed background

Brunol4Ff/Brunol4Ff

        involves: BALB/cByJ * C57BL/6J
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:123744)
    • only 7.4% of mice survive until 4 weeks on a BALB/cByJ, C57BL/6 mixed background

Brunol4Ff/Brunol4Ff

        involves: 129S1/Sv * C57BL/6J
  • life span-post-weaning/aging
  • premature death (MGI Ref ID J:123744)
    • only 8.2% of mice survive until 4 weeks on a 129S1, C57BL/6 mixed background

Gene & Allele Details

Allele Symbol Brunol4Ff
Allele Name frequent flyer
Common Name(s) Ff;
Strain of OriginC57BL/6J
Gene Symbol and Name Brunol4, bruno-like 4, RNA binding protein (Drosophila)
Chromosome 18
Gene Common Name(s) A230070D14Rik; BRUNOL-4; Brul4; C130060B05Rik; CELF4; RIKEN cDNA A230070D14 gene; RIKEN cDNA C130060B05 gene;
Molecular Note Multiple copies (>3) of a non-expressing transgene inserted into the first intron of Brunol4 gene. In total RNA samples from newborn mice, no Brunol4 transcript was detected in homozygotes and approximately 45% reduction was seen in heterozygotes. [MGI Ref ID J:123744]

Research Applications

This mouse can be used to support research in many areas including:

Neurobiology Research
Epilepsy

References

Selected Reference(s)

Adelstein S; Pritchard-Briscoe H; Anderson TA; Crosbie J; Gammon G; Loblay RH; Basten A; Goodnow CC. 1991. Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science 251(4998):1223-5. [PubMed: 1900950]  [MGI Ref ID J:127344]

Additional References

Price and Supply Information

Strain Name: C57BL/6J-Brunol4Ff/Frk
Stock Number: 008131

Price Details

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Supply Details

Standard SupplyRepository-Cryopreserved. Must Be Recovered. Please refer to pricing and supply notes for further information.
Supply Notes Cryorecovery - Standard.
The recovery process begins when a signed agreement form is returned to the Customer Service Department after order placement. Although results vary by strain, at least two males and two females (two pairs) will be provided, typically within 15 weeks of our receipt of the signed agreement form. If the first recovery attempt is unsuccessful or only one pair is recovered, a second recovery will be done, extending the delivery time to approximately 25 weeks. At least one member of each pair will be of known genotype and will carry the mutation if it is a mutant strain. Please note that pairs may not reflect the mating scheme utilized by The Jackson Laboratory prior to cryopreservation of the strain. Mating schemes are sometimes modified for successful cryopreservation. Price represents a repository maintenance fee, which includes the cost of recovery of the strain from the cryopreservation resource and the periodic replacement of the frozen embryos used for recovery.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice.
One to two pairs will be recovered to establish a Dedicated Supply of mice. Price by quotation. For more information on Dedicated Supply, please contact JAX® Services: Tel: 1-800-422-6423 or 1-207-288-5845; Email: jaxservices@jax.org.

LicensingSee General Terms and Conditions below  

General Terms and Conditions

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The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.
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